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See detailEnhanced Efficiency Of A Targeted Fusogenic Peptide
Decout, A.; Labeur, C.; Goethals, M. et al

in Biochimica et Biophysica Acta-Biomembranes (1998), 1372(1), 102-16

Membrane targeting was investigated as a potential strategy to increase the fusogenic activity of an isolated fusion peptide. This was achieved by coupling the fusogenic carboxy-terminal part of the beta ... [more ▼]

Membrane targeting was investigated as a potential strategy to increase the fusogenic activity of an isolated fusion peptide. This was achieved by coupling the fusogenic carboxy-terminal part of the beta-amyloid peptide (Abeta, amino acids 29-40), involved in Alzheimer's disease, to a positively charged peptide (PIP2-binding peptide, PBP) interacting specifically with a naturally occurring negatively charged phospholipid, phosphatidylinositol 4, 5-bisphosphate (PIP2). Peptide-induced vesicle fusion was spectroscopically evidenced by: (i) mixing of membrane lipids, (ii) mixing of aqueous vesicular contents, and (iii) an irreversible increase in vesicle size, at concentrations five to six times lower than the Abeta(29-40) peptide. In contrast, at these concentrations the PBP-Abeta(29-40) peptide did not display any significant activity on neutral vesicles, indicating that negatively charged phospholipids included as targets in the membranes, are required to compensate for the lower hydrophobicity of this peptide. When the alpha-helical structure of the chimeric peptide was induced by dissolving it in trifluoroethanol, an increase of the fusogenic potential of the peptide was observed, supporting the hypothesis that the alpha-helical conformation of the peptide is crucial to trigger the lipid-peptide interaction. The specificity of the interaction between PIP2 and the PBP moiety, was shown by the less efficient targeting of the chimeric peptide to membranes charged with phosphatidylserine. These data thus demonstrate that the specific properties of both the Abeta(29-40) and the PBP peptide are conserved in the chimeric peptide, and that a synergetic effect is reached through chemical linkage of these two fragments. [less ▲]

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See detailEnhanced exploratory activity in woodlice exposed to random visuo-tactile patterns
Anselme, Patrick ULg

in Learning & Motivation (2015), 50

In birds and mammals, randomness is known to have excitatory effects on exploratory behavior, but this phenomenon has not extensively been studied in invertebrates. Four experiments examined the ... [more ▼]

In birds and mammals, randomness is known to have excitatory effects on exploratory behavior, but this phenomenon has not extensively been studied in invertebrates. Four experiments examined the propensity of woodlice (Porcellio scaber) to choose between the exploration of an environment composed of random visuo-tactile patterns and the exploration of an environment composed of regular visuo-tactile patterns. Rearing-up behavior and distance traveled were measured to determine (i) woodlice’s reactivity to a forced exposure to random or regular patterns, (ii) the effect of random and regular patterns on exploratory choice, (iii) the effect of random and regular patterns on exploratory choice in preexposed animals, and (iv) the effect of a shelter available in the less explored environment on exploratory choice. The results suggest that random visuo-tactile patterns have an excitatory effect on the exploratory behavior of woodlice and that this effect develops more rapidly if the woodlice were initially preexposed to those patterns. They also suggest that exploration is related to the search for better habitat conditions because the presence of a shelter abolishes that behavior. [less ▲]

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See detailEnhanced expression in seminoma of human zinc finger genes located on chromosome 19
Ogawa, Takehiko; Poncelet, Dominique A; Kinoshita, Yuzo et al

in Cancer Genetics & Cytogenetics (1998), 100(1), 36-42

Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same ... [more ▼]

Six Kruppel-type zinc finger (ZF) genes were cloned from a seminoma cDNA library. One, ZFS-1, showed high sequence homology to the ZNF91 KRAB (Kruppel-associated box) ZF gene family and also the same chromosomal assignment. Interestingly, Northern blot analyses using ZFS-1 and ZNF91 revealed that multiple ZF genes on chromosome 19 were predominantly expressed in seminomas. In addition, the testis and the seminoma showed specific expression of 2.3 kb transcript. Our results suggest that ZF genes on chromosome 19 may be implicated in the development and/or growth of seminomas. [less ▲]

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See detailEnhanced FEM-based Modeling of Brain Shift Deformation in Image-Guided Neurosurgery
Vigneron, Lara M.; Boman, Romain ULg; Ponthot, Jean-Philippe ULg et al

in Journal of Computational & Applied Mathematics (2010), 234

We consider the problem of improving outcomes for neurosurgery patients by enhancing intraoperative navigation and guidance. Current navigation systems do not accurately account for intraoperative brain ... [more ▼]

We consider the problem of improving outcomes for neurosurgery patients by enhancing intraoperative navigation and guidance. Current navigation systems do not accurately account for intraoperative brain deformation. We focus on the brain shift deformation that occurs just after the opening of the skull and dura. The heart of our system is a nonrigid registration technique using a biomechanical model. We specifically work on two axes: the representation of the structures in the biomechanical model and the evaluation of the surface landmark displacement fields between intraoperative MR images. Using the modified Hausdorff distance as an image similarity measure, we demonstrate that our approach significantly improves the alignment of the intraoperative images. ' 2009 Elsevier B.V. All rights reserved. [less ▲]

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See detailEnhanced insulin sensitivity variability in the first 3 days of ICU stay: Implications for TGC
Chase, J. Geoffrey; Le Compte, Aaron; Penning, Sophie ULg et al

in Critical Care (2011, March)

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See detailEnhanced insulin sensitivity variability in the first 3 days of ICU stay: Implications for TGC
Chase, Geoffrey; Le Compte, Aaron; Penning, Sophie ULg et al

Poster (2011, March)

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See detailEnhanced interpretation of newborn screening results without analyte cutoff values
Marquardt, G.; Currier, R.; McHugh, D. M. S. et al

in Genetics in Medicine (2012), 14(7), 648-655

Purpose: To improve quality of newborn screening by tandem mass spectrometry with a novel approach made possible by the collaboration of 154 laboratories in 49 countries. Methods: A database of 767,464 ... [more ▼]

Purpose: To improve quality of newborn screening by tandem mass spectrometry with a novel approach made possible by the collaboration of 154 laboratories in 49 countries. Methods: A database of 767,464 results from 12,721 cases affected with 60 conditions was used to build multivariate pattern recognition software that generates tools integrating multiple clinically significant results into a single score. This score is determined by the overlap between normal and disease ranges, penetration within the disease range, differences between conditions, and weighted correction factors. Results: Ninety tools target either a single condition or the differential diagnosis between multiple conditions. Scores are expressed as the percentile rank among all cases with the same condition and are compared to interpretation guidelines. Retrospective evaluation of past cases suggests that these tools could have avoided at least half of 279 false-positive outcomes caused by carrier status for fatty-acid oxidation disorders and could have prevented 88% of known false-negative events. Conclusion: Application of this computational approach to raw data is independent from single analyte cutoff values. In Minnesota, the tools have been a major contributing factor to the sustained achievement of a false-positive rate below 0.1% and a positive predictive value above 60%. © 2012 American College of Medical Genetics and Genomics. [less ▲]

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See detailEnhanced mechanical properties after cold process of fabrication of non-linear metallic profiles
Rossi, Barbara ULg; Pascon, Frédéric ULg; Degée, Hervé ULg

in Thin-Walled Structures (2009), 47(12), 1575-1589

It is well known that the cold-forming process is likely to significantly enhance the mechanical properties of the profile by strain hardening leading to increased resistance compared to a resistance ... [more ▼]

It is well known that the cold-forming process is likely to significantly enhance the mechanical properties of the profile by strain hardening leading to increased resistance compared to a resistance assessment based on nominal properties. It is thus necessary to accurately determine the mechanical properties after the cold process of fabrication. In this paper, experimental reference data and formulae calculating the increased proof strength in cold-formed stainless steel profiles are reviewed. A new theory-based formula for the evaluation of the actual mechanical properties of stainless steel structural members using the virgin sheet material properties is then established. This formula is dependent upon the radius of curvature to thickness ratio; it is not restricted to a single alloy but is valid for non-linear metallic materials. Prediction efficiency is evaluated against the collected experimental data and particular attention is paid to the set of experimental data related to hollow sections. The main thrust of the predictive model lies in its axiomatic roots in contrast to the traditional empirical formulae found in the literature. [less ▲]

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See detailEnhanced Multivariate Analysis of Mainstream Tobacco Smoke Particulate Phase by HS-SPME-GC×GC-TOFMS
Brokl, Michal ULg; Bishop, L; Wright, c et al

in Hyphenated Techniques in Chromatography HTC-13 - Book of abstracts (2014, January)

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See detailEnhanced Multivariate Analysis of Mainstream Tobacco Smoke Particulate Phase by HS-SPME-GC×GC-TOFMS
Brokl, Michal ULg; Bishop, L; Wright, C et al

Conference (2014, May 19)

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See detailEnhanced neural activation in brain regions mediating sexual responses following exposure to a conditioned stimulus that predicts copulation.
Taziaux, Mélanie ULg; Kahn, A.; Moore, J. et al

in Neuroscience (2008), 151(3), 644-58

Stimuli associated with sexual behavior increase reproductive success if presented prior to copulation. In Japanese quail, inseminations that take place in a context that predicts the arrival of a female ... [more ▼]

Stimuli associated with sexual behavior increase reproductive success if presented prior to copulation. In Japanese quail, inseminations that take place in a context that predicts the arrival of a female are more likely to result in fertilized eggs. We demonstrate here that in male Japanese quail a sexual conditioned stimulus (CS) also enhances activity in two brain regions that mediate sexual behavior, the medial preoptic area and the medial part of the bed nucleus of the stria terminalis. C-fos expression, a marker of neural activation, was higher in these areas in subjects exposed sequentially to a sexual CS and copulation than in subjects exposed to copulation or the CS alone or in subjects exposed to no sexual stimulus, either an identical, untrained CS or an empty arena. These results suggest a link between a proximate result of sexual CS presentation, male brain activation, and a known ultimate outcome, increased fertilizations. [less ▲]

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See detailEnhanced neutralizing activity of anti-BVD monoclonal antibodies with anti-mouse Ig goat serum or when some Mabs are mixed
Boulanger, D.; Waxweiler, S.; Karelle-Bui, L. et al

Poster (1990)

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See detailEnhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation.
Maquoi, Erik ULg; Demeulemeester, Diego; Vörös, Gabor et al

in Thrombosis and Haemostasis (2003), 89(4), 696-704

To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat ... [more ▼]

To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3(-/-)) and wild-type (MMP-3(+/+)) controls were kept on a high fat diet (HFD) for 15 weeks. MMP-3(-/-) mice were hyperphagic and gained more weight than the MMP-3(+/+) mice. At the time of sacrifice, the body weight of the MMP-3(-/-) mice was significantly higher than that of the MMP-3(+/+) mice, as was the weight of the isolated subcutaneous (SC) and gonadal (GON) fat deposits. Significant adipocyte hypertrophy was observed in the GON but not in the SC adipose tissue of MMP-3(-/-) mice. Fasting plasma glucose and cholesterol levels were comparable in both genotypes, whereas triglyceride levels were significantly lower in MMP-3(-/-) mice. Staining with an endothelial cell specific lectin revealed a significantly higher blood vessel density and larger total stained area in the GON adipose tissues of MMP-3(-/-) mice. Thus, in a murine model of nutritionally induced obesity, MMP-3 impairs adipose tissue development, possibly by affecting food intake and/or adipose tissue-related angiogenesis. [less ▲]

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See detailEnhanced ocean carbon storage from anaerobic alkalinity generation in coastal sediments
Thomas, H.; Schiettecatte, L.-S.; Suykens, Kim ULg et al

in Biogeosciences (2009), 6

The coastal ocean is a crucial link between land, the open ocean and the atmosphere. The shallowness of the water column permits close interactions between the sedimentary, aquatic and atmospheric ... [more ▼]

The coastal ocean is a crucial link between land, the open ocean and the atmosphere. The shallowness of the water column permits close interactions between the sedimentary, aquatic and atmospheric compartments, which otherwise are decoupled at long time scales ( =1000 yr) in the open oceans. Despite the prominent role of the coastal oceans in absorbing atmospheric CO2 and transferring it into the deep oceans via the continental shelf pump, the underlying mechanisms remain only partly understood. Evaluating observations from the North Sea, a NW European shelf sea, we provide evidence that anaerobic degradation of organic matter, fuelled from land and ocean, generates total alkalinity (AT) and increases the CO2 buffer capacity of seawater. At both the basin wide and annual scales anaerobic AT generation in the North Sea’s tidal mud flat area irreversibly facilitates 7–10%, or taking into consideration benthic denitrification in the North Sea, 20–25% of the North Sea’s overall CO2 uptake. At the global scale, anaerobic AT generation could be accountable for as much as 60% of the uptake of CO2 in shelf and marginal seas, making this process, the anaerobic pump, a key player in the biological carbon pump. Under future high CO2 conditions oceanic CO2 storage via the anaerobic pump may even gain further relevance because of stimulated ocean productivity. [less ▲]

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See detailEnhanced ocean temperature forecast skills through 3-D super-ensemble multi-model fusion
Lenartz, Fabian ULg; Mourre, B.; Barth, Alexander ULg et al

in Geophysical Research Letters (2010), 37(L19606),

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See detailEnhanced or Reduced Fetal Growth Induced by Embryo Transfer into Smaller or Larger Breeds Alters Post-Natal Growth and Metabolism in Pre-Weaning Horses
Peugnet, Pauline; Wimel, Laurence; Duchamp, Guy et al

in PLoS ONE (2014), 9(7), 102044

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See detailEnhanced osteoclast development in collagen-induced arthritis in interferon-gamma receptor knock-out mice as related to increased splenic CD11b(+) myelopoiesis
De Klerck, Bert; Carpentier, Isabelle; Lories, Rick J et al

in Arthritis Research & therapy (2004), 6(3), 220-231

Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b(+) myeloblasts. Both disease manifestations are more pronounced in interferon-gamma ... [more ▼]

Collagen-induced arthritis (CIA) in mice is accompanied by splenomegaly due to the selective expansion of immature CD11b(+) myeloblasts. Both disease manifestations are more pronounced in interferon-gamma receptor knock-out (IFN-gammaR KO) mice. We have taken advantage of this difference to test the hypothesis that the expanding CD11b(+) splenic cell population constitutes a source from which osteoclast precursors are recruited to the joint synovia. We found larger numbers of osteoclasts and more severe bone destruction in joints of IFN-gammaR KO mice than in joints of wild-type mice. Osteoclast-like multinucleated cells appeared in splenocyte cultures established in the presence of macrophage colony-stimulating factor (M-CSF) and stimulated with the osteoclast-differentiating factor receptor activator of NF-kappaB ligand (RANKL) or with tumour necrosis factor-alpha (TNF-alpha). Significantly larger numbers of such cells could be generated from splenocytes of IFN-gammaR KO mice than from those of wildtype mice. This was not accompanied, as might have been expected, by increased concentrations of the intracellular adaptor protein TRAF6, known to be involved in signalling of RANKL- and TNF-alpha-induced osteoclast formation. Splenocyte cultures of IFN-gammaR KO mice also produced more TNF-alpha and more RANKL than those of wild-type mice. Finally, splenocytes isolated from immunised IFN-gammaR KO mice contained comparatively low levels of pro-interleukin-1beta (pro-IL-1beta) and pro-caspase-1, indicating more extensive conversion of pro-IL-1beta into secreted active IL-1beta. These observations provide evidence that all conditions are fulfilled for the expanding CD11b(+) splenocytes to act as a source of osteoclasts and to be indirectly responsible for bone destruction in CIA. They also provide a plausible explanation for the higher susceptibility of IFN-gammaR KO mice to CIA. [less ▲]

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See detailEnhanced pinning and proliferation of matching effects in a superconducting film with a Penrose array of magnetic dots
Silhanek, Alejandro ULg; Gillijns, W.; Moshchalkov, V. V. et al

in Applied Physics Letters (2006), 89(15),

The vortex dynamics in superconducting films deposited on top of a fivefold Penrose array of magnetic dots is studied by means of transport measurements. The authors show that in the low pinning regime ... [more ▼]

The vortex dynamics in superconducting films deposited on top of a fivefold Penrose array of magnetic dots is studied by means of transport measurements. The authors show that in the low pinning regime (demagnetized dots) a few periodic and aperiodic matching features coexist. In the strong pinning regime (magnetized dots) a richer structure of unforeseen periodic and aperiodic vortex patterns appear, giving rise to a clear enhancement of the critical current in a broader field range. Possible stable vortex configurations are determined by molecular dynamics simulations. (c) 2006 American Institute of Physics. [less ▲]

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See detailEnhanced pinning in superconducting thin films with graded pinning landscapes
Motta, M.; Colauto, F.; Ortiz, W.A. et al

in Applied Physics Letters (2013), 102

A graded distribution of antidots in superconducting a-Mo79Ge21 thin films has been investigated by magnetization and magneto-optical imaging measurements. The pinning landscape has maximum density at the ... [more ▼]

A graded distribution of antidots in superconducting a-Mo79Ge21 thin films has been investigated by magnetization and magneto-optical imaging measurements. The pinning landscape has maximum density at the sample border, decreasing linearly towards the center. Its overall performance is noticeably superior than that for a sample with uniformly distributed antidots: For high temperatures and low fields, the critical current is enhanced, whereas the region of thermomagnetic instabilities in the field-temperature diagram is significantly suppressed. These findings confirm the relevance of graded landscapes on the enhancement of pinning efficiency, as recently predicted by Misko and Nori [Phys. Rev. B 85, 184506 (2012)]. [less ▲]

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See detailEnhanced Platelet Reactivity to Collagen and Shear Stress in Transgenic Mice Overexpressing the Platelet P2X1 Ion Channel
Oury, Cécile ULg; Kuijpers, Marijke; Toth-Zsamboki, Emese et al

in Blood (2002), 100

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