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See detailEarly abortion in reciprocal crosses between phaseolus vulgaris and phaseolus polyanthus, and in vitro culture of immature embryos from these species
Toussaint, André ULg; Geerts, P.; Clement, F. et al

in Belgian Journal of Botany (2004), 137(1), 47-54

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See detailEarly activation of cardiac and renal endothelin systems in experimental heart failure
Motte, S.; van Beneden, R.; Mottet, J. et al

in American Journal of Physiology - Heart and Circulatory Physiology (2003), 285(6), 2482-2491

We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased ... [more ▼]

We investigated the time course of the expression of cardiac and renal endothelin systems in tachycardia-induced heart failure in dogs. Eleven beagles underwent rapid pacing at a progressively increased rate over a period of 5 wk, with a weekly clinical examination, echocardiography, measurement of circulating and urinary endothelin-1 (ET-1), and myocardial and renal tissue biopsies. Real-time quantitative PCR was used for determinations of tissue prepro-ET-1 (ppET-1), ET-1-converting enzyme (ECE-1), and ETA and ETB receptor mRNA. Cardiac and renal tissue ET-1 contents were evaluated by immunostaining and measured by radioimmunoassay at autopsy. Rapid pacing caused a progressive increase in end-systolic and end-diastolic ventricular volumes (P<0.05) from week 2 together with a decrease in ejection fraction and in mean velocity of circumferential shortening (P<0.05) from week 1. These changes were tightly correlated to myocardial ppET-1 and renal ETA receptor mRNA and less so to myocardial ECE-1 mRNA, and they occurred before any increase in plasma and urinary ET-1 (P<0.05 from week 4) and clinical signs of heart failure. Renal ppET-1 did not change. Both cardiac and renal ET-1 peptide contents were increased at autopsy. We conclude that tachycardia-induced heart failure in dogs is characterized by an early activation of the cardiac and renal tissue endothelin systems, which occurs before any changes in circulating and urinary ET-1 and is closely related to altered ventricular function. [less ▲]

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See detailEARLY ALLOGRAFT DYSFUNCTION DECREASES PATIENT SURVIVAL AFTER LIVER TRANSPLANTATION
MEURISSE, Nicolas ULg; FIEUWS, S; JOCHMANS, I et al

Poster (2014, April)

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See detailEarly and late onset manifestations of cerebral vasculitis related to varicella zoster.
Hausler, M. G.; RAMAEKERS, Vincent ULg; Reul, J. et al

in Neuropediatrics (1998), 29(4), 202-7

Varicella-zoster associated cerebral vasculitis (VZCV) as a cause of cerebral infarction has hitherto been considered a rare condition. Ischemic stroke in previously healthy children has occurred during ... [more ▼]

Varicella-zoster associated cerebral vasculitis (VZCV) as a cause of cerebral infarction has hitherto been considered a rare condition. Ischemic stroke in previously healthy children has occurred during recovery from chickenpox or has been attributed to virus reactivation among immunosuppressed patients. The clinical, radiologic and immunologic findings in four children with VZCV will be reported. Clinical manifestations included sudden onset of hemiparesis, motor aphasia and disturbed consciousness in previously healthy children. Only one child had a history of chickenpox six weeks prior to the onset of stroke, whereas a latency period of up to four years between chickenpox and the onset of stroke was found in the other three children. Diagnosis of VZCV was confirmed repeatedly by demonstrating intrathecal production of varicella-zoster IgG antibodies in three children or a four-fold increase of varicella-zoster serum IgA-antibodies in one child. Intrathecal production of antibodies against other latent viruses and borreliosis could be excluded. PCR for varicella on CSF, performed in two patients, remained negative. No intrathecal production of varicella-zoster antibodies has been found in a control group of twenty clinically healthy children (age range from 2-18 years) with a previous varicella infection. During follow-up two children recovered completely whereas two children still suffer from serious neurological deficits. Immunological investigations, performed in three children, showed circulating immune-complexes with slightly lowered complement concentrations in two patients. In addition a lowered T-helper/T-suppressor cell ratio of unknown origin was found in three children. These immunological findings will be discussed in the light of the pathophysiology of VZCV. [less ▲]

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See detailEarly and transient reverse transcription during primary deltaretroviral infection of sheep.
Pomier, Carole; Alcaraz, Maria Teresa Sanchez; Debacq, Christophe et al

in Retrovirology (2008), 5

BACKGROUND: Intraindividual genetic variability plays a central role in deltaretrovirus replication and associated leukemogenesis in animals as in humans. To date, the replication of these viruses has ... [more ▼]

BACKGROUND: Intraindividual genetic variability plays a central role in deltaretrovirus replication and associated leukemogenesis in animals as in humans. To date, the replication of these viruses has only been investigated during the chronic phase of the infection when they mainly spread through the clonal expansion of their host cells, vary through a somatic mutation process without evidence for reverse transcriptase (RT)-associated substitution. Primary infection of a new organism necessary involves allogenic cell infection and thus reverse transcription. RESULTS: Here we demonstrate that the primary experimental bovine leukemia virus (BLV) infection of sheep displays an early and intense burst of horizontal replicative dissemination of the virus generating frequent RT-associated substitutions that account for 69% of the in vivo BLV genetic variability during the first 8 months of the infection. During this period, evidence has been found of a cell-to-cell passage of a mutated sequence and of a sequence having undergone both RT-associated and somatic mutations. The detection of RT-dependent proviral substitution was restricted to a narrow window encompassing the first 250 days following seroconversion. CONCLUSION: In contrast to lentiviruses, deltaretroviruses display two time-dependent mechanisms of genetic variation that parallel their two-step nature of replication in vivo. We propose that the early and transient RT-based horizontal replication helps the virus escape the first wave of host immune response whereas somatic-dependent genetic variability during persistent clonal expansion helps infected clones escape the persistent and intense immune pressure that characterizes the chronic phase of deltaretrovirus infection. [less ▲]

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See detailEarly assessment of risk in patients with acute myocardial infarction.
Chapelle, Jean-Paul ULg; Albert, A.; Smeets, J. P. et al

in European Heart Journal (1981), 2(3), 187-96

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See detailEarly asteroseismic results from Kepler: structural and core parameters of the hot B subdwarf KPD 1943+4058 as inferred from g-mode oscillations
Van Grootel, Valérie ULg; Charpinet, Stéphane; Fontaine, Gilles et al

in Astrophysical Journal Letters (2010), 718

We present a seismic analysis of the pulsating hot B subdwarf KPD 1943+4058 (KIC 005807616) on the basis of the long-period, gravity-mode pulsations recently uncovered by Kepler. This is the first time ... [more ▼]

We present a seismic analysis of the pulsating hot B subdwarf KPD 1943+4058 (KIC 005807616) on the basis of the long-period, gravity-mode pulsations recently uncovered by Kepler. This is the first time that g-mode seismology can be exploited quantitatively for stars on the extreme horizontal branch, all previous successful seismic analyses having been confined so far to short-period, p-mode pulsators. We demonstrate that current models of hot B subdwarfs can quite well explain the observed g-mode periods, while being consistent with independent constraints provided by spectroscopy. We identify the 18 pulsations retained in our analysis as low- degree (l = 1 and 2), intermediate-order (k = −9 through −58) g-modes. The periods (frequencies) are recovered, on average, at the 0.22% level, which is comparable to the best results obtained for p-mode pulsators. We infer the following structural and core parameters for KPD 1943+4058 (formal fitting uncertainties only): Teff = 28,050 ± 470 K, log g = 5.52 ± 0.03, M∗ = 0.496 ± 0.002 M⊙, log (Menv/M∗) = −2.55 ± 0.07, log (1 − Mcore/M∗) = −0.37 ± 0.01, and Xcore (C+O) = 0.261 ± 0.008. We additionally derive the age of the star since the zero-age extended horizontal branch 18.4 ± 1.0 Myr, the radius R = 0.203 ± 0.007 R⊙, the luminosity L = 22.9 ± 3.13 L⊙, the absolute magnitude MV = 4.21 ± 0.11, the reddening index E(B − V ) = 0.094 ± 0.017, and the distance d = 1180 ± 95 pc. [less ▲]

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See detailEarly Bifrontal Brain Injury: Disturbances in Cognitive Function Development
Bonnier, Christine; Costet, Aurélie; Hmaimess, Ghassan et al

in Neurology Research International (2010)

We describe six psychomotor, language, and neuropsychological sequential developmental evaluations in a boy who sustained a severe bifrontal traumatic brain injury (TBI) at 19 months of age. Visuospatial ... [more ▼]

We describe six psychomotor, language, and neuropsychological sequential developmental evaluations in a boy who sustained a severe bifrontal traumatic brain injury (TBI) at 19 months of age. Visuospatial, drawing, and writing skills failed to develop normally. Gradually increasing difficulties were noted in language leading to reading and spontaneous speech difficulties. The last two evaluations showed executive deficits in inhibition, flexibility, and working memory. Those executive abnormalities seemed to be involved in the other impairments. In conclusion, early frontal brain injury disorganizes the development of cognitive functions, and interactions exist between executive function and other cognitive functions during development. [less ▲]

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See detailEarly bifrontal brain injury: sequential neuropsychological developmental features
Bonnier, Christine; Potelle, Dominique; Buelens, M et al

in Revista de neurologia (2006)

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See detailEarly boost and slow consolidation in motor skill learning
Hotermans, C.; Peigneux, Philippe ULg; Maertens De Noordhout, Alain ULg et al

in Learning & Memory (Cold Spring Harbor, N.Y.) (2006), 13(5, Sep-Oct), 580-583

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories Suggest that this off-line improvement ... [more ▼]

Motorskill learning is a dynamic process that continues covertly after training has ended and eventually leads to delayed increments in performance. Current theories Suggest that this off-line improvement takes time and appears only after several hours. Here we show an early transient and short-lived boost in performance, emerging as early as 5-30 min after training but no longer observed 4 h later. This early boost is predictive of the performance achieved 48 h later, Suggesting its functional relevance for memory processes. [less ▲]

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See detailEarly Bronze Age Houses in Upper Mesopotamia: Evidence of Dwellings or Private Enterprises?
Mas, Juliette ULg

in Buccellati, Federico; Helms, Tobias; Tamm, Alexander (Eds.) House and Household Economies in 3rd Millennium B.C.E. Syro-Mesopotamia (2014)

This paper deals with the research I carried out on domestic architecture and private economy during Early Bronze Age in Upper-Mesopotamia. Archaeological records, as well as textual evidence, has been ... [more ▼]

This paper deals with the research I carried out on domestic architecture and private economy during Early Bronze Age in Upper-Mesopotamia. Archaeological records, as well as textual evidence, has been used to try to define private households activities and their relationships with official institutions. Households were the main source of production, distribution and consumption during the Early Bronze Age. As it seems that these private economic entities produced goods and crafts in their own houses, analyzing domestic architecture could be a way to approach Mesopotamian economic activities. In Northern Mesopotamia the economic system was already strongly articulated; beyond palatial organizations it was also largely based on private group activities, often structured by kinship. [less ▲]

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See detailEarly Bronze Age Houses in Upper Mesopotamia: Evidence of Dwellings or Private Enterprises?
Mas, Juliette ULg

Conference (2012, October)

This paper dealt with the research I carried out on domestic architecture and private economy during Early Bronze Age in Upper-Mesopotamia. Archaeological records, as well as textual evidence, has been ... [more ▼]

This paper dealt with the research I carried out on domestic architecture and private economy during Early Bronze Age in Upper-Mesopotamia. Archaeological records, as well as textual evidence, has been used to try to define private households activities and their relationships with official institutions. Households were the main source of production, distribution and consumption during the Early Bronze Age. As it seems that these private economic entities produced goods and crafts in their own houses, analyzing domestic architecture could be a way to approach Mesopotamian economic activities. In Northern Mesopotamia the economic system was already strongly articulated; beyond palatial organizations it was also largely based on private group activities, often structured by kinship. [less ▲]

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See detailEarly Carboniferous events along the north-eastern Gondwanan margin: an example from the Mobarak Formation of the Central Alborz Mountains, Northern Iran.
Sardar Abadi, Mehrdad ULg; Da Silva, Anne-Christine ULg; Poty, Edouard ULg et al

Poster (2015, July 14)

The transition from the Late Devonian to the Early Carboniferous was marked by tectonic events, environmental change and global oceanic biological turnover that influenced sedimentary regimes. The end ... [more ▼]

The transition from the Late Devonian to the Early Carboniferous was marked by tectonic events, environmental change and global oceanic biological turnover that influenced sedimentary regimes. The end-Devonian faunal extinction event, for example, eliminated most of the reef building taxa, which, coupled with an increasing rate of subsidence in response to the opening of the Paleo–Tethys and a sea-ward shift of carbonate factories during the Lower Carboniferous, led to the formation of extensive carbonate ramp platforms along the Laurasian and Gondwanan margins. This development has already been reported from the western Gondwanan and southern Laurasian margins but not from northern to north-eastern Gondwanan margin yet. We aim to improve the knowledge on the main factors controlling the development and growth of carbonate ramps during the Lower Carboniferous by examining the Alborz basin along the northern margin of Gondwana. The Lower Carboniferous Mobarak Formation records the development of a storm-sensitive pervasive carbonate factory on the southern Paleo-Tethys passive margin following the opening of the Paleo-Tethys Ocean into the Alborz basin along the northern margin of Gondwana. Four outcrops in the central Alborz Mountains were studied: the Jaban, Aroo, Shahmirzad and Labnesar sections. Four events have been described as the principal factors controlling carbonate platform evolution in the Lower Carboniferous: (1) A transgression linked to global temperature rise in the Early Tournaisian (Middle Hastarain) resulted in the formation of thick-bedded argillaceous limestones. This interval is represented by massive beds of dark mudstones–wackestones to packstones that laterally interfinger with finely laminated limestones, and with bed thickness ranging on the centimeter to meter scale. This interval correlates with Lower Tournaisian nodular to argillaceous limestones of the Moravia Basin (Czech Republic), the Rhenish Slate Mountains (Poland) and the Dinant Basin (Belgium). (2) Late Hastarian–Early Ivorian glaciations were identified in Southern Gondwana but had not been evidenced in Northern Gondwana yet. This glaciation regime is recorded through the appearance of inner-ramp channel-form facies in mid– and outer-ramp settings. (3) During Late Ivorian–Early Visean?, a differentiation block faulting regime along the basin’s margin caused uplift of the westernmost parts of the Alborz basin and resulted in a sub-marine collapse in the eastern part of the central basin. This caused vast sub-aerial exposure and brecciation the top of the Mobarak Formation at the Jaban and Aroo sections. The sub-marine collapse was recorded through the occurrence of Zoophycos bearing fine-grained limestones in the top of the Labnesar and Shahmirzad sections. (4) Tectonic activity that coincided with considerable and abrupt sea level falls as an indirect consequence of the Viséan and Serpukhovian glaciations phases. This progressive sea level drop led to the stagnation of the carbonate factory, which is expressed as an erosional surface at the top of the Mobarak Formation. [less ▲]

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See detailEarly changes in myocardial carbohydrate oxidative metabolism during E. Coli endotoxin infusion in dog
D'Orio, Vincenzo ULg; EL ALLAF, D; VAIRA, S et al

in Archives Internationales de Physiologie et de Biochimie (1985), 93

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See detailEarly clinical experience with subcutaneous naratriptan in the acute treatment of migraine: a dose-ranging study.
Dahlof, C.; Hogenhuis, L.; Olesen, J. et al

in European Journal of Neurology (1998), 5(5), 469-477

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to ... [more ▼]

Naratriptan is a novel, potent agonist at the 5HT1B/1D receptor. A total of 335 migraine patients were treated in this randomized, double-blind, placebo-controlled, dose-ranging, in-clinic study, to evaluate the efficacy, safety and tolerability of five doses of subcutaneous (sc) naratriptan (0.5, 1, 2.5, 5 or 10 mg) in comparison with sc sumatriptan (6 mg) and placebo in the acute treatment of a moderate/severe migraine attack. Headache relief [reduction of headache severity from moderate or severe (grade 2/3) to mild or none (grade 1/0)] at 1 and 2 h after each dose, was reported by a statistically significantly higher proportion of patients for all doses of sc naratriptan and sc sumatriptan (6 mg) than for placebo. The percentages of patients with headache relief at 2 h post-dose were: naratriptan (0.5 mg) 65%, (1 mg) 75%, (2.5 mg) 83%, (5 mg) 94% and (10 mg) 91%; sumatriptan (6 mg) 89%; placebo 41%, (P < 0.005). The earliest report of a statistically significant difference compared with placebo for the times assessed was with sc naratriptan (10 mg) at 10 min post-dose (P = 0.023). The percentages of patients reporting adverse events were dose-related; sc naratriptan (0.5 mg) 33%, (1 mg) 29%, (2.5 mg) 43%, (5 mg) 59% and (10 mg) 71%; sc sumatriptan 53%; placebo 22%. There were no clinically significant changes in electrocardiogram (ECG), vital signs or laboratory parameters. Systemic exposure increased proportionally to the dose, the absorption of sc naratriptan was rapid (tmax = 10 min) and the half-life was 5 h. In conclusion, sc naratriptan was an effective and well-tolerated acute treatment for migraine. Copyright 1998 Lippincott Williams & Wilkins [less ▲]

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