Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
See detailLe discours « néo-réactionnaire ». Transgressions conservatrices
Durand, Pascal ULg; Sindaco, Sarah ULg

Book published by CNRS éditions (2015)

« Les nouveaux réactionnaires » : l’appellation trouve sa source dans un bref pamphlet paru en 2002 sous ce titre. La polémique, aussitôt très vive, n’a pas cessé, depuis, d’envenimer l’espace médiatique ... [more ▼]

« Les nouveaux réactionnaires » : l’appellation trouve sa source dans un bref pamphlet paru en 2002 sous ce titre. La polémique, aussitôt très vive, n’a pas cessé, depuis, d’envenimer l’espace médiatique et intellectuel français. Quoi de commun pourtant entre la pensée d’un Marcel Gauchet et les best-sellers d’un Éric Zemmour ? Entre la phraséologie aristocratique d’un Richard Millet et le parler peuple d’un Robert Ménard ? Entre la mélancolie indignée d’un Alain Finkielkraut et le dandysme revenu de tout d’un Michel Houellebecq ? Un tempérament réfractaire sans doute, articulant transgression et conservatisme ; une même volonté d’en découdre avec le « politiquement correct » et la « police de la pensée » ; une même propension, aussi, à se penser en représentants minoritaires d’une majorité opprimée, sur fond de désenchantement démocratique et de hantise du déclin. Romanciers, philosophes, intellectuels « médiatiques », historiens, journalistes : le spectre des « néo-réactionnaires » est large, au risque de la confusion et de l’amalgame. Les auteurs réunis dans le présent ouvrage entendent contribuer à un examen dépassionné de cette nébuleuse, en soulignant la diversité des champs d’appartenance et des registres d’expression de ceux qui la composent ou s’y trouvent rangés à leur corps plus ou moins défendant. [less ▲]

Detailed reference viewed: 670 (21 ULg)
Full Text
Peer Reviewed
See detailDiscours, pratiques et pouvoirs. Les médecins et la santé publique au XIXe siècle
Havelange, Carl ULg

in L'initiative publique des communes en Belgique (1986)

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailDiscours, violence, civilité
Delruelle, Edouard ULg

in De Smet, François (Ed.) La liberté d'expression, menacée ou menaçante ? (2015, September)

La question philosophique et politique pertinente est celle des conditions de la liberté d'expression, pas celle de ses limites. La véritable question est : quelles sont les conditions pour que la liberté ... [more ▼]

La question philosophique et politique pertinente est celle des conditions de la liberté d'expression, pas celle de ses limites. La véritable question est : quelles sont les conditions pour que la liberté d’expression soit une liberté effective pour tous — pour l’athée comme pour le croyant, l’employé comme l’employeur, l’allochtone comme l’autochtone, le fou comme le sain d’esprit, le chômeur comme le professeur d’Université, etc. ? [less ▲]

Detailed reference viewed: 27 (1 ULg)
Peer Reviewed
See detailDiscourse functions of antonymy in French
Steffens, Marie ULg

Conference (2016, September)

Detailed reference viewed: 18 (0 ULg)
Full Text
See detailDiscourse Theory and Cultural Analysis. Media, Arts and Literature
Spinoy, Erik ULg

Book published by Hampton Press (2008)

This book presents a series of chapters which reflect on ways in which Discourse Theory (Laclau, Mouffe) can be operationalized for use in cultural analysis, especially in the fields of media, arts and ... [more ▼]

This book presents a series of chapters which reflect on ways in which Discourse Theory (Laclau, Mouffe) can be operationalized for use in cultural analysis, especially in the fields of media, arts and literature. [less ▲]

Detailed reference viewed: 90 (5 ULg)
Full Text
Peer Reviewed
See detailDiscourses and Coexistence, Intercultural Cohabitation in the Belgian City of Verviers
Gsir, Sonia ULg; Mandin, Jérémy ULg

in Revista de Ciencias Sociales (2012), 18

Detailed reference viewed: 64 (15 ULg)
Full Text
Peer Reviewed
See detailDiscovering main genetic interactions with LABNet LAsso-based network inference.
Gadaleta, Francesco ULg; Van Steen, Kristel ULg

in PloS one (2014), 9(11), 110451

Genome-wide association studies can potentially unravel the mechanisms behind complex traits and common genetic diseases. Despite the valuable results produced thus far, many questions remain unanswered ... [more ▼]

Genome-wide association studies can potentially unravel the mechanisms behind complex traits and common genetic diseases. Despite the valuable results produced thus far, many questions remain unanswered. For instance, which specific genetic compounds are linked to the risk of the disease under investigation; what biological mechanism do they act through; or how do they interact with environmental and other external factors? The driving force of computational biology is the constantly growing amount of big data generated by high-throughput technologies. A practical framework that can deal with this abundance of information and that consent to discovering genetic associations and interactions is provided by means of networks. Unfortunately, high dimensionality, the presence of noise and the geometry of data can make the aforementioned problem extremely challenging. We propose a penalised linear regression approach that can deal with the aforementioned issues that affect genetic data. We analyse the gene expression profiles of individuals with a common trait to infer the network structure of interactions among genes. The permutation-based approach leads to more stable and reliable networks inferred from synthetic microarray data. We show that a higher number of permutations determines the number of predicted edges, improves the overall sensitivity and controls the number of false positives. [less ▲]

Detailed reference viewed: 66 (0 ULg)
Full Text
Peer Reviewed
See detailDiscovering novel enzymes y functional screening of plurigenomic libraries from alga-associated Flavobacteriia and Gammaproteobacteria
Martin, Marjolaine ULg; Vandermies, Marie ULg; Joyeux, Coline et al

in Microbiological Research (2016), 186

Alga-associated microorganisms, in the context of their numerous interactions with the host and thecomplexity of the marine environment, are known to produce diverse hydrolytic enzymes with ... [more ▼]

Alga-associated microorganisms, in the context of their numerous interactions with the host and thecomplexity of the marine environment, are known to produce diverse hydrolytic enzymes with originalbiochemistry. We recently isolated several macroalgal-polysaccharide-degrading bacteria from the sur-face of the brown alga Ascophyllum nodosum. These active isolates belong to two classes: the Flavobacteriiaand the Gammaproteobacteria. In the present study, we constructed two “plurigenomic” (with multi-ple bacterial genomes) libraries with the 5 most interesting isolates (regarding their phylogeny andtheir enzymatic activities) of each class (Fv and Gm libraries). Both libraries were screened for diversehydrolytic activities. Five activities, out of the 48 previously identified in the natural polysaccharolyticisolates, were recovered by functional screening: a xylanase (GmXyl7), a beta-glucosidase (GmBg1), anesterase (GmEst7) and two iota-carrageenases (Fvi2.5 and Gmi1.3). We discuss here the potential role ofthe used host-cell, the average DNA insert-sizes and the used restriction enzymes on the divergent screen-ing yields obtained for both libraries and get deeper inside the “great screen anomaly”. Interestingly, thediscovered esterase probably stands for a novel family of homoserine o-acetyltransferase-like-esterases,while the two iota-carrageenases represent new members of the poorly known GH82 family (contain-ing only 19 proteins since its description in 2000). These original results demonstrate the efficiencyof our uncommon “plurigenomic” library approach and the underexplored potential of alga-associatedcultivable microbiota for the identification of novel and algal-specific enzymes. [less ▲]

Detailed reference viewed: 51 (7 ULg)
Full Text
Peer Reviewed
See detailDiscovering schizophrenia endophenotypes in randomly ascertained pedigrees.
Glahn, David C.; Williams, Jeff T.; McKay, D. Reese et al

in Biological Psychiatry (2015), 77(1), 75-83

BACKGROUND: Although case-control approaches are beginning to disentangle schizophrenia's complex polygenic burden, other methods will likely be necessary to fully identify and characterize risk genes ... [more ▼]

BACKGROUND: Although case-control approaches are beginning to disentangle schizophrenia's complex polygenic burden, other methods will likely be necessary to fully identify and characterize risk genes. Endophenotypes, traits genetically correlated with an illness, can help characterize the impact of risk genes by providing genetically relevant traits that are more tractable than the behavioral symptoms that classify mental illness. Here, we present an analytic approach for discovering and empirically validating endophenotypes in extended pedigrees with very few affected individuals. Our approach indexes each family member's risk as a function of shared genetic kinship with an affected individual, often referred to as the coefficient of relatedness. To demonstrate the utility of this approach, we search for neurocognitive and neuroanatomic endophenotypes for schizophrenia in large unselected multigenerational pedigrees. METHODS: A fixed-effects test within the variance component framework was performed on neurocognitive and cortical surface area traits in 1606 Mexican-American individuals from large, randomly ascertained extended pedigrees who participated in the Genetics of Brain Structure and Function study. As affecteds were excluded from analyses, results were not influenced by disease state or medication usage. RESULTS: Despite having sampled just 6 individuals with schizophrenia, our sample provided 233 individuals at various levels of genetic risk for the disorder. We identified three neurocognitive measures (digit-symbol substitution, facial memory, and emotion recognition) and six medial temporal and prefrontal cortical surfaces associated with liability for schizophrenia. CONCLUSIONS: With our novel analytic approach, one can discover and rank endophenotypes for schizophrenia, or any heritable disease, in randomly ascertained pedigrees. [less ▲]

Detailed reference viewed: 9 (0 ULg)
Full Text
See detailDiscovering the colliding wind binary HD 93129A
Marcote, Benito; Benaglia, Paula; Moldon, Javier et al

in PoS - Proceedings of Science (2014, December 01)

HD 93129A is a binary system including an O2 If+ and probably an O3.5 V-star orbiting at a distance of about 140 AU (55 mas given the distance of 2.5 kpc), which potentially makes the system the most ... [more ▼]

HD 93129A is a binary system including an O2 If+ and probably an O3.5 V-star orbiting at a distance of about 140 AU (55 mas given the distance of 2.5 kpc), which potentially makes the system the most massive one in the Galaxy, ahead of eta-Carina. Its non-thermal radio emission was proposed to be originated by the collision between the winds of both stars. HST/FGS data have been reanalyzed to derive an accurate absolute position of the stars to compare them with the radio emission. The analysis of ATCA radio observations along several years reveals a power-law spectrum with an increase on the radio flux density along time. We conducted an observation with the Australian Long Baseline Array (LBA) at 2.3 GHz in 2008 to resolve the radio source and its location within the stellar system. These radio data revealed a bow-shape extended emission located between both stars, as expected in a wind collision region. The observed structure allows us to roughly estimate the mass-loss rate ratio for the two stars in the system, concluding that it is about 0.7. The multiwavelength analysis points out that the detected radio emission is likely to be originated by one of the most massive collision wind binary in the Galaxy. [less ▲]

Detailed reference viewed: 23 (0 ULg)
Full Text
Peer Reviewed
See detailDiscovering the lichen diversity of a remote tropical island: working list of species collected on Reunion (Mascarene archipelago, Indian Ocean)
van den Boom, Pieter P. G.; Brand, Maarten; Ertz, Damien et al

in Herzogia (2011), 24(2), 325-349

463 lichen taxa are reported from the island of Reunion (Mascarene archipelago) in the Indian Ocean. This report is based on extensive collections recently made by the authors or hosted in B and LG. A ... [more ▼]

463 lichen taxa are reported from the island of Reunion (Mascarene archipelago) in the Indian Ocean. This report is based on extensive collections recently made by the authors or hosted in B and LG. A total of c. 600 species is estimated for the number of lichenized fungi present on the island; although this is a low figure for a varied tropi- cal area, this is plausible due to its small size and remoteness. The significance of the lichen diversity of the island lays in its endemics, which need further study for a reliable assessment, and in the occurrence of a poorly known southern hemisphere element (“austral” species). The discovery of the following in Reunion is of special interest as it considerably enlarges their distribution range: Anzia corallophora, Caloplaca caesiosorediata, Coccocarpia delicatula, Fuscopannaria praetermissa, Gomphillus morchelloides, G. pedersenii, Gyalideopsis bispora, Heterodermia koyana, Hypotrachyna evansii, Lithogyalideopsis zeylandica, Lobaria asperula, Megaloblastenia marginiflexa var. dimota, Menegazzia capitata, Myeloconis erumpens and Pannaria squamulosa. [less ▲]

Detailed reference viewed: 245 (15 ULg)
Full Text
Peer Reviewed
See detailDiscovery and Atmospheric Characterization of Giant Planet Kepler-12b: An Inflated Radius Outlier
Fortney, Jonathan J; Demory, Brice-Olivier; Désert, Jean-Michel et al

in Astrophysical Journal Supplement Series (2011), 197

We report the discovery of planet Kepler-12b (KOI-20), which at 1.695 ± 0.030 R [SUB]J[/SUB] is among the handful of planets with super-inflated radii above 1.65 R [SUB]J[/SUB]. Orbiting its slightly ... [more ▼]

We report the discovery of planet Kepler-12b (KOI-20), which at 1.695 ± 0.030 R [SUB]J[/SUB] is among the handful of planets with super-inflated radii above 1.65 R [SUB]J[/SUB]. Orbiting its slightly evolved G0 host with a 4.438 day period, this 0.431 ± 0.041 M [SUB]J[/SUB] planet is the least irradiated within this largest-planet-radius group, which has important implications for planetary physics. The planet's inflated radius and low mass lead to a very low density of 0.111 ± 0.010 g cm[SUP]-3[/SUP]. We detect the occultation of the planet at a significance of 3.7σ in the Kepler bandpass. This yields a geometric albedo of 0.14 ± 0.04; the planetary flux is due to a combination of scattered light and emitted thermal flux. We use multiple observations with Warm Spitzer to detect the occultation at 7σ and 4σ in the 3.6 and 4.5 μm bandpasses, respectively. The occultation photometry timing is consistent with a circular orbit at e < 0.01 (1σ) and e < 0.09 (3σ). The occultation detections across the three bands favor an atmospheric model with no dayside temperature inversion. The Kepler occultation detection provides significant leverage, but conclusions regarding temperature structure are preliminary, given our ignorance of opacity sources at optical wavelengths in hot Jupiter atmospheres. If Kepler-12b and HD 209458b, which intercept similar incident stellar fluxes, have the same heavy-element masses, the interior energy source needed to explain the large radius of Kepler-12b is three times larger than that of HD 209458b. This may suggest that more than one radius-inflation mechanism is at work for Kepler-12b or that it is less heavy-element rich than other transiting planets. [less ▲]

Detailed reference viewed: 40 (3 ULg)
Full Text
Peer Reviewed
See detailDiscovery and biochemical characterisation of four novel biomarkers for osteoarthritis.
DE SENY, Dominique ULg; Sharif, Mohammed; Fillet, Marianne ULg et al

in Annals of the Rheumatic Diseases (2011), 70(6), 1144-52

OBJECTIVE: Knee osteoarthritis (OA) is a heterogeneous, complex joint pathology of unknown aetiology. Biomarkers have been widely used to investigate OA but currently available biomarkers lack specificity ... [more ▼]

OBJECTIVE: Knee osteoarthritis (OA) is a heterogeneous, complex joint pathology of unknown aetiology. Biomarkers have been widely used to investigate OA but currently available biomarkers lack specificity and sensitivity. Therefore, novel biomarkers are needed to better understand the pathophysiological processes of OA initiation and progression. METHODS: Surface enhanced laser desorption/ionisation-time of flight-mass spectrometry proteomic technique was used to analyse protein expression levels in 284 serum samples from patients with knee OA classified according to Kellgren and Lawrence (K&L) score (0-4). OA serum samples were also compared to serum samples provided by healthy individuals (negative control subjects; NC; n=36) and rheumatoid arthritis (RA) patients (n=25). Proteins that gave similar signal in all K&L groups of OA patients were ignored, whereas proteins with increased or decreased levels of expression were selected for further studies. RESULTS: Two proteins were found to be expressed at higher levels in sera of OA patients at all four K&L scores compared to NC and RA, and were identified as V65 vitronectin fragment and C3fpeptide. Of the two remaining proteins, one showed increased expression (unknown protein at m/z of 3762) and the other (identified as connective tissue-activating peptide III protein) was decreased in K&L scores >2 subsets compared to NC, RA and K&L scores 0 or 1 subsets. CONCLUSION: The authors detected four unexpected biomarkers (V65 vitronectin fragment, C3f peptide, CTAP-III and m/z 3762 protein) that could be relevant in the pathophysiological process of OA as having significant correlation with parameters reflecting local inflammation and bone remodelling, as well as decrease in cartilage turnover. [less ▲]

Detailed reference viewed: 72 (26 ULg)
See detailDiscovery and characterization of an ozone layer in Venus’atmosphere
Montmessin, F.; Bertaux, J.-L.; Lefèvre, F. et al

Conference (2011)

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailDiscovery and characterization of an unknown blue-green Maya pigment: Veszelyite
Moreno, R Garcia; Mathis, François ULg; Mazel, V. et al

in Archaeometry (2008), 50(4), 658-667

Blue-green mosaic and polychrome masks and funerary offerings from the royal tombs of Calakmul, Mexico, were analysed by scanning electron microscope equipped with energy dispersive X-ray spectroscopy ... [more ▼]

Blue-green mosaic and polychrome masks and funerary offerings from the royal tombs of Calakmul, Mexico, were analysed by scanning electron microscope equipped with energy dispersive X-ray spectroscopy (SEM-EDS), X-ray diffraction (XRD), and particle induced X-ray emission (PIXE). This led to the first identification of the use of veszelyite, a rare hydrated copper-zinc phosphate, as green pigment. Analyses of a geological sample of this mineral have been done to confirm the characterization of this Mayan pigment, which might help determine pre-Columbian trade routes of precious and luxury objects in the ancient Maya Classic period (ad 250-800). [less ▲]

Detailed reference viewed: 108 (14 ULg)
Full Text
Peer Reviewed
See detailDiscovery and characterization of auxiliary proteins encoded by type 3 Simian T-cell Lymphotropic Viruses
Turpin, Jocelyn; Journo, Chloé; Ling Ko, Nga et al

in Journal of Virology (2015)

Detailed reference viewed: 51 (21 ULg)
Full Text
Peer Reviewed
See detailDiscovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry
Echterbille, Julien; Gilles, Nicolas; Araoz, Romulo et al

in Toxicon (2017), 130

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α ... [more ▼]

Animal toxins are peptides that often bind with remarkable affinity and selectivity to membrane receptors such as nicotinic acetylcholine receptors (nAChRs). The latter are, for example, targeted by α-conotoxins, a family of peptide toxins produced by venomous cone snails. nAChRs are implicated in numerous physiological processes explaining why the design of new pharmacological tools and the discovery of potential innovative drugs targeting these receptor channels appear so important. This work describes a methodology developed to discover new ligands of nAChRs from complex mixtures of peptides. The methodology was set up by the incubation of Torpedo marmorata electrocyte membranes rich in nAChRs with BSA tryptic digests (>100 peptides) doped by small amounts of known nAChRs ligands (α-conotoxins). Peptides that bind to the receptors were purified and analyzed by MALDI-TOF/TOF mass spectrometry which revealed an enrichment of α-conotoxins in membrane-containing fractions. This result exhibits the binding of α-conotoxins to nAChRs. Negative controls were performed to demonstrate the specificity of the binding. The usefulness and the power of the methodology were also investigated for a discovery issue. The workflow was then applied to the screening of Conus ermineus crude venom, aiming at characterizing new nAChRs ligands from this venom, which has not been extensively investigated to date. The methodology validated our experiments by allowing us to bind two α-conotoxins (α-EI and α-EIIA) which have already been described as nAChRs ligands. Moreover, a new conotoxin, never described to date, was also captured, identified and sequenced from this venom. Classical pharmacology tests by radioligand binding using a synthetic homologue of the toxin confirm the activity of the new peptide, called α-EIIB. The Ki value of this peptide for Torpedo nicotinic receptors was measured at 2.2 ± 0.7 nM. [less ▲]

Detailed reference viewed: 31 (6 ULg)
Full Text
Peer Reviewed
See detailDiscovery and Characterization of R/S-N-3-Cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea, a New Histone Deacetylase Class III Inhibitor Exerting Antiproliferative Activity against Cancer Cell Lines
Schnekenburger, M; Goffin, Eric ULg; Lee, J-Y et al

in Journal of Medicinal Chemistry (2017), 60(11), 4714-4733

A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting ... [more ▼]

A new series of N-aryl-N'-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)ureas bearing an alkoxycarbonylamino group at the 6-position were synthesized and examined as putative anticancer agents targeting sirtuins in glioma cells. On the basis of computational docking combined to in vitro sirtuin 1/2 inhibition assays, we selected compound 18 [R/S-N-3-cyanophenyl-N'-(6-tert-butoxycarbonylamino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)urea] which displays a potent antiproliferative activity on various glioma cell types, assessed by quantitative videomicroscopy, eventually triggering senescence. The impact on normal glial cells was lower with a selectivity index of >10. Furthermore, human U373 and Hs683 glioblastoma cell lines served to demonstrate the inhibitory activity of 18 against histone deacetylase (HDAC) class III sirtuins 1 and 2 (SIRT1/2) by quantifying acetylation levels of histone and non-histone proteins. The translational potential of 18 was validated by an NCI-60 cell line screen and validation of growth inhibition of drug resistant cancer cell models. Eventually, the anticancer potential of 18 was validated in 3D glioblastoma spheroids and in vivo by zebrafish xenografts. In summary, compound 18 is the first representative of a new class of SIRT inhibitors opening new perspectives in the medicinal chemistry of HDAC inhibitors. [less ▲]

Detailed reference viewed: 24 (3 ULg)