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See detailEvidence of cutinase activity released by Ascochyta pinodes and Ascochyta pisi.
Nasraoui, B.; Lepoivre, Philippe ULg; Barthelemy, Jean-Paul ULg et al

in Mededelingen van de Faculteit Landbouwwetenschappen (Rijksuniversiteit te Gent) (1990), 55(3a),

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See detailEvidence of food quality limitation in benthic river insects
Darchambeau, François ULg; Glémet, Hélène; Bélanger, Tommy et al

Conference (2007, July 12)

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See detailEvidence of food quality limitation in benthic river insects
Darchambeau, François ULg; Glémet, Hélène; Bélanger, Tommy et al

Conference (2007, August 16)

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See detailEvidence of health benefits of of polyphenols enriched foods : from In Vitro studies to clinical trials performed at university - CHU of Liège, Belgium
PINCEMAIL, Joël ULg; Kevers, Claire ULg; Tabart, Jessica ULg et al

in University of Ferrara (Ed.) Second Internaional conference on environmental stressors in biology and medicine (2011, October)

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See detailEvidence of HLA-mediated immune response driving the maintenance of CTL-escape variants in patients with undetectable viral load
Dilernia, D.; Lourtau, L.; Jones, L.R. et al

in AIDS Research and Human Retroviruses (2008, October 13), 4(1), 79

Evidence of HLA-mediated immune response driving the maintenance of CTL-escape variants in patients with undetectable viral load. Dario A Dilernia, L Lourtau, L Jones, S Rodriguez, C Bautista, M Gomez ... [more ▼]

Evidence of HLA-mediated immune response driving the maintenance of CTL-escape variants in patients with undetectable viral load. Dario A Dilernia, L Lourtau, L Jones, S Rodriguez, C Bautista, M Gomez-Carrillo, M Losso, and H Salomon. Immune response drives the selection of CTL-escape mutations during the course of HIV infection. After initiation of HAART, antiviral drugs exert a stronger selective force leading to a higher limitation of viral replication. Our objective was to evaluate the effectiveness of immune response as a selective force in a context of extremely reduced viral population size. Gag gene was sequenced and HLA-A and B genotyped over 108 samples from drug-naïve HIV-1 positive individuals. Associations between HLA alleles and viral polymorphisms were assessed by logistic regression. Multiple comparison corrections were addressed by the BH method (q-values). Phylogeny correction was performed by a Bayesian Markov-Chain Monte-Carlo method. Analysis of site-specific synonymous and non-synonymous substitution rate was assessed through the codon-based ML IFEL method. For four patients with viral load < 50 copies/ml (identified according to their HLA profile), RNA extraction was performed from 7 ml of plasma through an ultracentrifugation-based method and gag gene amplified through a Hi-Fi PCR. 20-40 clones were sequenced in samples obtained previously and during HAART. We found that HLA-B57 and A03 were the most efficient alleles in forcing CTL-escape, targeting mainly the previously characterized epitopes TSTLQEQIGW(p=0.0002) and RLRPGGKKK(p<10E-7), respectively. Sites under significant positive selection (p<0.05) during HAART were position 20 (within A03-restricted RLRPGGKK) for patient A02A3B35B39, position 385 (within A3-restricted RGNFRNQRK) for patient A3A31B7B45 and position 84 (within A2-restricted SLYNTVATL) for patient A2A3B39B57. Epitopes sequences of RLRPGGKKK and TSTLQEQIGWF were in the escape state for patients harboring the selective alleles. In spite of the low viral diversity achieved during HAART, we detected sites under positive selection. Our results show that during successful HAART, targeted CTL-epitopes are still forced to evolve adaptively, suggesting that CTL-mediated immune response would be able to keep driving the evolution of HIV variants even in viral population with a remarkable low replication rate. [less ▲]

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See detailEvidence of involvement of yeast proliferating cell nuclear antigen in DNA mismatch repair
Johnson, Robert; Kovvali, G.; Guzder, Sami et al

in Journal of Biological Chemistry (1996), 271(45), 27897-90

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See detailEvidence of marine food chains by means of stable natural carbon isotopes
Dauby, Patrick ULg; Mosora, Florentina

Conference (1987, September)

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See detailEvidence of mast-cell activation in a subset of patients with eosinophilic chronic obstructive pulmonary disease
Louis, Renaud ULg; Cataldo, Didier ULg; Buckley, M. G. et al

in European Respiratory Journal (2002), 20(2), 325-331

Although asthma has been viewed mainly, as an eosinophilic disease, and chronic obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown increased neutrophil counts in ... [more ▼]

Although asthma has been viewed mainly, as an eosinophilic disease, and chronic obstructive pulmonary disease (COPD) as a neutrophilic disease, recent studies have shown increased neutrophil counts in severe asthma and sputum eosinophilia in sonic COPD patients. In an attempt to further characterise these two syndromes according to pathology, the current authors have conducted a study of induced sputum in 15 subjects with COPD, 17 asthmatics, and 17 nonatopic healthy individuals. Sputum was analysed for cytology and levels of eosinophil cationic protein (ECP), albumin, tryptase and soluble intercellular adhesion molecule-1. The COPD subjects differed from the asthmatics as they had higher sputum neutrophil and lower columnar epithelial cell counts, but there were no differences in any soluble marker studied. When compared to control subjects, both the asthmatic and COPD subjects had raised eosinophil counts and ECP levels. In a subset of COPD subjects with Sputum eosinophilia (>3% of total cells), significantly increased levels of tryptase were detected. In conclusion, although chronic obstructive pulmonary disease is a more neutrophilic disease than asthma, the two diseases are difficult to distinguish on the basis of sputum levels of the soluble markers traditionally associated with asthma. However, a subset of patients with chronic obstructive pulmonary disease with airway eosinophilia and mast-cell activation might represent a distinct pathological phenotype. [less ▲]

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See detailEvidence of nutriceutical effectiveness in the treatment of osteoarthritis
Reginster, Jean-Yves ULg; Gillot, Vincent; Bruyère, Olivier ULg et al

in Current Rheumatology Reports (2000), 2(6), 472-477

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See detailEvidence of pre-prosomatostatin mRNA in human normal and tumoral anterior pituitary gland
Pagesy, P.; Li, J. Y.; Rentier-Delrue, Françoise ULg et al

in Molecular Endocrinology (1989), 3(8), 1289-94

Expression of the SRIH gene was investigated in six human normal anterior pituitaries, six GH-, three PRL-, three mixed GH/PRL-secreting and four nonsecreting adenomas. Total cellular RNA and poly(A ... [more ▼]

Expression of the SRIH gene was investigated in six human normal anterior pituitaries, six GH-, three PRL-, three mixed GH/PRL-secreting and four nonsecreting adenomas. Total cellular RNA and poly(A+) mRNAs were analyzed by dot and Northern blot hybridization to a 3'-end labeled oligonucleotide probe specific for the human pre-proSRIH mRNA. A weak but detectable pre-proSRIH hybridization signal was present in human normal anterior pituitaries and in the four groups of adenomas. The size of this pre-proSRIH mRNA was indistinguishable from that found in our hypothalamic samples and close to that described in the literature. The wide variation of the signal intensity from one case to the other in each group of the different types of normal and tumoral antehypophyseal samples prevented establishment of any correlation between the level of pre-proSRIH mRNA and the nature of the pituitary tissue. The presence of SRIH mRNA in human normal and tumoral anterior pituitary tissues provides a sound basis to substantiate the hypothesis of a SRIH biosynthesis in the human anterior pituitary gland. [less ▲]

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See detailEvidence of rainbow trout prolactin interaction with its receptor through unstable homodimerisation.
Le Rouzic, Philippe; Sandra, Olivier; Grosclaude, Jeanne et al

in Molecular & Cellular Endocrinology (2001), 172(1-2), 105-13

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow ... [more ▼]

This study aims to characterise Prolactin receptor (PRLR) in rainbow trout for which no information is available despite the availability of Salmonid PRL preparations. By screening a freshwater rainbow trout intestine cDNA library with a probe corresponding to the extracellular domain (ECD) of tilapia PRLR, we have cloned a 2.5 kb insert coding for the PRLR. The mature protein of 614 amino acid residues is similar to PRLR isolated in tilapia and also the long form of mammalian PRLR. Analysis of PRLR gene expression in osmoregulatory organs revealed the presence of a unique transcript, thus confirming the involvement of this hormone in the control of osmoregulation in this fish species. By using surface plasmon resonance (SPR) technology, kinetic measurement of interaction between trout PRL and its receptor ECD was studied. This approach allowed us to demonstrate the formation of a transient, unstable homodimeric complex. This unstability could explain the inability to perform binding experiments using homologous PRL. In contrast, heterologous lactogenic ligands were able to interact through a more stable complex. Whether these characteristics of PRL-receptor interaction in rainbow trout are different to what occurs in tilapia where a homologous radioreceptor assay was developed would require further studies. [less ▲]

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See detailEvidence of the Image. A few Suggestions for a Cultural History of Photography
Havelange, Carl ULg

in WIMBÖCK, Gabriele; LEONHARD, Karin; FRIEDRICH, Markus (Eds.) Evidentia. Reichweiten visueller Wahrnehmung in der Frühen Neuzeit (2007)

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See detailEvidence of upward filed-aligned currents at the open-closed field line boundary in Saturn's noon magnetosphere: observations and theory
Bunce, E. J.; Cowley, S. W. H.; Talboys, D. L. et al

Conference (2007, June 26)

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See detailEvidence of West European defined miospore zones in the Uppermost Devonian and Lower Carboniferous of the Amazonas Basin (Brazil).
Loboziak, S; Streel, Maurice ULg; Caputo, M.V. et al

in Geobios (1991), 24(1), 5-11

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See detailEvidence of wind-induced temperature anomalies in the tropical and subtropical North Atlantic Ocean in winter-spring 2010
Troupin, Charles ULg; Machín, Francis

Poster (2011, April)

During the first months of 2010, the tropical and subtropical North Atlantic displayed anomalously high temperatures, with values seldom observed during the last decades. In situ and remote sensing data ... [more ▼]

During the first months of 2010, the tropical and subtropical North Atlantic displayed anomalously high temperatures, with values seldom observed during the last decades. In situ and remote sensing data are used to evaluate horizontal, vertical and temporal extensions of the anomalies. The repercussions on the seasonal evolution of the mixed layer are examined; in particular, it is shown that the northwest Africa coastal upwelling is significantly weakened in comparison to previous years. The consequences on the biological variables are examined by means of satellite-derived measurements. A simple mechanism related to changes in wind intensity is proposed in order to explain our observations. The wind weakening coincides with a strongly negative value of the North Atlantic Oscillation index. [less ▲]

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See detailEvidence on the Determinants of Innovation in a Sample of Spanish firms
Artige, Lionel ULg

E-print/Working paper (2011)

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See detailEvidence That Breast Cancer Associated Microcalcifications Are Mineralized Malignant Cells
Castronovo, Vincenzo ULg; Bellahcene, Akeila ULg

in International Journal of Oncology (1998), 12(2), 305-8

Microcalcifications are often associated with both benign and malignant human breast lesions. Around 40% of mammary carcinoma present such ectopic mineralization and frequently, they are the only ... [more ▼]

Microcalcifications are often associated with both benign and malignant human breast lesions. Around 40% of mammary carcinoma present such ectopic mineralization and frequently, they are the only mammographic feature that indicate the presence of a tumoral lesion. Microcalcifications associated with breast cancer are usually composed of hydroxyapatite, the bone specific mineral. The mechanisms responsible for the formation of such crystals within breast malignant tissue have not been elucidated. A possible clue could be provided by the recent demonstration that breast cancer cells express several bone matrix proteins including osteonectin, osteopontin and bone sialoprotein (BSP). This latter phospho-protein is involved in the initiation of hydroxyapatite crystallisation and its expression in breast cancer has been associated to the presence of hydroxyapatite microcalcifications. We examined 10 human breast cancer lesions which were characterized by the presence of microcalcifications and high expression of BSP. Histological examination of the lesions suggested, in most of the cases, that the microcalcifications were breast cancer cells which became mineralized. Hydroxyapatite stained in blue by hematoxylin appears concentrated around single of associated cancer cells. Staining of these tissue sections with 4',6 diamidino-2-phenylindole which specifically labels DNA led us to demonstrate that the mineralizated structures contain cells. These data are the first direct demonstration that breast microcalcifications are fossils of cancer cells. The mechanisms for such a phenomenon remain to be demonstrated. We speculate that the high expression of BSP could create an appropriate microenvironment for the crystallisation of calcium and phosphate into hydroxyapatite. [less ▲]

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