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See detailDioxins in Human Milk from Different Regions of France: Pilot of the French Longitudinal Study of Children (ELFE)
Vandentoren, S; Frery, N; Bidondo, ML et al

in Organohalogen Compounds (2011), 73

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See detailDioxins in our food: Where are we 14 years after the Belgian chicken-gate?
Focant, Jean-François ULg

Conference (2013, October)

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See detailDioxins! Hunting the Great White Shark
Focant, Jean-François ULg

Scientific conference (2017, March)

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See detailDioxins! Hunting the Great White Shark
Focant, Jean-François ULg

Scientific conference (2016, November)

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See detailDioxins! Hunting the Great White.
Focant, Jean-François ULg

Scientific conference (2016, October)

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See detailDioxins, furans and co-planar PCBs in juvenile harbour porpoises (Phocoena phocoena) from the Belgian coasts
Beans, Cristina ULg; Das, Krishna ULg; Jauniaux, Thierry ULg et al

Poster (2003)

Dioxins, furans and PCBs are lipophilic anthropogenic contaminants that have found their way into marine food webs and accumulate in top predators such as marine mammals, adding a stress factor to an ... [more ▼]

Dioxins, furans and PCBs are lipophilic anthropogenic contaminants that have found their way into marine food webs and accumulate in top predators such as marine mammals, adding a stress factor to an already vulnerable population. In this study 7 congeners of dioxins (PCDDs), 10 congeners of furans (PCDFs) and 4 congeners of coplanar PCBs (cPCBs) were determined using high resolution gas chromatography and mass spectrometry in the blubber of 19 juvenile harbour porpoises (Phocoena phocoena) stranded along the Belgian North Sea coastline between 1995 and 2001. These results were contrasted with nutritional status (emaciated or not), sex and trophic level (through stable carbon and nitrogen isotope analysis). Mean blubber concentrations of SPCDD/Fs were 12.8 pg/g lw (lipid weight) and mean related toxicity 1.84 pg TEQs/g lw (TEQs = TCDD toxic equivalents). Mean cPCB concentrations were 223,5 pg/g lw and mean related toxicity 4,47 pg TEQs/g lw. The levels detected in these individuals were of the same order as those found in a previous study in the Wadden Sea (Bruhn, 1999). Both sexes show rather similar levels. No significant relationship was observed between stable carbon or nitrogen isotope values and pollutant levels. Concentrations and toxicity show a tendency to be higher in emaciated ndividuals than in nonemaciated ones. This could indicate a possible relationship between the nutritional status of the animals and dioxinlike pollutants (which could participate in weakening the animal). This situation should be further studied on adult individuals in order to obtain a more global view of the possible effects on the population. [less ▲]

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See detailDioxins, furans and dioxin-like PCBs in juvenile harbour porpoises (Phocoena Phocoena) from the North sea
Beans, Cristina; Debacker, Virginie ULg; Jauniaux, Thierry ULg et al

in Organohalogen Compounds (2003)

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See detailDioxins: Hunting the Great White
Focant, Jean-François ULg

Scientific conference (2016, August)

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See detailA dip into the world of veterinary nuclear medicine: equine lung scintigraphy
Votion, Dominique ULg; Lekeux, Pierre ULg

in Clinical Techniques in Equine Practice (2003), 2(3), 222-230

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology ... [more ▼]

The clinical and experimental uses of equine lung scintigraphy have largely expanded in recent years. Lung imaging using large animals is of great interest for the understanding of general lung physiology, for the knowledge of animal peculiarities, for the study and diagnosis of equine respiratory disorders as well as for the development of their treatment. This article surveys some methodological constraints due to the scanning of a noncooperative large-sized animal, reviews the contribution of equine nuclear imaging in lung physiology and pathology, and discusses future clinical and fundamental applications of lung scintigraphy. [less ▲]

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See detailDip-coating of fibrous natural materials for alumina tube manufacturing
Gaydardzhiev, Stoyan ULg; Wilker, Viola; Scheffler, Michael

in Advanced Engineering Materials (2008), 10(3), 223-226

Results from preliminary studies for development of hollow ceramic tubes by dip-coating of fibrous plants with water based gel-casting slurries are presented. Hemp and coconut fibres have been tested as ... [more ▼]

Results from preliminary studies for development of hollow ceramic tubes by dip-coating of fibrous plants with water based gel-casting slurries are presented. Hemp and coconut fibres have been tested as templates reflecting in different macro and micro structures of the obtained ceramic tubes. Good correlation between the diameters of the template fibres and the developed channels has been documented, the ordering of the channels inside the tubes being function of the mode of fibres implementation: as singles or as bundles. By coating hemp fibres in bundle, multi channel pattern has been developed, resulting from splitting of the bundle. By using single coconut fibre as template, uniform mono channels with 250 – 400 µm in diameter were observed. The developed tubes have been characterized by good end finish. The observed differences in their microstructure offer possibilities for adjusting the physical properties towards prospective application niches. [less ▲]

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See detailDipeptidyl peptidase IV activity in plasma of dogs : physiological determinants and effect of heart failure
Gomez, Nelson; Matheeussen, V.; Tamborini, A. et al

in 21th ECVIM Meeting - Séville, Espagne - du 6 au 10 septembre 2011 (2011, September)

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See detailDipeptidylpeptidase-4 (DPP-4) inhibitors are favourable to glucagon-like peptide-1 (GLP-1) receptor agonists: yes.
SCHEEN, André ULg

in European Journal of Internal Medicine (2012), 23(2), 126-31

The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since the availability of incretin-based therapies. Compared with other glucose-lowering strategies ... [more ▼]

The pharmacological treatment of type 2 diabetes (T2DM) is becoming increasingly complex, especially since the availability of incretin-based therapies. Compared with other glucose-lowering strategies, these novel drugs offer some advantages such as an absence of weight gain and a negligible risk of hypoglycaemia and, possibly, better cardiovascular and beta-cell protection. The physician has now multiple choices to manage his/her patient after secondary failure of metformin, and the question whether it is preferable to add an oral dipeptidylpeptidase-4 (DPP-4) inhibitor (gliptin) or an injectable glucagon-like peptide-1 (GLP-1) receptor agonist will emerge. Obviously, DPP-4 inhibitors offer several advantages compared with GLP-1 receptor agonists, especially regarding easiness of use, tolerance profile and cost. However, because they can only increase endogenous GLP-1 concentrations to physiological (rather than pharmacological) levels, they are less potent to improve glucose control, promote weight reduction ("weight neutrality") and reduce blood pressure compared to GLP-1 receptor agonists. Of note, none of the two classes have proven long-term safety and positive impact on diabetic complications yet. The role of DPP-4 inhibitors and GLP-1 receptor agonists in the therapeutic armamentarium of T2DM is rapidly evolving, but their respective potential strengths and weaknesses should be better defined in long-term head-to-head comparative controlled trials. Instead of trying to answer the question whether DPP-4 inhibitors are favourable to GLP-1 receptor agonists (or vice versa), it is probably more clinically relevant to look at which T2DM patient will benefit more from one or the other therapy considering all his/her individual clinical characteristics ("personalized medicine"). [less ▲]

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See detailDipeptidylpeptitase-4 inhibitors (gliptins): focus on drug-drug interactions.
Scheen, André ULg

in Clinical Pharmacokinetics (2010), 49(9), 573-88

Patients with type 2 diabetes mellitus (T2DM) are generally treated with many pharmacological compounds and are exposed to a high risk of drug-drug interactions. Indeed, blood glucose control usually ... [more ▼]

Patients with type 2 diabetes mellitus (T2DM) are generally treated with many pharmacological compounds and are exposed to a high risk of drug-drug interactions. Indeed, blood glucose control usually requires a combination of various glucose-lowering agents, and the recommended global approach to reduce overall cardiovascular risk generally implies administration of several protective compounds, including HMG-CoA reductase inhibitors (statins), antihypertensive compounds and antiplatelet agents. New compounds have been developed to improve glucose-induced beta-cell secretion and glucose control, without inducing hypoglycaemia or weight gain, in patients with T2DM. Dipeptidylpeptidase-4 (DPP-4) inhibitors are novel oral glucose-lowering agents, which may be used as monotherapy or in combination with other antidiabetic compounds, metformin, thiazolidinediones or even sulfonylureas. Sitagliptin, vildagliptin and saxagliptin are already on the market, either as single agents or in fixed-dose combined formulations with metformin. Other compounds, such as alogliptin and linagliptin, are in a late phase of development. This review summarizes the available data on drug-drug interactions reported in the literature for these five DDP-4 inhibitors: sitagliptin, vildagliptin, saxagliptin, alogliptin and linagliptin. Possible pharmacokinetic interferences have been investigated between each of these compounds and various pharmacological agents, which were selected because there are other glucose-lowering agents (metformin, glibenclamide [glyburide], pioglitazone/rosiglitazone) that may be prescribed in combination with DPP-4 inhibitors, other drugs that are currently used in patients with T2DM (statins, antihypertensive agents), compounds that are known to interfere with the cytochrome P450 (CYP) system (ketoconazole, diltiazem, rifampicin [rifampin]) or with P-glycoprotein transport (ciclosporin), or agents with a narrow therapeutic safety window (warfarin, digoxin). Generally speaking, almost no drug-drug interactions or only minor drug-drug interactions have been reported between DPP-4 inhibitors and any of these drugs. The gliptins do not significantly modify the pharmacokinetic profile and exposure of the other tested drugs, and the other drugs do not significantly alter the pharmacokinetic profile of the gliptins or exposure to these. The only exception concerns saxagliptin, which is metabolized to an active metabolite by CYP3A4/5. Therefore, exposure to saxagliptin and its primary metabolite may be significantly modified when saxagliptin is coadministered with specific strong inhibitors (ketoconazole, diltiazem) or inducers (rifampicin) of CYP3A4/5 isoforms. The absence of significant drug-drug interactions could be explained by the favourable pharmacokinetic characteristics of DPP-4 inhibitors, which are not inducers or inhibitors of CYP isoforms and are not bound to plasma proteins to a great extent. Therefore, according to these pharmacokinetic findings, which were generally obtained in healthy young male subjects, no dosage adjustment is recommended when gliptins are combined with other pharmacological agents in patients with T2DM, with the exception of a reduction in the daily dosage of saxagliptin when this drug is used in association with a strong inhibitor of CYP3A4/A5. It is worth noting, however, that a reduction in the dose of sulfonylureas is usually recommended when a DPP-4 inhibitor is added, because of a pharmacodynamic interaction (rather than a pharmacokinetic interaction) between the sulfonylurea and the DPP-4 inhibitor, which may result in a higher risk of hypoglycaemia. Otherwise, any gliptin may be combined with metformin or a thiazolidinedione (pioglitazone, rosiglitazone), leading to a significant improvement in glycaemic control without an increased risk of hypoglycaemia or any other adverse event in patients with T2DM. Finally, the absence of drug-drug interactions in clinical trials in healthy subjects requires further evidence from large-scale studies, including typical subjects with T2DM - in particular, multimorbid and geriatric patients receiving polypharmacy. [less ▲]

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See detailLa diplocéline, un alcaloïde nouveau du Strychnos gossweileri
Coune, Claude; Angenot, Luc ULg

in Phytochemistry (1978), 17

Diploceline is the name given to a quaternary alkaloid isolated from Strychnos gossweileri roots. The structure was established on the basis of UV,IR, MS, CD and NMR spectra.

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See detailDiplocoria: el viaje de una semilla
Culot, Laurence ULg

Scientific conference (2008, June 04)

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See detailDiploma thesis presentation
Léonard, Grégoire ULg

Scientific conference (2009, November 09)

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See detailDiplomacia mediática en la expropiación de YPF a Repsol: la Unión Europea y su discurso en la prensa argentina
Azpíroz Manero, María Luisa ULg

Conference (2015, May)

La diplomacia pública es una actividad diplomática y de comunicación política internacional que busca influenciar a públicos extranjeros con el fin de contribuir a logros de política exterior y/o generar ... [more ▼]

La diplomacia pública es una actividad diplomática y de comunicación política internacional que busca influenciar a públicos extranjeros con el fin de contribuir a logros de política exterior y/o generar una imagen positiva. Entre sus elementos principales se encuentran las acciones de información y comunicación estratégica (diplomacia mediática), diseñadas para transmitir el discurso político de modo efectivo y convincente. La expropiación de YPF a Repsol, en 2012, estuvo acompañada de una intensa cobertura y debate en la prensa argentina. Esta investigación plantea las siguientes preguntas: ¿cuáles fueron las acciones clave de la diplomacia mediática de la Unión Europea (UE) respecto a la expropiación?¿qué aspectos destacó el discurso de la UE?¿en qué aspectos el discurso de la UE coincidió con el discurso transmitido por la prensa argentina? Para responderlas se elabora, en primer lugar, un marco contextual sobre la expropiación de YPF y sobre la diplomacia mediática de la UE en este caso. Después, con ayuda del análisis del discurso (teoría del framing), se realiza un análisis comparativo entre el discurso de la UE y el de dos periódicos argentinos de referencia y con líneas editoriales contrapuestas: La Nación y Página 12. La investigación también incluye información obtenida en entrevistas realizadas a oficiales del Servicio Europeo de Acción Exterior (SEAE), tanto en Bruselas como en Buenos Aires. [less ▲]

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See detailLa diplomacia pública estadounidense de la "Guerra contra el Terror": Análisis y evaluación de su influencia en la prensa española
Azpíroz Manero, María Luisa ULg

Doctoral thesis (2011)

Public diplomacy is an international political communication activity that experienced renewed importance in the United States after the 9/11 terrorist attacks. The War on Terror promoted by the Bush ... [more ▼]

Public diplomacy is an international political communication activity that experienced renewed importance in the United States after the 9/11 terrorist attacks. The War on Terror promoted by the Bush Administration was accompanied by the implementation of public diplomacy strategies designed to reinforce the fight against terrorism and to diminish the levels of anti-Americanism, especially in the Muslim world, through the exercise of soft power. The object of this thesis is, in the first place, to study public diplomacy as an international political communication activity. In the second place, to carry out empirical research that, resorting to framing theory as a methodological tool, analyzes and evaluates the influence of Bush¿s declarations and speeches, as a part of American mediatic diplomacy, in the Spanish press, in two case studies on the War on Terror (the first case study spans the period from 9/11 to November 2001, and the second, the months prior to the Iraq War). To do so, the content of this thesis is set out in six chapters. The first chapter presents a theoretical framework of public diplomacy, the second chapter explains the methodology that is used in the empirical study and the third chapter offers a context for the case studies where that methodology is applied. Chapters four, five and six constitute the empirical part of the work: in the first two the results of the analysis of mediatic diplomacy in two specific periods of the War on Terror are exposed, and, in the last, an evaluation of its influence based on the results of the analysis and on the consideration of other relevant factors is performed. [less ▲]

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