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See detailEvaluatie van de nieuwe dopamine-agonist CV 205-502 in de behandeling van prolactinomen
Verhelst, J.; Abs, R.; Beckers, Albert ULg et al

in Acta Antwerpiensia (1992), 9

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See detailEvaluating a calibration method for the estimation of fragmented rocks 3D-size-distribution out of 2D images
Outal, Souhail; Schleifer, Jacques; Pirard, Eric ULg

in Sanchidrian, J. A. (Ed.) Fragblast 9 (2009)

Image analysis is a tool having great potential for the quantification of fragmented rocks size-distribution. This recent technique should be validated according to sieving measurements. Current acquisi ... [more ▼]

Image analysis is a tool having great potential for the quantification of fragmented rocks size-distribution. This recent technique should be validated according to sieving measurements. Current acquisi-tion allows the obtaining of only 2D information from images. In addition, the 3D passage is extremely prob-lematic. Firstly, the usual stereological methods do not work because the reasoning is carried out on non-random projections. Secondly, estimated sizes differ from those measured by sieving. Last, a quantity of mat-terial measured during sieving remains inaccessible by image analysis, due to masking and segregation. This paper evaluates a method directly connecting 2D raw data to 3D sieving measurements. The cited problems are reduced as much as possible thanks to the adoption of an isotropic 2D sorting criterion, and thanks to samples without masking and segregation. Important results have been obtained. Firstly, the characteristic size is correctly estimated in 2D, giving access to computing the uniformity index through known models. Secondly, the stereological approach, bringing into play proportions, is not sufficiently robust to reconstruct easily volume distributions. Limits of this kind of methods, which are, unfortunately, currently used in several granulometric applications, are analyzed. [less ▲]

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See detailEvaluating an ICT-Mediated Innovative Training Service from Users’ Perspective. An Exploratory Case Study
Peters, Stéphanie ULg; Ledent, Maryse ULg; Hansez, Isabelle ULg

Conference (2008, July)

By the way of a case study, this paper aims at evaluating the innovative dimension of a training service mediated through Information and Communication Technology (ICT): the so-called e-WOCCQ. The ... [more ▼]

By the way of a case study, this paper aims at evaluating the innovative dimension of a training service mediated through Information and Communication Technology (ICT): the so-called e-WOCCQ. The originality of this article is twofold: (1) to question innovation, and (2) to consider the training more commonly as a service, whose major particularity is the implication of the user in the process. The theoretical framework emphasises on the definition of a service and on the concept of added-value. As this experience took place at the very beginning of the project development, an empirical methodology was developed. We assume that the so-called e-WOCCQ is an innovation as it represents an added value for the users. Results show that e-WOCCQ generates costs and benefits of different order, and that the ratio is influenced by factors mostly linked either with the user. Practical (improvements and targeting) and theoretical (modelisation) implications are discussed. [less ▲]

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See detailEvaluating an ICT-mediated innovative training service from users' perspective: an explorative case study
Peters, Stéphanie ULg; Ledent, M.; Hansez, Isabelle ULg

in Proceedings of the ED-Media Conference 2008 (2008)

By the way of a case study, this paper aims at evaluating the innovative dimension of a training service mediated through Information and Communication Technology (ICT): the so-called e-WOCCQ. The ... [more ▼]

By the way of a case study, this paper aims at evaluating the innovative dimension of a training service mediated through Information and Communication Technology (ICT): the so-called e-WOCCQ. The originality of this article is twofold: (1) to question innovation, and (2) to consider the training more commonly as a service, whose major particularity is the implication of the user in the process. The theoretical framework emphasises on the definition of a service and on the concept of added-value. As this experience took place at the very beginning of the project development, an empirical methodology was developed. We assume that the so-called e-WOCCQ is an innovation as it represents an added value for the users. Results show that e-WOCCQ generates costs and benefits of different order, and that the ratio is influenced by factors mostly linked either with the user. Practical (improvements and targeting) and theoretical (modelisation) implications are discussed. [less ▲]

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See detailEvaluating analytical results reliability using a Bayesian probability criterion
Rozet, Eric ULg; Lebrun, Pierre ULg; Boulanger, Bruno ULg et al

Poster (2010, December 02)

In pharmaceutical industries, quantitative analytical methods such as HPLC play a key role. Indeed, the analytical results obtained from them are used to make crucial decisions such as the release of ... [more ▼]

In pharmaceutical industries, quantitative analytical methods such as HPLC play a key role. Indeed, the analytical results obtained from them are used to make crucial decisions such as the release of batches of drugs, the evaluation of safety and efficacy of new drug candidates or the monitoring of patients health. Prior to their routine use, analytical methods are submitted to a stringent validation study where they have to demonstrate that they are fit for their final purpose, i.e. providing accurate result . Typically this demonstration is made by either providing point estimates of systematic error (bias) and random error (variance) or sometimes by providing interval estimates of these statistical parameters at several well defined concentration levels of the target analyte. They are then compared to maximum acceptable levels. More recently, tolerance intervals approaches have been proposed that are evaluated in a similar way at these key concentration levels. However none of these decision approaches allow knowing the probability to obtain accurate results over the whole concentration range of interest. Frequentist approximations have been proposed to estimate this probability but only at the concentration levels experimentally tested and not for the whole range of interest. In this work, a linear hierarchical Bayesian approach is proposed. It takes into account the potential random characteristic of the slope and intercept observed from one analytical run to the other, and also integrates the possible covariance between the parameters. Additionally, heteroscedasticity of the residual variance over the concentration range investigated is taken into account. A situation regularly observed in practice. Finally a reliability profile for the whole concentration range studied is obtained using MCMC sampling. This profile provides the probability (Prel) to obtain accurate results over the full concentration range investigated. This profile is then compared to a minimum reliability probability (Pmin) that will define the valid concentration range of the analytical method. The usefulness of this approach is illustrated through the validation of a bioanalytical method and also compared with a one concentration level at a time frequentist approach derived from tolerance intervals. [less ▲]

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See detailEvaluating bound on voltage and thermal security margins under power transfer uncertainty.
Van Cutsem, Thierry ULg

(2002, June)

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximal pre-contingency power transfer between either a generation and ... [more ▼]

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximal pre-contingency power transfer between either a generation and a load area or two generation areas, such that specirfied contingencies do not overload lines or make the system voltage unstable. The minimum and maximum margins are computed for given intervals of variations of bus injections. Each bound is the solution of a constrained L1-norm minimization (or maximization) problem, for which specific algorithms are given. Thermal overloads are handled through linearization, while for voltage stability, fast time simulation and instability mode analysis are used. Nonlinear situations of branch overload are also considered. The method is illustrated on an 80-bus test system. [less ▲]

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See detailEvaluating bounds on voltage and thermal security margins under power transfer uncertainty
Capitanescu, Florin ULg; Van Cutsem, Thierry ULg

(2002, June)

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximual pre-contingency power transfer between either a generation ... [more ▼]

This paper deals with the evaluation of bounds on voltage and thermal security margins with respect to contingencies. A margin is the maximual pre-contingency power transfer between either a generation and a load area or two generation areas, such that the specified contingencies do not overload lines or make the system voltage unstable. The minimum and maximum margins are computed for given intervals of variations of bus injections. Each bound is the solution of a constrained L1-norm minimization (or maximization) problem, for which specific algorithms are given. Thermal overloads are handled through linearization, while for voltage stability, fast time simulation and instability mode analysis are used. Nonlinear situations of branch overloads are also considered. The method is illustrated on an 80-bus test system. [less ▲]

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See detailEvaluating climate model performance with various parameter sets using observations over the recent past
Loutre, M.-F.; Mouchet, Anne ULg; Fichefet, T. et al

in Climate of the Past (2011), 7

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See detailEvaluating COSMO’s lake module (FLake) for an East-African lake using a comprehensive set of lake temperature profiles
Thiery, Wim; Martynov, Andrey; Darchambeau, François ULg et al

Conference (2012, April)

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See detailEvaluating Effects of Tyrosine Phosphatase Inhibitors on T Cell Receptor Signaling
Rahmouni, Souad ULg; Delacroix, Laurence ULg; Liu, Wallace et al

in Phosphatase Modulators, Methods in Molecular Biology (2013)

The importance of tyrosine phosphorylation in normal cell physiology is well established, highlighted by the many human diseases that stem from abnormalities in protein tyrosine kinase (PTK) and protein ... [more ▼]

The importance of tyrosine phosphorylation in normal cell physiology is well established, highlighted by the many human diseases that stem from abnormalities in protein tyrosine kinase (PTK) and protein tyrosine phosphatase (PTP) function. Contrary to earlier assumptions, it is now clear that both PTKs and PTPs are highly specific, non-redundant, and tightly regulated enzymes. Hematopoietic cells express particularly high numbers of PTKs and PTPs, and aberrant function of these proteins have been linked to many hematopoietic disorders. While PTK inhibitors are among FDA approved drugs for the treatment of leukemia and other cancers, efforts to develop therapeutics that target specific PTPs are still in its infancy. Here, we describe methods on how to evaluate effects of PTP inhibitors on T cell receptor signaling. Moreover, we provide a comprehensive strategy for compound prioritization, applicable to any drug discovery project involving T cells. We present a testing funnel that starts with relatively high-throughput luciferase reporter assays, followed by immunoblot, calcium flux, flow cytometry, and proliferation assays, continues with cytokine bead arrays, and finishes with specificity assays that involve RNA interference. We provide protocols for experiments in the Jurkat T cell line, but more importantly give detailed instructions, paired with numerous tips, on how to prepare and work with primary human T cells. [less ▲]

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See detailEvaluating experimental design of ERT for soil moisture monitoring in contour hedgerow intercropping systems
Garré, Sarah ULg; Günther, Thomas; Diels, Jan et al

in Vadose Zone Journal (2012)

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See detailEvaluating functional data for the European Middle Palaeolithic
Rots, Veerle ULg

Conference (2014)

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See detailEvaluating global ocean carbon models: The importance of realistic physics
Doney, S. C.; Lindsay, K.; Caldeira, K. et al

in Global Biogeochemical Cycles (2004), 18(3),

A suite of standard ocean hydrographic and circulation metrics are applied to the equilibrium physical solutions from 13 global carbon models participating in phase 2 of the Ocean Carbon-cycle Model ... [more ▼]

A suite of standard ocean hydrographic and circulation metrics are applied to the equilibrium physical solutions from 13 global carbon models participating in phase 2 of the Ocean Carbon-cycle Model Intercomparison Project (OCMIP-2). Model-data comparisons are presented for sea surface temperature and salinity, seasonal mixed layer depth, meridional heat and freshwater transport, 3-D hydrographic fields, and meridional overturning. Considerable variation exists among the OCMIP-2 simulations, with some of the solutions falling noticeably outside available observational constraints. For some cases, model-model and model-data differences can be related to variations in surface forcing, subgrid-scale parameterizations, and model architecture. These errors in the physical metrics point to significant problems in the underlying model representations of ocean transport and dynamics, problems that directly affect the OCMIP predicted ocean tracer and carbon cycle variables (e.g., air-sea CO2 flux, chlorofluorocarbon and anthropogenic CO2 uptake, and export production). A substantial fraction of the large model-model ranges in OCMIP-2 biogeochemical fields (+/-25-40%) represents the propagation of known errors in model physics. Therefore the model-model spread likely overstates the uncertainty in our current understanding of the ocean carbon system, particularly for transport-dominated fields such as the historical uptake of anthropogenic CO2. A full error assessment, however, would need to account for additional sources of uncertainty such as more complex biological-chemical-physical interactions, biases arising from poorly resolved or neglected physical processes, and climate change. [less ▲]

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See detailEvaluating Portfolio Performance: Reconciling Asset Selection and Market Timing
Cavé, Arnaud; Hübner, Georges ULg; Lejeune, Thomas ULg

in Baker, H. Kent; Filbeck, Georges (Eds.) Portfolio Theory and Management (2013)

This chapter examines the performance measurement of mutual funds when both security selection and market timing management skills are considered. In an option replication approach, linear and quadratic ... [more ▼]

This chapter examines the performance measurement of mutual funds when both security selection and market timing management skills are considered. In an option replication approach, linear and quadratic coefficients of the Treynor and Mazuy regression are combined to assess performance in presence of market timing. This new correction has the potential to overcome the “artificial timing” bias and delivers particularly encouraging results on a sample of 1,413 U.S. mutual funds selected for an empirical analysis. Unlike alternative approaches proposed in the literature, most of positive market timers seem to be rewarded for the convexity they add to their portfolio, while negative market timers are penalized, and a correlation between abnormal performance and the convexity parameter is found. [less ▲]

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See detailEvaluating product temperature during thin bed drying.
Bera, François ULg

in Berichte Der Bundesforschungsanstalt Für Ernährung (1987, February)

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See detailEvaluating radical conservation futures: strategies for assessing the potential for Eurasian lynx in the Benelux countries
Bouyer, Yaëlle ULg; Poncin, Pascal ULg; Beudels-Jamar, Roseline et al

Poster (2011, July 08)

Tolerance of anthropic environment has allowed large carnivores to recolonize and to be reintroduced within Europe in the last forty years. This indicates that, even in areas where the return of large ... [more ▼]

Tolerance of anthropic environment has allowed large carnivores to recolonize and to be reintroduced within Europe in the last forty years. This indicates that, even in areas where the return of large carnivores seems unlikely, their presence and establishment is possible, even in highly modified environments. In the current context of the return of large carnivores in Europe, there is a need for scientific conservation tools to assess the full potential and consequences of the return of large carnivores in Europe, and in particular to evaluate potential impact on game and livestock. Today, the return of the Eurasian Lynx (Lynx lynx) in areas where it has been absent for long periods is becoming increasingly probable, and this requires further investigations. Three main lines of research will be particularly important: the use of habitat by Eurasian Lynx, the effect of habitat on predation behavior, and potential sources of conflict with human populations. The research project will address fine scale habitat use, the effect of prey‘s spatial variation on Lynx predation behavior, the use of different statistical methods to estimate Lynx‘s viability in various habitats and landscape, and a review of current conflicts throughout Europe. Results should allow better understanding of the Lynx redeployment potentials in lowland Western Europe [less ▲]

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See detailEvaluating risk in unstable angina: role of pharmacological stress echocardiography.
Pierard, Luc ULg

in European heart journal (2000), 21(13), 1041-3

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See detailEvaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations.
Scheen, André ULg

in Expert opinion on drug metabolism & toxicology (2014)

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 ... [more ▼]

Introduction: Inhibitors of sodium-glucose cotransporters type 2 (SGLT2), which increase urinary glucose excretion independently of insulin, are proposed as a novel approach for the management of type 2 diabetes mellitus (T2DM). Areas covered: An extensive literature search was performed to analyze the pharmacokinetic characteristics, toxicological issues and safety concerns of SGLT2 inhibitors in humans. This review focuses on three compounds (dapagliflozin, canagliflozin, empagliflozin) with results obtained in healthy volunteers (including drug-drug interactions), patients with T2DM (single dose and multiple doses) and special populations (those with renal or hepatic impairment). Expert opinion: The three pharmacological agents share an excellent oral bioavailability, long half-life allowing once-daily administration, low accumulation index and renal clearance, the absence of active metabolites and a limited propensity to drug-drug interactions. No clinically relevant changes in pharmacokinetic parameters were observed in T2DM patients or in patients with mild/moderate renal or hepatic impairment. Adverse events are a slightly increased incidence of mycotic genital and rare benign urinary infections. SGLT2 inhibitors have the potential to reduce several cardiovascular risk factors, and cardiovascular outcome trials are currently ongoing. The best positioning of SGLT2 inhibitors in the armamentarium for treating T2DM is still a matter of debate. [less ▲]

Detailed reference viewed: 18 (1 ULg)