Formes pharmaceutiques à libération prolongée en médecine vétérinaire : systèmes à rétention dans le réticulo-rumen = Sustained-released veterinary dosage forms : retention devices in the reticulorumen

in STP Pharma Pratiques (1996), 6(6), 479-486

L'industrialisation des productions animales a mis en évidence la nécessité d'éviter des administrations réitérées chez des animaux dont la manipulation est difficile, et de développer des formes à ... [more ▼]

L'industrialisation des productions animales a mis en évidence la nécessité d'éviter des administrations réitérées chez des animaux dont la manipulation est difficile, et de développer des formes à libération contrôlée ou du moins fortement prolongée. L'anatomie particulière du tube digestive des ruminants offre en outre des possibilités inédites pour le développement de tels systèmes thérapeutiques, notamment grâce à la rétention dans le réticulo-rumen. De telles formes ont essentiellement été développées pour l'administration de médicaments antiparasitaires et antibactériens, de suppléments nutritionnels et de promoteurs croissance. Cette revue décrit les applications potentielles de la technologie des formes à libération contrôlée et prolongée en médecine vétérinaire et les différents dispositifs à rétention dans le réticulo-rumen décrits dans la littérature, brevetés ou commercialisés. More intensive methods ofanimal husbandry have revealed the necessity of avoiding repeated administration ofmedication to animals which are difficult to handle and of developing controlled and sustained release dosage forms. The physiological characteristics of the digestive tract of ruminants provide unique opportunity for controlled release technology, especially due to the animal's reticulo-rumen retention ability. The majorareas of application of these controlled and sustained release dosage forms include the delivery of antibiotic and antiparasitic agents, trace nutrients and growth promoting agents. This review describes the potential applications of controlled and sustained release technology in veterinary medicine and the various reticulo-rumen retention devices which are patented, marketed or described in the literature. [less ▲]

Formic acid above the Jungfraujoch during 1985–2007: observed variability, seasonality, but no long-term background evolution

in Atmospheric Chemistry and Physics (2010), 10(20), 10047--10065

This paper reports on daytime total vertical column abundances of formic acid (HCOOH) above the Northern mid-latitude, high altitude Jungfraujoch station (Switzerland; 46.5° N, 8.0° E, 3580 m alt.). The ... [more ▼]

This paper reports on daytime total vertical column abundances of formic acid (HCOOH) above the Northern mid-latitude, high altitude Jungfraujoch station (Switzerland; 46.5° N, 8.0° E, 3580 m alt.). The columns were derived from the analysis of infrared solar observations regularly performed with high spectral resolution Fourier transform spectrometers during over 1500 days between September 1985 and September 2007. The investigation was based on the spectrometric fitting of five spectral intervals, one encompassing the HCOOH ν6 band Q branch at 1105 cm−1, and four additional ones allowing to optimally account for critical temperature-sensitive or time-evolving interferences by other atmospheric gases, in particular HDO, CCl2F2 and CHClF2. The main results derived from the 22 years long database indicate that the free tropospheric burden of HCOOH above the Jungfraujoch undergoes important short-term daytime variability, diurnal and seasonal modulations, inter-annual anomalies, but no significant long-term background change. A major progress in the remote determination of the atmospheric HCOOH columns reported here has resulted from the adoption of new, improved absolute spectral line intensities for the infrared ν6 band of trans-formic acid, resulting in retrieved free tropospheric loadings being about a factor two smaller than if derived with previous spectroscopic parameters. Implications of this significant change with regard to earlier remote measurements of atmospheric formic acid and comparison with relevant Northern mid-latitude findings, both in situ and remote, will be assessed critically. Sparse HCOOH model predictions will also be evoked and assessed with respect to findings reported here. [less ▲]

Forming forces in single point incremental forming: prediction by finite element simulations, validation and sensitivity

in Computational Mechanics (2011), 47

The aim of this article is to study the accuracy of finite element simulations in predicting the tool force occurring during the single point incremental forming (SPIF) process. The forming of two cones ... [more ▼]

The aim of this article is to study the accuracy of finite element simulations in predicting the tool force occurring during the single point incremental forming (SPIF) process. The forming of two cones in soft aluminum was studied with two finite element (FE) codes and several constitutive laws (an elastic–plastic law coupled with various hardening models). The parameters of these laws were identified using several combinations of a tensile test, shear tests, and an inverse modeling approach taking into account a test similar to the incremental forming process. Comparisons between measured and predicted force values are performed. This article shows that three factors have an influence on force prediction: the type of finite element, the constitutive law and the identification procedure for the material parameters. In addition, it confirms that a detailed description of the behavior occurring across the thickness of the metal sheet is crucial for an accurate force prediction by FE simulations, even though a simple analytical formula could provide an otherwise acceptable answer. [less ▲]

Forms and functions of accentuation in Dutch, French, and English

Conference (2006)

Formulation and characterisation of submicronic emulsions

Conference (2001)

Formulation and in vitro evaluation of inhalable dry powders containing solid lipid nanoparticles

Poster (2007)

Formulation and integrated use of two antagonistic yeasts to postharvest treatments against diseases on apples

in Proceedings of an EC Workshop: Biological control of fruit and Foliar diseases (1993)

Formulation Arbitraire Lagrangienne-Eulérienne pour le contact lubrifié entre solides. Applications aux opérations de mise à forme.

Report (1999)

Formulation Arbitraire Lagrangienne-Eulérienne pour le contact lubrifié entre solides. Applications aux opérations de mise à forme.

Report (2000)

Formulation de l'étude linéarisée des structures précontraintes

Report (1976)

Pre-stress may have a consderable effect on the behaviour of thin walled structures. The general case is non linear. However, there is a class of situations where the study remains linear, as for example ... [more ▼]

Pre-stress may have a consderable effect on the behaviour of thin walled structures. The general case is non linear. However, there is a class of situations where the study remains linear, as for example, a plate with a membranar pre-stress. The present paper focuses on the basic hypotheses of such a linearized analysis an on its exact formulation. [less ▲]