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See detailEvaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]

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See detailEvaluating somatic cell scores with a Bayesian Gaussian linear state-space model.
Detilleux, Johann ULg; Theron, Léonard ULg; Reding, E. et al

in Animal : an international journal of animal bioscience (2014), 8(3), 477-83

Because accurate characterization of health state is important for managing dairy herds, we propose to validate the use of a linear state-space model (LSSM) for evaluating monthly somatic cell scores ... [more ▼]

Because accurate characterization of health state is important for managing dairy herds, we propose to validate the use of a linear state-space model (LSSM) for evaluating monthly somatic cell scores (SCSs). To do so, we retrieved SCS from a dairy database and collected reports on clinical mastitis collected in 20 farms, during the period from January 2008 to December 2011 in the Walloon region of Belgium. The dependent variable was the SCS, and the independent variables were the number of days from calving, year of calving and parity. The LSSM also incorporated an error-free underlying variable that described the trend across time as a function of previous clinical and subclinical status. We computed the mean sum of squared differences between observed SCS and median values of the posterior SCS distribution and constructed the receiver operating characteristic (ROC) curve for SCS thresholds going from 0 to 6. Our results show SCS estimates are close to observed SCS and area under the ROC curve is higher than 90%. We discuss the meaning of the parameters in light of our current knowledge of the disease and propose methods to incorporate, in LSSM, this knowledge often expressed in the form of ordinary differential equations. [less ▲]

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See detailEvaluating the attainment of LOGO objectives in a constructivist approach
Denis, Brigitte ULg

in Schuyten, Gilberte (Ed.) Proceedings : Second European LOGO conference, Gent, August 1989 (1989)

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See detailEvaluating the effectiveness of a 10-years old great ape conservation project in Cameroon
Tagg, Nikki; Petre, Charles-Albert ULg; Willie, Jacob

in Pan Africa News (2011), 18(2), 21-23

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See detailEvaluating the impacts of a network on healthy eating promotion practices in schools
Vandoorne, Chantal ULg; Van Hoye, Aurélie ULg

in Archives of Public Health (2009), 67(Supplement 2), 72-73

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See detailEvaluating the Performance of Courts in France and Belgium : A Difficult Circle to Square
Ficet, Joël ULg

Conference (2009, September 09)

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See detailEvaluating the performance of the Eastern Canadian Diatom Index (IDEC) at integrating water chemistry variability
Lavoie, Isabelle; Campeau, Stéphane; Darchambeau, François ULg et al

Conference (2006, January 06)

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See detailEvaluating the psychological impact of practice dispatch-assisted cardiopulmonary instructions using the ALERT protocol: preliminary results in Liege dispatching centre.
Hirtz, Elodie; Ghuysen, Alexandre ULg; STIPULANTE, Samuel ULg et al

Poster (2013, July)

ABSTRACT Background. The ALERT algorithm, an effective compression-only phone cardiopulmonary resuscitation (CPR) protocol has the potential to help bystanders initiate CPR. This study evaluates the ... [more ▼]

ABSTRACT Background. The ALERT algorithm, an effective compression-only phone cardiopulmonary resuscitation (CPR) protocol has the potential to help bystanders initiate CPR. This study evaluates the psychological impact of the CPR’s practice on untrained persons (UP). Methods. This is a quasi experimental longitudinal study (n = 153). We used: demographics data, CPR’ emotional characteristics; the Peritraumatic Dissociative Experiences Questionnaire ; the Way of Coping Check List and the Impact of Event Scale. Findings. Two psychological profiles: UP at high risk to develop a post traumatic disorder (higher average scores ; high emotional distress during the CPR) versus UP at low risk. Discussion. These preliminary results highlight the importance of identifying the psychological profile of the UP. For a CPR, UP at high risk should be treated differently: first, take the time to reduce emotional distress and then only talk about the CPR. This step could reduce the risk for PTSD [less ▲]

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See detailEvaluating the reliability of analytical results using a probability criterion: a Bayesian perspective
Rozet, Eric ULg; Govaerts, B.; Lebrun, Pierre ULg et al

in Analytica Chimica Acta (2011), 705

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the ... [more ▼]

Methods validation is mandatory in order to assess the fitness of purpose of the developed analytical method. Of core importance at the end of the validation is the evaluation of the reliability of the individual results that will be generated during the routine application of the method. Regulatory guidelines provide a general framework to assess the validity of a method, but none address the issue of results reliability. In this study, a Bayesian approach is proposed to address this concern. Results reliability is defined here as “the probability of an analytical method to provide analytical results within predefined acceptance limits around their reference or conventional true concentration values over a defined concentration range and under given environmental and operating conditions.” By providing the minimum reliability probability needed for the subsequent routine application of the method, as well as specifications or acceptance limits , the proposed Bayesian approach provides the effective probability of obtaining reliable future analytical results over the whole concentration range investigated. This is summarized in a single graph: the reliability profile. This Bayesian reliability profile is also compared to two frequentist approaches, the first one derived from the work of Dewé et al. [Dewé W., Govaerts B., Boulanger B., Rozet E., Chiap P., Hubert Ph., Chemometr. Intell. Lab. Syst. 85 (2007) 262-268] and the second proposed by Govaerts et al. [B. Govaerts, W. Dewé, M. Maumy, B. Boulanger, Qual. Reliab. Engng. Int. 24 (2008) 667-680]. Furthermore, to illustrate the applicability of the Bayesian reliability profile, this approach is also applied here to a bioanalytical method dedicated to the determination of ketoglutaric acid (KG) and hydroxymethylfurfural (HMF) in human plasma by SPE-HPLC-UV. [less ▲]

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See detailEvaluating the social costs and benefits of surveillance: the case of HPAI in Vietnam
Delabouglise, alexis; Antoine-Moussiaux, Nicolas ULg; Phan Dang, Thang et al

Conference (2014, May 08)

Economic evaluations of animal health surveillance systems are critical components of the assessment of their long-term sustainability and the improvement of their cost- effectiveness. Social costs and ... [more ▼]

Economic evaluations of animal health surveillance systems are critical components of the assessment of their long-term sustainability and the improvement of their cost- effectiveness. Social costs and benefits of health information release through the surveillance systems are fundamental determinants of the acceptability and efficacy of surveillance and are often neglected in the evaluation process. This study presents the evaluation of social costs and benefits of Highly Pathogenic Avian Influenza (HPAI) surveillance in Vietnam. Three field studies were conducted in the South and North of the country. Data on animal health information flow networks and social costs and benefits were collected using participatory approaches. Non-monetary costs and benefits were quantified using a newly developed tool based on stated choice method and participatory techniques. The study showed that private actors incur many transaction costs in reporting the information. However social costs mainly arise from price drops due to information release on market which has strong influences on the decision to disclose sanitary information. This applies at all levels including farmers and veterinary authorities. Private actors of the poultry sector valued information on occurring disease outbreaks, which is perceived as a social benefit. However avian influenza information is scarcely disclosed in private networks as stakeholders fear its potential impact on markets. [less ▲]

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See detailEvaluating xen for router virtualization
Egi, N.; Greenhalgh, A.; Handley, M. et al

in Computer Communications and Networks, 2007. ICCCN 2007. Proceedings of 16th International Conference on (2007)

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See detailEvaluation of the volatile emission changes from Arabidopsis thaliana Col-0 in response to temperature stress and Myzus persicae infestation interaction by HS-SPME-GC/MS
Hien, Truong Thi Dieu ULg

Poster (2013, February 08)

Volatile organic compounds (VOCs) are considered to be priming agents in plant responsive defense to protect themselves against abiotic or/and biotic stresses. Such stresses often influence on plant ... [more ▼]

Volatile organic compounds (VOCs) are considered to be priming agents in plant responsive defense to protect themselves against abiotic or/and biotic stresses. Such stresses often influence on plant photosynthesis and defense responses, resulting in a variety of volatile profiles. We investigated how different temperature regimes affect the VOCs emission capacity of Arabidopsis thaliana Col-0 (A.t Col-0) in the presence and absence of a sucking insect – Myzus persicae (green peach aphid). VOCs analyses were made with solid-phase micro-extraction coupled with gas chromatography - mass spectrometry (SPME- GC/MS) under controlled and various stress treatments. In response to temperature stresses, alcohols, ketones, aldehydes and terpenes were the most emitted VOCs. Moreover, the compared results showed that the percent emission of several compounds changed significantly. The interaction between temperature stresses and aphids released some new volatile components; like isothiocynates, esters, sulfur compound and nitrile. Besides, the qualitative and overall proportion of volatile blends differed significantly from plants subjected to the stress treatments within different time intervals (0-24h; 24-48h and 48-72h). Overall, both stress treatments correlated with increased or decreased levels of VOCs classes from Arabidopsis shoot organs. Knowledge of how the temperature – aphids interaction influences on VOCs emission in this study also provides interesting information for evaluating the responsive resistance in plants under natural environments. [less ▲]

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See detailEVALUATION SANCTIONNANTE D’ÉTUDIANTS DANS UN DISPOSITIF SUSCITANT LA RÉFLEXIVITÉ EN 2E CYCLE D’ÉTUDES MÉDICALES DANS UN COURS DE « MÉDECINE PALLIATIVE ET DE FIN DE VIE » DONT LES MOYENS UTILISÉS SONT LE PORTFOLIO ÉLECTRONIQUE, LE TUTORAT ET DES COURS THÉORIQUES
Giet, Didier ULg; MASSART, Valérie ULg; Deum, Mélanie ULg et al

in Bulletin de l'ADMEE 2001/1 (2011)

Le cours de Médecine Palliative est dispensé aux étudiants en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours est dispensé ... [more ▼]

Le cours de Médecine Palliative est dispensé aux étudiants en avant-dernière année des études médicales de 2e cycle par deux enseignants, Médecin Généraliste et Médecin Hospitalier. Ce cours est dispensé depuis 10 ans selon un format traditionnel ex cathedra. De nouveaux objectifs et de nouvelles modalités pédagogiques ont été introduits en 2010-2011. L’objectif principal est l’apprentissage réflexif des étudiants. Les outils pédagogiques sont le portfolio électronique, une vignette clinique évolutive, l’accompagnement à distance de chaque étudiant par un tuteur, des cours en présentiel. La pratique réflexive de chaque étudiant est évaluée au terme du dispositif selon des critères et des indicateurs préalablement communiqués. Des perspectives ont émergé sur base des analyses des forces et faiblesses. [less ▲]

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See detailEvaluation : "ni pensée unique ni bonnes ou mauvaises méthodes"
Vandoorne, Chantal ULg; Jabot, Françoise; Fond-Harmant, Laurence

in La Santé de l'Homme (2007), (390), 12-13

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See detailEvaluation : réponses à des questions qui dérangent
Vandoorne, Chantal ULg

in La Santé de l'Homme (2007), (390), 24-25

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See detailEvaluation à long terme du couple ischio-jambiers quadriceps après ligamentoplastie du genou
Croisier, Jean-Louis ULg; Bernard, P.; Huskin, Jean-Pierre ULg et al

in Expériences en Rééducation Locomotrice (1992)

Detailed reference viewed: 49 (7 ULg)
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See detailL'évaluation actuarielle des engagements de pension selon l'IAS 19 et ses perspectives d'évolution
Sougné, Danielle ULg

in Revue française de comptabilité (2009)

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See detailEvaluation agromorphologique et sélection des meilleures accessions de Pourghère (Jatropha curcas L.) introduites au Bénin
Ahoton, L. E.; Quenum, F.; Mergeai, Guy ULg

in International Journal of Biological and Chemical Sciences (2011), 5(4), 1619-1627

Detailed reference viewed: 23 (7 ULg)