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See detailEffect of intermittent and continuous exposure to electromagnetic fields on cultured hippocampal cells
Boland, André ULg; Gabriel, Danielle ULg; Breeur, Danielle ULg et al

in Bioelectromagnetics (2002), 23(2), 97-105

This study was designed to assess the effect of 50 Hz electromagnetic fields (EMFs) on hippocampal cell cultures in the presence or absence of either sodium nitroprusside (SNP, a NO donor) or Fe2+ induced ... [more ▼]

This study was designed to assess the effect of 50 Hz electromagnetic fields (EMFs) on hippocampal cell cultures in the presence or absence of either sodium nitroprusside (SNP, a NO donor) or Fe2+ induced oxidative stress. One week old cultured rat hippocampal cells were exposed to either intermittent EMFs (IEMFs, 50 Hz, 0-5 mT, 1 min ON/OFF cycles, repeated 10 times every 2 h, 6 times/day during 48 h) or continuous EMFs (CEMFs, 50 Hz, 0-5 mT for 48 h). In a second set of experiments, the effect on such EMFs applied in combination with oxidative stress induced by 0.5 microM Fe2+ or SNP was estimated. At the end of both sets of experiments, cell mortality was assessed by lactate dehydrogenase measurements (LDH). Neither type of exposure to EMFs was observed to modify the basal rate of cell mortality. The exposure to CEMFs in presence of either NO or Fe2+ did not induce any significant increase in cell death. However, when cells were exposed to EMFs in the presence of NO, we observed a significant increase in cell death of 11 and 23% (P<0.001) at 2.5 and 5 mT, respectively. This effect had some specificity because IEMFs did not modify the effect of Fe2+ on cell mortality. Although the effects of IEMFs reported in this study were only observed at very high intensities, our model may prove valuable in trying to identify one cellular target of EMFs. [less ▲]

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See detailEffect of intra-operative magnesium sulphate on pain relief and patient comfort after major lumbar orthopaedic surgery
Levaux, Christine ULg; Bonhomme, Vincent ULg; Dewandre, Pierre-Yves et al

in Anaesthesia (2003), 58(2), 131-135

The effects of intra-operative magnesium sulphate on pain relief after major lumbar surgery were investigated in 24 patients. Patients were randomly allocated to receive either an infusion of 50 mg x kg ... [more ▼]

The effects of intra-operative magnesium sulphate on pain relief after major lumbar surgery were investigated in 24 patients. Patients were randomly allocated to receive either an infusion of 50 mg x kg(-1) magnesium sulphate or an equivalent volume of saline at induction of anaesthesia. Anaesthesia was induced with propofol and remifentanil. Tracheal intubation was facilitated using rocuronium. Maintenance was achieved with remifentanil and sevoflurane in nitrous oxide/ oxygen. Intra-operative monitoring included standard equipment and neuromuscular transmission. During surgery, neuromuscular block recovery was longer in the magnesium group. Postoperative opioid consumption and pain scores were lower in the magnesium group. The first night's sleep and the global satisfaction scores were better in the magnesium group. The results of the study support magnesium sulphate as a useful adjuvant for postoperative analgesia after major lumbar surgery. [less ▲]

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See detailThe effect of intraoperative 6% balanced hydroxyethyl starch (130/0.4) during cardiac surgery on transfusion requirements.
HANS, Grégory ULg; Ledoux, Didiier; Roediger, Laurence et al

in Journal of cardiothoracic and vascular anesthesia (2015), 29(2), 328-32

OBJECTIVES: To compare transfusion requirements in adult cardiac surgery patients when balanced hydroxyethyl starches (HES) (130/0.4) or balanced crystalloids is used for pump prime and intraoperative ... [more ▼]

OBJECTIVES: To compare transfusion requirements in adult cardiac surgery patients when balanced hydroxyethyl starches (HES) (130/0.4) or balanced crystalloids is used for pump prime and intraoperative fluid therapy. DESIGN: Data were obtained retrospectively from medical records and perfusion charts. Matching based on propensity scores was used to adjust for potential confounders. SETTING: A university hospital. PARTICIPANTS: Adult patients undergoing cardiac surgery with the use of cardiopulmonary bypass. INTERVENTIONS: Allocation to one of the study groups according to whether balanced HES or balanced crystalloids was used for pump prime and intraoperative fluid therapy. MEASUREMENTS AND MAIN RESULTS: 240 propensity-matched patients were retained for final analyses. Forty-eight patients (40%) of the colloid group and 28 patients (23.3%) of the crystalloid group received blood products, with an odd ratio (95% CI) of 2.1(1.2-3.8 (P=0.009). After bypass HES patients had lower hemoglobin levels (8.4 [1.3] gr/dL vs 9.6 [2] gr/dL; P<0.001) and a higher cumulative chest drain output after 3 hours (180 [210] mL vs 140 [100] mL, P<0.001]. Heparinase thromboelastogram (TEG(R)) showed longer K times (2.5[1.1] vs 1.6[0.8], P<0.001) and lower maximal amplitudes (55.1[12.5] vs 63.4[9.8], P=0.008). CONCLUSIONS: HES patients required more transfusions, owing to greater hemodilution, HES-induced clotting disturbances, and bleeding. [less ▲]

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See detailThe Effect of Intravenous Administration of Web 2086 on Paf-Induced Platelet Aggregation in Healthy Friesian Calves
Bastos da Silva, Miriam; Gustin, Pascal ULg; Herion, Francine ULg et al

in Veterinary Research Communications (1997), 21(7), 521-531

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet ... [more ▼]

The in vivo ability of the specific PAF-antagonist WEB 2086, a thienotriazolodiazepine, to inhibit platelet-activating factor (PAF) in cattle was investigated by in vitro determination of platelet aggregation curves. WEB 2086 was infused intravenously into a group of 5 healthy male Friesian calves in a dose of 3 mg/kg over 1 min. The resultant inhibition peaked between 30 min and 1 h after administration of WEB 2086. The inhibition was significantly reduced after 3 h and became non-significant after 6 h, but maximal pre-treatment aggregation had not been restored by 24 h after the injection of WEB 2086. These results confirm previous results obtained in vitro and suggest that WEB 2086 is a potent antagonist of PAF activity in calves. They also suggest that further clinical studies with WEB 2086 in cattle are desirable. [less ▲]

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See detailEffect of intravenous and aerosol administration of 5-hydroxytryptamine on pulmonary function values in healthy calves
Desmecht, Daniel ULg; Linden, Annick ULg; Rollin, Frédéric ULg et al

in American Journal of Veterinary Research (1992), 53(3), 315-320

Effects of IV and aerosol administration of 5-hydroxytryptamine (5-HT) on ventilation, pulmonary mechanics values, pulmonary arterial pressure, and heart rate were investigated in healthy unsedated ... [more ▼]

Effects of IV and aerosol administration of 5-hydroxytryptamine (5-HT) on ventilation, pulmonary mechanics values, pulmonary arterial pressure, and heart rate were investigated in healthy unsedated Friesian calves. Minute volume increased significantly, mainly because of an increase in respiratory rate. Except for total pulmonary resistance after bolus injection, continuous administration of 5-HT given by either route caused significant alterations of lung dynamic compliance and total pulmonary resistance, the former decreasing to one-fifth of its baseline value and the latter increasing twofold. Pulmonary arterial pressure increased significantly, whatever the speed or route of administration. Administration of a bolus did not affect heart rate, whereas continuous IV administration of 5-HT as well by perfusion or by aerosol resulted in sustained tachycardia. It was concluded that 5-HT induces reversible bronchoconstriction and pulmonary vasoconstriction in healthy unsedated calves, 5-HT-induced functional alterations depend on the speed of administration, and excess of 5-HT production or depression in uptake by the lungs during bovine respiratory tract diseases could contribute to pulmonary dysfunction. [less ▲]

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See detailEffect of intravenous infusion of lidocaine on spontaneous recovery from cisatracurium-induced neuromuscular block: Preliminary results: 9AP4--3
HANS, Grégory ULg; Defresne, A.; Ki, B. et al

in European Journal of Anaesthesiology (2010), 27(47), 149

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See detailEffect of intravenous lidocaine on the depth of propofol anesthesia assessed by the bispectral index (BIS)
Delangh, Virginie; Hans, Grégory ULg; Kaba, Abdourahmane ULg et al

in Acta Anaesthesiologica Belgica (2008, June 14), 59(3), 206

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See detailEffect of Intravenous Lidocaine on the Depth of Propofol Anesthesia Measured by the Bispectral Index
HANS, Grégory ULg; Lauwick, Severine; Defechereux, Thierry et al

in Anesthesiology (2007), 107

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See detailEffect of Intravenous Platelet-Activating Factor on Bovine Pulmonary Mast Cells
Jolly, Sandra ULg; Thomas, Cédric; Genicot, Bruno et al

in Journal of Comparative Pathology (2001), 125(Aug-Oct), 81-89

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six ... [more ▼]

The effect of platelet-activating factor (PAF) on bovine pulmonary mast cells (MCs) was investigated in calves aged 1-4 months. PAF was administered over a 5-min period at a rate of 50 ng/kg/min to six animals, which were killed approximately 10 min later. No macroscopical lesions were observed in the lung tissue of five control calves. On semi-thin toluidine-blue stained sections, MC cytoplasm showed profuse deep-blue granulation. In the lung tissues of PAF-treated calves, striking interstitial, alveolar and interlobular oedema and emphysema were observed. MC granules occurred at the periphery of the cytoplasm and MC nuclei were easily detectable. Moreover, the number of granules in the MC cytoplasm was remarkably low. A few granules with some metachromatic material were sometimes detected outside the cell limits. Ultrastructurally, the matrix pattern of the MC granules in lung tissues of control calves was either amorphous or granular. In lung tissues of the PAF-treated calves, the granular matrix pattern was pronounced, varying from fine- to coarse-grained, and the MCs were of reduced size, with many filiform processes and exocytotic vesicles. These findings indicate that pulmonary MC degranulation was induced by PAF in healthy calves. [less ▲]

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See detailEffect of inulin and wheat bran in the creep feed of neonatal piglets
Li, Bing ULg; Leblois, Julie ULg; Bindelle, Jérôme ULg et al

Conference (2015, May 22)

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See detailEffect of inventory plot patterns in the floristic analysis of tropical woodland and dense forest
Houeto, Georges; Glele Kakai, Romain L.; Salako, Valère et al

in African Journal of Ecology (2013), 51(3),

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See detailEffect of iodised fertilisation on iodine content in grass and on thyroid hormones concentrations in dairy heifers.
Dufrasne, Isabelle ULg; Dotreppe, Olivier ULg; Meura, S. et al

in Permanent and temporary grassland plant, environment and economy, A De Vliegher an L. Carlier editors, Book of abstracts of 14th Symposium of European Grassland Federation (2007)

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See detailEffect of ionic aggregation on ionomer chain dimensions. 1. Telechelic polystyrenes
Register, Richard A; Cooper, Stuart L; Thiyagarajan, Pappannan et al

in Macromolecules (1990), 23(11), 2978-2983

Carboxy-telechelic polystyrenes with degrees of polymerization of ca. 70 were examined by small-angle neutron scattering in the Na+ ionomer and methyl ester forms to ascertain the effect of ionic ... [more ▼]

Carboxy-telechelic polystyrenes with degrees of polymerization of ca. 70 were examined by small-angle neutron scattering in the Na+ ionomer and methyl ester forms to ascertain the effect of ionic aggregation on the chain dimensions. The ionomers contain ionic aggregates, as demonstrated by smallangle X-ray scattering. The chain dimensions were found to be identical for the ionomer and ester, in agreement with the predictions of Squires et al. but in disagreement with the theories of Forsman and Dreyfus. Detailed analysis of the data showed that the contacts between the two isotopic types were random, as intended. The data were satisfactorily described by a polydisperse assembly of wormlike chains, with a Kuhn statistical length comparable to that for homopolystyrene. [less ▲]

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See detailThe effect of IR-helium-neon laser in human chondrocyte cultivated in three dimensions
Bassleer, C; Reginster, Jean-Yves ULg; Dachy, M et al

in Calcified Tissue International (1985), 38(S1), 38

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See detailEffect of iron nanoparticles synthesized by a sol-gel process on Rhodococcus erythropolis T902.1 for biphenyl degradation
Wannoussa, Wissal ULg; Masy, Thibaut ULg; Lambert, Stéphanie ULg et al

in Journal of Water Resource and Protection (2015), 7

Nanoparticles (NPS) are considered as a new generation of compounds to improve environmental remediation and biological processes. The aim of this study is to investigate the effect of iron NPS ... [more ▼]

Nanoparticles (NPS) are considered as a new generation of compounds to improve environmental remediation and biological processes. The aim of this study is to investigate the effect of iron NPS encapsulated in porous silica (SiO2) on the biphenyl biodegradation by Rhodococcus erythropolis T902.1 (RT902.1). The iron NPS (major iron oxide FexOy form) were dispersed in the porosity of a SiO2 support synthesized by sol-gel process. These Fe/SiO2 NPS offer a stimulating effect on the biodegradation rate of biphenyl, an organic pollutant that is very stable and water-insoluble. This positive impact of NPS on the microbial biodegradation was found to be dependent on the NPS concentration ranging from 10−6 M to 10−4 M. After 18 days of incubation the cultures containing NPS at a concentration of 10−4 M of iron improved RT902.1 growth and degraded 35% more biphenyl than those without NPS (positive control) or with the sole SiO2 particles. Though the microorganism could not interact directly with the insoluble iron NPS, the results show that about 10% and 35% of the initial 10−4 M iron NPS encapsulated in the SiO2 matrix would be incorporated inside or adsorbed on the cell surface respectively and 35% would be released in the supernatant. These results suggest that RT902.1 would produce siderophore-like molecules to attract iron from the porous silica matrix. [less ▲]

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See detailEffect of isoflurane on the auditory steady-state response and on consciousness in human volunteers.
Plourde, Gilles; Villemure, Chantal; Fiset, Pierre et al

in Anesthesiology (1998), 89(4), 844-51

BACKGROUND: The auditory steady state response (ASSR) is a sustained electrical response of the brain to auditory stimuli delivered at fast rates (30-50 responses/s). The aim of this study was to evaluate ... [more ▼]

BACKGROUND: The auditory steady state response (ASSR) is a sustained electrical response of the brain to auditory stimuli delivered at fast rates (30-50 responses/s). The aim of this study was to evaluate the effect of 0.26-0.50% isoflurane on the ASSR and on consciousness, defined as responsiveness to verbal commands. METHODS: Ten volunteers (21-31 yr) participated. Isoflurane was administered at three stable, end-tidal concentrations: 0.26%, 0.38%, and 0.50%. The ASSR in response to 18,000 stimuli (500-Hz tonebursts, 10 ms, 82-dB, the right ear, 35-45 bursts/s) was recorded from the vertex with reference to the right mastoid. Recordings were made during baseline, at each isoflurane concentration, and during recovery. RESULTS: The mean (SD) ASSR amplitudes were 0.32 (0.23) microV during baseline, 0.24 (0.17) microV during 0.26% isoflurane, 0.09 (0.05) microV during 0.38% isoflurane, 0.04 (0.03) microV during 0.50% isoflurane, and 0.29 (0.33) microV during recovery. The amplitude during baseline and recovery was larger than during 0.38% and 0.50% isoflurane (P < 0.001). The amplitude at 0.26% was larger than at the other concentrations (P < 0.025). The logarithm of the ASSR amplitude was related linearly to the concentration of isoflurane (r = 0.85; P < 0.0001). The prediction probability (Pk) for loss of consciousness was 0.95 for both ASSR and measured isoflurane concentration. An ASSR amplitude < 0.07 microV was always associated with unconsciousness. CONCLUSIONS: The ASSR is attenuated in a concentration-dependent manner by isoflurane. Suppression of consciousness and maximal attenuation of ASSR occur in the same isoflurane concentration range. Profound attenuation of ASSR appears to reflect unconsciousness, defined as unresponsiveness to verbal commands. [less ▲]

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See detailEffect of isoprostanes on bronchial smooth muscle in healthy and asthma-like horses
Kirschvink, Nathalie; Lekeux, Pierre ULg; Art, Tatiana ULg et al

in American Journal of Respiratory & Critical Care Medicine (2000), 161(3), 274

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See detailEffect of isothermal ageing on the Zn-Al alloys creep characteristics
Lecomte-Beckers, Jacqueline ULg; Terziev; Wegria et al

in Proceedings of The 3rd International Conference on Zn-Al Alloys - Advances in Science, Technology and Applications of Zn-Al Alloys (1994)

The aim of this study is to correlate the creep parameters of aged Zn-Al samples with the microstructure developed during heat treatment, and to point out the practical interest of such microstructure ... [more ▼]

The aim of this study is to correlate the creep parameters of aged Zn-Al samples with the microstructure developed during heat treatment, and to point out the practical interest of such microstructure modifications. Two different isothermal ageings were carried out at 100°C and at 250°C for different periods of times (from 30 min. to 8 weeks). During those ageings, complex precipitations occur. The decomposition of the initial supersaturated solid solution begins with a cellular reaction leading to cfc and hcp lamellar. The cfc phase decomposes into transition phases. The ageing temperature (100 or 250°C) influences the decomposition stages. Creep testson aged samples reveal the influence of the microstructure developed during the heat treatment at 100 or 250°C. An improvement of the creep properties by one order of magnitude can be observed when the sample exhibits the appropriate structure. [less ▲]

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See detailEffect of itraconazole and rifampin on the pharmacokinetics of olaparib table formulation in patients with advanced solid tumors : phase I open-label studies
Plummer, Elizabeth R.; Verheul, Henk M.W.; Rottey, Sylvie et al

in Journal of Clinical Oncology (2015), 33(suppl : abstr 2565),

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