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See detailEffects of marginal iron overload on iron homeostasis and immune function in alveolar macrophages isolated from pregnant and normal rats.
Ward, Roberta J; Wilmet, Stephanie; Legssyer, Rachida et al

in Biometals (2009), 22(2), 211-23

The effects of changes in macrophage iron status, induced by single or multiple iron injections, iron depletion or pregnancy, on both immune function and mRNA expression of genes involved in iron influx ... [more ▼]

The effects of changes in macrophage iron status, induced by single or multiple iron injections, iron depletion or pregnancy, on both immune function and mRNA expression of genes involved in iron influx and egress have been evaluated. Macrophages isolated from iron deficient rats, or pregnant rats at day 21 of gestation, either supplemented with a single dose of iron dextran, 10 mg, at the commencement of pregnancy, or not, showed significant increases of macrophage ferroportin mRNA expression, which was paralleled by significant decreases in hepatic Hamp mRNA expression. IRP activity in macrophages was not significantly altered by iron status or the inducement of pregnancy +/- a single iron supplement. Macrophage immune function was significantly altered by iron supplementation and pregnancy. Iron supplementation, alone or combined with pregnancy, increased the activities of both NADPH oxidase and nuclear factor kappa B (NFkappaB). In contrast, the imposition of pregnancy reduced the ability of these parameters to respond to an inflammatory stimuli. Increasing iron status, if only marginally, will reduce the ability of macrophages to mount a sustained response to inflammation as well as altering iron homeostatic mechanisms. [less ▲]

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See detailEffects of marrow grafting on preleukemia cells and thymic nurse cells in C57BL/Ka mice after a leukemogenic split-dose irradiation.
Defresne, Marie-Paule ULg; Greimers, Roland ULg; Lenaerts, Patrick et al

in Journal of the National Cancer Institute (1986), 77(5), 1079-85

A split-dose regimen of whole-body irradiation (4 X 175 rad at weekly intervals) induced thymic lymphomas in C57BL/Ka mice after a latent period of 3-9 months. Meanwhile, preleukemia cells arose in the ... [more ▼]

A split-dose regimen of whole-body irradiation (4 X 175 rad at weekly intervals) induced thymic lymphomas in C57BL/Ka mice after a latent period of 3-9 months. Meanwhile, preleukemia cells arose in the thymus and bone marrow and persisted until the onset of lymphomas. Simultaneously, thymic lymphopoiesis was impaired; thymocyte numbers were subnormal and thymic nurse cells disappeared in a progressive but irreversible fashion. The depletion of these lymphoepithelial complexes, which are normally involved in the early steps of thymic lymphopoiesis, was related to altered prothymocyte activity in bone marrow and to damaged thymic microenvironment, perhaps as a consequence of the presence of preleukemia cells. The grafting of normal bone marrow cells after irradiation prevented the development of lymphomas. However, marrow reconstitution did not inhibit the induction of preleukemia cells. They disappeared from the thymus during the second part of the latent period. At the same time, thymic lymphopoiesis was restored; thymocytes and nurse cell numbers returned to normal as a consequence of the proliferation of grafted marrow-derived cells within the thymus. The results thus demonstrated an intimate relationship between preleukemia cells and an alteration of thymic lymphopoiesis, which particularly involved the nurse cell microenvironment. Some preleukemia cells in marrow-reconstituted, irradiated mice derived from the unirradiated marrow inoculate. Thus these cells acquired neoplastic potential through a factor present in the irradiated tissues. The nature of this indirect mechanism was briefly discussed. [less ▲]

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See detailEffects of maternal dietary EPA and DHA supplementation and breeder age on embryonic and post-hatch performance of broiler offspring
Koppenol, A.; Delezie, E.; Wang, Y. et al

in Journal of Animal Physiology and Animal Nutrition (2015), 99(S1), 36-47

Breeder age and nutrition are amongst the most important factors affecting progeny growth and development. The present experiment was carried out to evaluate the effects of n-3 fatty acid (FA), with ... [more ▼]

Breeder age and nutrition are amongst the most important factors affecting progeny growth and development. The present experiment was carried out to evaluate the effects of n-3 fatty acid (FA), with special emphasis on the ratio of eicosapentaenoic (EPA, 20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) acid, provided to the diet of ageing broiler breeder hens at different ratios, on the incubation parameters and the performance of the offspring. Four hundred and eighty Ross-308 broiler breeder hens were fed one of four different diets (120/treatment), with an equal fat content. The control diet was a basal diet, rich in n-6 FAs (CON). Blends of fish oil were used to enrich the three other diets in n-3 FA and to obtain different EPA/DHA ratios of 1/1 (EPA=DHA), 1/2 (DHA) or 2/1 (EPA). Every 5 weeks, incubation parameters were assessed. Every 15 weeks, offspring was reared until slaughter age on a standard diet. Breeder age affected almost all incubation and post-hatch parameters, whereas n-3 FA treatment only lowered egg weight (p < 0.0001) and consequently hatched chick weight (p < 0.0001). Supplementation of EPA resulted in a higher proportional liver weight (p = 0.0219) at hatch, a lower body weight up to 28 days post-hatch (p = 0.0418), a lower daily weight gain (p = 0.0498) and a higher feed conversion ratio (p = 0.0395) during the starter period (p = 0.0498), resulting in a higher overall offspring feed conversion ratio (p = 0.0317) compared to the control diet. DHA supplementation, on the other hand, resulted in a lower residual yolk weight (p = 0.0220) and a higher overall offspring mortality (p = 0.0125). In conclusion, supplementation of n-3 FA could not counter the adverse effect of breeder flock age, but did not harm incubation or improve post-hatch performance, either. EPA and DHA affected offspring development differently during early post-hatch life. � 2015 Blackwell Verlag GmbH. [less ▲]

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See detailEffects of melody and technique on acoustical and musical features of Western operatic singing voices
Larrouy, Pauline ULg; Magis, David ULg; Morsomme, Dominique ULg

in Journal of Voice (2014)

Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains ... [more ▼]

Objective: The operatic singing technique is frequently employed in classical music. Several acoustical parameters of this specific technique have been studied but how these parameters combine remains unclear. This study aims to further characterize the Western operatic singing technique by observing the effects of melody and technique on acoustical and musical parameters of the singing voice. Methods: Fifty professional singers performed two contrasting melodies (popular song and romantic melody) with two vocal techniques (with and without operatic singing technique). The common quality parameters (energy distribution, vibrato rate and extent), perturbation parameters (standard deviation of the fundamental frequency, signal-to-noise ratio, jitter and shimmer) and musical features (fundamental frequency of the starting note, average tempo, and sound pressure level) of the 200 sung performances were analyzed. Results: The results regarding the effect of melody and technique on the acoustical and musical parameters show that the choice of melody had a limited impact on the parameters observed, whereas a particular vocal profile appeared depending on the vocal technique employed. Conclusions: This study confirms that vocal technique affects most of the parameters examined. In addition, the observation of quality, perturbation and musical parameters contributes to a better understanding of the Western operatic singing technique. [less ▲]

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See detailEffects of meloxicam compared to acetylsalicylic acid in human articular chondrocytes
Bassleer, Corinne; Magotteaux, Jacques ULg; Geenen, Vincent ULg et al

in Pharmacology (1997), 54

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See detailEffects of metabolism inhibitors, antiestrogens and antiandrogens on the androgen and estrogen induced sexual behavior in Japanese quail.
Alexandre, Corine; Balthazart, Jacques ULg

in Physiology & Behavior (1986), 38(4), 581-91

The relative contribution of androgenic and estrogenic metabolites of testosterone to the activation of sexual behavior was studied in Japanese quail by using inhibitors of testosterone metabolism ... [more ▼]

The relative contribution of androgenic and estrogenic metabolites of testosterone to the activation of sexual behavior was studied in Japanese quail by using inhibitors of testosterone metabolism, antiestrogens and antiandrogens. These compounds were tested in castrated birds whose sexual behavior had been activated by silastic implants of testosterone (T) or daily injections of testosterone propionate (TP) or diethylstilboestrol (DES). The aromatase inhibitor ATD only depressed T-induced behavior when injected at high doses and the 5 alpha-reductase inhibitor, 4MA was inactive in this respect. The antiestrogens, tamoxifen (TAM) and nitromifene citrate (CI-628) strongly depressed sexual behavior but they also drastically reduced the crowing behavior which is typically androgen-dependent which throws some doubts on the specificity of their action. The antiandrogens, flutamide and cyproterone acetate (CA), only had limited inhibitory effects on the copulatory behavior but similarly decreased only marginally the crowing. As they strongly depressed the cloacal gland growth, it can be ascertained that they were injected in sufficient amounts and their lack of action on crowing questions the ability of these compounds to inhibit brain processes even when they are androgen-dependent. Taken together with the results of previous experiments which tested the behavioral effects of the testosterone metabolites, the present data confirm the implication of both androgenic and estrogenic metabolites of testosterone in the activation of behavior. Their interaction remains, however, poorly defined and its understanding will probably require the identification of the biochemical processes which in the brain mediate the behavior. [less ▲]

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See detailEffects of metals on mouse B16 melanoma and 3T3 fibroblasts
Siwek, Brigitte; Bahbouth, E; De Pauw-Gillet, Marie-Claire ULg et al

Poster (1990, October)

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See detailEffects of methane on giant planet’s UV emissions and implications for the auroral characteristics
Gustin, Jacques ULg; Gérard, Jean-Claude; Grodent, Denis ULg et al

in Journal of Molecular Spectroscopy (2013)

This study reviews methods used to determine important characteristics of giant planet’s UV aurora (brightness,energy of the precipitating particles, altitude of the emission peak,. . .), based on the ... [more ▼]

This study reviews methods used to determine important characteristics of giant planet’s UV aurora (brightness,energy of the precipitating particles, altitude of the emission peak,. . .), based on the absorbing properties of methane and other hydrocarbons. Ultraviolet aurorae on giant planets are mostly caused by inelastic collisions between energetic magnetospheric electrons and the ambient atmospheric H2 molecules. The auroral emission is situated close to a hydrocarbon layer and may be attenuated by methane (CH4), ethane (C2H6) and acetylene (C2H2) at selected wavelengths. As methane is the most abundant hydrocarbon, it is the main UV absorber and attenuates the auroral emission shorward of 1350 Å. The level of absorption is used to situate the altitude/pressure level of the aurora, hence the energy of the precipitated electrons, whose penetration depth is directly related to their mean energy. Several techniques are used to determine these characteristics, from the color ratio method which measures the level of absorption from the ratio between an absorbed and an unabsorbed portion of the observed auroral spectrum, to more realistic methods which combine theoretical distributions of the precipitating electrons with altitude dependent atmospheric models. The latter models are coupled with synthetic or laboratory H2 spectra and the simulated emergent spectra are compared to observations to determine the best auroral characteristics. Although auroral characteristics may be very variable with time and locations, several typical properties may be highlighted from these methods: the Jovian aurora is the most powerful, with brightness around 120 kR produced by electrons of mean energy 100 keV and an emission situated near the 1 lbar level ( 250 km above the 1 bar level) while Saturn’s aurora is fainter ( 10 kR), produced by electrons less than 20 keV and situated near the 0.2 lbar level ( 1100 km). [less ▲]

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See detailEffects of methionine sources in interaction with dietary protein content on performance and oxidative status of broiler chickens
Swennen, Q.; Buyse, Johan; Mercier, Yves et al

Poster (2010)

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See detailEffects of Methylmercury on Harbour Seal Peripheral Blood Leucocytes In Vitro Studied by Electron Microscopy
Dupont, Aurélie; De Pauw-Gillet, Marie-Claire ULg; Schnitzler, Joseph ULg et al

in Archives of Environmental Contamination & Toxicology (2016), 70(1), 133-142

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal ... [more ▼]

Methylmercury MeHg is highly immunotoxic and can alter the health status of the harbour seal, Phoca vitulina, from the North Sea. To investigate the mechanism of MeHg-induced toxicity in harbour seal lymphocytes, ConA-stimulated peripheral blood leucocytes were exposed in vitro to sub-lethal concentrations of MeHgCl (0.2, 1 and 2 µM) for 72h, and then analysed for their viability and ultrastructure. After 72h of incubation, cells were counted with a propidium iodide staining technique, a metabolic MTS assay was performed, and cells exposed to 1 µM MeHgCl were observed by transmission electron microscopy (TEM). Alive cell numbers decreased with increased MeHgCl concentrations. In presence of ConA and 1µM of MeHgCl, TEM images revealed a higher frequency of apoptotic cells. Exposed cells displayed condensation of the chromatin at the nuclear membrane and mitochondrial damages. The results suggest that in vitro MeHgCl induced apoptosis in harbour seal lymphocytes through a mitochondrial pathway. [less ▲]

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See detailEffects of micellar adsorption on the photosensitizing properties of xanthènes dyes
Hoebeke, Maryse ULg; Gandin, Ezio; Decuyper, Jean et al

in Journal of photochemistry (1986), 35

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See detailEffects of mild heat stress periods on milk production, milking frequency and rumination time of grazing cows milked by an automatic milking system
Lessire, Françoise ULg; Hornick, Jean-Luc ULg; Dufrasne, Isabelle ULg

in Hopkins, A; Collins, Rosemary; Fraser, Mariecia (Eds.) et al EGF at 50: The future of European grasslands (2014, September 10)

Grazing dairy cows milked by an automatic system (AS) experienced mild heat stress (HS) periods, twice during the summer. The daily temperature humidity index (THI) during these periods were higher than ... [more ▼]

Grazing dairy cows milked by an automatic system (AS) experienced mild heat stress (HS) periods, twice during the summer. The daily temperature humidity index (THI) during these periods were higher than 72. Milk production, as well as milking frequency, rumination time and milk fat to protein ratio (F/P) during these periods were compared to adjacent periods with mean THI of 61. The daily milking frequency, the total number of visits to AS and the milk production were significantly higher in HS periods (2.12 vs 1.97, 2.99 vs 2.69, and 19.7 vs 18.5 kg milk per cow, respectively). There were significant interactions between times and periods for milking frequency and number of visits, while the daily rumination time was significantly lower (339 vs 419 min) and the F/P in milk tended to be decreased (1.17 vs 1.23). These results could be explained by changes in cow behaviour during HS periods. [less ▲]

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See detailEffects of Mild Hypothermic Cardiopulmonary Bypass on Eeg Bispectral Index
Dewandre, Pierre-Yves; Hans, Pol ULg; Bonhomme, Vincent ULg et al

in Acta Anaesthesiologica Belgica (2000), 51(3), 187-90

We studied the effect of mild hypothermic cardiopulmonary bypass (30 degrees C) on the EEG Bispectral Index in 10 patients undergoing elective CABG. BIS was recorded at 11 event-related time points during ... [more ▼]

We studied the effect of mild hypothermic cardiopulmonary bypass (30 degrees C) on the EEG Bispectral Index in 10 patients undergoing elective CABG. BIS was recorded at 11 event-related time points during the procedure. After a significant decrease at the induction of anaesthesia, BIS was not further modified during the procedure. BIS was neither affected by surgical stimulation nor by CPB and mild hypothermia. We conclude that we did not find any reason to preclude the use of BIS to assess the hypnotic effects of anaesthetics during normothermic or mild hypothermic CPB. [less ▲]

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See detailEffects of mixing on Penicillium canescens and xylanase productivity.
Gaspar, A.; Bruxelmane, M.; Smirani, R. et al

Poster (1997, August)

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See detailEffects of moderate rotation on stellar pulsations, nonperturbative methods
Neuforge, C.; Briquet, Maryline ULg; Scuflaire, R.

Poster (2000, September 25)

Detailed reference viewed: 3 (0 ULg)