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See detailThe Epidemiology of pituitary tumors : Results of an international collaborative study
Daly, Adrian ULg; Cogne, M.; Jaffrain-Réa, M. L. et al

in The Endocrine Society's - 89 Annual Meeting : Toronto, Canada, 2-5 june 2007 (2007, June)

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See detailEpidemiology of Prolactinomas
Beckers, Albert ULg; Vandeva, S.

in American Pediatric (2009, September)

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See detailThe Epidemiology of Prolactinomas
Ciccarelli, A.; Daly, Adrian ULg; Beckers, Albert ULg

in Pituitary (2005), 8(1), 3-6

Prolactin-secreting tumors (prolactinomas), the most frequently occurring pituitary tumor, have a frequency that varies with age and sex. They occur most frequently in females aged 20 to 50 years old, at ... [more ▼]

Prolactin-secreting tumors (prolactinomas), the most frequently occurring pituitary tumor, have a frequency that varies with age and sex. They occur most frequently in females aged 20 to 50 years old, at which time the female-to-male ratio is approximately 10:1. In the pediatric-adolescent age group, prolactinomas have a prevalence of 100/million population, and account for less than 2% of all intracranial tumors. Prolactinomas occur in approximately 30% of patients with multiple endocrine neoplasia type 1 and in this setting, they may be more aggressive than their sporadic counterparts. Patients with Carney complex or McCune-Albright syndrome may exhibit hyperprolactinemia due to a pituitary tumor derived from somatomammotropic cells that secrete both growth hormone and prolactin. Few familial cases of prolactinoma unrelated to MEN-1 are reported in literature. [less ▲]

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See detailEpidemiology of Q fever in animals and humans in the 21st century
Mainil, Jacques ULg; Porter, S.; Czaplicky, G. et al

Conference (2011)

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See detailEpidemiology of the metabolic syndrome in Luxembourg findings from ORISCAV-LUX study
Alkerwi, A; Sauvageot, N; Donneau, Anne-Françoise ULg et al

Conference (2011)

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See detailEpidemiology of the transition from early to late Crohn's disease.
LOUIS, Edouard ULg

in Digestive Diseases (2012), 30(4), 376-9

Phenotypically, the transition from early to late Crohn's disease is characterized by the occurrence of complications including strictures, intra-abdominal fistulas and perianal fistulas, all of them ... [more ▼]

Phenotypically, the transition from early to late Crohn's disease is characterized by the occurrence of complications including strictures, intra-abdominal fistulas and perianal fistulas, all of them leading to various types of surgeries and currently non-reversible tissue damage. It must, however, be kept in mind that this transition is not at all a uniform and linear process. According to these simple phenotypic criteria, Crohn's disease can already be a late disease at diagnosis while in other patients, it can still be an early disease after 20 years of evolution. This simply highlights the relativity of time in this field, actually reflecting the nature, location and severity of the inflammatory process. The risk over time of the development of these complications has been described, first in cohort studies and then in population-based studies. Globally, at diagnosis, between 19 and 38% only of Crohn's disease patients have complicated Crohn's disease. After 10 years, between 56 and 65% of patients have developed either stricturing or penetrating complications. After 20 years, these numbers are between 61 and 88%. In parallel to these structural changes, changes in the immunobiology of the disease also seem to occur; the latter seem to happen quicker with major modification already within 2 years of the diagnosis. Beside these general figures, important questions remain pending. First, the real timing of these changes is still unclear. Second, the precise role of genetics and environment in the development of these changes remains to be clarified. Third, the correlation between changes in immunobiology and intestinal structural damages has not been specifically studied. [less ▲]

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See detailEpidemiology of trace elements deficiencies in Belgian beef and dairy cattle herds.
Guyot, Hugues ULg; Saegerman, Claude ULg; Lebreton, Pascal et al

in Journal of Trace Elements in Medicine and Biology (2009), 23(2), 116-23

Selenium (Se), iodine (I), zinc (Zn) and copper (Cu) deficiencies in cattle have been reported in Europe. These deficiencies are often associated with diseases. The aim of the study was to assess trace ... [more ▼]

Selenium (Se), iodine (I), zinc (Zn) and copper (Cu) deficiencies in cattle have been reported in Europe. These deficiencies are often associated with diseases. The aim of the study was to assess trace element status in Belgian cattle herds showing pathologies and to compare them to healthy cattle herds. Eighty-two beef herds with pathologies, 11 healthy beef herds, 65 dairy herds with pathologies and 20 healthy dairy herds were studied during barn period. Blood and/or milk samples were taken in healthy animals. Plasma Zn, Cu, inorganic I (PII) and activity of glutathione peroxidase in erythrocytes (GPX) were assayed. In milk, I concentration was measured. Data about pathologies and nutrition in the herds were collected. According to defined thresholds, it appeared that a large proportion of deficient herds belonged to "sick" group of herds. This conclusion was supported by the mean value of trace elements and by the fact that a majority of individual values of trace elements was below the threshold. Dairy herds had mean values of trace elements higher than beef herds. More concentrates and minerals were used in healthy herds versus "sick" herds. These feed supplements were also used more often in dairy herds, compared to beef herds. Trace elements deficiencies are present in cattle herds in Belgium and are linked to diseases. Nutrition plays a major role in the trace elements status. [less ▲]

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See detailEpidemiology of VAP and VAC
LAYIOS, Nathalie ULg; DAMAS, Pierre ULg

Poster (2014, May)

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See detailEpidemiology of Visceral Leishmaniasis in Algeria: An Update
Adel, A; Boughoufalah, A; Saegerman, Claude ULg et al

in PLoS ONE (2014), 9(6), 99207

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See detailEpidemiology, assessment, and management of excess abdominal fat in persons with HIV infection.
Moyle, Graeme; Moutschen, Michel ULg; Martinez, Esteban et al

in AIDS Reviews (2010), 12(1), 3-14

Metabolic and morphologic abnormalities in persons with HIV remain common contributors to stigma and morbidity. Increased abdominal circumference and visceral adiposity were first recognized in the late ... [more ▼]

Metabolic and morphologic abnormalities in persons with HIV remain common contributors to stigma and morbidity. Increased abdominal circumference and visceral adiposity were first recognized in the late 1990s, soon after the advent of effective combination antiretroviral therapy. Visceral adiposity is commonly associated with metabolic abnormalities including low HDL-cholesterol, raised triglycerides, insulin resistance, and hypertension, a constellation of risk factors for cardiovascular disease and diabetes mellitus known as "the metabolic syndrome". Medline and conference abstracts were searched to identify clinical research on factors associated with visceral adiposity and randomized studies of management approaches. Data were critically reviewed by physicians familiar with the field. A range of host and lifestyle factors as well as antiretroviral drug choice were associated with increased visceral adiposity. Management approaches included treatment switching and metformin, both of which have shown benefit for insulin-resistant individuals with isolated fat accumulation. Testosterone supplements may also have benefits in a subset of individuals. Supra-physiological doses of recombinant human growth hormone and the growth hormone releasing hormone analog tesamorelin both significantly and selectively reduce visceral fat over 12-24 weeks; however, the benefits are only maintained if doping is continued. In summary, the prevention and management of visceral adiposity remains a substantial challenge in clinical practice. [less ▲]

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See detailEpidemiology, clinical presentation and diagnostic strategy of gastro-esophageal reflux
Louis, Edouard ULg

in Acta Endoscopica (2003), 33

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See detailEpidémiosurveillance de l'encéphalopathie spongiforme bovine en Belgique : bilan de l'année 1998
Saegerman, Claude ULg; Dechamps, P.; Vanopdenbosch, E. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailEpidémiosurveillance de la rage animale en Belgique : un seul cas détecté en 1998
Brochier, B.; Dechamps, P.; Costy, F. et al

in Annales de Médecine Vétérinaire (1999), 143

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See detailEpidémiosurveillance des événements rares chez les bovins en Belgique
Saegerman, Claude ULg

in Annales de Médecine Vétérinaire (2006), 150(Sp. Iss. SI), 4-9

Epidémiosurveillance des événements rares chez les bovins en Belgique. Thèse de doctorat en sciences vétérinaires défendue le 29 septembre 2004.

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See detailEpidémiosurveillance des événements rares chez les bovins en Belgique
Saegerman, Claude ULg

Doctoral thesis (2004)

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See detailEpidermal Calprotectin Expression in Lymphocyte-Depleted Cutaneous Graft-versus-Host Reaction
Pierard, Gérald ULg; Nikkels, Nazli ULg; Nikkels, Arjen ULg et al

in Archivos Argentinos de Dermatologia (1998), 48

One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates ... [more ▼]

One of the most important complications associated with bone marrow transplantation (BMT) is graft-versus-host reaction (GVHR) altering different organs. The immunosuppressive regimen frequently abates the severity of cutaneous lesions to a peculiar lymphocyto-depleted GVHR (LD-GVHR) with scant recognizable inflammatory cells and almost absence of epidermal injury. The recently revisited histological criteria for cutaneous GVHR are of little help in diagnosing such LD-GVHR. As calprotectin (L1-protein) has been reported to be expressed in several types of stressed epithelia, we assessed the epidermal calprotectin expression during LD-GVHR. Calprotectin expression was studied by immuno-histochemistry using the Mac 287 moAb in 50 cases of LD-GVHR and 40 cases of toxic reactions due to the conditioning regimens or to post-transplant drugs. Calprotectin was evidenced in normal looking keratinocytes of all cutaneous LD-GVHR cases and in the vast majority of cytotoxic drug-induced dermatitis. It is concluded that calprotectin immunoreactivity appears to be a diagnostic clue in LD-GVHR. The epidermal calprotectin expression occurs early in GVHD, irrespective of the histological grading. However, it cannot be used alone to distinguish early LD-GVHR from drug-induced dermatitis. [less ▲]

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See detailThe epidermal cell which selectively adheres to a collagen substrate is the basal cell.
Stanley, J. R.; Foidart, Jean-Michel ULg; Murray, J. C. et al

in Journal of Investigative Dermatology (1980), 74(1), 54-8

In order to determine whether a specific subpopulation of epidermal cells selectively attaches to collagen substrates in vitro, epidermal cell suspensions, obtained by trypsinization of guinea pig skin ... [more ▼]

In order to determine whether a specific subpopulation of epidermal cells selectively attaches to collagen substrates in vitro, epidermal cell suspensions, obtained by trypsinization of guinea pig skin, were incubated on type I or type IV collagen-coated glass cover slips. It was noted, morphologically and by electronic volume measurements, that small round cells, as opposed to the larger angulated flat cells, adhered to the collagen substrates. To further characterize the attached cells, the percentage of basal cells was determined in the attached cell population and in the initial epidermal cell suspension. Basal cells were identified by indirect immunofluorescence in 2 ways: (1) by the presence of pemphigoid antigen and (2) by the absence of upper cytoplasmic antigen, which is present in all keratinocytes except the basal cells. Whereas in the initial guinea pig epidermal cell suspensions about 50% of the cells were basal cells using either of these 2 criteria, 86-97% of the cells which adhered to the collagen substrates were basal cells. Human basal cells, as defined by pemphigoid antigen, also selectively adhered to the collagen substrates. [less ▲]

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