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Peer Reviewed
See detailDevelopment and epidemiological evaluation of a monoclonal ELISA detecting Bovine Viral Diarrhœa Pestivirus antigens in field blood samples of persistently infected cattle
Mignon, Bernard ULiege; Dubuisson, J.; Waxweiler, S. et al

in Steven, Edwards (Ed.) ESVV-Proceedings of the second symposium on pestiviruses (1993)

Detailed reference viewed: 11 (7 ULiège)
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See detailDevelopment and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies such as osteoarthritis.
Réeff, Jonathan; Oprenyeszk, Frédéric ULiege; Franck, Thierry ULiege et al

in International Journal of Pharmaceutics (2015), 490

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the ... [more ▼]

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the developed hydrolipidic gels were evaluated by measuring the production of ROS by polymorphonuclear leukocytes (PMNs). In addition, the biocompatibility and effectiveness of two selected gel candidates were evaluated in vivo by evaluating the benefit of a single intraarticular injection of these new treatments in a model of osteoarthritis in rabbits. The in vitro study demonstrated that the carrier F1 did not have a pro-oxidative effect and even protected PMNs against natural auto-activation, regardless of the incorporation of either clonidine chlorhydrate or betamethasone dipropionate. The in vivo study demonstrated that F1 and F1-BDP induced a loss of cartilage quality in comparison to the control and reference groups but that the lesions of cartilage observed were generally mild, with not much full-depth erosion. Moreover, no exacerbating inflammation was observed when considering the synovial membranes and the PGE2 and CRP levels. These results seemed to demonstrate that the sustained-release formulation based on GMO could be well-tolerated after intraarticular injection. Moreover, it could have the potential to prevent inflammatory conditions while sustaining drug activity locally over weeks. [less ▲]

Detailed reference viewed: 37 (3 ULiège)
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See detailDevelopment and Evaluation of a VTOL Observation Platform
Buysschaert, F.; Yacoubi, M.; Alami, A. et al

in Proceedings of the 27th International Congress of the Aerospace Sciences (2010, September)

An aerodynamic study of the ULB-developed ducted rotor MAV using the results of full-scale wind tunnel tests allowed the determination of the platform’s positive speed envelope, power requirements and ... [more ▼]

An aerodynamic study of the ULB-developed ducted rotor MAV using the results of full-scale wind tunnel tests allowed the determination of the platform’s positive speed envelope, power requirements and endurance characteristics for ISA sea level conditions. In this study, the power consumption appears to be majorly depending on the rotor rotational speed, while an increase in horizontal speed results in a duct operating more as a circular wing, also unveiling a power bucket as is the case with conventional helicopters. A positive influence of the ground proximity on the total thrust has been monitored. [less ▲]

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See detailDevelopment and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.
Rubins, Daniel J.; Melega, William P.; Lacan, Goran et al

in NeuroImage (2003), 20(4), 2100-18

An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were ... [more ▼]

An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were defined on a set of digitized cryosectioned images of the rat brain. For VOI placement, each PET study was registered with a synthetic PET target constructed from the VOI template. Registration was accomplished with an automated algorithm that maximized the mutual information content of the image volumes. The accuracy and precision of this method for VOI placement was determined using datasets from PET studies of the striatal dopamine and hippocampal serotonin systems. Each evaluated PET study could be registered to at least one synthetic PET target without obvious failure. Registration was critically dependent upon the initial position of the PET study relative to the synthetic PET target, but not dependent on the amount of synthetic PET target smoothing. An evaluation algorithm showed that resultant radioactivity concentration measurements of selected brain structures had errors=2% due to misalignment with the corresponding VOI. Further, radioligand binding values calculated from these measurements were found to be more precise than those calculated from measurements obtained with manually drawn regions of interest (ROIs). Overall, evaluation results demonstrated that this atlas-derived VOI method can be used to obtain unbiased measurements of radioactivity concentration from PET studies. Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures. [less ▲]

Detailed reference viewed: 61 (5 ULiège)
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See detailDevelopment and evaluation of injectable nanosized drug delivery systems for apigenin
Karim, Reatul ULiege; Palazzo, Claudio ULiege; Laloy, Julie et al

in International Journal of Pharmaceutics (2017), 532(2), 757-768

The purpose of this study was to develop different injectable nanosized drug delivery systems (NDDSs) i.e. liposome, lipid nanocapsule (LNC) and polymeric nanocapsule (PNC) encapsulating apigenin (AG) and ... [more ▼]

The purpose of this study was to develop different injectable nanosized drug delivery systems (NDDSs) i.e. liposome, lipid nanocapsule (LNC) and polymeric nanocapsule (PNC) encapsulating apigenin (AG) and compare their characteristics to identify the nanovector(s) that can deliver the largest quantity of AG while being biocompatible. Two liposomes with different surface characteristics (cationic and anionic), a LNC and a PNC were prepared. A novel tocopherol modified poly(ethylene glycol)-b-polyphosphate block-copolymer was used for the first time for the PNC preparation. The NDDSs were compared by their physicochemical characteristics, AG release, storage stability, stability in serum, complement consumption and toxicity against a human macrovascular endothelial cell line (EAhy926). The diameter and surface charge of the NDDSs were comparable with previously reported injectable nanocarriers. The NDDSs showed good encapsulation efficiency and drug loading. Moreover, the NDDSs were stable during storage and in fetal bovine serum for extended periods, showed low complement consumption and were non-toxic to EAhy926 cells up to high concentrations. Therefore, they can be considered as potential injectable nanocarriers of AG. Due to less pronounced burst effect and extended release characteristics, the nanocapsules could be favorable approaches for achieving prolonged pharmacological activity of AG using injectable NDDS. [less ▲]

Detailed reference viewed: 60 (21 ULiège)
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See detailDevelopment and evaluation of real-time PCR targets for the detection of insect in feed
Gerard, Amaury ULiege; Debode, Frédéric; Marien, Aline et al

Poster (2016, October 19)

Insects are rich in proteins and could be an alternative source of proteins to feed animals. Numerous companies started the production of insects at small or larger scale as feed for chicken and fish ... [more ▼]

Insects are rich in proteins and could be an alternative source of proteins to feed animals. Numerous companies started the production of insects at small or larger scale as feed for chicken and fish. Most of the business models for feed production are based on the black soldier fly (Hermetia illucens) or the mealworm (Tenebrio molitor). In Europe, these novel feed are not yet authorized and products are commercialized outside Europe or eventually used as pet food (e.g. wild birds). For further authorization in Europe, many questions must be clarified concerning the presence of antinutritional compounds, the risk associated to pathogens, to residues (pesticides, antibiotics, heavy metals) and to allergens. To authorize such products on the market, methods to detect if a product really contains insects and to authenticate insect products are also mandatory. European Commission Regulation No 51/2013 named the Polymerase Chain Reaction as a reference method to determine the constituents of animal origin in feed. Targets focused on insects (target common to all insects) and targets specific to particular insect species are required. PCR methods are developed at CRA-W in this way. Among the methods developed, three of them already gave interesting results. The first one (81 bp) is specific to all insects excepting individuals from the Diptera order. The two others (94 bp and 114 bp) are specific to Tenebrio molitor. The specificity of the targets was tested against 45 insect species and on 10 commercial insect-based feed products (real-processed feed material samples). The sensitivity of the method was assessed through the AFNOR XP V03-020-2 standard approach using the LOD6 method. The three methods reached the recommended performance criteria (LOD≤ 20 copies). [less ▲]

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See detailThe development and experimental validation of a reduced ternary kinetic mechanism for the auto-ignition at HCCI conditions, proposing a global reaction path for ternary gasoline surrogates
Machrafi, Hatim ULiege; Cavadias, Simeon; Amouroux, Jacques

in Fuel Processing Technology (2009), 90(2), 247-263

To acquire a high amount of information of the behaviour of the Homogeneous Charge Compression Ignition (HCCI) auto-ignition process, a reduced surrogate mechanism has been composed out of reduced n ... [more ▼]

To acquire a high amount of information of the behaviour of the Homogeneous Charge Compression Ignition (HCCI) auto-ignition process, a reduced surrogate mechanism has been composed out of reduced n-heptane, iso-octane and toluene mechanisms, containing 62 reactions and 49 species. This mechanism has been validated numerically in a OD HCCI engine code against more detailed mechanisms (inlet temperature varying from 290 to 500 K, the equivalence ratio from 0.2 to 0.7 and the compression ratio from 8 to 18) and experimentally against experimental shock tube and rapid compression machine data from the literature at pressures between 9 and 55 bar and temperatures between 700 and 1400 K for several fuels: the pure compounds n-heptane, iso-octane and toluene as well as binary and ternary mixtures of these compounds. For this validation, stoichiometric mixtures and mixtures with an equivalence ratio of 0.5 are used. The experimental validation is extended by comparing the surrogate mechanism to experimental data from an HCCI engine. A global reaction pathway is proposed for the auto-ignition of a surrogate gasoline, using the surrogate mechanism, in order to show the interactions that the three compounds can have with one another during the auto-ignition of a ternary mixture. (C) 2008 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 62 (1 ULiège)
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See detailDevelopment and experimental validation of an Organic Rankine cycle model
Lemort, Vincent ULiege; Quoilin, Sylvain ULiege; Cuevas, Critian et al

(2007)

This paper presents both a numerical model of an Organic Rankine Cycle (ORC) and an experimental study carried out on a prototype of such a cycle working with refrigerant HCFC-123, and whose heat sources ... [more ▼]

This paper presents both a numerical model of an Organic Rankine Cycle (ORC) and an experimental study carried out on a prototype of such a cycle working with refrigerant HCFC-123, and whose heat sources consist in two hot air flows. The ORC model s built by connecting different sub-models: the heat exchanger models, a volumetric pump model and a scroll expander model. Measured performances of the ORC prototype are presented and allow the validation of the ORC model. This model is finally used to investigate potential improvements of the prototype. [less ▲]

Detailed reference viewed: 592 (30 ULiège)
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See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULiege; Revie, James A.; Paeme, Sabine ULiege et al

Conference (2012, August 31)

Detailed reference viewed: 62 (6 ULiège)
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See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULiege; Revie, James A.; Paeme, Sabine ULiege et al

in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August)

Detailed reference viewed: 48 (10 ULiège)
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See detailDevelopment and implementation of a methodology for hybrid fire testing applied to concrete structures with elastic boundary conditions
Sauca, Ana ULiege

Doctoral thesis (2017)

Fire tests remain a precious tool to comprehend the behavior of structures under accidental fire conditions. The common practice in fire testing is to isolate the tested element in a furnace in which the ... [more ▼]

Fire tests remain a precious tool to comprehend the behavior of structures under accidental fire conditions. The common practice in fire testing is to isolate the tested element in a furnace in which the mechanical support conditions are maintained constant throughout the test. However, such tests fail to capture the effect of the structure surrounding the element of interest when this effect cannot be realistically modeled by a free or fixed support condition. It has been observed in large-scale tests that the behavior of entire structures under fire is different compared with the behavior observed in traditional tests on isolated elements. This indicates the importance of capturing accurately the boundary conditions between the element and the remainder of the structure when characterizing the behavior of this element in fire. The literature describes a few attempts at performing fire tests under realistic boundary conditions. In the latter, the tests were still performed on isolated elements but the boundary conditions were updated during the test taking into account the characteristics of the remainder structure. This technique, called hybrid testing, represents an appealing solution to test structural elements under realistic boundary conditions. Hybrid testing is a methodology which offers the advantage of testing singular structural elements (or a group of structural elements) named physical substructure PS while at the same time considering the characteristics of the remainder substructure named numerical NS, thus allowing to model realistic boundary conditions. Pioneering work has been done in the seismic field where this technique is now well described, but the implementation of this methodology for structural fire testing raises important challenges due to the specificities of the field. A few hybrid fire tests have been performed in the past on columns and slabs. Their analysis shows that they all use a similar methodology, which is referred to as the first generation method in this work. The objective of the thesis was to develop and implement a hybrid fire testing methodology on a reinforced concrete beam extracted from a moment resisting frame. Initially, it was intended to build on the first generation method, but after its detailed analysis in the development stage it has been observed that the process can be unstable. The value of the stiffness ratio between the numerical substructure and the physical substructures has been identified as critical in governing the stability of the test, dictating whether the hybrid test needs to be applied in displacement control or force control. This is a severe drawback of the first generation method, as the stiffness ratio is unknown and changing during the test; besides different degrees-of-freedom can require different procedures during the test. Therefore, it has been shown that the first generation method should not be applied as it can lead to instability prematurely during the tests. To overcome the drawbacks of the first generation method, the objective was to develop a new technique that leads to interface equilibrium and compatibility while at the same time is unconditionally stable (i.e. independently of the stiffness ratio). Thus a novel methodology was developed and applied to the case of a concrete beam (PS) being part of a concrete moment resisting frame (NS). The novel method makes use of the PS’s stiffness in addition to the NS’s stiffness as it was the case in the first generation method. The stiffness matrix of the PS is unknown during the test therefore the initial tangent stiffness matrix is considered during the calculations. The latter choice influences the value of the time step to be adopted during the test. Every time step the boundary conditions are updated and it will be discussed how the chosen value can influence the results. A predetermined matrix is used to describe the behavior of the NS during the hybrid fire tests. This approach does not capture the nonlinearity of the remainder but at the same time the implementation is relative simple and the negative effect of the time calculation is eliminated. The procedure to compute the predetermined matrix of the NS is presented in this thesis. One possible direction in the future development of hybrid fire testing is to model the NS in the finite element model. The algorithm of the proposed method is developed and implemented in nonlinear finite element software SAFIR in order to perform virtual hybrid fire tests. The same algorithm is translated in order to be implemented by the company in charge of the control system at the CERIB furnace facility. The thesis also presents a traditional fire test that has been performed on the beam, in order to highlight the differences when testing structural element without and with the real boundary conditions. For the hybrid test, three degrees-of-freedom are controlled at the interface. The furnace facility has an important role to perform successful test where the equilibrium and compatibility are ensured and no instability occurs during the test. The impediments encountered during the tests will be discussed along with the recommendation for a successful hybrid fire test. [less ▲]

Detailed reference viewed: 194 (43 ULiège)
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Peer Reviewed
See detailDevelopment and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications
Roether, J. A.; Boccaccini, Aldo R.; Hench, L. L. et al

in Biomaterials (2002), 23(18), 3871-3878

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and ... [more ▼]

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering. [less ▲]

Detailed reference viewed: 146 (3 ULiège)
See detailDevelopment and integration of entomopathogenic fungi for crops protection in Democratic Republic of Congo
Fingu Mabola, Junior Corneille ULiege; Bawin, Thomas; Nsevolo Miankeba, Papy et al

Poster (2017)

The Democratic Republic of the Congo (DR Congo) has enormous agricultural potentialities likely to contribute to its economic development. However, the sector is characterized by significant yield losses ... [more ▼]

The Democratic Republic of the Congo (DR Congo) has enormous agricultural potentialities likely to contribute to its economic development. However, the sector is characterized by significant yield losses due notably to the pressure of pests. In response to this situation, most farmers use synthetic chemical pesticides, despite the problems of residues on harvested materials and their widely documented side effects on biodiversity. Up to now, efforts are made to promote healthy farming in the long term, taking into account both economic and environmental aspects. According to this principals, pest management is now achieved through the combination of agronomic, biological and physical means, chemical control being the last resort if necessary. Considering the context of DR Congo, biological control remains by far the least developed of all means in pest management. This is due to the lack of technical equipment. Nevertheless, compared to entomophagous macroorganisms, microorganisms offer the advantage of not requiring substantial resources for their integration into agriculture. This is notably the case for entomopathogenic fungi (EF): in addition to the fact that they may be multiplied on readily available substrates, their abundance in nature makes it possible to isolate new, more efficient strains with more or less marked selectivity. However, very little research on EF is carried out in this country. The present study aims to integrate these biological control agents into the pest management strategy in DR Congo. This research project will focus on two approaches: (1) evaluation of the genetic diversity of EF strains in DR Congo, which will lead to the establishment of a reference collection; and (2) screening of potential candidates for biopesticide development. Researches will be carried out on the southwestern part of the country, focusing on insect cadavers and soil samples from cultivated areas. Pure strains will be isolated on synthetic culture media then identified according to their morphological, physiological and molecular traits. Biological tests including virulence and effectiveness under various environmental conditions in laboratory will be carried out against the most important agricultural pests to be determined following a field monitoring. Finally, culture trials of EF with locally available resources at low cost will be conducted to encourage the adoption of the technology. [less ▲]

Detailed reference viewed: 102 (2 ULiège)
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See detailDevelopment and Layout of a ACC-System by means of Evolutionary Algorithms
Christen, Fréderic ULiege

Scientific conference (2007, August 22)

Detailed reference viewed: 10 (0 ULiège)
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See detailDevelopment and numerical validation of a 2-scale computational model to study the mechanical behavior of nanocrystalline metals
Péron, Vincent ULiege

Doctoral thesis (2014)

This work aims at predicting the mechanical behavior of nanocrystalline structure using a 2-scale approach. Molecular simulations using the quasicontinuum method (QC) are performed to obtain the ... [more ▼]

This work aims at predicting the mechanical behavior of nanocrystalline structure using a 2-scale approach. Molecular simulations using the quasicontinuum method (QC) are performed to obtain the mechanical responses of the grain-boundaries and grains at the nanoscale. A finite element model is then calibrated using these atomistic results. This 2-scale model accounts for intergranular and intragranular plasticity, can predict the intergranular failure, and is able to study large structures. [less ▲]

Detailed reference viewed: 177 (30 ULiège)
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See detailDevelopment and optimisation of methods to synthesise sol-gel nanoparticles and sol-gel core-shell nanoparticles to produce nanosensors
De Bleye, Charlotte ULiege

Master's dissertation (2011)

The aim of this project was to synthesise nanosensors. It can be defined as an inert, biofriendly matrix in which sensing molecules are entrapped, allowing determination of analytes concentration. Two ... [more ▼]

The aim of this project was to synthesise nanosensors. It can be defined as an inert, biofriendly matrix in which sensing molecules are entrapped, allowing determination of analytes concentration. Two types of nanosensors were synthesised according to the Stöber method and characterised by a scanning electron microscope and a CPS disc centrifuge. The nanosensors were calibrated with succes using a fluorimeter. [less ▲]

Detailed reference viewed: 72 (20 ULiège)