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See detailDiabetes and the kidney disease risk
Krzesinski, Jean-Marie ULg

Conference (2017, April 26)

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See detailDiabetes does not influence treatment decisions regarding revascularization in patients with stable coronary artery disease
Breeman, A.; de Boer, M. J.; Bertrand, M. E. et al

in Diabetes Care (2006), 29(9), 2003-2011

OBJECTIVE - To evaluate whether in stable angina preference for coronary revascularization by either percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) is influenced by ... [more ▼]

OBJECTIVE - To evaluate whether in stable angina preference for coronary revascularization by either percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) is influenced by diabetes status and whether this has prognostic implications. RESEARCH DESIGN AND METHODS - A total of 2,928 consecutive patients with stable angina who were enrolled in the prospective Euro Heart Survey on Coronary Revascularization were studied. Multivariable analyses were applied to evaluate the relation between diabetes, treatment decision, and 1-year outcome. RESULTS - Diabetes was documented in 587 patients (20%) who had more extensive coronary disease. Revascularization was intended in 74% of patients with diabetes and in 77% of those without diabetes. In patients selected for revascularization, CABG was intended in 35% of diabetic and in 33% of nondiabetic patients. Multivariable analyses did not change these findings, but in some subgroups diabetes influenced treatment decisions. For example, diabetic subjects with mild heart failure had more often intended revascularization (91%) than those without diabetes (67%, P < 0.001). Treatment decisions in patients with more extensive (left main, multivessel, or proximal left anterior descending artery) disease were not influenced by diabetes status. Diabetes was not associated with an increased incidence of all-cause death, nonfatal cerebrovascular accident, or nonfatal myocardial infarction at 1 year, regardless of preferred treatment. The incidence of the combined end points was 7.3% in diabetic and 6.8% in nondiabetic patients (adjusted hazard ratio 1.0 [95% CI 01.7-1.41]). CONCLUSIONS - in stable angina, treatment decisions regarding revascularization or the choice for CABG or PCI were not influenced by the presence of diabetes. Diabetes was not associated with a poor prognosis. [less ▲]

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See detailDiabètes iatrogènes : importance d’une analyse critique du rapport bénéfices/risques des traitements en cause
SCHEEN, André ULg

in Médecine des Maladies Métaboliques (2015), 9(3), 1-3

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See detailDiabetes is a risk factor for knee osteoarthritis progression
Eymard, F; Parsons, C; Edwards, M et al

in Osteoarthritis and Cartilage (2015), 23

Purpose Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology ... [more ▼]

Purpose Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology of knee osteoarthritis (OA). We investigated their impact on radiographic progression by an annualised measure of the joint space narrowing (JSN) of the medial tibiofemoral compartment. Methods 559 patients older than 50 years with symptomatic knee OA were recruited for the placebo arm of the SEKOIA trial. The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview. BMI was calculated, obesity was considered >30 kg/m2. MetS was defined by the sum of metabolic factors ≥3. Minimal medial tibiofemoral joint space on plain radiographs was measured by an automated method at baseline and then annually for up to 3 years. Results The mean age of patients was 62.8 [62.2-63.4] years; 392 were women. A total of 43.8% was obese, 6.6% had type 2 diabetes, 45.1% hypertension, 27.6% dyslipidemia and 13.6% MetS. Mean annualised JSN was greater for patients with type 2 diabetes than without diabetes (0.26 [-0.35 - -0.17] vs. 0.14 [-0.16 - -0.12] mm; p=0.001). This association remained significant after adjustment for sex, age, BMI, hypertension and dyslipidemia (p=0.018). In subgroup analysis, type 2 diabetes was a significant predictor of JSN in males but not females. The other metabolic factors and MetS were not associated with annualised JSN. Conclusion Type 2 diabetes was a predictor of joint space reduction in men with established knee OA. No relationships were found between MetS or other metabolic factors and radiographic progression. [less ▲]

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See detailDiabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?
Scheen, André ULg

in Diabètes & Métabolism (2005), 31 Spec No 2

Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function ... [more ▼]

Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function is due to an inevitable consequence of "biological aging" or due to environmental or lifestyle variables. Indeed, increased adiposity/altered fat distribution, decreased fat free mass/abnormal muscle composition, poor dietary habits and physical inactivity all contribute to reduce insulin sensitivity. Insulin resistance in elderly people appears to predominate in skeletal muscle, whereas hepatic glucose output seems to be almost unaffected. Several abnormalities in islet beta-cell and insulin secretion were also pointed out in elderly people such as increased amyloid deposition and decreased amylin secretion, impaired insulin secretion pulsatility, decreased insulin sensitivity of pancreatic beta-cells to insulinotropic gut hormones and diminished insulin response to non-glucose stimuli such as arginine. Controversial results were reported concerning the effects of aging on absolute insulin secretion in response to oral or intravenous glucose. However, insulin secretion appears to decrease with age, with significantly diminished beta-cell sensitivity and acute insulin response to glucose, provided it is analyzed relative to concomitant decreased insulin sensitivity. Thus, there is an interplay between decreased insulin secretion and increased insulin resistance that largely explains the abnormal glucose metabolism seen in elderly. Weight loss, especially reduction of abdominal adiposity, and increased physical activity may contribute to improve insulin sensitivity and glucose tolerance, and prevent the development of type 2 diabetes in elderly people. [less ▲]

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See detailDiabètes secondaires à une endocrinopathie.
Borges-Martins, L.; Betea, Daniela ULg; Daly, Adrian ULg et al

in Revue Médicale de Liège (2005), 60(5-6), 442-447

Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal ... [more ▼]

Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal secretion, which alters insulin secretion or action. It is characterized by the absence of ketosis because of the persistence of endogenous insulin secretion. Diabetes is usually reversible with successful treatment of the underlying endocrine disorder and the correction of hormonal overproduction. Most important endocrine diseases associated with diabetes mellitus are briefly described and the underlying mechanisms of glucose abnormalities are discussed. [less ▲]

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See detailDiabetes: Time for reconciliation between cardiologists and diabetologists.
Scheen, André ULg

in Nature Reviews. Cardiology (2016)

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See detailDiabetogenic coxsackievirus B4 modifies cytokine secretion by human thymic epithelial cells
Brilot, Fabienne; Chehadeh, Wassim; Renard, Chantal et al

in Diabetologia (2000), 43 (Suppl. 1)

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See detailLe Diable et les vierges
Dor, Juliette ULg

in Carruthers, Leo (Ed.) Anges et démons dans la littérature anglaise du Moyen Âge (2002)

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See detail"Les Diables rouges sont-ils instrumentalisés en politique ?"
Verjans, Pierre ULg

Article for general public (2016)

"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de ... [more ▼]

"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de s’abstenir. Ils ne vont pas s’enthousiasmer un drapeau tricolore à la main. Il y a une évidente contradiction entre leur vision flamande avant tout et la diversité et le bilinguisme qu’affichent les Diables." [less ▲]

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See detail"Diabolo-Manques", histoire d'une évaluation
Grignard, Sophie ULg; Vandoorne, Chantal ULg

in Education Santé (2008), (236), 2-3

Cet article présente les grandes lignes d’une brochure, coéditée par l’APES-ULg et par la Maison du Social de la Province de Liège, et intitulée «Diabolo-Manques - Une exploration à la découverte de soi ... [more ▼]

Cet article présente les grandes lignes d’une brochure, coéditée par l’APES-ULg et par la Maison du Social de la Province de Liège, et intitulée «Diabolo-Manques - Une exploration à la découverte de soi - L'évaluation d'un programme de prévention des assuétudes en Province de Liège». Cette brochure d’une vingtaine de pages décrit de façon synthétique et intégrée les différentes phases d’évaluation de ce programme ainsi que leurs résultats. [less ▲]

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See detailDiacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO
Pavelka, Karel; Bruyère, Olivier ULg; Cooper, Cyrus et al

in Drugs & Aging (2016), 33(2), 75-85

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been ... [more ▼]

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit–risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated [less ▲]

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