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See detailEstimation under left parametric truncation and right censoring
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

Scientific conference (2012)

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See detailEstimation under left parametric truncation and right censoring
Heuchenne, Cédric ULg; Laurent, Géraldine ULg

Scientific conference (2012)

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See detailEstimation, prévision et contrôle du gisement solaire en région wallonne
Doutreloup, Sébastien ULg; Fettweis, Xavier ULg; Erpicum, Michel ULg

Poster (2012, April 23)

Présentation des activités et des recherches du Laboratoire de Climatologie et Topoclimatologie de l'Université de Liège dans le domaine du rayonnement solaire

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See detailEstimations du taux de la plus-value en Belgique (1948-1994): méthode et résultats
Geerkens Provin, Eric ULg

in Contradictions (1996), (78-79), 85-98

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See detailEstimations of the Influence of the Non-Linearity of the Aerodynamic Coefficients on the Skewness of the Loading
Denoël, Vincent ULg; Degée, Hervé ULg

in Proceedings of the 6th Asia-Pacific Conference on Wind Engineering (2005)

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however ... [more ▼]

This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however shown that it is possible to account for the non linearity of this loading. This non linearity can come (i) from the squared velocity or (ii) from the shape of the aerodynamic coefficients (as functions of the wind angle of attack). In this paper, we show that this second origin can have significant implications on the design of the structure, particularly when the non linearity of the aerodynamic coefficient is important (obvious, isn’t it?) or when the transverse turbulence is important. This paper is devoted to the non linear quasi-steady aerodynamic loading. A linear approximation is often used to compute the response of structures to buffeting forces. Some researchers have however shown that it is possible to account for the non linearity of this loading. This non linearity can come (i) from the squared velocity or (ii) from the shape of the aerodynamic coefficients (as functions of the wind angle of attack). In this paper, we show that this second origin can have significant implications on the design of the structure, particularly when the non linearity of the aerodynamic coefficient is important (obvious, isn’t it?) or when the transverse turbulence is important. [less ▲]

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See detailEstime de soi, comportement à risque et qualité de vie chez des adolescents de 13 à 18 ans
Etienne, Anne-Marie ULg; Riga, Sébastien; Missotten, Pierre ULg et al

Conference (2011, September 08)

L’objectif de l’étude était d’évaluer les capacités de changement d’un adolescent présentant un comportement à risque : être fumeur. Septante adolescents (13 à 18 ans) ont été recrutés : le groupe ... [more ▼]

L’objectif de l’étude était d’évaluer les capacités de changement d’un adolescent présentant un comportement à risque : être fumeur. Septante adolescents (13 à 18 ans) ont été recrutés : le groupe expérimental comprend trente-sept jeunes fumeurs ; le groupe contrôle trente-trois jeunes non -fumeurs. Les fumeurs ont été vus trois fois alors que les sujets du groupe contrôle ont été vus 2 fois sur une période de trois mois. Les principaux questionnaires sont : un questionnaire sociodémographique, l’échelle d’estime de soi de Rosenberg, l’Inventaire Systémique de Qualité de Vie pour Adolescents, trois questions ouvertes qui portent sur le changement, les ressources et la confiance en soi. Les techniques d’intervention sont la balance décisionnelle de l’entretien motivationnel et l’implémentation d’un comportement. Les résultats montrent un effet des entretiens motivationnels chez les fumeurs sur la perception d’être prêt au changement (p = 0,002), sur une meilleure perception de leurs ressources (p<0,001) et sur une augmentation de leur confiance en leur capacité de changement (p = 0,02). L’estime de soi et le score d’écart de qualité de vie restent stables pendant les trois mois à l’exception du score de but des jeunes fumeurs. L’implication clinique de ces résultas sera discutée lors de la présentation orale. [less ▲]

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See detailEstradiol and Progesterone Regulate the Proliferation of Human Breast Epithelial Cells
Foidart, Jean-Michel ULg; Colin, Carine; Denoo, Xavier et al

in Fertility and Sterility (1998), 69(5), 963-9

OBJECTIVE: To study the effects of estradiol and progesterone on the proliferation of normal human breast epithelial cells in vivo. DESIGN: Double-blind randomized study. SETTING: Departments of ... [more ▼]

OBJECTIVE: To study the effects of estradiol and progesterone on the proliferation of normal human breast epithelial cells in vivo. DESIGN: Double-blind randomized study. SETTING: Departments of gynecology and of cell biology at a university hospital. PATIENT(S): Forty postmenopausal women with untreated menopause and documented plasma FSH levels of >30 mIU/mL and estradiol levels of <20 pg/mL. INTERVENTION(S): Daily topical application to both breasts of a gel containing a placebo, estradiol, progesterone, or a combination of estradiol and progesterone during the 14 days preceding esthetic breast surgery or excision of a benign lesion. MAIN OUTCOME MEASURE(S): Plasma and breast tissue concentrations of estradiol and progesterone. Epithelial cell cycles were evaluated in normal breast tissue by counting mitoses and performing quantitative proliferating cell nuclear antigen immunolabeling analyses. RESULT(S): Increasing the estradiol concentration enhanced the number of cycling epithelial cells, whereas increasing the progesterone concentration significantly limited the number of cycling epithelial cells. CONCLUSION(S): Exposure to progesterone for 14 days reduced the estradiol-induced proliferation of normal breast epithelial cells in vivo. [less ▲]

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See detailEstradiol contributes to the postnatal demasculinization of female Japanese quail (Coturnix coturnix japonica).
Balthazart, Jacques ULg; Schumacher, M.

in Hormones and Behavior (1984), 18(3), 287-97

Two experiments were performed to characterize the process of postnatal demasculinization in Japanese quail. In the first experiment, it was shown that estradiol (E2) can complete female demasculinization ... [more ▼]

Two experiments were performed to characterize the process of postnatal demasculinization in Japanese quail. In the first experiment, it was shown that estradiol (E2) can complete female demasculinization during the first 4 weeks of life. By contrast, E2 did not demasculinize sexual behavior and cloacal gland in neonatally castrated males. Neonatally gonadectomized females preferentially performed mount attempts when tested in their home cage by comparison to a test arena. In Experiment 2, E2 Silastic implants (40-mm) maintained full copulatory behavior in castrated males but not in females. This large dose of E2 did not demasculinize adult sexually active birds (males or females) even if treatment lasted for 1 month. It is concluded that E2 can demasculinize sexual behavior only in females and only if treatment is performed in very young birds. [less ▲]

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See detailEstradiol Pharmacokinetics after Transdermal Application of Patches to Postmenopausal Women: Matrix Versus Reservoir Patches
Reginster, Jean-Yves ULg; Donazzolo, Y.; Brion, N. et al

in Climacteric : The Journal of the International Menopause Society (2000), 3(3), 168-75

OBJECTIVE: A new matrix 17 beta-estradiol transdermal patch incorporating lauric acid to improve estradiol skin absorption has been designed for hormone replacement therapy. Estradiol pharmacokinetics ... [more ▼]

OBJECTIVE: A new matrix 17 beta-estradiol transdermal patch incorporating lauric acid to improve estradiol skin absorption has been designed for hormone replacement therapy. Estradiol pharmacokinetics obtained with the prototype, its industrial counterpart, a matrix-type, System 50, and a reservoir-type, Estraderm TTS 50, transdermal patch have been compared. Each device delivers 50 micrograms estradiol daily. METHODS: Twenty postmenopausal women received each of the four formulations for 3 days in a Latin-square design and with a minimum 4-day wash-out period between treatments. Estradiol plasma concentrations were measured by radioimmunoassay at 6, 12, 24, 48 and 72 h after application. RESULTS: The prototype patch and its industrial counterpart showed no significant difference in estradiol delivery, with 72-h systemic exposure to estradiol similar to that of the reservoir patch but greater than that of the reference matrix formulation, with average baseline-corrected concentrations (SEM) of 35 (4), 32 (3), 32 (2) and 19 (1.8) pg/ml, respectively. In addition, they ensured more stable delivery, with coefficients of variation of plasma estradiol concentrations (12-72 h) of 29, 41, 63 and 84%, respectively. All matrix patches demonstrated the same patients to be poor estradiol absorbers, different from those encountered with the reservoir patch type, despite an improved estradiol bioavailability with the lauric acid-containing matrix patch. CONCLUSION: Matrix patches incorporating lauric acid led to estradiol plasma levels more stable than with the reference matrix and reservoir patches, and greater than those with the reference matrix patch. [less ▲]

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See detailEstradiol rapidly activates male sexual behavior and affects brain monoamine levels in the quail brain
Cornil, Charlotte ULg; Dalla, C.; Papadopoulou-Daifoti, Z. et al

in Behavioural Brain Research (2006), 166(1), 110-123

Steroids are generally viewed as transcription factors binding to intracellular receptors and activating gene transcription. Rapid cellular effects mediated via non-genomic mechanisms have however been ... [more ▼]

Steroids are generally viewed as transcription factors binding to intracellular receptors and activating gene transcription. Rapid cellular effects mediated via non-genomic mechanisms have however been identified and one report showed that injections of estradiol rapidly stimulate chemoinvestigation and mounting behavior in castrated male rats. It is not known whether such effects take place in other species and what are the cellular underlying mechanisms. We show here that a single injection of estradiol (500 wg/kg) rapidly and transiently activates copulatory behavior in castrated male quail pre-treated with a dose of testosterone behaviorally ineffective by itself. The maximal behavioral effect was observed after 15 min. In a second experiment, the brain of all subjects was immediately collected after behavioral tests performed 15 min after injection. The preoptic area-hypothalamus (HPOA), hindbrain, telencephalon and cerebellum were isolated and monoamines measured by HPLC-ED. Estradiol increased levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and 5-HIAA/serotonin ratios in the telencephalon and hindbrain independently of whether animals had mated or not. Estradiol also affected these measures in HPOA and cerebellum but this effect was correlated with the level of sexual activity so that significant effects of the treatment only appeared when sexual activity was used as a covariate. Interactions between estradiol effects and sexual activity were also observed for dopamine in the HPOA and for serotonin in the hindbrain and cerebellum. Together, these data demonstrate that a single estradiol injection rapidly activates male sexual behavior in quail and that this behavioral effect is correlated with changes in monoaminergic activity. (c) 2005 Elsevier B.V. All rights reserved. [less ▲]

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See detailEstradiol stimulation of Pulsatile gonadotropin-releasing hormone secretion in vitro: Correlation with perinatal exposure to sex steroids and induction of sexual precocity in vivo
Matagne, V.; Rasier, G.; LEBRETHON, Marie-Christine ULg et al

in Endocrinology (2004), 145(6), 2775-2783

Our aim was to study the effect of estradiol (E2) on pulsatile GnRH secretion in vitro in relation to sex and development. When hypothalamic explants obtained from 5- and 15-d-old female rats were exposed ... [more ▼]

Our aim was to study the effect of estradiol (E2) on pulsatile GnRH secretion in vitro in relation to sex and development. When hypothalamic explants obtained from 5- and 15-d-old female rats were exposed to E2 (10(-7) m), a reduction of GnRH interpulse interval (IPI) occurred but not at 25 and 50 d of age. This effect was prevented by the estrogen receptor antagonist ICI 182.780 and the AMPA/kainate receptor antagonist DNQX but not by the AMPA and N-methyl-D-aspartate receptor antagonists SYM 2206 and MK-801. E2 did not affect GnRH IPI in hypothalamic explants obtained from male rats. Therefore, the possible relation between the female-specific effects of E2 in vitro and perinatal sexual differentiation was investigated. When using explants obtained from female rats masculinized through testosterone injection on postnatal d 1, E2 was no longer effective in vitro at 5 and 15 d. In addition, with explants obtained from male rats demasculinized through perinatal aromatase inhibitor treatment, E2 became capable of decreasing GnRH IPI in vitro at 15 d. To study the possible pathophysiological significance of early hypothalamic E2 effects, female rats received a single E2 injection on postnatal d 10. This resulted in reduced GnRH IPI in vitro on d 15 as well as advancement in age at vaginal opening and first estrus. In conclusion, E2 decreases the GnRH IPI in the immature female hypothalamus in vitro through a mechanism that depends on perinatal brain sexual differentiation and that could be involved in some forms of female precocious puberty. [less ▲]

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See detailEstradiol, a key endocrine signal in the sexual differentiation and activation of reproductive behavior in quail
Balthazart, Jacques ULg

in Comparative Biochemistry & Physiology Part A : Molecular & Integrative Physiology (2007, August), 148(Suppl. 1), 27

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See detailEstradiol, a key endocrine signal in the sexual differentiation and activation of reproductive behavior in quail.
Balthazart, Jacques ULg; Cornil, Charlotte ULg; Charlier, Thierry ULg et al

in Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology (2009), 311(5), 323-45

In Japanese quail, estrogen's effects on sexual behavior can be divided into three classes based on the underlying mechanisms and time-course of action and release. During embryonic life, the embryonic ... [more ▼]

In Japanese quail, estrogen's effects on sexual behavior can be divided into three classes based on the underlying mechanisms and time-course of action and release. During embryonic life, the embryonic ovary secretes large amounts of estrogens. In contrast to what is observed in mammals where sexual differentiation essentially proceeds via masculinization of the males, in quail, females are demasculinized by their endogenous ovarian estrogens, an effect that can be blocked by injection of an aromatase inhibitor and mimicked in male embryos by an injection of estradiol. In adulthood, testosterone secreted by the testes is converted into estrogens by the preoptic aromatase. Locally produced estrogens activate male sexual behavior largely through the activation of estrogen receptors resulting in the transcription of a variety of genes, including brain aromatase (genomic effect). Both changes in estrogen production and action are observed within latencies ranging from a few hours to a few days, and are completely reversible. Additionally, brain aromatase activity can be modulated within minutes by calcium-dependent phosphorylations, triggered by variations in glutamatergic neurotransmission. These rapid changes in aromatase activity affect with relatively short latencies (10-15 min) the expression of male sexual behavior in quail and also in mice. Overall, the effects of estrogens on sexual behavior can thus be categorized into three classes: organizational (irreversible genomic action during ontogeny), activational (reversible genomic action during adulthood) and rapid nongenomic effects. Rapid and slower changes in brain aromatase activity match well with the two modes of estrogen action on behavior and provide temporal variations in the estrogens' bioavailability that should be able to support the entire range of established effects for this steroid. [less ▲]

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See detailEstrategias sociopreventivas del hooliganismo
Comeron, Manuel ULg

in Colome, Gabriel (Ed.) Politica y Deporte (2001)

Une analyse comparative en Europe (Angleterre, Belgique, France, Espagne): évolution des politiques sportives, le sport et l'Etat, la lutte contre le hooliganisme, les stratégies préventives, le sport ... [more ▼]

Une analyse comparative en Europe (Angleterre, Belgique, France, Espagne): évolution des politiques sportives, le sport et l'Etat, la lutte contre le hooliganisme, les stratégies préventives, le sport comme spectacle médiatique. [less ▲]

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See detailEstrogen activation revisited: control of local metabolism in the brain
Charlier, Thierry ULg

Scientific conference (2012)

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See detailEstrogen and pain: a study in aromatase knock-out mice using the formalin model.
Multon, Sylvie ULg

Conference (2004, September)

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