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See detailDevelopment of new biomimetic biopolymers
Grandfils, Christian ULiege

Scientific conference (2013, June 27)

Detailed reference viewed: 14 (0 ULiège)
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See detailDevelopment of new catalysts for proton exchange membrane fuel cells (PEMFCs)
Zubiaur, Anthony ULiege

Doctoral thesis (2017)

Detailed reference viewed: 14 (3 ULiège)
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See detailDevelopment of new drugs for an old target — the penicillin binding proteins.
Zervosen, Astrid ULiege; Sauvage, Eric ULiege; Frère, Jean-Marie ULiege et al

in Molecules (2012), 17(11), 12478-505

The widespread use of β-lactam antibiotics has led to the worldwide appearance of drug-resistant strains. Bacteria have developed resistance to β-lactams by two main mechanisms: the production of β ... [more ▼]

The widespread use of β-lactam antibiotics has led to the worldwide appearance of drug-resistant strains. Bacteria have developed resistance to β-lactams by two main mechanisms: the production of β-lactamases, sometimes accompanied by a decrease of outer membrane permeability, and the production of low-affinity, drug resistant Penicillin Binding Proteins (PBPs). PBPs remain attractive targets for developing new antibiotic agents because they catalyse the last steps of the biosynthesis of peptidoglycan, which is unique to bacteria, and lies outside the cytoplasmic membrane. Here we summarize the “current state of the art” of non-β-lactam inhibitors of PBPs, which have being developed in an attempt to counter the emergence of β-lactam resistance. These molecules are not susceptible to hydrolysis by β-lactamases and thus present a real alternative to β-lactams. We present transition state analogs such as boronic acids, which can covalently bind to the active serine residue in the catalytic site. Molecules containing ring structures different from the β-lactam-ring like lactivicin are able to acylate the active serine residue. High throughput screening methods, in combination with virtual screening methods and structure based design, have allowed the development of new molecules. Some of these novel inhibitors are active against major pathogens, including methicillin-resistant Staphylococcus aureus (MRSA) and thus open avenues new for the discovery of novel antibiotics. [less ▲]

Detailed reference viewed: 52 (9 ULiège)
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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULiege; Christgau, Stephan; Henriksen, Dennis et al

in Arthritis and Rheumatism (2002, September), 46(number 9 (suppl.)), 496

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See detailDevelopment of new immunoassays for the quantification of inflammatory related cartilage degradation
Deberg, Michelle ULiege; Christgau, Stephan; Cloos, Paul et al

in Osteoporosis International (2002, November), 13(Suppl. 3), 54

Detailed reference viewed: 33 (4 ULiège)
See detailDevelopment of new strategies against the tomato leafminer, Tuta absoluta Meyrick
De Backer, Lara ULiege; Francis, Frédéric ULiege; Verheggen, François ULiege

Conference given outside the academic context (2013)

The tomato leafminer, Tuta absoluta (Meyrick), is a Lepidoptera considered as one of the major pest of Solanaceae. It causes important yield loss in South America, where it is originated, and in the West ... [more ▼]

The tomato leafminer, Tuta absoluta (Meyrick), is a Lepidoptera considered as one of the major pest of Solanaceae. It causes important yield loss in South America, where it is originated, and in the West Palearctic region, where it was introduced in 2006. Insecticide applications and the use of the sexual pheromone have been the main control method used against T. absoluta. Insecticides are inefficient because of the endophytic habit of larvae, which are protected in the leaf mesophyll or inside fruits. Moreover, resistances against various insecticides have been reported. The sexual pheromone based strategies also provide poor results. One explanation has been recently provided by the demonstration of a parthenogenetic reproduction in T. absoluta, from the research group in Gembloux Agro-Bio Tech (ULg). Because there is a real need to improve crop protection against T. absoluta and in the meanwhile reducing the use of synthetic insecticidal compounds, researches aim at providing new perspectives to further biocontrol strategies against T. absoluta. [less ▲]

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See detailDevelopment of new thrombolytic agents using recombinant DNA technology.
Pierard, Luc ULiege; Bollen, A.

in Journal of biotechnology (1990), 15(4), 283-304

The increasing incidence of thromboembolic diseases has sustained the search for new agents able to stimulate the natural fibrinolytic system. The first generation of antithrombotic agents include ... [more ▼]

The increasing incidence of thromboembolic diseases has sustained the search for new agents able to stimulate the natural fibrinolytic system. The first generation of antithrombotic agents include bacterial streptokinase and human urine urokinase. Because these molecules lack specificity for the fibrin clot, important efforts have been made to produce, using recombinant DNA technology, agents presenting higher fibrin clot selectivity such as t-PA (tissue-type plasminogen activator) and scu-PA (single chain urokinase-type plasminogen activator). In parallel, several laboratories are presently attempting to create mutants and hybrids plasminogen activators displaying improved thrombolytic properties with respect to the natural molecules. In this paper, we describe briefly the mechanisms of fibrinolysis and the role of the different natural thrombolytic agents. In addition, we review the possibilities of genetic engineering for the production of natural and novel plasminogen activators. [less ▲]

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See detailDevelopment of non invasive genetic identification methods for the Pyrenean desman (Galemys pyrenaicus) and first study of its genetic structure in France
Gillet, François ULiege; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

Poster (2011, July)

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the north of the Iberic Peninsula. Many biologic aspects of this species are currently suffering from a major lack of information, particularly those concerning its genetics. Therefore the implementation of conservative efforts for the Pyrenean desman remains extremely difficult. In order to improve the knowledge of this vulnerable species and notably, to better understand its distribution area, the first aim of our research was to develop non invasive genetic identification methods based on faeces. The second aim was to have a first look at the phylogeographic structure of the Pyrenean desman. The identification methods were developed on the basis of the sequencing of a small mitochondrial DNA (cyt b) fragment as well as a RFLP method. These approaches led to the identification of the Pyrenean desman and to the differentiation of the latter from two other species living in the same type of habitat, the white-throated dipper (Cinclus cinclus) and the water shrew (Neomys fodiens). Two haplotypes were found in the studied Pyrenean populations but no phylogeographic structure could be established. A dozen of microsatellites markers were also developed during this work and 5 of these were found to be polymorphic. The results of this preliminary work tend to show a low genetic diversity for the Pyrenean desman but this result needs to be confirmed in the future with a more extended and complete study. [less ▲]

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See detailDevelopment of non radioactive multi-analyte methodes based on the use of a recombinant human beta2-agonists and antagonists residues in food-producing animals
Danyi, Sophie ULiege; Degand, Guy ULiege; Granier, Benoît et al

in Proceedings Euroresidue V conference on residues of veterinary drugs in food (2004, May)

Detailed reference viewed: 12 (4 ULiège)
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See detailDevelopment of non-linear Electro-Thermo-Mechanical Discontinuous Galerkin formulations
Homsi, Lina ULiege

Doctoral thesis (2017)

A coupled Electro-Thermo-Mechanical Discontinuous Galerkin (DG) method is developed considering the non-linear interactions of electrical, thermal, and mechanical fields. The numerical properties of the ... [more ▼]

A coupled Electro-Thermo-Mechanical Discontinuous Galerkin (DG) method is developed considering the non-linear interactions of electrical, thermal, and mechanical fields. The numerical properties of the DG are demonstrated, such as uniqueness, consistency, stability and the optimal convergence rate. The framework is applied to simulate the response of smart composite materials, where the shape memory effect is triggered by the Joule effect. [less ▲]

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See detailDevelopment of noninvasive genetic identification methods and polymorphic microsatellites for the Pyrenean desman (Galemys pyrenaicus)
Gillet, François ULiege; Cabria Garrido, Maria Teresa; Némoz, Mélanie et al

Poster (2012, August)

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the ... [more ▼]

The Pyrenean desman (Galemys pyrenaicus) is probably one of the most threatened European mammal species. This small insectivorous and semi-aquatic species is endemic to the Pyrenean Mountains and of the north of the Iberic Peninsula. Many biologic aspects of this species are currently suffering from a major lack of information, particularly those concerning its genetics. Therefore the implementation of conservative efforts for the Pyrenean Desman remains extremely difficult. In order to improve the knowledge of this vulnerable species and notably, to better understand its distribution area, the first aim of our research was to develop non invasive genetic identification methods based on faeces. The second aim was the development of several polymorphic microsatellites markers in order to have a first look at the genetic structure of the Pyrenean Desman in its French distribution area. The identification methods were developed on the basis of the sequencing of a small mitochondrial DNA (cyt b) fragment as well as a RFLP method. These approaches led to the identification of the Pyrenean desman and to the differentiation of the latter from two other species living in the same type of habitat, the white-throated dipper (Cinclus cinclus) and the water shrew (Neomys fodiens). More than fifteen polymorphic microsatellites markers could be found for the Pyrenean Desman and their genotyping revealed a low number of alleles per locus (two to five). The results of this preliminary work tend to show a low genetic diversity for the Pyrenean Desman but this result needs to be confirmed in the future with a more extended and complete study. [less ▲]

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Peer Reviewed
See detailDEVELOPMENT OF NOVEL CATIONIC AND LIGAND-GRAFTED ANIONIC LIPOSOMES FOR BRAIN-TARGETED DRUG DELIVERY
Karim, Reatul ULiege; Palazzo, Claudio ULiege; Laloy, Julie et al

Poster (2016, September 27)

Detailed reference viewed: 33 (3 ULiège)
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See detailDevelopment of novel SOlid Materials for high power Li polymer BATteries (SOMABAT). Recyclability of components.
Zubizarreta, Leire; Gil-Agusti, Mayte; Garcia. et al

in Briec, E.; Müller., B. (Eds.) Electric Vehicle Batteries: Moving from Research towards Innovation. Lecture notes on mobility (2015)

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See detailDevelopment of nuclear SNP markers for genetic tracking of Iroko, Milicia excelsa and Milicia regia
Blanc-Jolivet, Céline; Kersten, Birgit; Daïnou, Kasso ULiege et al

in Conservation Genetics Resources (2017)

Iroko, Milicia excelsa, is an economically important tropical hardwood species widely distributed in tropical Africa, from Ivory Coast in Western Africa to Tanzania in Eastern Africa. The species occurs ... [more ▼]

Iroko, Milicia excelsa, is an economically important tropical hardwood species widely distributed in tropical Africa, from Ivory Coast in Western Africa to Tanzania in Eastern Africa. The species occurs at low densities in contrasting habitats such as rainforest and woodlands. Former studies using chloroplast and nuclear sequences, as well as nSSRs, revealed a strong differentiation within the species among West and Central African populations and the presence of three genetic groups in Central Africa (Daïnou et al. 2010, 2014). The genus Milicia also includes another species, M. regia, co-occurring with M. excelsa in West Africa. Both species can be identified genetically and morphologically (Daïnou et al. 2014), but identification is difficult in the field. Although the spatial genetic structure of the species is well described, it is mostly based on nSSRs. Despite their lower diversity, SNP markers provide several advantages including the uncomplicated standardization of data among laboratories and the easy, rapid and low-cost development of markers for large sets of loci. These features make SNPs the ideal markers for setting up genetic reference data for timber tracking (Blanc-Jolivet and Liesebach 2015; Degen et al. 2017; Jardine et al. 2016; Pakull et al. 2016). In this paper, we describe the development of a new set of nuclear SNPs on M. excelsa meant to be used for genetic timber tracking. [less ▲]

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See detailDevelopment of nuclear SNP markers for the timber tracking of the African tree species Sapelli, Entandrophragma cylindricum
Blanc-Jolivet, Céline; Kersten, Birgit; Bourland, Nils et al

in Conservation Genetics Resources (2017)

We describe the development of new nuclear SNP markers for the genetic timber tracking of the geographical origin of Sapelli, Entandrophragma cylindricum (Meliaceae). Restriction associated DNA sequencing ... [more ▼]

We describe the development of new nuclear SNP markers for the genetic timber tracking of the geographical origin of Sapelli, Entandrophragma cylindricum (Meliaceae). Restriction associated DNA sequencing (RADseq) of two reference individuals yielded 1131 putative SNPs. Among those, 131 were selected to design four MassARRAY multiplexes and screened at 178 individuals. Seventy-two loci were selected for further use in genetic tracking. [less ▲]

Detailed reference viewed: 33 (14 ULiège)
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See detailDevelopment of Numerical Algorithms for Practical Computation of Nonlinear Normal Modes
Peeters, Maxime ULiege; Georgiades, Fotios; Viguié, Régis ULiege et al

in International Conference on Noise and vibration Engineering, Leuven, 2006 (2006)

When resorting to numerical algorithms, we show that nonlinear normal mode (NNM) computation is possible with limited implementation effort, which paves the way to a practical method for determining the ... [more ▼]

When resorting to numerical algorithms, we show that nonlinear normal mode (NNM) computation is possible with limited implementation effort, which paves the way to a practical method for determining the NNMs of nonlinear mechanical systems. The proposed method relies on two main techniques, namely a shooting procedure and a method for the continuation of NNM motions. In addition, sensitivity analysis is used to reduce the computational burden of the algorithm. A simplified discrete model of a nonlinear bladed disk is considered to demonstrate the developments. [less ▲]

Detailed reference viewed: 62 (10 ULiège)
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See detailDevelopment of Object and Grasping Knowledge by Robot Exploration
Kraft, Dirk; Detry, Renaud ULiege; Pugeault, Nicolas et al

in IEEE Transactions on Autonomous Mental Development (2010), 2(4), 368--383

Detailed reference viewed: 25 (0 ULiège)
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See detailDevelopment of optical ground verification method for mu m to sub-mm reflectors
Stockman, Yvan ULiege; Thizy, Cédric ULiege; Lemaire, Philippe ULiege et al

in Warmbein, B. (Ed.) Proceedings of the 5th International Conference on Space Optics (ICSO) (2004, April 02)

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The ... [more ▼]

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. The challenging tasks of on-ground testing are to achieve the required accuracy in the measurement of the reflector shapes and antenna structures and to verify their performance under simulated space conditions (vacuum, low temperatures). A small number of infrared interferometers have been commercially developed over the last 10 years but their applications have also been limited due to poor dynamic range and the restricted spatial resolution of their detectors. It has therefore been considered essential, from the viewpoint of supporting future ESA exploration missions, to develop and realise suitable verification tools based on infrared interferometry and other optical techniques for testing large reflector structures, telescope configurations and their performances under simulated space conditions. Two methods and techniques are developed at CSL. The first one is an IR-phase shifting interferometer with high spatial resolution. This interferometer shall be used specifically for the verification of high precision IR, FIR and sub-mm reflector surfaces and telescopes under both ambient and thermal vacuum conditions. The second one presented hereafter is a holographic method for relative shape measurement. The holographic solution proposed makes use of a home built vacuum compatible holographic camera that allows displacement measurements from typically 20 nanometres to 25 microns in one shot. An iterative process allows the measurement of a total of up to several mm of deformation. Uniquely the system is designed to measure both specular and diffuse surfaces [less ▲]

Detailed reference viewed: 33 (2 ULiège)
See detailDevelopment of optical ground verification method for mum to sub-mm reflectors
Stockman, Yvan ULiege; Thizy, Cédric ULiege; Lemaire, Philippe ULiege et al

in 5th International Conference on Space Optics (2004, June 01)

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. Scientific ... [more ▼]

Large reflectors and antennas for the IR to mm wavelength range are being planned for many Earth observation and astronomical space missions and for commercial communication satellites as well. Scientific observatories require large telescopes with precisely shaped reflectors for collecting the electro-magnetic radiation from faint sources. The challenging tasks of on-ground testing are to achieve the required accuracy in the measurement of the reflector shapes and antenna structures and to verify their performance under simulated space conditions (vacuum, low temperatures). Due to the specific surface characteristics of reflectors operating in these spectral regions, standard optical metrology methods employed in the visible spectrum do not provide useful measurement results. The current state-of-the-art commercial metrology systems are not able to measure these types of reflectors because they have to face the measurement of shape and waviness over relatively large areas with a large deformation dynamic range and encompassing a wide range of spatial frequencies. 3-D metrology (tactile coordinate measurement) machines are generally used during the manufacturing process. Unfortunately, these instruments cannot be used in the operational environmental conditions of the reflector. The application of standard visible wavelength interferometric methods is very limited or impossible due to the large relative surface roughnesses involved. A small number of infrared interferometers have been commercially developed over the last 10 years but their applications have also been limited due to poor dynamic range and the restricted spatial resolution of their detectors. These restrictions affect also the surface error slopes that can be captured and makes their application to surfaces manufactured using CRFP honeycomb technologies rather difficult or impossible. It has therefore been considered essential, from the viewpoint of supporting future ESA exploration missions, to develop and realise suitable verification tools based on infrared interferometry and other optical techniques for testing large reflector structures, telescope configurations and their performances under simulated space conditions. The first one is an IR-phase shifting interferometer with high spatial resolution. This interferometer shall be used specifically for the verification of high precision IR, FIR and sub-mm reflector surfaces and telescopes under both ambient and thermal vacuum conditions. The second one presented hereafter is a holographic method for relative shape measurement. The holographic solution proposed makes use of a home built vacuum compatible holographic camera that allows displacement measurements from typically 20 nanometres to 25 microns in one shot. An iterative process allows the measurement of a total of up to several mm of deformation. Uniquely the system is designed to measure both specular and diffuse surfaces. [less ▲]

Detailed reference viewed: 12 (3 ULiège)