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See detailEvidence for basement membranes in rat tail tendon sheaths.
Guizzardi, S.; Foidart, Jean-Michel ULg; Leonardi, L. et al

in Basic and Applied Histochemistry (1987), 31(2), 177-81

The presence of anti-laminin antibodies and a basement membrane-like thin electrondense lamina has been demonstrated in the peritendineum of the rat tail tendon by indirect immunofluorescence and electron ... [more ▼]

The presence of anti-laminin antibodies and a basement membrane-like thin electrondense lamina has been demonstrated in the peritendineum of the rat tail tendon by indirect immunofluorescence and electron microscopy. [less ▲]

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See detailEvidence for behavioral sensitization to cocaine in preweanling rat pups
Wood, R. D.; Tirelli, Ezio ULg; Snyder, K. J. et al

in Psychopharmacologia (1998), 138(2), 114-123

Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to ... [more ▼]

Sought to determine whether promoting context-dependent sensitization might facilitate expression of sensitization in preweanlings. Sprague-Dawley rats were injected daily from postnatal day 14 to postnatal day 20 with 0, 5, 15, or 30 mg/kg cocaine hydrochloride and placed for 30 min in either the experimental chamber or home cage. On postnatal day 21 (test day), Ss were challenged with either 15 mg/kg cocaine or saline prior to placement in the experimental chamber. Significant sensitization of cocaine-induced stereotyped head movements was evident in animals given 15 or 30 mg/kg chronically in the experimental chamber, but not when these same doses were given in the home cage. Less consistent evidence for cocaine-induced sensitization was seen when examining locomotion, although trends for sensitization of this behavior were seen in animals chronically injected in either the test chamber or home cage. Thus, preweanlings can exhibit cocaine sensitization, particularly in terms of stereotypy, when tested shortly after the chronic exposure period, with expression of this sensitization being facilitated by pairing the chronic injections with the test context. ((c) 1998 APA/PsycINFO, all rights reserved) [less ▲]

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See detailEvidence for cooperative effects in the exchange reaction catalysed by the oxoglutarate translocator of rat-heart mitochondria.
Sluse, Francis ULg; Sluse-Goffart, Claudine; Duyckaerts, Claire ULg et al

in European Journal of Biochemistry (1975), 56(1), 1-14

The initial rates of the exchange external oxoglutarate/internal malate through the inner membrane of rat-heart mitochondria, for various concentrations of the two substrates, have been reinvestigated for ... [more ▼]

The initial rates of the exchange external oxoglutarate/internal malate through the inner membrane of rat-heart mitochondria, for various concentrations of the two substrates, have been reinvestigated for an extended range of concentrations of the external oxoglutarate. This has been made possible by use of the inhibitor-stop technique that allows 100 times smaller incubation times than the centrifugation-stop technique used previously. Under the experimental conditions the uptake of the external-labelled oxoglutarate into the mitochondrial-matrix space is mediated by the oxoglutarate translocator performing a ono-to-one exchange of the anions oxoglutarate (external) and malate (internal). Two intermediary-plateau regions are observed in the kinetic saturation curve of the translocator by the external oxoglutarate, revealing a complex rate equation which is found to be the product of two one-substrate functions. Analysing these features it is shown that the model, proposed earlier, of a "double carrier" as catalyst in a rapid-equilibrium random bi-bi mechanism, is still applicable but that several external binding sites have to be considered. As already noticed the external and the internal substrates bind to their respective sites independently of each other. Furthermore, some additional requirements imposed by the observed kinetics suggest that the exchange reaction is performed by only one translocator species made of identical interacting subunits. The anion exchange is tentatively viewed as a rotation of a subunit around an axis situated in the plane of the membrane after two independent local configuration changes induced by the binding of the two substrates on this subunit. [less ▲]

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See detailEvidence for cross-talk between the LH receptor and LH during implantation in mice
Gridelet, Virginie ULg; Tsampalas, Marie; Berndt, Sarah et al

in Reproduction, Fertility and Development (2013), 25

The present study investigated the first interaction that occurs between the blastocyst and endometrium during implantation. Given the ethical objections to studying implantation in humans, a mouse model ... [more ▼]

The present study investigated the first interaction that occurs between the blastocyst and endometrium during implantation. Given the ethical objections to studying implantation in humans, a mouse model was used to study the dialogue between luteinising hormone (LH) and luteinising hormone receptor (LHCGR). Several studies performed on LHCGR-knockout mice have generated controversy regarding the importance of the dialogue between LH and LHCGR during implantation. There has been no demonstration of a bioactive LH-like signal produced by the murine blastocyst. The first aim of the present study was to examine and quantify, using radioimmunoassay, the generation of a bioactive LH signal by the murine blastocyst. We went on to examine and quantify endometrial Lhcgr expression to validate the mouse model. Expression of LHCGR in mouse uteri was demonstrated using immunohistochemistry and western blot analysis. To quantify the expression of Lh in the mouse blastocyst and Lhcgr in the endometrium, reverse transcription–polymerase chain reaction (RT-PCR) and real-time quantitative (q) RT-PCR were performed. The results demonstrate that Lhcgr expression in BALB/c mouse endometrial epithelium is increased at the time of implantation and indicate that LHCGR may contribute to the implantation process. In support of this hypothesis, we identified a bioactive LH signal at the time of murine blastocyst implantation. [less ▲]

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See detailEvidence for decoupling of atmospheric CO2 and global climate during the Phanerozoic eon
Veizer, J.; Godderis, Y.; François, Louis ULg

in Nature (2000), 408(6813), 698-701

Atmospheric carbon dioxide concentrations are believed to drive climate changes from glacial to interglacial modes', although geological(1-3) and astronomical(4-6) mechanisms have been invoked as ultimate ... [more ▼]

Atmospheric carbon dioxide concentrations are believed to drive climate changes from glacial to interglacial modes', although geological(1-3) and astronomical(4-6) mechanisms have been invoked as ultimate causes. Additionally, it is unclear(7,8) whether the changes between cold and warm modes should be regarded as a global phenomenon, affecting tropical and high-latitude temperatures alike(9-13), or if they are better described as an expansion and contraction of the latitudinal climate zones, keeping equatorial temperatures approximately constant(14-16). Here we present a reconstruction of tropical sea surface temperatures throughout the phanerozoic eon (the past similar to 550 Myr) from our database(17) of oxygen isotopes in calcite and aragonite shells. The data indicate large oscillations of tropical sea surface temperatures in phase with the cold-warm cycles, thus favouring the idea of climate variability as a global phenomenon. But our data conflict with a temperature reconstruction using an energy balance model that is forced by reconstructed atmospheric carbon dioxide concentrations(18). The results can be reconciled if atmospheric carbon dioxide concentrations were not the principal driver of climate variability on geological timescales for at least one-third of the Phanerozoic eon, or if the reconstructed carbon dioxide concentrations are not reliable. [less ▲]

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See detailEvidence for distinct roles for basal ganglia and SMA in automatic and unconscious inhibition of voluntary actions
D'Ostilio, Kevin ULg; Garraux, Gaëtan ULg

Poster (2009, June)

Introduction: Although previous research highlighted the importance of automatic and unconscious inhibition in motor control, the neural correlates of such processes remain unclear. Basal ganglia ... [more ▼]

Introduction: Although previous research highlighted the importance of automatic and unconscious inhibition in motor control, the neural correlates of such processes remain unclear. Basal ganglia dysfunctions have long been associated with impairment in automatic motor control. In addition, Sumner & al. (2007) suggested a key role of the medial frontal cortex by administrating a masked priming task (e.g., Eimer & Schlaghecken 2003) to a patient with a small lesion restricted to the supplementary motor area (SMA)., Here, we used fMRI in normal subjects to better delineate the respective roles of SMA and basal ganglia in automatic and unconscious motor inhibition. Methods: We used event-related BOLD fMRI at 3T to record brain activity in 26 healthy volunteers (22 ± 2 years) as they performed the subliminal masked priming task. In this visuomotor task, participants are asked to make speeded button presses with the left or right hand following leftward or rightward pointing arrows, which are preceded by masked prime arrows. Here, two experimental variables were manipulated: the interval between the mask and the target (SOA: 0,100,150,200 or 250 ms) and the prime/target direction (compatible or incompatible). Imaging data processing and analysis were performed using SPM8b. Results: using Repeated Measures ANOVA of behavioral data (global interaction SOA*compatibility, p<0.0000001), we replicated the masked priming effects showing faster reaction times (i.e., motor response facilitation) in compatible than incompatible trials at 0-SOA (positive compatibility effect: diff = 21 ms, linear contrast : p<0.0000001) and the reverse (negative compatibility effect) at 100 (diff = -12 ms, p= 0.01) and 150-SOA (diff= -12 ms, p= 0.008) suggesting motor response inhibition. At 200 & 250 SOA, we no longer found significant compatibility effects (p>0.05) By applying a similar statistical model to imaging data, we observed a stronger activity in the in several regions, the SMA (p<0.001, uncorrected), caudate (p=0.002, uncorrected) and thalamus (p<0.001, uncorrected) showing stronger activity in compatible than incompatible trials at 100 and 150-SOA, as compared with 0-SOA. Moreover, the differential activity in the SMA was correlated with the negative compatibility effect (p= 0.01). When testing for a main effect of SOAs we didn’t find a differential activation of the SMA, but a stronger deactivation of the caudate (p=0.009, uncorrected) and the thalamus (p=0.007, uncorrected) at 100-150 SOA (inhibition conditions) compared to 0-SOA (facilitation condition). In a prime identification task administered after the fMRI experiment, subjects’ performance was at chance levels for primes displayed for 17 ms as in the main study, suggesting that the prime was not consciously perceived. Conclusions: These new findings suggest that automatic and unconscious inhibition of an activated motor response is mediated by the basal ganglia whereas medial frontal regions seem to be more implicated in the control of response conflict related to inhibition. [less ▲]

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See detailEvidence for enhanced inflammatory cell activity, ICAM-1 expression and eosinophil chemotactic activity in the sputum of asthmatics.
Louis, Renaud ULg; Shute, J.; Biaggi, S. et al

in American Journal of Respiratory & Critical Care Medicine (1997), 155(2), 466-472

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma ... [more ▼]

We have applied the technique of sputum induction by hypertonic saline in asthmatics and nonatopic control subjects to study an array of indices of airway inflammation believed to be relevant to asthma pathogenesis. Compatible with a central role for eosinophils and mast cells in asthma, sputum of asthmatic subjects contained increased numbers of eosinophils and levels of eosinophil cationic protein (ECP) and mast cell tryptase. Eosinophil numbers, and ECP and histamine levels correlated with the degree of methacholine airways responsiveness, and ECP, tryptase, and histamine correlated with raised concentrations of albumin. Using the micro-Boyden chamber technique eosinophil chemotactic activity was identified only in the sputum from asthmatics. The correlation between the raised levels of total IgA, IL- 8/IgA complexes, and tryptase and the degree of sputum eosinophilia and ECP levels, suggests possible mechanisms for eosinophil chemotaxis and activation in asthma. Row cytometric analysis of sputum lymphocytes showed an increase in CD4+ T cells and T cells expressing intercellular adhesion molecule-1 (ICAM-1) in asthma which, together with the finding of raised levels of soluble ICAM-1 in the sputum, indicates upregulation of this adhesion molecule. Finally, the proportion of CD16+ natural killer (NK) cells was reduced in the sputum of asthmatics. These observations highlight the importance of the airway inflammation in causing asthma and further confirm the usefulness of sputum induction as a tool in asthma research. [less ▲]

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See detailEvidence for Expansion of Host-derived CMV-specific CD8+ T cells after Allogeneic Transplantation with Non-Myeloablative Conditioning
MENTEN, Catherine ULg; Castermans, E.; Hannon, Muriel ULg et al

in Belgian Journal of Hematology (2012), Abstracts book(Supplement of 27th General Meeting of the Belgian Hematological Society), 16

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See detailEvidence for expression of some Microtubule-associated Protein 1B in neurons as a plasma membrane glycoprotein.
Franzen, Rachelle ULg; Tanner, Sandy; Jaffe, Howard et al

in Journal of Neurochemistry (2000), 75

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See detailEvidence for Free Radical Formation During Human Kidney Transplantation
Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg; Franssen, Christine ULg et al

in Free Radical Biology & Medicine (1993), 15(3), 343-8

Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of ... [more ▼]

Fourteen patients undergoing kidney transplantation were studied for evidence of the production of free radicals as assessed by the measurement of vitamin E (an index of lipid peroxidation) and of myeloperoxidase (a marker of neutrophil activation) in the systemic blood. Early (2 min) and late revascularization (30 min) of the kidney were respectively associated with a significant decrease of 35.5 and 40% of the initial level of plasma vitamin E. This consumption paralleled to the decrease of the vitamin E/total lipids ratio, a better indicator of vitamin E status. Heparin administration preceding renal artery clamping resulted in a twofold significant increase of baseline plasma myeloperoxidase (MPO) level (523 +/- 214 ng/ml). At kidney reperfusion, MPO concentration rose again and reached a maximum value of 1,653 +/- 882 ng/ml, indicating the presence of considerable neutrophil activation. A return to the baseline value was observed after 30 min of reperfusion. A short discussion about the possible origin of this MPO increase is given. Taken together, these data strongly suggest that free radical production, leading to lipid peroxidation phenomena, can occur within the early phase of kidney revascularization. Preliminary data using electron spin resonance with the spin-trapping technique strengthen this hypothesis. [less ▲]

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See detailEvidence for free radical generation in ischemia-reperfusion
Franssen, Colette ULg; Pincemail, Joël ULg; Defraigne, Jean-Olivier ULg et al

in Teaching and research in intensive care medicine - Proceeding book (1992)

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See detailEvidence for HLA-DQA1 locus being associated with abdominal aortic aneurysms in the Belgian population
Ogata, T.; Gregoire, L.; Goddard, K. A. et al

in Circulation (2005, April 12), 111(14), 219

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See detailEvidence for increased upper brain stem activity following STN-DBS in Parkinson's disease: An (18)FDG-PET study
Desoullieres, Aurélie; KASCHTEN, Bruno ULg; CREMERS, Julien ULg et al

in Movement Disorders : Official Journal of the Movement Disorder Society (2009), 24(Suppl. 1), 186-187

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See detailEvidence for line-profile variability in the spectrum of the O supergiant HD 152249: preliminary results
Gosset, Eric ULg; Sana, H.; Linder, N. et al

in Communications in Asteroseismology (2009, July 01), 158

Already suspected to be variable, the O9Ib((f)) supergiant HD 152249 has been the subject of a dedicated follow-up spectroscopic run. We report here on the preliminary results. This star is definitely ... [more ▼]

Already suspected to be variable, the O9Ib((f)) supergiant HD 152249 has been the subject of a dedicated follow-up spectroscopic run. We report here on the preliminary results. This star is definitely exhibiting significant line-profile variations which are most probably a sign of the existence of non-radial pulsations. HD 152249 could thus belong to the newly identified group of pulsating OB supergiants. [less ▲]

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See detailEvidence for neo-generation of T cells by the thymus after non-myeloablative conditioning.
Castermans, Emilie ULg; Baron, Frédéric ULg; Willems, Evelyne ULg et al

in Haematologica (2008), 93(2), 240-7

BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning ... [more ▼]

BACKGROUND: Background and objective. We investigated immune recovery in 50 patients given either unmanipulated or CD8-depleted allogeneic peripheral blood stem cells after non-myeloablative conditioning. DESIGN AND METHODS: Fifty patients were randomized to receive either CD8-depleted (n=22) or non-manipulated (n=28) peripheral blood stem cells. The median patients age was 57 (range 36-69) years. The conditioning regimen consisted of 2 Gy total body irradiation with or without added fludarabine. Twenty patients received grafts from related donors, 14 from 10/10 HLA-allele matched unrelated donors, and 16 from HLA-mismatched unrelated donors. Graft-versus-host disease pro-phylaxis consisted of mycophenolate mofetil and cyclosporine. Immune recovery during the first year after hematopoietic cell transplantation was assessed by flow cytometry phenotyping, analyses of the diversity of the TCRBV repertoire, and quantification of signal-joint T-cell receptor excision circles (sjTREC). RESULTS: CD8-depletion of the graft reduced the recovery of CD8(+) T-cell counts in the first 6 months following transplantation (p<0.0001) but had no significant impact on the restoration of other T-cell subsets. Both sjTREC concentration and CD3(+) T-cell counts increased significantly between day 100 and 365 (p=0.010 and p=0.0488, respectively) demonstrating neo-production of T cells by the thymus. Factors associated with high sjTREC concentration 1 year after transplantation included an HLA-matched unrelated donor (p=0.029), a high content of T cells in the graft (p=0.002), and the absence of chronic graft-versus-host disease (p<0.0001). CONCLUSIONS: Our data suggest that while immune recovery is mainly driven by peripheral expansion of the graft-contained mature T cells during the first months after non-myeloablative transplantation, T-cell neo-generation by the thymus plays an important role in long term immune reconstitution in transplanted patients. [less ▲]

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See detailEvidence for Network Evolution in an Arabidopsis Interactome Map
Arabidopsis Interactome Mapping Consortium; Braun, Pascal; Carvunis, Anne-Ruxandra et al

in Science (2011), 333(6042), 601-607

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We ... [more ▼]

Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops. [less ▲]

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See detailEvidence for nonlinear resonant mode coupling in the beta Cephei star HD 180642 (V1449 Aquilae) from CoRoT photometry
Degroote, P.; Briquet, Maryline ULg; Catala, C. et al

in Astronomy and Astrophysics (2009), 506

Context: We present the CoRoT light curve of the β Cep star HD 180642, assembled during the first long run of the space mission, as well as archival single-band photometry. <BR />Aims: Our goal is to ... [more ▼]

Context: We present the CoRoT light curve of the β Cep star HD 180642, assembled during the first long run of the space mission, as well as archival single-band photometry. <BR />Aims: Our goal is to analyse the detailed behaviour present in the light curve and interpret it in terms of excited-mode frequencies. <BR />Methods: After describing the noise properties in detail, we use various time series analyses and fitting techniques to model the CoRoT light curve, for various physical assumptions. We apply statistical goodness-of-fit criteria that allow us to select the most appropriate physical model fit to the data. <BR />Results: We conclude that the light-curve model based on nonlinear resonant frequency and phase locking provides the best representation of the data. Interpretation of the residuals is dependent on the chosen physical model used to prewhiten the data. <BR />Conclusions: Our observational results constitute a fruitful starting point for detailed seismic stellar modelling of this large-amplitude and evolved β Cep star. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain. Appendix A is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http://cdsweb.u-strasbg.fr/cgi-bin/qcat?J/A+A/506/111 Postdoctoral Fellow of the Fund for Scientific Research, Flanders. [less ▲]

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See detailEvidence for phase-locked X-ray variations from the colliding-wind massive binary Cyg OB2 #8A
De Becker, Michaël ULg; Rauw, Grégor ULg

in Rauw, G.; Nazé, Y.; Blomme, R. (Eds.) et al Massive Stars and High-Energy Emission in OB Associations (2005, November)

We report on preliminary results of a multi-observatory investigation of the X-ray emission from the massive colliding wind binary Cyg OB2 #8A (O6If + O5.5III(f)). On the basis of our new XMM-Newton-EPIC ... [more ▼]

We report on preliminary results of a multi-observatory investigation of the X-ray emission from the massive colliding wind binary Cyg OB2 #8A (O6If + O5.5III(f)). On the basis of our new XMM-Newton-EPIC observations, along with archive ASCA-SIS and ROSAT-PSPC data, we show strong evidence for a significant phase-locked variability of the X-ray emission from Cyg OB2 #8A with the period of 21.9 days determined by De Becker et al. (2004). These results lend further support to the colliding wind scenario that was already suggested by optical data (De Becker & Rauw 2005). We briefly discuss the behaviour of the X-ray emission from this binary system as a function of phase in the context of the colliding wind scenario. [less ▲]

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See detailEvidence for short-term variations in two O-type stars
De Becker, Michaël ULg; Linder, Natacha ULg; Rauw, Grégor ULg

in Information Bulletin on Variable Stars (2008), 5841

Only a few O-type stars are known to display short-term (a fraction of a day) variations. Intense spectroscopic monitoring of the ON8V star HD 13268 revealed low amplitude variations with periods of ... [more ▼]

Only a few O-type stars are known to display short-term (a fraction of a day) variations. Intense spectroscopic monitoring of the ON8V star HD 13268 revealed low amplitude variations with periods of several hours. In addition, observations of the SB1 system HD 15137 revealed variations on a time scale of a few hours. We consider these stars to be a good candidates for non radial pulsations, even though variations related to inhomogeneities in a circumstellar disk can not be rejected. [less ▲]

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