Gastroenterology - Clinical and genetic factors associated with sacroiliitis in Crohn's disease

in Journal of Gastroenterology and Hepatology (2008), 23(1), 132-137

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with ... [more ▼]

Background and Aim: Radiographic sacroiliitis (SI), often asymptomatic, is considered the most frequent extra-intestinal manifestation (EIM) of Crohn's disease (CD). Data on the association of SI with other clinical features of CD are limited. Association of SI with CARD15 polymorphisms has recently been suggested. In a multicenter study, we investigated the association of SI in CD patients with clinical phenotypes, other EIM and CARD15 polymorphisms. Methods: Radiographs of the sacroiliac joints were taken in 251 CD patients from three Belgian university hospitals and scored by two blinded rheumatologists. Clinical features were obtained from medical records. Forty-three percent of patients carried at least one CARD15 polymorphism. Results: Sacroiliitis, defined as the presence of at least grade 2 unilateral changes, was diagnosed in 65 of the 244 scorable radiographs (27%). Only 16 of these patients were previously diagnosed with ankylosing spondylitis (AS). HLA-B27 positivity was observed in 53% of patients with AS and 7% of patients with radiographic SI. In univariate and multivariate analysis, associations between the presence of SI and peripheral arthritis (P = 0.005) and between AS and uveitis (P = 0.005) were found. No associations with other recorded clinical features or with CARD15 polymorphisms were observed. Conclusion: We confirm the high prevalence of radiographic sacroiliitis in a multicenter CD cohort. Uveitis is only associated with AS whereas all patients with SI are more prone to develop peripheral arthritis during their disease course, suggesting similar pathogenetic mechanisms in the development of these EIM. The previously reported association between SI and CARD15 polymorphisms was not confirmed. [less ▲]

Gastrointestinal prokinetics'efficiency and risk factors of development of postoperative ileus: clinical study.

Conference (2006, June 29)

Because of the lack of clinical data in the area, this clinical study was performed to evaluate gastrointestinal prokinetics’ efficiency. Material used includes 2 groups composed each one by 25 horses ... [more ▼]

Because of the lack of clinical data in the area, this clinical study was performed to evaluate gastrointestinal prokinetics’ efficiency. Material used includes 2 groups composed each one by 25 horses which underwent surgery for small intestinal lesions in the University of Liège between january 1997 and august 2005. The 2 groups were formed by a selection resulting in similar (or not significantly different) mean values for the age, gravity score, shock score, packed cell volume on admission in the clinic and length of resected intestine when an enterectomy was performed. Between the 2 groups, we searched also equal (or not significantly different) proportions of Belgian Warmblood, of females/males, of horses wich underwent an enterectomy, of horses which had a concomitant lesion of the large intestine and of horses wich needed 1 or more sedative α2 agonist drug during the postoperative period. One group was treated with gastrointestinal prokinetics (lidocaine, erythromycin, metoclopramide) systematically, whereas the other one not and the incidence and duration of postoperative ileus was evaluated. No significant difference in the incidence or the duration of postoperative ileus was found between the 2 groups. Because our results did not show any effect of prokinetics, a statistical analysis searched in these 50 horses the risk factors of postoperative ileus among the following parameters: breed, age, sex, gravity score, shock score, packed cell volume on admission in the clinic, protocol of induction of anaesthesia, duration of anaesthesia, performing an enterectomy and length of the resected intestine, concomitant lesion of the large intestine, and administration of sedative α2 agonists during the postoperative period. Only the Belgian warmblood breed and the administration of sedative α2 agonist drugs after the recovery from anaesthesia were significantly more important in the group where horses developed a postoperative ileus. Undoubdtedly, this study includes only 50 cases selected for the homogeneity of their parameters and not all the cases of small intestine surgery during the test period. In view of these results, it would be interesting performing this study again on a larger number of cases in a prospective manner. [less ▲]

Le "Gate fever" : la cristallisation du temps carcéral

Scientific conference (2014, May 21)

Gauche de la gauche

in Durand, Pascal (Ed.) Les Nouveaux Mots du Pouvoir. Abécédaire critique (2007)

GAUFRE: a tool for an automated determination of atmospheric parameters from spectroscopy

in 40th Liege International Astrophysical Colloquium 'Ageing low-mass stars: from red giants to white dwarfs' (2013, January 01)

We present an automated tool for measuring atmospheric parameters (T_eff, log(g), [Fe/H]) for F-G-K dwarf and giant stars. The tool, called GAUFRE, is written in C++ and composed of several routines ... [more ▼]

We present an automated tool for measuring atmospheric parameters (T_eff, log(g), [Fe/H]) for F-G-K dwarf and giant stars. The tool, called GAUFRE, is written in C++ and composed of several routines: GAUFRE-RV measures radial velocity from spectra via cross-correlation against a synthetic template, GAUFRE-EW measures atmospheric parameters through the classic line-by-line technique and GAUFRE-CHI2 performs a chi^2 fitting to a library of synthetic spectra. A set of F-G-K stars extensively studied in the literature were used as a benchmark for the program: their high signal-to-noise and high resolution spectra were analysed by using GAUFRE and results were compared with those present in literature. The tool is also implemented in order to perform the spectral analysis after fixing the surface gravity (log(g)) to the accurate value provided by asteroseismology. A set of CoRoT stars, belonging to LRc01 and LRa01 fields was used for first testing the performances and the behaviour of the program when using the seismic log(g). [less ▲]

Gaussian beams and Fourier Optics

in Akos, G.; Lippényi, T.; Lupkovics, G. (Eds.) et al Proceedings of the 16th Congress of the international commission for Optics: Optics as a Key to High Technology ICO-16 (1993, July 26)

Gawrah Tepe

in Anastasio, Stefano; Lebeau, Marc; Sauvage, Martin (Eds.) Atlas of Preclassical Upper Mesopotamia (2004)

"Gaz" de gouttes sur une surface liquide vibrée verticalement

Conference (2010, January 29)

Gazing at Gawain: Reconsidering Tournaments, Courtly Love, and the Lady Who Looks

in Medieval Feminist Forum [= MFF] (2009), 42

Historians have long acknowledged the importance of the female spectator in actual, staged, tournaments, and literary critics have noted her intrinsic role in the tournaments of romance texts.In both ... [more ▼]

Historians have long acknowledged the importance of the female spectator in actual, staged, tournaments, and literary critics have noted her intrinsic role in the tournaments of romance texts.In both cases, she functions as an inspiration to the male knight performing on the field, and as a means of constructing his masculinity.The potential agency of this female spectator who was able to look down on male bodies from a privileged viewing position has, however, been generally overlooked by art historians.This article uses the tournament context, in which women look at men (and vice versa), as a way of moving beyond the binary oppositions such as masculine/feminine, active/passive, that have traditionally structured discussions of gender and the gaze. By looking in particular at the imagery on carved ivory objects made for women, and their relationship to contemporary literature, I will argue for a more nuanced consideration of the ways women were able to look in the Middle Ages. [less ▲]

GBS AND THE NEONATE: PREVENTION STRATEGIES

in MELIN, Pierrette (Ed.) Abstract book of 30th Annual Meeting of the European Society for Paediatric Infectious Diseases (2012, May)

Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). Where consensus guidelines to detect ... [more ▼]

Streptococcus agalactiae, or group B streptococcus (GBS), remains the leading cause of neonatal sepsis and meningitis, early onset and late onset diseases (EOD, LOD). Where consensus guidelines to detect and treat intrapartum women with GBS colonization have been widely adopted, incidence of neonatal EOD has dramatically declined. In response to both successful impacts on the incidence of GBS-EOD and analyses of missed opportunities, the first American guidelines for prevention issued in the 90s have since been adapted in several stages to improve their efficacy. In some countries in Europe, nationwide guidelines, whether screening-based or risk-based, for the prevention of neonatal GBS diseases have also been issued and adopted, with the expected impact on incidence of GBS-EOD. In spite of universal screening, in spite of the great progress that has been made, GBS-EOD continues to occur and the GBS burden remains a significant public health issue. Continuous efforts to improve screening for GBS status continue to be important and may be able to take advantage of new rapid diagnostic technologies. The current screening-based strategy for prevention is highly effective but imperfect. Given the challenges, limitations and potential complications of maternal intrapartum prophylaxis, a new approach is still needed. Maternal immunization against GBS is an attractive alternative for the prevention of not only neonatal diseases but also stillbirths and maternal diseases. Vaccines against GBS may likely become the most effective and sustainable long-term preventive strategy. [less ▲]