Documents, textes, œuvres. Perspectives sémiotiques
Badir, Sémir ; ;
Book published by Presses Universitaires de Rennes (2014)Detailed reference viewed: 18 (1 ULg)
Does a 'Massive transfusion protocol' activation necessarily mean massive transfusion ?
Conference (2016, January 30)
We implemented in June 2013 a Massive Transfusion Protocol MTP in our institution (1). It can be activated in the presence of a hypovolemic shock associated with a proven or highly suspected hemorrhage ... [more ▼]
We implemented in June 2013 a Massive Transfusion Protocol MTP in our institution (1). It can be activated in the presence of a hypovolemic shock associated with a proven or highly suspected hemorrhage with no response to intravenous crystalloid bolus. Massive Transfusion MT is traditionally defined as the transfusion of 10 or more units of Packed Red Blood Cells PRBC within 24 hours. After MTP activation, how much blood products did we actually transfused? [less ▲]Detailed reference viewed: 18 (2 ULg)
Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer?
; ; et al
in European Journal of Cancer (2006), 42(1), 42-9
The purpose of this study was to determine whether baseline patients' self reported health-related quality of life (HRQOL) parameters could predict survival beyond key biomedical prognostic factors in ... [more ▼]
The purpose of this study was to determine whether baseline patients' self reported health-related quality of life (HRQOL) parameters could predict survival beyond key biomedical prognostic factors in patients with metastatic colorectal cancer. The analysis was conducted on 299 patients. HRQOL baseline scores were assessed using the European Organisation for Research and Treatment of Cancer, Quality of Life Questionnaire-Core30 (EORTC QLQ-C30). The Cox proportional hazards regression model was used for both univariate and multivariate analyses of survival. In addition, a bootstrap resampling technique was used to assess the stability of the outcomes. The final multivariate Cox regression model retained four variables as independent prognostic factors for survival: white blood cell (WBC) count with a hazard ratio (HR) of 1.961 (95% CI, 1.439-2.672; P<0.001), alkaline phosphatase with HR=1.509 (95% CI, 1.126-2.022; P=0.005), number of sites involved with HR=1.108 (95% CI, 1.024-1.198; P=0.01) and the patient's score on the social functioning scale with HR=0.991 (95% CI, 0.987-0.996; P<0.001) which translates into a 9% decrease in the patient's hazard of death for any 10 point increase. The independent prognostic importance of social functioning and the stability of the final Cox regression model were also confirmed by the additional bootstrap model averaging analysis, based on 1000 bootstrap-generated samples. The results suggest that social functioning, acts as a prognostic measure of survival beyond a number of previously known biomedical parameters. [less ▲]Detailed reference viewed: 10 (2 ULg)
Does a patient's self-reported health-related quality of life predict survival beyond key biomedical data in advanced colorectal cancer? (vol 42, pg 42, 2006)
; ; et al
in European Journal of Cancer (2007), 43(3), 633-633Detailed reference viewed: 21 (3 ULg)
DOES A TWO-DAY POSTGRADUATE COURSE ON THE MANAGEMENT OF CHRONIC MUSCULO-SKELETAL PAIN INCREASES THE PHYSIOTHERAPISTS’ PAIN NEUROPHYSIOLOGY KNOWLEDGE?
; ; et al
Conference (2016)Detailed reference viewed: 14 (4 ULg)
Does accelerated GIS development hamper possible application ?
in Geographic Information Research at the Millennium (1997)Detailed reference viewed: 9 (0 ULg)
Does Acepromazine reduce the cardiovascular toxicity of Norepinephrine in the horse
; ; Sandersen, Charlotte et al
in Proceedings of the Congress of Veterinary Anesthesia (2005)Detailed reference viewed: 13 (0 ULg)
Does Aconitum septentrionale chemically protect floral rewards to the advantage of specialist bumblebees?
; ; Vanderplanck, Maryse et al
in Ecological Entomology (2013), 38(4), 400-407
Chemical protection of plants against herbivory is a well-studied phenomenon. However, chemical protection of floral rewards remains relatively unexplored. As with herbivore-plant interactions, toxic ... [more ▼]
Chemical protection of plants against herbivory is a well-studied phenomenon. However, chemical protection of floral rewards remains relatively unexplored. As with herbivore-plant interactions, toxic rewards may impact generalist and specialist foragers in different ways. This study focuses on the toxic plant Aconitum septentrionale (Ranunculaceae). This plant is visited by specialist and generalist bumblebees. Alkaloid concentrations and profiles for the different parts of A. septentrionale were analysed to detect a potential chemical toxicity of floral rewards. In the same way, sequestration of alkaloids was tested on a pollen specialist species Bombus consobrinus and a generalist species Bombus wurflenii. A liquid chromatography-quadrupole time-of-flight mass spectrometry method was developed to discriminate 16 major compounds in the plant. These alkaloids were present in all parts of the plant, but in different ratios. The concentration was high in the roots but also in pollen, providing evidence of chemical protection of this reward. By contrast, nectar had the lowest concentration of alkaloids. Only six alkaloids were detected in B. consobrinus tissues, at trace levels. For the generalist bumblebee B. wurflenii, no traces of alkaloids were detected. Lappaconitine was the major alkaloid compound in pollen, nectar and B. consobrinus tissues. Low accumulation of alkaloids in B. consobrinus tissues could be an ecological advantage for this specialist species in terms of pathogen and predatory avoidance. © 2013 The Royal Entomological Society. [less ▲]Detailed reference viewed: 10 (0 ULg)
Does an Acute COPD Crisis Modify the Cardiorespiratory and Ventilatory Adjustments to Exercise in Horses?
Art, Tatiana ; ; Votion, Dominique et al
in Journal of Applied Physiology (Bethesda, Md. : 1985) (1998), 84(3), 845-52
The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD ... [more ▼]
The present study was conducted to understand better the mechanisms leading to the decrease in exercise capacity observed in horses suffering from chronic obstructive pulmonary disease (COPD). Five COPD horses were submitted to a standardized submaximal treadmill exercise test while they were in clinical remission or in acute crisis. Respiratory airflow, O2 and CO2 fractions in the respired gas, pleural pressure changes and heart rate were recorded, and arterial and mixed venous blood were analyzed for gas tensions, hemoglobin, and plasma lactate concentrations. O2 consumption, CO2 production, expired minute ventilation, tidal volume, alveolar ventilation, cardiac output, total pulmonary resistance, and mechanical work of breathing were calculated. The results showed that, when submaximally exercised, COPD horses in crisis were significantly more hypoxemic and hypercapnic and that their total pulmonary resistance and mechanical work of breathing were significantly higher and their expired minute ventilation significantly lower than when they were in remission. However, their O2 consumption remained unchanged, which was probably due to the occurrence of compensatory mechanisms, i.e., higher heart rate, cardiac output, and hemoglobin concentration. Last, their net anaerobic metabolism seemed to be more important. [less ▲]Detailed reference viewed: 52 (16 ULg)
Does annual repetition of estrous induction influence the fertility of goats after A.I. at a fixed time ?
Drion, Pierre ; ; et al
in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2001), 5(1), 28-29Detailed reference viewed: 34 (9 ULg)
Does Belgian bioethanol comply with European Renewable Energy Directive ?
Belboom, Sandra ; Bodson, Bernard ; Léonard, Angélique
Poster (2013, November)
The craze for biofuels has increased in recent years mainly to reduce greenhouse gas emissions and fossil fuel consumptions. The European Renewable Energy Directive (RED), published in 2009, defined ... [more ▼]
The craze for biofuels has increased in recent years mainly to reduce greenhouse gas emissions and fossil fuel consumptions. The European Renewable Energy Directive (RED), published in 2009, defined guidelines to assess carbon footprint of a biofuel depending on biomass source. It also provided generic values of GHG emissions relative to each step of the life cycle taking into account all steps from the cultivation to the end-of-life. These values are used to evaluate the sustainability of European biofuels depending on the used crops and the used transformation technology. This study, based on local crops cultivated in Belgium (sugar beet and wheat), compares specific Belgian values with European generic ones. Belgium yields for both crops are among the best of the continent. Specific Belgian values for fertilizers and pesticides are used. The transformation of wheat into bioethanol is modelled using industrial data. As recommended by the RED, no land use change is taken into account for Belgium. Greenhouse gas emissions induce by the life cycle of Belgium sugar beet bioethanol are similar to the ones mentioned in the European directive but impact repartition is different. In our case, the transformation step achieves a higher part of the impact. That can be explained by the higher cultivation yield. Belgian wheat bioethanol obtains better results than those mentioned by the European directive with a 9% higher reduction. Cultivation step is the major step for this impact. Importance of fertilizers consumptions and associated emissions are highlighted. The comparison of both bioethanols impacts for climate change category, using an energy basis, shows that wheat allows a higher reduction of GHG emissions than sugar beet. If the comparison is performed on a cultivated area basis, results are reversed and sugar beet achieves a twofold reduction compared with wheat. Sensitivity analyses are performed on the importance of N fertilizers and associated emissions and on energy consumptions relative to the transformation step. These analyses reveal non-negligible impact variations. A range of GHG reduction that can be reached using Belgian sugar beet and wheat bioethanol are then calculated. In any case, sugar beet does not achieve the amount of reduction given by the RED, while the opposite effect is shown for wheat with a reduction at least as high as the RED default value. These results indicate the importance of make use of specific values to assess the sustainability of bioethanol for a specific country using a specific crop and a specific technology. Further measurements and research about emission factors due to fertilizers application could improve the accuracy of our results. [less ▲]Detailed reference viewed: 74 (5 ULg)
Does biobased polymer achieve better environmental impacts than fossil polymer? Comparison of fossil HDPE and biobased HDPE produced from sugar beet and wheat
Belboom, Sandra ; Léonard, Angélique
in Biomass & Bioenergy (2016), 85
Polymers are one of the most used materials and the majority of their production is based on fossil fuels. Due to the decrease of oil resources and concerns about climate change, alternatives are needed ... [more ▼]
Polymers are one of the most used materials and the majority of their production is based on fossil fuels. Due to the decrease of oil resources and concerns about climate change, alternatives are needed, the transformation of biobased ethanol into biobased polymer being one of them. This paper undertakes an environmental evaluation of the production of biobased polymer produced from two different feedstock cultivated in Belgium: sugar beet and wheat. Both crops cultivation are studied as well as their transformation into biobased ethanol, first, and then to biobased ethylene, focusing on high-density polyethylene (HDPE) as final product. These scenarios are analyzed and compared with the production of conventional polymer using the life-cycle assessment (LCA) methodology with reference to relevant environmental impact categories. This study shows a reduction of impact of around 60% for both climate change and fossil fuel depletion categories when using biobased HDPE instead of its fossil counterpart. For all other impact categories, fossil HDPE achieves better results than the biobased product. [less ▲]Detailed reference viewed: 72 (8 ULg)
Does cardiac surgery in newborn infants compromise blood cell reactivity to endotoxin?
; ; et al
in Critical Care (2005), 9(5), 549-55
INTRODUCTION: Neonatal cardiac surgery is associated with a systemic inflammatory reaction that might compromise the reactivity of blood cells against an inflammatory stimulus. Our prospective study was ... [more ▼]
INTRODUCTION: Neonatal cardiac surgery is associated with a systemic inflammatory reaction that might compromise the reactivity of blood cells against an inflammatory stimulus. Our prospective study was aimed at testing this hypothesis. METHODS: We investigated 17 newborn infants with transposition of the great arteries undergoing arterial switch operation. Ex vivo production of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha), of the regulator of the acute-phase response IL-6, and of the natural anti-inflammatory cytokine IL-10 were measured by enzyme-linked immunosorbent assay in the cell culture supernatant after whole blood stimulation by the endotoxin lipopolysaccharide before, 5 and 10 days after the operation. Results were analyzed with respect to postoperative morbidity. RESULTS: The ex vivo production of TNF-alpha and IL-6 was significantly decreased (P < 0.001 and P < 0.002, respectively), whereas ex vivo production of IL-10 tended to be lower 5 days after the operation in comparison with preoperative values (P < 0.1). Ex vivo production of all cytokines reached preoperative values 10 days after cardiac surgery. Preoperative ex vivo production of IL-6 was inversely correlated with the postoperative oxygenation index 4 hours and 24 hours after the operation (P < 0.02). In contrast, postoperative ex vivo production of cytokines did not correlate with postoperative morbidity. CONCLUSION: Our results show that cardiac surgery in newborn infants is associated with a transient but significant decrease in the ex vivo production of the pro-inflammatory cytokines TNF-alpha and IL-6 together with a less pronounced decrease in IL-10 production. This might indicate a transient postoperative anti-inflammatory shift of the cytokine balance in this age group. Our results suggest that higher preoperative ex vivo production of IL-6 is associated with a higher risk for postoperative pulmonary dysfunction. [less ▲]Detailed reference viewed: 48 (2 ULg)
Does co-treatment with immunosuppressors improve outcome in patients with Crohn's disease treated with adalimumab?
; LOUIS, Edouard ; Belaiche, Jacques et al
in Alimentary Pharmacology & Therapeutics (2012), 36(11-12), 1040-8
BACKGROUND: There is clear benefit from combination therapy with infliximab and immunosuppressive drugs (IS), but few data are available for adalimumab (ADA). AIM: To assess the efficacy of ADA ... [more ▼]
BACKGROUND: There is clear benefit from combination therapy with infliximab and immunosuppressive drugs (IS), but few data are available for adalimumab (ADA). AIM: To assess the efficacy of ADA monotherapy and ADA+IS for induction and maintenance therapy in Crohn's disease. METHODS: Retrospective study of patients with Crohn's disease treated with ADA in Oxford, UK or Liege, Belgium. Treatment periods were divided into 6-month semesters. A combination therapy semester was defined as ADA+IS for at least 3 months; successful induction meant clinical response; a semester with flare as ADA dose escalation, starting steroids, perianal complication, or surgery; and ADA failure as ADA withdrawal for secondary loss of response or intolerance. Semesters with and without flares were compared through univariate and multivariate analysis. RESULTS: Successful induction was achieved in 171/207 (83%) patients, with no significant difference between ADA+IS and ADA monotherapy (85% vs. 82%, P = 0.50). Five hundred and sixty-two semesters in 181 patients were included for maintenance analysis. ADA+IS was not associated with fewer semesters with flare (34% vs. 35%, P = 0.96), or with ADA failure (6% vs. 8%, P = 0.43). Nevertheless, combination therapy in the first semester was associated with a lower risk of ADA failure (5% vs. 10%, P = 0.04, OR = 0.48) and combination therapy beyond 6 months was associated with fewer semesters with flares (14% vs. 36%, P = 0.02, OR = 0.31). CONCLUSIONS: There may be a benefit from adalimumab+immunosuppressive drugs combination therapy during the first semester of initiating adalimumab, with a slight decrease in adalimumab failure and lower need for adalimumab dosage escalation. [less ▲]Detailed reference viewed: 34 (3 ULg)
Does cognitive impairment influence burden in caregivers of patients with Alzheimer’s disease?
Germain, Sophie ; Adam, Stéphane ; Olivier, Catherine et al
in Journal of Alzheimer's Disease [=JAD] (2009), 17(1), 105-114
Alzheimer's disease is characterized by a progressive deterioration of various cognitive and behavioral abilities and it also has a health impact on the patients’ caregiver. Our aim was to determine the ... [more ▼]
Alzheimer's disease is characterized by a progressive deterioration of various cognitive and behavioral abilities and it also has a health impact on the patients’ caregiver. Our aim was to determine the patient (and to a lesser extent the caregiver’s) characteristics that contribute most to the caregiver burden. We used the baseline data from the ICTUS study, a European longitudinal cohort of patients with mild to moderate AD. Data from 1091 patients and their caregivers has been used for analysis. Three principal components analyses were performed on variables from the domains of cognition, neuropsychiatric symptoms and daily function using MMSE plus ADAS-Cog, NPI and IADL subscores respectively. These were followed by a stepwise logistic regression to identify patient characteristics which best predict caregiver burden. The regression model (R2 = 0.35, p < .001) shows that the best explanatory variables are (1) neuropsychiatric symptoms (NPI), (2) difficulties in the IADL, (3) time taken by caregiving, (4) demographic variables such as caregiver’s age and patient sex and (5) severity of cognitive impairment. In conclusion, our results demonstrate that although the strongest determinant of the caregiver burden is behavioral disturbance, the impact of the degree of cognitive impairment on burden is also significant. [less ▲]Detailed reference viewed: 153 (37 ULg)
Does combining a wheat and pea mixture with methyl salicylate reduces aphid populations in both crops?
Chevalier Mendes Lopes, Thomas ; Fassotte, Bérénice ; Hatt, Séverin et al
Conference (2015, August 25)
Aphids are important pests of wheat and pea. Among the alternative methods to control them with less reliance on insecticides, crop associations already proved to be efficient. However, if increasing the ... [more ▼]
Aphids are important pests of wheat and pea. Among the alternative methods to control them with less reliance on insecticides, crop associations already proved to be efficient. However, if increasing the chemical and structural complexity of vegetation can disrupt their host plants location, the searching efficiency of predators and parasitoids can also be reduced. Therefore, these beneficials may not always be more abundant in such systems. Combining crop associations with attractive semiochemicals for natural enemies can be interesting to solve this problem. In this research, we compared the effect of a wheat and pea pure stand, wheat and pea mixture, and wheat and pea mixture combined with methyl salicylate (MeSA) formulated in alginate gel beads, on the abundance and diversity of aphids and their natural enemies. These were weekly observed on plants during 2013 and 2014 growing seasons. Over these two years, significantly higher numbers of pea aphids (Acyrthosiphon pisum (H.)) were observed in the pure stand of pea compared with both mixtures (with and without MeSA). No significant differences were observed between treatments for wheat aphids (Sitobion avenae (F.), Metopolophium dirhodum (W.) and Rhopalosiphum padi (L.)), which were significantly less abundant than pea aphids. Aphid natural enemies were mainly observed on pea plants. Hoverfly larvae abundance was not significantly different between treatments during both years. The same phenomenon occurred with hoverfly pupae in 2013, while these were significantly more abundant in both mixtures compared with the pure stand in 2014. However, their number did not differ significantly between the mixture with and without MeSA. Few ladybirds and lacewings were observed. No significant differences were observed between treatments for parasitoid mummies in 2013. Their abundance was significantly higher in the pure stand of pea compared with both mixtures in 2014. Results from this study show that mixing wheat and pea is an efficient method to maintain aphid populations at a very low level on pea. The use of MeSA did not show significant effects on natural enemies. However, mixing these crops may be enough to reduce aphid populations under an acceptable threshold. [less ▲]Detailed reference viewed: 68 (19 ULg)
Does comfort therapy during controlled donation after circulatory death shorten the life of potential donors?
LEDOUX, Didier ; DELBOUILLE, Marie-Hélène ; DE ROOVER, Arnaud et al
in Clinical transplantation (2014), 28(1), 47-51
INTRODUCTION: Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this ... [more ▼]
INTRODUCTION: Controlled donation after circulatory death (DCD) remains ethically controversial. The authors developed a controlled DCD protocol in which comfort therapy is regularly used. The aim of this study was to determine whether this policy shortens the DCD donors' life. METHODS: The authors retrospectively analyzed prospectively collected data on patients proposed for DCD at the University Hospital of Liege, Belgium, over a 56-month period. The survival duration of these patients, defined as duration between the time of proposal for DCD and the time of circulatory arrest, was compared between patients who actually donated organs and those who did not. RESULTS: About 128 patients were considered for controlled DCD and 54 (43%) became donors. Among the 74 non-donor patients, 34 (46%) objected to organ donation, 38 patients (51%) were denied by the transplant team for various medical reasons, and two potential DCD donors did not undergo procurement due to logistical and organizational reasons. The survival durations were similar in the DCD donor and non-donor groups. No non-donor patient survived. CONCLUSIONS: Survival of DCD donors is not shortened when compared with non-donor patients. These data support the ethical and respectful approach to potential DCD donors in the authors' center, including regular comfort therapy. [less ▲]Detailed reference viewed: 43 (10 ULg)
Does delay release the verbal overshadowing effect in child and adult eyewitnesses?
Vanootighem, Valentine ; Brédart, Serge ; Dehon, Hedwige
in Perception (2012), 41(supplement), 194
The verbal overshadowing effect (VO) (eg, Schooler and Engstler-Schooler, 1990 Cognitive Psychology 22(1) 36–71) suggests that the fact of generating a verbal description of a previously seen face may ... [more ▼]
The verbal overshadowing effect (VO) (eg, Schooler and Engstler-Schooler, 1990 Cognitive Psychology 22(1) 36–71) suggests that the fact of generating a verbal description of a previously seen face may impair subsequent performance on a lineup identification task in adults. Previous research has examined whether descriptions also impaired children’s identification abilities but no evidence of VO was found (Memon and Rose, 2002 Psychology, Crime and Law 8(3), 229–242). However, the method might not have been appropriate to observe this effect as, for instance, a 24-hour delay between the description and the identification tasks (associated with a release of the VO effect in adults) was used. Hence, in this current experiment, groups of children (7–8, 10–11, 13–14 years old) and adults were presented with a short video and then assigned to a description or a no description condition before the identification task. Participants were also assigned either to a “no delay”, a “24-hour post encoding delay” or a “24-hour post description delay” condition to determine the influence of delay on the VO effect. Results indicated that, compared to the control condition, the description decreased correct identification performance in both children and adults and no release of VO was found with delay. [less ▲]Detailed reference viewed: 117 (11 ULg)