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See detailDexamethasone pretreatment provides antiinflammatory and myocardial protection in neonatal arterial switch operation.
Heying, Ruth; Wehage, Edith; SCHUMACHER, Katharina ULiege et al

in Annals of Thoracic Surgery (2012), 93(3), 869-76

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the ... [more ▼]

BACKGROUND: This prospective double-blinded randomized study tested the hypothesis that preoperative treatment with dexamethasone would attenuate inflammatory priming of the myocardium, reduce the systemic inflammatory reaction upon cardiac operation, and provide organ protection in neonates. METHODS: Twenty neonates (age, 8 to 21 days) with transposition of the great arteries scheduled for arterial switch operation were included. Nine received dexamethasone (1 mg/kg body weight) 4 hours before cardiopulmonary bypass, and 11 received natrium chloride. We studied intramyocardial messenger RNA expression of interleukin (IL)-6, IL-8, IL-1beta, and tumor necrosis factor-alpha (TNF-alpha), as well as IL-10 and expression of TNF-alpha on protein level in right atrial tissue taken before institution of CPB. We measured plasma levels of IL-6, IL-10, lipopolysaccharide binding protein, and cardiac troponin T. Cytokine expression was related to postoperative outcome. RESULTS: Pretreatment with dexamethasone led to a significant decrease in myocardial expression of IL-6, IL-8, IL-1beta, and TNF-alpha messenger RNA and to a decrease in protein synthesis of TNF-alpha. Plasma concentrations of IL-6 were significantly lower and those of IL-10 significantly higher in pretreated patients. This was associated with lower cardiac troponin T values and lower dobutamine requirement. Levels of lipopolysaccharide binding protein were significantly higher postoperatively in pretreated neonates. CONCLUSIONS: Dexamethasone administration before arterial switch operation leads to a shift in the myocardial and systemic cytokine expression profile in neonates with transposition of the great arteries, with downregulation of proinflammatory and upregulation of antiinflammatory cytokines. Lower myocardial cell damage and lower catecholamine requirement suggest myocardial protection in treated patients. [less ▲]

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See detailDexamethasone suppression test and MMPI scales
Ansseau, Marc ULiege; Geenen, Vincent ULiege; Franck, Georges et al

in Neuropsychobiology (1986), 16

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See detailThe dexamethasone suppression test in violent suicide attempters with major depression.
Pitchot, William ULiege; Hansenne, Michel ULiege; Gonzalez Moreno, A. et al

in Biological Psychiatry (1995), 37(4), 273-4

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See detailDexamethasone-induced accumulation of a fibronectin and collagen extracellular matrix in transformed human cells.
Furcht, L. T.; Mosher, D. F.; Wendelschafer-Crabb, G. et al

in Nature (1979), 277(5695), 393-5

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See detailThe dexamethasone-induced inhibition of proliferation, migration and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors.
Piette, Caroline ULiege; Deprez, Manuel ULiege; Roger, Th et al

in Journal of Biological Chemistry (2009), 284(47), 32483-92

Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema ... [more ▼]

Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema. Few in vitro studies have suggested that GCs inhibit the migration and invasion of GBM cells through the induction of MAPK phosphatase 1 (MKP-1). Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs. Recently, MIF has been involved in tumor growth and migration/invasion and specific MIF inhibitors have been developed on their capacity to block its enzymatic tautomerase activity site. In this study, we characterized several glioma cell lines for their MIF production. U373 MG cells were selected for their very low endogenous levels of MIF. We showed that dexamethasone inhibits the migration and invasion of U373 MG cells, through a glucocorticoid receptor (GR)- dependent inhibition of the ERK1/2 MAPK pathway. Oppositely, we found that exogenous MIF increases U373 MG migration and invasion through the stimulation of the ERK1/2 MAP kinase pathway and that this activation is CD74 independent. Finally, we used the Hs 683 glioma cells that are resistant to GCs and produce high levels of endogenous MIF, and showed that the specific MIF inhibitor ISO-1 could restore dexamethasone sensitivity in these cells. Collectively, our results indicate an intricate pathway between MIF expression and GC resistance. They suggest that MIF inhibitors could increase the response of GBMs to corticotherapy. [less ▲]

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See detailLe défi des générations, sous la direction de J. Grand’Maison, L. Baroni et J.-M. Gauthier (compte rendu)
Fournier, Bernard ULiege

in Recherches Sociographiques : Revue Pluridisciplinaire d'Etudes sur le Québec et le Canada français. (1999), XL(1)

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See detailDFT investigation of the reaction mechanism for the guanidine catalyzed ring-opening of cyclic carbonates by aromatic and alkyl-amines
Alves, Margot ULiege; Méreau, Raphaël; Grignard, Bruno ULiege et al

in RSC Advances (2017), 7(31), 18993-19001

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the ... [more ▼]

The guanidine catalysed aminolysis of propylene carbonate has been investigated using the density functional theory (DFT) and highlights that different reaction pathways are involved depending on the aromatic or aliphatic nature of the amine. The structural ability of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) to simultaneously give and receive protons was demonstrated by a detailed mechanistic investigation. The bifunctional activity (base/H-bond donor) of TBD significantly reduces the Gibbs energy of the reaction and allows understanding its higher efficiency compared to its methyl counterpart (MTBD). [less ▲]

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See detailDFT studies of solvation effects on the nanosize bare, thiolated and redox active ligated Au55 cluster
Periyasamy, Ganga ULiege; Durgun, Engin; Raty, Jean-Yves ULiege et al

in Journal of Physical Chemistry C: Nanomaterials, Interfaces, and Hard Matter (2010), Protected Metallic Clusters, Quantum Wells and Metal-Nanocrystal Molecules Symposium

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See detailDGTs, a complementary tool towards more efficient biomonitoring practices
Richir, Jonathan ULiege; Lepoint, Gilles ULiege; Donnay, Annick et al

Conference (2015, October 01)

Among the diversity of contaminants, trace elements (TEs) remain of concern because of their persistence, their ability to accumulate in biota and their toxicity. The direct measurement of their dissolved ... [more ▼]

Among the diversity of contaminants, trace elements (TEs) remain of concern because of their persistence, their ability to accumulate in biota and their toxicity. The direct measurement of their dissolved concentrations only gives punctual and fluctuating information, and often remains below detection limits of analytical methods. The more appropriate use of sentinel organisms, or bioindicators, to monitor TEs has thus often been preferred in environmental surveys. The introduction of the diffusive gradients in thin films (DGTs) technique has however participated to progressively change this binary view - bioindicator vs water - of the coastal monitoring of TEs, and DGTs rapidly became a relevant complementary tool to bioindicators, has illustrated below. In the framework of the STARECAPMED project, the ecology and the ecotoxicology of TEs were studied in the seagrass Posidonia oceanica (L.) Delile and the mussel Mytilus galloprovincialis Lamarck, 1819. DGTs (free- and pore-water probes) were deployed before sampling of organisms. TEs were also analyzed in suspended matter (dissolved and suspended-particulate TE speciation). Studies were performed in the Calvi Bay (Corsica, France), northwestern Mediterranean. TE concentrations in organisms and suspended matter or in DGT resins were measured by DRC-ICP-MS after HNO3/H202 mineralization or after a 24h elution in HNO3 1M, respectively. (1) TE bioaccumulation was first seasonally studied in P. oceanica over 3 years. Dissolved TE concentrations monitored with DGTs were low to very low. TE bioaccumulation dynamics in P. oceanica could thus be linked to the natural physiological cycle of the plant, in clean environmental conditions. (2) To complement that field survey, isolated seagrasses were in situ contaminated with TEs at environmental relevant concentrations. Through the use of DGTs, TE uptake kinetics were modelled for seagrasses exposed to know bioavailable concentrations of contaminants, as were loss kinetics during the following depuration phase. The TE sequestration ability of a healthy P. oceanica meadow facing sudden trace metal contamination events could also be quantified. (3) The deployment of pore-water DGT probes in bare-sand or seagrass colonized sediments further showed that, through its stabilizing function of the seabed, P. oceanica maintained higher TE levels in the pore-water. P. oceanica meadows thus offer a significant “depuration-filtering” ecological service along highly anthropized Mediterranean coasts. M. galloprovincialis are widely used in large spatial scale coastal monitoring surveys. (4) The deployment of caged mussels together with DGTs showed that the little contaminated water body of the Calvi Bay was relatively homogenous. It also allowed to calculate TE bioaccumulation towards mussels in reference conditions, and to compare it to native mussel populations. (5) Finally, during a 5 months mussel caging survey, mussels and suspended matter were collected weekly to monthly, such as were deployed DGTs. The physiological status of mussels, the speciation of TEs between their dissolved and suspended-particulate phases, and their relative influence on TE bioaccumulation dynamics in mussels were investigated. In conclusion, these case studies properly demonstrate how DGT probes can be used as a relevant and complementary tool to bioindicators. Their concomitant use should therefore be privileged in monitoring surveys. [less ▲]

Detailed reference viewed: 75 (7 ULiège)
See detailDHCo Délivrance d'héroïne sous contrôle médical
Ansseau, Marc ULiege; Gustin, Frédéric; Hodiaumont, Fabienne et al

Book published by Academia Press (2005)

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See detailDHEA et intracrinologie de jouvence pour la peau? Entre raison et magie.
Bourguignon, Raphael; Uhoda, I.; Henry, Frédérique ULiege et al

in Revue Médicale de Liège (2002), 57(7), 438-42

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In ... [more ▼]

Slowing down ageing is a goal for a large part of the population. Some mercantile claims hold out bright prospects to DHEA. The effects of this hormone manifest themselves after intracrine conversion. In the skin, sebaceous glands enlarge and seborrhoea increases in post-menopausal women. No other effect is clinically discernable on the skin. At this level, DHEA does not show efficacy comparable to that of other anti-ageing compounds. [less ▲]

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See detailDi sesso femminile
Tuil, Karine; Ricciardi, Stefania ULiege

Book published by Voland (2005)

Detailed reference viewed: 52 (0 ULiège)
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See detail(Di)-aminoguanidine Functionalization through Transamination: An Avenue to an Auspicious Class of Supramolecular Synthons
Naik, Anil D; Tinant, Bernard; Léonard, Alexandre ULiege et al

in Crystal Growth & Design (2011), 11

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See detail« La diabase de Challes, près de Stavelot» : Rapport sur une note de M. A. Renard par C. Malaise
Malaise, Constantin ULiege

in Bulletin de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique. Sciences (1878), 2e série(46), 186-188

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See detailDiabète : aspects particuliers. Microangiopathie et macroangiopathie diabétique
RADERMECKER, Régis ULiege

Scientific conference (2011, March 18)

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See detailLe diabete de l'enfant et de l'adolescent. 1. Prise en charge par le Service Universitaire de Pediatrie et la Cellule "Education-Diabete en Pediatrie"
LEBRETHON, Marie-Christine ULiege; Philippart, D.; Rocour-Brumioul, D. et al

in Revue Médicale de Liège (2005), 60(5-6, May-Jun), 313-9

The management and follow up of diabetes in youth is a multidisciplinary challenge due to both short and long term objectives. Awareness of the feelings and problems faced by the families is critical. The ... [more ▼]

The management and follow up of diabetes in youth is a multidisciplinary challenge due to both short and long term objectives. Awareness of the feelings and problems faced by the families is critical. The experience of our team has started in the 1960s and is briefly described and updated in this article. [less ▲]

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See detailLe diabète de l'enfant et de l'adolescent. 2 Aspects particuliers chez l'adolescent
BOURGUIGNON, Jean-Pierre ULiege; Rocour-Brumioul, Danielle ULiege; COLLARD, J et al

in Revue Médicale de Liège (2005), 60(5-6), 320-321

L'adolescent diabétique confronte les "soignants" à quelques aspects spécifiques, tant au moment du diagnostic que lors du suivi. L'existence de diabète de type 2 ne doit pas être méconnue, étant donné la ... [more ▼]

L'adolescent diabétique confronte les "soignants" à quelques aspects spécifiques, tant au moment du diagnostic que lors du suivi. L'existence de diabète de type 2 ne doit pas être méconnue, étant donné la fréquence croissante de celui-ci en relation avec la progression de l'obésité chez les sujets jeunes. Lors de l'éducation initiale, la place des parents doit être prise en compte et réfléchie, tout en créant un espace propre pour l'adolescent. Dans le suivi, toutes les dimensions du processus adolescentaire seront prises en considération en plus du diabète. Ceci implique, notamment, les comportements exploratoires ou à risques, les sentiments de marginalisation, voire la révolte, et les difficultés de prendre en compte le risque de complications à long terme. Une attention particulière sera portée sur la période de transition vers une consultation pour adultes. [less ▲]

Detailed reference viewed: 26 (1 ULiège)