Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension : web addenda
GALIE, Nazzareno; HUMBERT, Marc; VACHIERY, Jean-Luc et al

in European Respiratory Journal (2015)

Detailed reference viewed: 50 (0 ULg)
Full Text
Peer Reviewed
See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galie, Nazzareno; Humbert, Marc; Vachiery, Jean-Luc et al

in The European respiratory journal (2015), 46(4), 903-75

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management ... [more ▼]

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk-benefit ratio of particular diagnostic or therapeutic means. Guidelines and recommendations should help health professionals to make decisions in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. [less ▲]

Detailed reference viewed: 47 (1 ULg)
Full Text
Peer Reviewed
See detail2015 FMA Annual Meeting
Platania, Federico ULg; Lambert, Marie ULg; Moreno, Manuel

Conference (2015, October)

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally ... [more ▼]

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally abandon the project before completion whenever the investment cost turns out to be larger than the expected net cash flow stream. On the other hand, the proposed model accounts for two different sources of uncertainty, those are technical and economic risk. This model incor- porates a novel economic state vector where each economic state captures the interaction among different market and economic forces using Fourier series as the particular basis for the economic function space. In this sense, Fourier series are considered as an aggregate of forces playing a relevant role in the process evolution determining the cash flow structure and also allowing us to properly define an economic scenario where the project will be developed. [less ▲]

Detailed reference viewed: 21 (0 ULg)
Full Text
Peer Reviewed
See detail2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, Piotr; Voors, Adriaan A.; Anker, Stefan D. et al

in European Heart Journal (2016)

Detailed reference viewed: 21 (3 ULg)
Full Text
Peer Reviewed
See detail2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Ponikowski, Piotr; Voors, Adriaan A.; Anker, Stefan D. et al

in European Journal of Heart Failure (2016)

Detailed reference viewed: 19 (2 ULg)
Full Text
Peer Reviewed
See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in European Heart Journal (2016), 37(38), 2893-2962

Detailed reference viewed: 32 (0 ULg)
Full Text
Peer Reviewed
See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery (2016), 50(5), 1-88

Detailed reference viewed: 14 (0 ULg)
Full Text
Peer Reviewed
See detail2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS.
Kirchhof, Paulus; Benussi, Stefano; Kotecha, Dipak et al

in Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology (2016), 18(11), 1609-1678

Detailed reference viewed: 24 (0 ULg)
Full Text
Peer Reviewed
See detail2016 ESC/EAS Guidelines for the Management of Dyslipidaemias
Catapano, Alberico L.; Graham, Ian; De Backer, Guy et al

in European Heart Journal (2016)

Detailed reference viewed: 16 (1 ULg)
Full Text
Peer Reviewed
See detail2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, Massimo F.; Hoes, Arno W.; Agewall, Stefan et al

in European Heart Journal (2016)

Detailed reference viewed: 25 (2 ULg)
Full Text
See detail2016-2017 Notice pédagogique atelier Bac 1
Bianchi, Michaël ULg; Wang, Antoine ULg; Serrão, Margarida ULg et al

Learning material (2016)

Detailed reference viewed: 28 (5 ULg)
Full Text
Peer Reviewed
See detail214 Fractal Structure in Volumetric Contrast Enhancement of Malignant Gliomas Correlates With Oxidative Metabolic Pathway Gene Expression.
Miller, Kai; Berendsen, Sharon; Seute, Tatjana et al

in Neurosurgery (2016), 63 Suppl 1

INTRODUCTION: Fractal structure is found throughout many processes in nature, and often arises from sets of simple rules. We examined the contrast enhancement pattern in glioblastoma brain tumor MRIs for ... [more ▼]

INTRODUCTION: Fractal structure is found throughout many processes in nature, and often arises from sets of simple rules. We examined the contrast enhancement pattern in glioblastoma brain tumor MRIs for evidence of fractal structure, which might then be compared with expression of specific gene sets obtained from surgical specimens of each tumor. METHODS: Volumetric T1 postcontrast imaging was obtained in 39 patients prior to surgical resection of pathology-confirmed glioblastoma lesions. For each tumor, we calculated the fractal dimension (Minkowski Bouligand dimension) using a box-counting (cubic scaling) approach. RNA expression microarray data from resected tissue were explored by gene set enrichment analysis (GSEA). RESULTS: We found robust evidence for fractal structure in the contrast enhancement pattern, with an average fractal dimension of 2.17 +/- 0.10, with a visually apparent split at 2.10. GSEA analysis showed a definitive association between this split in fractal dimension and 6 gene sets (of 4080), all 6 of which are linked to mitochondrial respiration/ATP production pathways. CONCLUSION: There is fractal structure in the volumetric enhancement pattern of glioblastoma tumors, with dimension approximately 2.15. Variation in this fractal dimension, and therefore the complexity of contrast enhancement it reflects, is specifically associated with genetic correlates of a shift to glycolytic metabolism in tumor cells. Drugs that shift glioblastoma to oxidative metabolism have recently been identified as independent therapeutic agents as well as sensitizing agents for irradiation. Therefore, a radiogenomic marker of glucose metabolism, such as this fractal structure in enhancement, might help to guide individualized therapy. [less ▲]

Detailed reference viewed: 24 (0 ULg)