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See detailEfficiency of calcium and vitamin D supplementation in the management of osteoporosis
Hiligsmann, Mickaël ULg; Bruyère, Olivier ULg; Ethgen, Olivier ULg et al

in Osteoporosis International (2008, April), 19(S1), 113

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See detailEfficiency of day seven collection of bovine embryosafter superovulation by flushing the oviducts and the uterin horns.
Havlicek, V.; Kuzmany, A.; Beckers, Jean-François ULg et al

in Reproduction, Fertility and Development (2010), 22(1), 363

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See detailEfficiency of delivery observed treatment in hemodialysis patients: the example of the native vitamin D therapy
DELANAYE, Pierre ULg; CAVALIER, Etienne ULg; Fafin, Coraline et al

in Journal of Nephrology (in press)

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies ... [more ▼]

Introduction Adherence to therapy is a relevant challenge in chronic hemodialysis patients. The directly observed therapy (DOT) could be an effective method to increase adherence for specific therapies. We aimed to study the performance of DOT versus home medication. We follow the impact of providing native vitamin D directly by the nurse after a dialysis session on the 25-hydroxyvitamin [25(OH)D] concentrations. Methods In this observational study, we included 38 dialysis patients treated by stable dosage of cholecalciferol. DOT was implemented in December 2010. We considered the concentrations of 25-OH vitamin D three times before (T1 = June 2010, T2 = July 2010 and T3 = September 2010) and three times after the modification of prescription (T4 = February 2011, T5 = March 2011 and T6 = April 2011). Results Median age was 72 [62; 79] years and 48 % were diabetics. Mean body mass index was 26 ± 5 kg/m2 and median dialysis vintage was 20 [8; 46] months. The patients were compared to themselves. Before DOT, median concentrations of 25(OH)D were 27 (14–36), 23 (17–31), 31 (22–38) ng/mL at T1, T2 and T3, respectively. When DOT was effective, the concentrations significantly increased to 34 (28–44), 35 (29–41), 39 (32–47) ng/mL at T4, T5 and T6, respectively. Before DOT, 19 patients (50 %) reached the target of 30 ng/mL. After DOT, 29 patients (76 %) reached the target concentration of 30 ng/ mL. Conclusions In hemodialysis patients, DOT is both simple and effective to increase the therapeutic impact to native vitamin D. [less ▲]

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See detailThe efficiency of different simulation-based design methods in improving building performance
Nguyen, Anh Tuan; Reiter, Sigrid ULg

in Brebbia,, C.A.,; Pulselli, R. (Eds.) WIT Transactions on Ecology on The Built Environment, vol. 142 (2014, September)

This paper presents a pioneering effort to define the efficiency of the most common simulation-based design methods, namely the parametric simulation method (PSM) and the simulation-based optimization ... [more ▼]

This paper presents a pioneering effort to define the efficiency of the most common simulation-based design methods, namely the parametric simulation method (PSM) and the simulation-based optimization method (SOM), in improving two building performance indicators: thermal comfort and energy consumption. Three case-study houses were selected and their indoor conditions were continuously monitored during one summer month in 2012. Computer EnergyPlus models of these houses were established and then carefully calibrated by the monitoring data to improve the reliability of the numerical methods. Thermal performances of these houses during a year were simulated, then improved by the PSM and finally optimized by the SOM. By comparing the results of these two simulation-based design methods, this research found that both the PSM and SOM were very effective in improving these building performance indicators. This study found that the SOM is almost two times more efficient than the PSM in improving thermal comfort in naturally ventilated (NV) houses and life cycle cost in air-conditioned (AC) houses. In average, the discomfort period in NV houses could be reduced by 44.9% by the PSM while as high as 86.1% by the SOM, compared with the reference cases. The life cycle cost of AC houses had smaller reductions with 6.2% and 14.6% cut-off by the PSM and SOM, respectively. The results of this work give a strong and explicit insight of the actual efficiency of each design method. This work also shows great advantages of applications of advanced numerical approaches in the design of high performance buildings. [less ▲]

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See detailEfficiency of elisa : a new french-language triage algorithm
JOBE, Jérôme ULg; Ghuysen, Alexandre ULg; Gerard, P. et al

in Acta Clinica Belgica (2011)

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See detailEfficiency of embryonic development after Intra-Follicular and Intra-Oviductal transfer of in vitro and in vivo matured horse oocytes
Deleuze, Stefan ULg; Goudet, Ghylène; Caillaud, Maud et al

in Theriogenology (2009), 72(2), 203

In vivo techniques, such as intra-oviductal Oocyte Transfer (OT) and Intra-Follicular Oocyte Transfer (IFOT) can be considered as alternatives to bypass the lack of efficient superovulation treatments and ... [more ▼]

In vivo techniques, such as intra-oviductal Oocyte Transfer (OT) and Intra-Follicular Oocyte Transfer (IFOT) can be considered as alternatives to bypass the lack of efficient superovulation treatments and the inadequacy of conventional in vitro fertilization techniques in the horse. We compared embryo production following transfer of in vivo recovered oocytes (1) into a recipient’s oviduct or (2) into her preovulatory follicle either immediately after ovum pick up or (3) after in vitro maturation. Recipients were inseminated with fresh semen of a stallion with a known normal fertility. Ten days after surgery, rates of embryos collected in excess to the number of ovulations were calculated and compared for each group. Embryo collection rates were 32.5% (13/40), 5.5% (3/55) and 12.8% (6/47) for OT, post-IVM and immediate IFOT respectively. OT significantly yielded more embryos than immediate and post-IVM IFOT did. We also showed that in vitro matured oocytes could succesfully be used for IFOT. Our results also suggest that improvement of the IFOT technique could turn it into an inexpansive and easy to perform procedure that could be an answer to the inefficiency of superovulation treatments in the mare. [less ▲]

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See detailEfficiency of haplotype-based methods to fine-map QTLs and embryonic lethal variants affecting fertility: Illustration with a deletion segregating in Nordic Red cattle
Kadri, Naveen Kumar ULg; Sahana, Goutam; Guldbrandtsen, Bernt et al

in Livestock Science (2014), 166

Despite its importance, fertility has been declining in many cattle populations. In dairy cattle, this decline is often attributed to the negative correlation between fertility and productions traits ... [more ▼]

Despite its importance, fertility has been declining in many cattle populations. In dairy cattle, this decline is often attributed to the negative correlation between fertility and productions traits. Recent studies showed that embryonic lethal variants might also account for a non-negligible fraction of the fertility decline. Therefore identification of such embryonic lethal variants is essential to improve fertility. We herein illustrate, with an example of a large recessive lethal deletion recently identified in Nordic Red cattle, that haplotype-based method are particularly efficient to identify such embryonic lethal variants. We first show that haplotypes can be used in traditional QTL mapping approaches and that they present very high linkage disequilibrium with underlying variants. Haplotypes can also be used in scan for lack of homozygosity. Indeed,if a haplotype is associated to a recessive lethal variant, significantly fewer living individuals will be homozygote for that haplotype than expected. For both approaches, haplotype- based methods were particularly efficient. The lack of homozygosity approach achieved higher significance than the QTL approach. Only frequent variants can be detected with both approaches unless huge genotyped cohorts are available. An alternative approach would rely on identifying potential harmful variants in next-generation sequencing data followed by the genotyping of a larger population for these variants. [less ▲]

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See detailThe Efficiency of In vitro Ovine Embryo Production Using an Undefined or a Defined Maturation Medium is Determined by the Source of the Oocyte.
Cocero, M.; Alabart, J.; Hammami, S. et al

in Reproduction in Domestic Animals (2011), 46(3), 463-470

In vitro oocyte maturation can be influenced by oocyte source and maturation media composition. The aim of the present study was to compare the efficiency of a defined in vitro maturation medium (TCM199 ... [more ▼]

In vitro oocyte maturation can be influenced by oocyte source and maturation media composition. The aim of the present study was to compare the efficiency of a defined in vitro maturation medium (TCM199 supplemented with cysteamine and epidermal growth factor; Cys + EGF) with an undefined medium (TCM199 supplemented with follicle-stimulating hormone and follicular fluid; FSH + FF) for in vitro production (IVP) of ovine embryos, using oocytes obtained by laparoscopic ovum pick-up from FSH-stimulated [n = 11; 158 cumulus-oocyte complexes (COCs)] and non-stimulated (n = 16; 120 COCs) live ewes, as well as abattoir-derived oocytes (170 COCs). The produced blastocysts were vitrified and some of them were transferred to synchronized recipients. The best and the worst final yields of embryo IVP observed in this study were obtained using oocytes from FSH-stimulated ewes matured in FSH + FF (41.3%; 33/80) and in Cys + EGF (19.2%; 15/78) medium, respectively (p < 0.01). No significant differences between both media were attained in the blastocyst development rate or in the final yield of embryo IVP using oocytes from non-stimulated ewes or abattoir-derived oocytes. The overall in vivo survival rate of the transferred vitrified blastocysts was 13.1% (8/61), without significant differences between oocyte sources or maturation media. In conclusion, under the experimental conditions of the present study, TCM199 supplemented with cysteamine and EGF is a convenient defined maturation medium for IVP of embryos from oocytes of live non-stimulated ewes or from oocytes of abattoir-derived ovaries. However, the best final yield of embryo IVP observed in this study was attained when oocytes came from FSH-stimulated donors and TCM199 was supplemented with FSH and follicular fluid [less ▲]

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See detailEfficiency of inventory plot patterns in quantitative analysis of vegetation : a case study of tropical woodland and dense forest in Benin
Salako, Valère K.; Glele Kakai, Romain L.; Assogbadjo, Achille E. et al

in Southern Forests : a Journal of Forest Science (2013), 75(3), 137-143

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See detailEfficiency of pheromone-based formulations against phytophagous pests
Fassotte, Bérénice ULg; Vandereycken, Axel ULg; Chevalier Mendes Lopes, Thomas ULg et al

Conference (2015, May 19)

Innovative integrated pest management methods are needed to overcome market withdrawal of synthetic pesticides. Therefore, the identification of environment-friendly bio-products carrying direct or ... [more ▼]

Innovative integrated pest management methods are needed to overcome market withdrawal of synthetic pesticides. Therefore, the identification of environment-friendly bio-products carrying direct or indirect biocide activity is one promising alternative option. Our researches focus on the identification of appropriate formulations releasing volatile organic compounds that are attractant for natural enemies of insect pests. However, the elaboration of slow-release devices that ensure stable and controlled release of active volatile compounds is quite challenging. Here, we developed a formulation based on E-β-farnesene and (-)-β-caryophyllene, these two semiochemicals having strong attractive potential on aphid natural enemies including lady beetles and hoverflies. Both compounds were encapsulated together in alginate gel beads. The blend efficiency was first evaluated through laboratory assays, and then in wheat and broad bean fields, by considering the abundance and diversity of aphids and their natural enemies. [less ▲]

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See detailEfficiency of sieving or classification for dry fractionation of aot mills and beta-glucans enrichment.
Roiseux, Olivier; Vanderbeke, E.; Blecker, Christophe ULg et al

Poster (2008, June)

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See detailEfficiency of T Cell Triggering by Anti-Cd3 Monoclonal Antibodies (Mab) with Potential Usefulness in Bispecific Mab Generation
Jacobs, Nathalie ULg; Mazzoni, A.; Mezzanzanica, D. et al

in Cancer Immunology, Immunotherapy (1997), 44(5), 257-64

T cell triggering can be achieved by monoclonal antibodies (mAbs) specific for the CD3/TcR complex. In the presence of appropriate costimulation and/or progression factors, such triggering permits the ... [more ▼]

T cell triggering can be achieved by monoclonal antibodies (mAbs) specific for the CD3/TcR complex. In the presence of appropriate costimulation and/or progression factors, such triggering permits the generation of effector cells for immunotherapy protocols involving the redirection of T cell lysis against tumor cells by mAbs bispecific for anti-CD3/anti-tumor cells (bs-mAbs). Focusing our analysis on the clinically relevant bs-mAb OC/TR, we found that bs-mAbs generated with the same anti tumor specificity, but two other anti-CD3 mAbs, TR66 and OKT3, have the same and a significantly lower lytic potential, respectively, compared with that of OC/TR. To evaluate the relevance of the anti-CD3 component, we examined several anti-CD3 mAbs with respect to binding parameters and the ability to trigger T lymphocytes. Competitive binding assays suggested that all anti-CD3 mAbs recognized the same or overlapping epitopes, although mAbs BMA030 and OC/TR bound with lower avidity than did alpha CD3 (the bivalent anti-CD3 mAb produced by the hybrid hybridoma OC/TR). TR66 and OKT3, as determined by measurement of the affinity constants. In all lymphocyte populations examined, which included resting peripheral blood mononuclear cells (PBMC), activated PBMC and T cell clones, OKT3, BMA033 and OC/TR failed to mobilize Ca2+ without cross-linking, whereas alpha CD3, in both murine and murine-human chimeric versions, TR66 and BMA030, did not require cross-linking. The ability to induce CD3 modulation was associated in part with the induction of Ca2+ fluxes. Despite the differences in the behavior of these mAbs in triggering the events that precede proliferation, all of them ultimately led to expression of the IL-2 receptor and to proliferation in T cells in the presence of accessory cells. Our data suggest that anti-CD3 mAbs that bind more rapidly (strong Ca2+ mobilizers) and more tightly under physiological conditions are good candidates for retargeting T cells in the bs-mAb clinical application. [less ▲]

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See detailEfficiency of Targeted Energy Transfers in Coupled Nonlinear Oscillators Associated with 1:1 Resonance Captures
Sapsis, T.; Vakakis, Alexander F.; Gendelman, O. V. et al

in 45th Technical Meeting of the Society of Engineering Science, Urbana Champaign, 2008 (2008)

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See detailEfficiency of targeted energy transfers in coupled nonlinear oscillators associated with 1:1 resonance captures:Part II, analytical study
Sapsis, T. P.; Vakakis, Alexander F.; Gendelman, O. V. et al

in Journal of Sound & Vibration (2009)

We study targeted energy transfer in a two degree-of-freedom damped system under the conditionof1:1transient resonance capture. The system consists of a linear oscillator strongly coupled to an ... [more ▼]

We study targeted energy transfer in a two degree-of-freedom damped system under the conditionof1:1transient resonance capture. The system consists of a linear oscillator strongly coupled to an essentially nonlinear attachment or nonlinear energy sink. In a companion paper[ Quinnetal., Efficiency of targeted energy transfers in coupled nonlinear oscillators associated with1:1resonance captures: part I, Journal of Sound and Vibration 311 (2008)1228–1248]we studied the under lying structure of the Hamiltonian dynamics of this system ,and showed that for sufficiently small values of viscous damping , nonlinear damped transitions are strongly influenced by the under lying topological structure of periodic and quasi periodic or bits of the Hamiltonian system. In this work direct analytical treatment of the governing strongly nonlinear damped equations of motion is performed through slow/fast partitions of the transient responses, in order to investigate analytically the parameter region of optimal targeted energy transfer .To this end, we determine the characteristic time scales of the dynamics that influence the capacity of the nonlinear attachment to passively absorb and locally dissipate broad band energy from the linear oscillator. Then, we prove that optimal targeted energy transfer is realized for initial energies close to the neighbourhood of a homo clinic or bit of the under lying Hamiltonian system. We study analytically transient orbits resulting as perturbations of the homo clinic or bit in the weak lydamped system, and show that this yields an additional slow-time scale in the averaged dynamics, and leads to optimal targeted energy transfer from the linear oscillator to the nonlinear energy sink in a single ‘‘super-slow’’ half-cycle. We show that at higher energies, this ‘‘super-slow’’ half-cycle is replaced by strong nonlinear beats, which lead to significant but suboptimal targeted energy transfer efficiency. Finally, we investigate numerically targeted energy transfer efficiency in this system over a wide range of system parameter sand verify the analytical predictions. 2009 Elsevier Ltd .All rights reserved. [less ▲]

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See detailEfficiency of TET in coupled oscillators associated with 1: resonance: Part 1
Quinn, D. Dane; Gendelman, Oleg; Kerschen, Gaëtan ULg et al

in Journal of Sound & Vibration (2008), 311

We study targeted energy transfers and nonlinear transitions in the damped dynamics of a two degree-of-freedom system of coupled oscillators (a linear oscillator with a lightweight, essentially nonlinear ... [more ▼]

We study targeted energy transfers and nonlinear transitions in the damped dynamics of a two degree-of-freedom system of coupled oscillators (a linear oscillator with a lightweight, essentially nonlinear, ungrounded attachment), caused by 1:1 resonance captures of the dynamics. Part I of this work deals with the underlying structure of the Hamiltonian dynamics of the system, and demonstrates that, for sufficiently small values of viscous damping, the damped transitions are strongly influenced by the underlying topological structure of periodic and quasiperiodic orbits of the corresponding Hamiltonian system. Focusing exclusively on 1:1 resonance captures in the system, it is shown that the topology of these damped transitions affect drastically the efficiency of passive energy transfer from the linear system to the nonlinear attachment. Then, a detailed computational study of the different types of nonlinear transitions that occur in the weakly damped system is presented, together with an analytical treatment of the nonlinear stability of certain families of periodic solutions of the underlying Hamiltonian system that strongly influence the said transitions. As a result of these studies, conditions on the system and forcing parameters that lead to effective or even optimal energy transfer from the linear system to the nonlinear attachment are determined. In Part II of this work, direct analytical treatment of the governing strongly nonlinear damped equations of motion is performed, in order to analytically model the dynamics in the region of optimal energy transfer, and to determine the characteristic time scales of the dynamics that influence the capacity of the nonlinear attachment to passively absorb and locally dissipate broadband energy from the linear oscillator. r 2007 Elsevier Ltd. All rights reserved [less ▲]

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See detailEfficiency of the sec-butyllithium/m-diisopropylbenzene diadduct as an anionic polymerization initiator in apolar solvents
Yu, Y. S.; Jérôme, Robert ULg; Fayt, Roger et al

in Macromolecules (1994), 27(21), 5957-5963

The 2/1 sec-butyllithium/1,3-diisopropenylbenzene adduct has been prepared and evaluated as an effective, hydrocarbon soluble, difunctional initiator for the synthesis of polystyrene-polybutadiene ... [more ▼]

The 2/1 sec-butyllithium/1,3-diisopropenylbenzene adduct has been prepared and evaluated as an effective, hydrocarbon soluble, difunctional initiator for the synthesis of polystyrene-polybutadiene-polystryene (SBS) thermoplastic elastomers in cyclohexane or benzene solution. The molecular weight distribution of both the PBD central block and the final block copolymer is narrow,and the expected molecular weight is obtained. However, mechanical testing, degradation of the PBD component, and use of an excess of s-BuLi compared to DIB suggest that the final copolymers are diblock instead of triblock as expected. The stoichiometric reaction of s-BuLi with DIB in an apolar solvent essentially results in the expected Li diadduct. This organolithium compound does not however react as a difunctional anionic initiator in a hydrocarbon solvent, but rather as a monofunctional compound more likely due to an association process. Addition of enough THF can make approximately two species active per DIB molecule. The addition of small amounts of triethylamine (<10 molecules per organolithium site) does not contribute to the formation of an acceptable difunctional initiator. The 1/1 addition of lithium tert-butoxide to the Li diadduct of DIB does not perturb the 1,4-microstructure of PBD, but it does not promote the activity of each metalated site of the initiator. [less ▲]

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See detailEfficiency of various nitrones used as precursors of nitroxides in radical polymerization of styrene
Sciannamea, Valérie; Detrembleur, Christophe ULg; Claes, Michaël et al

Poster (2003, May 16)

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See detailAn efficient 3D implicit approach for the thermomechanical simulation of elastic–viscoplastic materials submitted to high strain rate and damage
Jeunechamps, Pierre-Paul; Ponthot, Jean-Philippe ULg

in International Journal for Numerical Methods in Engineering (2013), 94

This paper aims at presenting a general consistent numerical formulation able to take into account, in a coupled way, strain rate, thermal and damage effects on the behavior of materials submitted to ... [more ▼]

This paper aims at presenting a general consistent numerical formulation able to take into account, in a coupled way, strain rate, thermal and damage effects on the behavior of materials submitted to quasistatic or dynamic loading conditions in a large deformation context. The main features of this algorithmic treatment are as follows: -A unified treatment for the analysis and implicit time integration of thermo-elasto-viscoplastic constitutive equations including damage that depends on the strain rate for dynamic loading conditions. This formalism enables us to use dynamic thermomechanically coupled damage laws in an implicit framework. -An implicit framework developed for time integration of the equations of motion. An efficient staggered solution procedure has been elaborated and implemented so that the inertia and heat conduction effects can be properly treated. - An operator split-based implementation, accompanied by a unified method to analytically evaluate the consistent tangent operator for the (implicit) coupled damage–thermo-elasto-viscoplastic problem. -The possibility to couple any hardening law, including rate-dependent models, with any damage model that fits into the present framework. All the developments have been considered in the framework of an implicit finite element code adapted to large strain problems. The numerical model will be illustrated by several applications issued from the impact andmetal-forming domains. All these physical phenomena have been included into an oriented object finite element code (implemented at LTAS-MN2L, University of Liège, Belgium) named Metafor. [less ▲]

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