Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Peer Reviewed
See detailDurée, fréquence et répartition des temps de repos de taurillons Pie-Noirs en stabulation entravée
Nicks, Baudouin ULg; Dechamps, Pierre; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1988), 132

Detailed reference viewed: 22 (13 ULg)
Peer Reviewed
See detailDurée, fréquence et répartition des temps de repos de vaches primipares en stabulation mixte, avant et après vêlage
Dechamps, P.; Nicks, Baudouin ULg; Canart, Bernard et al

in Annales de Médecine Vétérinaire (1988), 132(2), 131-139

Detailed reference viewed: 10 (0 ULg)
Full Text
See detailDurito, een cyber-ridder op pantoffels
Vanden Berghe, Kristine ULg

in Lie, Nadia; D'haen, Theo (Eds.) Zorro & co. Populaire personages en het koloniale verleden (2002)

Detailed reference viewed: 32 (1 ULg)
See detailDurkheim et la littérature
Ledent, David ULg

Scientific conference (2014, October 09)

Detailed reference viewed: 25 (3 ULg)
Full Text
Peer Reviewed
See detailDUSP3 genetic deletion confers M2-like−macrophage-dependent tolerance to septic shock
Singh, Pratibha; Dejager, Lien; Amand, Mathieu ULg et al

in Journal of Immunology (2015), 194(10), 4951-62

DUSP3 is a small dual-specificity protein phosphatase with an unknown physiological function. We report that DUSP3 is strongly expressed in human and mouse monocytes and macrophages and that its ... [more ▼]

DUSP3 is a small dual-specificity protein phosphatase with an unknown physiological function. We report that DUSP3 is strongly expressed in human and mouse monocytes and macrophages and that its deficiency in mice promotes tolerance to lipopolysaccharide (LPS)-induced endotoxin shock and to polymicrobial septic shock following cecal ligation and puncture. By using adoptive transfer experiments, we demonstrate that resistance to endotoxin is macrophage-dependent and transferable and that this protection is associated with a striking increase of M2-like macrophages in DUSP3-/- mice in both the LPS and cecal ligation and puncture models. We show that the altered response of DUSP3-/- mice to sepsis is reflected in decreased TNF production and impaired ERK1/2 activation. Our results demonstrate that DUSP3 plays a key and non-redundant role as a regulator of innate immune responses by mechanisms involving the control of ERK1/2 activation, TNF secretion and macrophage polarization. [less ▲]

Detailed reference viewed: 48 (14 ULg)
Full Text
Peer Reviewed
See detailDUSP3 Phosphatase Deficiency or Inhibition Limit Platelet Activation and Arterial Thrombosis
Musumeci, Lucia ULg; Kuijpers, Marijke; Gilio, Karen et al

in Circulation (2015), 131(7), 656-68

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet ... [more ▼]

Background A limitation of current antiplatelet therapies is their inability to separate thrombotic events from bleeding occurrences. Better understanding of the molecular mechanisms leading to platelet activation is of importance for the development of improved therapies. Recently, protein tyrosine phosphatases (PTPs) have emerged as critical regulators of platelet function. Methods and Results This is the first report implicating the dual-specificity phosphatase 3 (DUSP3) in platelet signaling and thrombosis. This phosphatase is highly expressed in human and mouse platelets. Platelets from DUSP3-deficient mice displayed a selective impairment of aggregation and granule secretion mediated through the collagen receptor glycoprotein VI (GPVI) and the C-type lectin-like receptor 2 (CLEC-2). DUSP3-deficient mice were more resistant to collagen- and epinephrine-induced thromboembolism, compared to wild-type mice, and showed severely impaired thrombus formation upon ferric chloride-induced carotid artery injury. Intriguingly, bleeding times were not altered in DUSP3-deficient mice. At the molecular level, DUSP3 deficiency impaired Syk tyrosine phosphorylation, subsequently reducing phosphorylation of PLCγ2 and calcium fluxes. To investigate DUSP3 function in human platelets, a novel small-molecule inhibitor of DUSP3 was developed. This compound specifically inhibited collagen and CLEC-2-induced human platelet aggregation, thereby phenocopying the effect of DUSP3 deficiency in murine cells. Conclusions DUSP3 plays a selective and essential role in collagen- and CLEC-2-mediated platelet activation and thrombus formation in vivo. Inhibition of DUSP3 may prove therapeutic for arterial thrombosis. This is the first time a PTP, implicated in platelet signaling, has been targeted with a small-molecule drug. [less ▲]

Detailed reference viewed: 136 (58 ULg)
Full Text
Peer Reviewed
See detailDUSP3 Phosphatase Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis
Tautz, Lutz; Rahmouni, Souad ULg; Oury, Cécile ULg et al

Conference (2015, June 27)

Detailed reference viewed: 28 (3 ULg)
Full Text
Peer Reviewed
See detailDUSP3 Phosphatase Deficiency or Inhibition Limits Platelet Activation and Arterial Thrombosis
Rahmouni, Souad ULg; MUSUMECI, Lucia ULg; Kuijpers, Marijke J et al

Conference (2015, June 24)

Detailed reference viewed: 50 (10 ULg)
Full Text
Peer Reviewed
See detailDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
Amand, Mathieu ULg; Erpicum, Charlotte ULg; BAJOU, Khalid ULg et al

in Molecular Cancer (2014)

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies ... [more ▼]

Background DUSP3 phosphatase, also known as Vaccinia-H1 Related (VHR) phosphatase, encoded by DUSP3/Dusp3 gene, is a relatively small member of the dual-specificity protein phosphatases. In vitro studies showed that DUSP3 is a negative regulator of ERK and JNK pathways in several cell lines. On the other hand, DUSP3 is implicated in human cancer. It has been alternatively described as having tumor suppressive and oncogenic properties. Thus, the available data suggest that DUSP3 plays complex and contradictory roles in tumorigenesis that could be cell type-dependent. Since most of these studies were performed using recombinant proteins or in cell-transfection based assays, the physiological function of DUSP3 has remained elusive. Results Using immunohistochemistry on human cervical sections, we observed a strong expression of DUSP3 in endothelial cells (EC) suggesting a contribution for this phosphatase to EC functions. DUSP3 downregulation, using RNA interference, in human EC reduced significantly in vitro tube formation on Matrigel and spheroid angiogenic sprouting. However, this defect was not associated with an altered phosphorylation of the documented in vitro DUSP3 substrates, ERK1/2, JNK1/2 and EGFR but was associated with an increased PKC phosphorylation. To investigate the physiological function of DUSP3, we generated Dusp3-deficient mice by homologous recombination. The obtained DUSP3-/- mice were healthy, fertile, with no spontaneous phenotype and no vascular defect. However, DUSP3 deficiency prevented neo-vascularization of transplanted b-FGF containing Matrigel and LLC xenograft tumors as evidenced by hemoglobin (Hb) and FITC-dextran quantifications. Furthermore, we found that DUSP3 is required for b-FGF-induced microvessel outgrowth in the aortic ring assay. Conclusions All together, our data identify DUSP3 as a new important player in angiogenesis. [less ▲]

Detailed reference viewed: 100 (26 ULg)
Full Text
See detailDUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase
Amand, Mathieu ULg; Erpicum, Charlotte ULg; BAJOU, Khalid ULg et al

Poster (2014, January 27)

Detailed reference viewed: 64 (24 ULg)
See detailDussart Frans
Merenne-Schoumaker, Bernadette ULg

in Nouvelle biographie nationale (2010)

Courte biographie du Prof F. Dussart de l'Université de Liège

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailDUst Around NEarby Stars. The survey observational results
Eiroa, C; Marshall, J; Mora, A et al

in Astronomy and Astrophysics (2013), 555

Context. Debris discs are a consequence of the planet formation process and constitute the fingerprints of planetesimal systems. Their solar system's counterparts are the asteroid and Edgeworth-Kuiper ... [more ▼]

Context. Debris discs are a consequence of the planet formation process and constitute the fingerprints of planetesimal systems. Their solar system's counterparts are the asteroid and Edgeworth-Kuiper belts. Aims. The DUNES survey aims at detecting extra-solar analogues to the Edgeworth-Kuiper belt around solar-type stars, putting in this way the solar system into context. The survey allows us to address some questions related to the prevalence and properties of planetesimal systems. Methods. We used Herschel/PACS to observe a sample of nearby FGK stars. Data at 100 and 160 μm were obtained, complemented in some cases with observations at 70 μm, and at 250, 350 and 500 μm using SPIRE. The observing strategy was to integrate as deep as possible at 100 μm to detect the stellar photosphere. Results. Debris discs have been detected at a fractional luminosity level down to several times that of the Edgeworth-Kuiper belt. The incidence rate of discs around the DUNES stars is increased from a rate of ∼ 12.1% ± 5% before Herschel to ∼ 20.2% ± 2%. A significant fraction (∼ 52%) of the discs are resolved, which represents an enormous step ahead from the previously known resolved discs. Some stars are associated with faint far-IR excesses attributed to a new class of cold discs. Although it cannot be excluded that these excesses are produced by coincidental alignment of background galaxies, statistical arguments suggest that at least some of them are true debris discs. Some discs display peculiar SEDs with spectral indexes in the 70–160 μm range steeper than the Rayleigh-Jeans one. An analysis of the debris disc parameters suggests that a decrease might exist of the mean black body radius from the F-type to the K-type stars. In addition, a weak trend is suggested for a correlation of disc sizes and an anticorrelation of disc temperatures with the stellar age. [less ▲]

Detailed reference viewed: 29 (4 ULg)
Full Text
Peer Reviewed
See detailThe dust environment of comet 67P/Churyumov-Gerasimenko from Rosetta OSIRIS and VLT observations in the 4.5 to 2.9 AU heliocentric distance range inbound
Moreno, F.; Snodgrass, C.; Hainaut, O. et al

in Astronomy and Astrophysics (2016), 587

Context. The ESA Rosetta spacecraft, currently orbiting around comet 67P/Churyumov-Gerasimenko, has already provided in situ measurements of the dust grain properties from several instruments,particularly ... [more ▼]

Context. The ESA Rosetta spacecraft, currently orbiting around comet 67P/Churyumov-Gerasimenko, has already provided in situ measurements of the dust grain properties from several instruments,particularly OSIRIS and GIADA. We propose adding value to those measurements by combining them with ground-based observations of the dust tail to monitor the overall, time-dependent dust-production rate and size distribution. <BR /> Aims: To constrain the dust grain properties, we take Rosetta OSIRIS and GIADA results into account, and combine OSIRIS data during the approach phase (from late April to early June 2014) with a large data set of ground-based images that were acquired with the ESO Very Large Telescope (VLT) from February to November 2014. <BR /> Methods: A Monte Carlo dust tail code, which has already been used to characterise the dust environments of several comets and active asteroids, has been applied to retrieve the dust parameters. Key properties of the grains (density, velocity, and size distribution) were obtained from Rosetta observations: these parameters were used as input of the code to considerably reduce the number of free parameters. In this way, the overall dust mass-loss rate and its dependence on the heliocentric distance could be obtained accurately. <BR /> Results: The dust parameters derived from the inner coma measurements by OSIRIS and GIADA and from distant imaging using VLT data are consistent, except for the power index of the size-distribution function, which is α = -3, instead of α = -2, for grains smaller than 1 mm. This is possibly linked to the presence of fluffy aggregates in the coma. The onset of cometary activity occurs at approximately 4.3 AU, with a dust production rate of 0.5 kg/s, increasing up to 15 kg/s at 2.9 AU. This implies a dust-to-gas mass ratio varying between 3.8 and 6.5 for the best-fit model when combined with water-production rates from the MIRO experiment. [less ▲]

Detailed reference viewed: 13 (1 ULg)
Full Text
Peer Reviewed
See detailDust exposure exacerbates the expression of ptx3, a recently discovered acute phase protein, in horses’ airways
Ramery, Eve ULg; Bureau, Fabrice ULg; Lekeux, Pierre ULg

Conference (2009)

Heaves is a common cause of recurrent airway obstruction (R.A.O) that occurs in mature horses stabled in a dusty environment. The long pentraxin PTX3 play an important role in the host defence and over ... [more ▼]

Heaves is a common cause of recurrent airway obstruction (R.A.O) that occurs in mature horses stabled in a dusty environment. The long pentraxin PTX3 play an important role in the host defence and over-expression of PTX3 may contribute to airways injury. Therefore, we hypothesised that PTX3 may have relevance in the understanding of the pathogenesis of recurrent airway obstruction (R.A.O). In the present study, we first investigated the equine PTX3 (ePTX3) structure by cloning, sequencing and western-blotting. A 120pb deletion was found in the second exon of ePTX3 in comparison to human PTX3. Moreover, an alternative splicing occurs with complete deletion of the second exon, resulting in two forms of the protein, “spliced” (32 kD) and “full length” (42 kD). The pentraxin domain is very well conserved in the two forms with 94% of amino-acids conserved between equines and humans. These findings could have implications for the comprehension of the function of each domain of the protein. Then, we studied the effects of dust exposure and subsequent R.A.O crisis on ePTX3 expression in the broncho-alveolar lavage fluid (BALF) and the bronchial epithelial cells. PTX3 could be detected in BALF macrophages, neutrophils, eosinophils and bronchial epithelial cells. It was over-expressed in the BALF supernatant from RAO-affected horses in crisis. Dust exposure induced PTX3 in BALF macrophages either in healthy horses or in R.A.O-affected horses. Conversely, PTX3 was strongly over-expressed in the bronchial epithelial cells from R.A.O-affected horses in crisis. Considering epithelial cells as one of the major cell types in the airways, PTX3 produced at this level may play an important role in inflammatory process. Moreover, it suggests that dust-induced expression of PTX3 is differentially regulated in macrophages and bronchial-epithelial cells. A JNK-dependant, NFκB-independent regulatory pathway has been described in lung epithelial cells. A comparable mechanism could be involved in bronchial epithelial cells. If this is confirmed, PTX3 expression in respiratory epithelial cells could be therapeutically targeted. [less ▲]

Detailed reference viewed: 28 (2 ULg)
Full Text
Peer Reviewed
See detailDust formation by the colliding wind WC5+O9 binary WR19 at periastron passage
Williams, P. M.; Rauw, Grégor ULg; van der Hucht, K. A.

in Monthly Notices of the Royal Astronomical Society (2009), 395

We present infrared photometry of the episodic dust-making Wolf-Rayet system WR19 (LS3), tracking its fading from a third observed dust formation episode in 2007 and strengthening the view that these ... [more ▼]

We present infrared photometry of the episodic dust-making Wolf-Rayet system WR19 (LS3), tracking its fading from a third observed dust formation episode in 2007 and strengthening the view that these episodes are periodic (P = 10.1 +/- 0.1y). Radial velocities (RVs) of the O9 component observed between 2001 and 2008 show RV variations consistent with WR19 being a spectroscopic binary of high eccentricity (e = 0.8), having periastron passage in 2007.14, shortly before the phase of dust formation. In this respect, WR19 resembles the archetypical episodic dust-making colliding wind binary system WR140. Based on observations collected at the European Southern Observatory, La Silla, Chile, in allocations 67.D-0043, 70.D-0266, 72.D-0070, 73.D-0027, 74.D-0116, 76.D-0029, 78.D-0001, 79.D-0092 and 80.D-0198. E-mail: pmw@roe.ac.uk [less ▲]

Detailed reference viewed: 54 (0 ULg)
Full Text
Peer Reviewed
See detailDust from Comet 209P/LINEAR during its 2014 Return: Parent Body of a New Meteor Shower, the May Camelopardalids
Ishiguro, Masateru; Kuroda, Daisuke; Hanayama, Hidekazu et al

in Astrophysical Journal Letters (2015), 798

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was ... [more ▼]

We report a new observation of the Jupiter family comet 209P/LINEAR during its 2014 return. The comet is recognized as a dust source of a new meteor shower, the May Camelopardalids. 209P/LINEAR was apparently inactive at a heliocentric distance r<SUB>h</SUB> = 1.6 AU and showed weak activity at r<SUB>h</SUB> <= 1.4 AU. We found an active region of <0.001% of the entire nuclear surface during the comet's dormant phase. An edge-on image suggests that particles up to 1 cm in size (with an uncertainty of factor 3-5) were ejected following a differential power-law size distribution with index q = –3.25 ± 0.10. We derived a mass-loss rate of 2-10 kg s<SUP>–1</SUP> during the active phase and a total mass of ≈5 × 10<SUP>7</SUP> kg during the 2014 return. The ejection terminal velocity of millimeter- to centimeter-sized particles was 1-4 m s<SUP>–1</SUP>, which is comparable to the escape velocity from the nucleus (1.4 m s<SUP>–1</SUP>). These results imply that such large meteoric particles marginally escaped from the highly dormant comet nucleus via the gas drag force only within a few months of the perihelion passage. [less ▲]

Detailed reference viewed: 28 (3 ULg)
Peer Reviewed
See detailDust historical record in ombrotrophic peat: The case study of a NW European bog
Allan, Mohammed ULg; Fagel, Nathalie ULg; Le Roux, Gael et al

Poster (2013, May 16)

Ombrotrophic peatlands are unique environmental archives of natural and anthropogenic atmospheric dust deposition because their surface layers are exclusively fed by atmospheric inputs. Lead (Pb) isotopes ... [more ▼]

Ombrotrophic peatlands are unique environmental archives of natural and anthropogenic atmospheric dust deposition because their surface layers are exclusively fed by atmospheric inputs. Lead (Pb) isotopes have been often used to evidence any anthropogenic influence in peat, but they only record trace metal pollution. Another radiogenic isotope, the Neodymium (Nd), could be also use to discriminate the sources of dust in peat bogs. Dust fluxes were investigated over the last 2500 years in the Misten peat bog in Eastern Belgium. Our aims were to use Nd isotope signature to decipher between local and distal dust supplies, the Pb isotopes to trace the antropogenic influences. To address these aims we analyzed REE and lithogenic element analyses, as well as the Nd and Pb isotopes, using HR-ICP-MS and MC-ICP-MS, respectively in peat layers dated by 210Pb and 14C. Changes in REE concentration variations in peat samples are correlated with Ti, Al, and Zr that are lithogenic conservative elements, suggesting that REE are immobile in the studied peat bogs and can be used as tracers of dust deposition. Dust fluxes show pronounced increase at BC300, AD600, 1000AD, 1200AD and from 1700AD, recording either influence of human activities (regional erosion due to forest clearing and soil cultivation activities) or local and regional climate changes. Lead enrichments reveal strong human impact over the last 300 years. Lead isotope signatures are consistent with local and regional contamination by coal combustion and smelting activities. Neodymium isotopes allow to identify three periods characterised by dominant-distal sources (at 320AD, 1000 AD and 1700AD). Those periods are consistent with local wetter intervals as indicated by lower humification degree. Local erosion prevails durier drier (higher humification) intervals (-100AD, 600AD). On a global scale more distal supplies are driven during colder periods, in particular Oort and Maunder minima, confirming the hypothesis that cold climate conditions favor distal supplies. Combining geochemical elementary content and isotope data in ombrotrophic peat allows to decipher between dust flux changes related to human and climate forcing. [less ▲]

Detailed reference viewed: 64 (3 ULg)
Full Text
See detailDust in LBV-type Nebulae
Hutsemekers, Damien ULg

in Luminous Blue Variables: Massive Stars in Transition. ASPC 120 (1997)

Some systematic properties of dust in LBV-type nebulae are reviewed on the basis of the far-infrared thermal emission measured by the IRAS satellite, and the scattering of visible stellar light.

Detailed reference viewed: 18 (1 ULg)