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See detailDouble manquement et sanctions financières des Etats (article 228, § 2 CE) : le point après quinze ans
Wildemeersch, Jonathan ULg; Wathelet, Melchior ULg

in Revue de la Faculté de Droit de l'Université de Liège (2008), (3), 324-345

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See detailLa double motivation : l’emprise d’Homère et d’Euripide sur l’imagerie de Grande-Grèce
Morard, Thomas ULg

in Estienne, Sylvie; Huet, Valérie; Lissarrague, François (Eds.) et al FIGVRA XIV – Construire le divin en images (in press)

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See detailThe double negation in the earliest Upanishads and the ancient philosophical Bhâshya
Verpoorten, Jean-Marie ULg

in Pirart, E (Ed.) Syntaxe des langues indo-européennes anciennes (1997)

Relevé de phrases des Upaniṣads ou du Śābarabhāṣya qui contiennent à la fois la négation na et un terme, simple ou composé, commençant par a-privatif ou par les préfixes vi- et niḥ-. Ce terme peut être un ... [more ▼]

Relevé de phrases des Upaniṣads ou du Śābarabhāṣya qui contiennent à la fois la négation na et un terme, simple ou composé, commençant par a-privatif ou par les préfixes vi- et niḥ-. Ce terme peut être un nom, un adjectif, un participe passé passif, un gérondif (en –tvā par ex.) La double négation peut se présenter dans une phrase élidée parallèle à l’énoncé positif, ce qui donne un groupe de 2 mots formé de na + terme privatif. Il existe aussi des phrases, notamment dans le Nyāyavārttika, qui contiennent 2 na, le premier équivalant à la proposition principale «il n’est pas possible/vrai que… » suivie de sa complétive négative. On rencontre aussi des phrases où la ou les négations se combinent avec etavatā, ce qui se traduirait par « Il ne serait pas juste de…simplement (etavatā) pour la raison que » et permettrait d’écarter une conclusion prématurée ou indésirable. Dans le commentaire aux sūtra’s de logique (Nyāyabhāṣya), les phrases à 2 négations ne se différencient pas des modèles des Upaniṣad’s, tandisque dans le sous-commentaire (Nyāyavārttika), le double na se fait moins rare. Le premier na est en tête de phrase, le second juste devant le verbe. Notons enfin que na peut faire partie d’un groupe pronominal ou adverbial qu’il rend négatif, comme na kaś cit « personne » (lit. « pas quelqu’un»). [less ▲]

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See detailDouble Objective Economic Statistical Design of the VPT2 Control Chart: Wald’s identity approach
Faraz, Alireza ULg; Heuchenne, Cédric ULg; Saniga, Erwin et al

in Journal of Statistical Computation & Simulation (2014), 84

Recent studies have shown that applying the control chart by using a variable parameters (VP) scheme yields more rapid detection of assignable causes than the classical method of taking fixed sample sizes ... [more ▼]

Recent studies have shown that applying the control chart by using a variable parameters (VP) scheme yields more rapid detection of assignable causes than the classical method of taking fixed sample sizes at fixed intervals of time. In this paper, the problem of economical statistical design of the VP T2 control chart is considered as a double-objective minimization problem with the statistical objective adjusted average time to signal and the economic objective expected cost per hour. Then we strive to find the Pareto-optimal designs in which the two objectives are met simultaneously by using a multi-objective Genetic Algorithm or GA. Through an illustrative example, we show that relatively large benefits accrue to the VP method relative to the classical policy; further another advantage of our approach is to provide a list of alternative solutions that can be explored graphically. This then ensures flexibility and adaptability, an important attribute of contemporary control chart design. [less ▲]

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See detailDouble radial immunodiffusion as a tool to identify pregnancy-associated glycoproteins in ruminant and nonruminant placentae
El Amiri, B.; Melo de Sousa, Noelita ULg; Mecif, K. et al

in Theriogenology (2003), 59(5-6), 1291-1301

Pregnancy-associated glycoproteins (PAGs) are antigens synthesized in the superficial layers of the ruminant trophoblast. Initially, they were identified either as proteins released into the maternal ... [more ▼]

Pregnancy-associated glycoproteins (PAGs) are antigens synthesized in the superficial layers of the ruminant trophoblast. Initially, they were identified either as proteins released into the maternal bloodstream (where they have applications in pregnancy diagnosis) (PAG1) or as molecules binding to the LH receptor (PAG2). In this study, double radial immunodiffusion was used to test the ability of antisera raised against different PAG molecules (bovine, ovine and caprine) to react with placental extracts from nonruminants (rabbit, cat, mouse, pig, and wild pig) and ruminants (cow, ewe, and goat). Placental extracts from all nonruminants tested except rabbit reacted with anti bovine PAG2 (anti-boPAG2). Extracts of ruminant placentas reacted with different antisera, confirming the expression of various PAG molecules. According to the time at which the placentas were collected (early or middle pregnancy), the reaction differed as regards the thickness, position, and number of precipitation lines, suggesting that PAG expression varies as pregnancy progresses. Bos indicus and Bos taurus placental extracts exhibited different reactions with anti-boPAG2: a single precipitation line in the former case and two lines in the latter. This suggests differential expression of boPAG2 related glycoproteins in these two subspecies. [less ▲]

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See detailDouble stigmatisation dans la maladie d'Alzheimer
Adam, Stéphane ULg

Scientific conference (2012, November 15)

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See detailDouble stigmatisation dans la maladie d'Alzheimer: Impact pour les patients et leurs proches
Adam, Stéphane ULg

Conference given outside the academic context (2013)

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See detailDouble stigmatisation en oncogériatrie
Adam, Stéphane ULg

Scientific conference (2012, October 05)

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See detailDouble stigmatization influence in oncogeriatry
Schroyen, Sarah ULg; Adam, Stéphane ULg; JERUSALEM, Guy ULg et al

in Psycho-oncology (2014, October 24)

Introduction Cancer is a major health problem widespread in elderly, which is inscribed in ageism context1. Negative influence of the vision that older people possess on aging on mental and physical ... [more ▼]

Introduction Cancer is a major health problem widespread in elderly, which is inscribed in ageism context1. Negative influence of the vision that older people possess on aging on mental and physical health2 is well established within “normal” aging. Consequently, we can ask ourselves what consequences age stigmas have in the realm of oncogeriatry. Moreover, cancerous patients face pathology-related stigmas because nowadays cancer still conveys a lot of negative representations. Method A group of 120 patients aged of 65 years old and more suffering from cancer (lung, breast or gynecological) will be followed during one year (0-3-6-12 months). Different instruments measuring quality of life, depression, symptoms, etc. are used as well as questions about their vision of aging and of cancer. Clinical parameters (weight, biologicals values, comorbidity…) are recorded too. Currently, we have 63 patients (31 breast cancer, 14 gynecological cancer and 18 lung cancer with distinction between smokers and non-smokers). Our analysis is only on the baseline at this moment, without any distinction between kinds of cancers. Results Double ANOVAs were used to analyze the data. A positive vision of aging is linked to a lower level of depression in comparison to a negative vision of aging (p = .04). Vision of pathology approach significance: less depression when vision is positive (p = .077). Concerning daily functioning (physical, emotional, social...), a positive vision of aging is related to a better functioning (p = .03) whereas vision of pathology has no effect. Eventually, a positive vision of aging and of cancer is related to a better quality of life (respectively p=.02, p=.002). Concerning clinical parameters, no results are observed. Conclusion These first results suggest that the vision patients have themselves of the age and of cancer is in relation with subjective mental and physical health. As we observe influence on vision of aging as well as pathology, we can talk about “double stigmatization”. Needless to say, more studies are needed to analyze the direction of these observation and longitudinal data analysis could bring some answers: is stigmatization provoke a less good mental and physical health or is it because I have health problem that I have a negative vision of aging and of my disease? 1. Penson, R. T., et al. (2004). The Oncologist, 9, 343-352. 2. Levy, B. (2009). Curr Dir Psychol Sci, 18, 332-336. [less ▲]

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See detailDouble sweep preconditioner for optimized Schwarz methods applied to the Helmholtz problem
Vion, Alexandre ULg; Geuzaine, Christophe ULg

in Journal of Computational Physics (2014), 266

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See detailDouble sweep preconditioner for Schwarz methods applied to the Helmholtz equation
Vion, Alexandre ULg; Geuzaine, Christophe ULg

in Proceedings of the 22nd International Conference on Domain Decomposition Methods (2013, September)

Observing that the optimized Schwarz algorithm is equivalent to the solution of a linear system, we design a new preconditioner as an approximate inverse of the iteration operator, in the particular case ... [more ▼]

Observing that the optimized Schwarz algorithm is equivalent to the solution of a linear system, we design a new preconditioner as an approximate inverse of the iteration operator, in the particular case of a layered decomposi- tion. We show that it can be rewritten as two independent sequences of subproblem solves (forward and back- ward), hence the name ‘double sweep’. The whole algorithm is implemented as a matrix-free GMRES iteration, that requires no more additional preprocessing than the original algorithm. Numerical experiments indicate that the convergence rate is independent of the wavenumber and number of subdomains when good approximations of the DtN maps are used, in both homogeneous and non-homogeneous cases. [less ▲]

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See detailDouble Sweep Preconditioners for propagation problems solved by Optimized Schwarz Methods
Vion, Alexandre ULg; Geuzaine, Christophe ULg

in Proceedings of the 6th International Conference on Advanced COmputational Methods in ENgineering, ACOMEN 2014 (2014, June)

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See detailDouble thermo-responsive hydrogels from poly(vinylcaprolactam) containing diblock and triblock copolymers
Thomassin, Jean-Michel ULg; Mathieu, Kevin ULg; Kermagoret, Anthony ULg et al

in Polymer Chemistry (2015), 6(10), 1856-1864

The thermally-induced gelation and gel properties of concentrated aqueous solutions of double thermoresponsive poly(N-vinylamide)-based di- and triblock copolymers are studied by rheology. The copolymers ... [more ▼]

The thermally-induced gelation and gel properties of concentrated aqueous solutions of double thermoresponsive poly(N-vinylamide)-based di- and triblock copolymers are studied by rheology. The copolymers under investigation, prepared by cobalt-mediated radical polymerization and coupling reactions, are composed of poly(vinylcaprolactam) (PNVCL) blocks and of a statistical poly(vinylcaprolactam-stat-vinylpyrrolidone) segment with a cloud point temperature (TCP) higher than that of PNVCL. Heating the di- and triblock solutions beyond the first phase transition temperature favors gel formation while heating above the second TCP leads to opaque gels without macroscopic demixing. Moduli of the triblock hydrogels are systematically higher than those of the corresponding diblocks, even above the second transition. Rheological data suggest distinct micellar structures for each copolymer architecture: densely packed micelles of diblocks and 3-D networks of bridged micelles for triblocks. Strain sweep experiments also emphasize the positive effect of the micelle bridging on the elasticity and stability of the hydrogels. The formation and properties of the obtained gels are also shown to depend on the copolymer concentration, block length, and composition. Addition of salt also allows us to tune the phase transition temperatures of these double thermoresponsive hydrogels. [less ▲]

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See detailDouble thermoresponsive di- and triblock copolumers based on N-vinylcaprolactam and N-vinylpyrrolidone: synthesis, micellisation ang gelation
Mathieu, Kevin ULg; Kermagoret, Anthony; Thomassin, Jean-Michel ULg et al

Poster (2016, February 15)

The development of stimuli-responsive polymers, especially thermo-responsive ones, has been a tremendous field of research in the last years. The solubility of such macromolecules can be reversibly ... [more ▼]

The development of stimuli-responsive polymers, especially thermo-responsive ones, has been a tremendous field of research in the last years. The solubility of such macromolecules can be reversibly triggered by small changes of temperature without additives. Poly(N-vinylcaprolactam) (PNVCL), which exhibits a lower critical solution temperature (LCST) around 36°C and a low toxicity, is of particular interest especially for biomedical applications. For these reasons, the insertion of well-defined PNVCL segments in more complex architectures is highly desirable but it requires efficient synthetic tools. In this context, we have developed a cobalt-mediated radical polymerization (CMRP) for synthesizing novel well-defined NVCL-based copolymers. First, the LCST of PNVCL was tuned over a wide range of temperature by incorporation of specific amounts of N-vinylpyrrolidone (NVP) in the backbone. Then, CMRP of NVCL followed by statistical NVCL/NVP copolymerization led to diblocks having two discrete LCSTs. Finally, double. The thermal response and multistep assembly behavior of these NVCL-containing di-and triblock copolymers were studied by turbidimetry and dynamic light scattering in dilute aqueous solution (~ 1 wt%). Rheological measurements performed on more concentrated copolymer solutions (~ 15 wt%) also emphasized their ability to form thermo-reversible gels. Gelation occurred at lower concentration and stronger gels were obtained with the triblocks because a real tridimensional network formed in this case. thermoresponsive triblocks were obtained by cobalt-mediated radical coupling (CMRC) of the parent diblocks upon treatment with isoprene. [less ▲]

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See detailDouble thermoresponsive di- and triblock copolymers based on N-vinylcaprolactam and N-vinylpyrrolidone: synthesis and comparative study of solution behaviour
Kermagoret, Anthony ULg; Mathieu, Kevin ULg; Thomassin, Jean-Michel ULg et al

in Polymer Chemistry (2014), 5(22), 6534-6544

Poly(N-vinylcaprolactam) (PNVCL) and poly(N-vinylpyrrolidone) (PNVP) are water soluble polymers of interest especially in the biomedical field. Moreover, PNVCL is characterized by a lower critical ... [more ▼]

Poly(N-vinylcaprolactam) (PNVCL) and poly(N-vinylpyrrolidone) (PNVP) are water soluble polymers of interest especially in the biomedical field. Moreover, PNVCL is characterized by a lower critical solution temperature close to 36 °C in water, which makes it useful for the design of thermoresponsive systems. In this context, we used the cobalt-mediated radical polymerization (CMRP) and reaction coupling (CMRC) for synthesizing a series of well-defined NVCL and NVP-based copolymers, including statistical copolymers as well as double thermoresponsive diblocks and triblocks. Dynamic light scattering and turbidimetry analyses highlighted the crucial impact of the copolymer composition and architecture on the cloud point temperature (TCP) of each segment and also their influence on the multistep assembly behaviour of block copolymers. Addition of NaCl enabled us to adjust the inter-TCP range of the di- and triblock in which selective precipitation of one block and self-assembly of the copolymer were favoured. Overall, data presented here provide a basis for the synthesis of a broad range of NVCL/NVP based copolymer architectures with a tunable thermal response in water. [less ▲]

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See detailDouble wake vortex lattice modeling of horizontal axis wind turbines
Prasad, Chandra Shekhar ULg; Dimitriadis, Grigorios ULg

in Proceedings of the 15th International Forum on Aeroelasticity and Structural Dynamics, IFASD 2011 (2011, June 29)

This paper presents the development of a vortex lattice based aerodynamic calculation for wind turbine blades. Emphasis is placed on the modeling of flow separation using the vortex lattice approach. This ... [more ▼]

This paper presents the development of a vortex lattice based aerodynamic calculation for wind turbine blades. Emphasis is placed on the modeling of flow separation using the vortex lattice approach. This modeling is carried out by shedding a second free wake at the leading edge, which travels downstream at the local air velocity. The decision on whether to shed a wake or not is taken by looking at the sectional lift characteristics of the blade’s airfoil. If the local angle of attack exceeds the maximum lift angle, then a leading edge wake element is shed. Results from the method are presented for both attached and separated flow and compared with predictions obtained from the Blade Element Momentum theory. It is shown that the shedding of the leading edge wake can increased significantly the agreement between vortex lattice and Blade Element results in cases where there are significant regions of separated flow. This improvement concerns mostly forces acting normal to the rotor plane; tangential forces depend more strongly on the drag and neither method calculates a full representation of the drag. [less ▲]

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See detailA double-blind placebo-controlled study of ketoconazole + desonide gel combination in the treatment of facial seborrheic dermatitis.
Pierard, Claudine ULg; Pierard, Gérald ULg

in Dermatology : International Journal for Clinical & Investigative Dermatology (2002), 204(4), 344-7

BACKGROUND: The pathobiology of seborrheic dermatitis is rooted in a peculiar inflammatory reaction to Malassezia spp. Both topical corticosteroids and antifungals are routinely used with success, either ... [more ▼]

BACKGROUND: The pathobiology of seborrheic dermatitis is rooted in a peculiar inflammatory reaction to Malassezia spp. Both topical corticosteroids and antifungals are routinely used with success, either singly or in combination. OBJECTIVE: To assess the effect of a new combination therapy in this condition. METHODS: Eighteen patients with facial seborrheic dermatitis were treated in a pilot double-blind trial with an anhydrous gel containing the combination of 2% ketoconazole and 0.05% desonide (n = 9) or the unmedicated gel (n = 9). The products were applied once daily for 3 consecutive weeks. Disease severity was assessed at the start and weekly during treatment, as well as 2, 4 and 8 weeks after the end of treatment or at the time of recurrence. The overall clinical assessments were performed using a visual analogue scale. Objective measurements included squamometry X after harvesting the stratum corneum and the erythema index yielded by narrow-band reflectance spectrophotometry. Data were evaluated in an intent-to-treat analysis. RESULTS: The combination therapy yielded reductions in the overall clinical symptom severity of 49, 84 and 92% after 1, 2 and 3 weeks of treatment, respectively. The corresponding improvements with the placebo gel were significantly smaller (p < 0.01), reaching 23, 29 and 42% at successive 1-week intervals. At the end of the 3-week treatment, the clinical signs had completely subsided in 6/9 patients treated with the medicated gel and in only 1/9 patients using the placebo gel. Thus, the clinical response rate was significantly faster (p < 0.01) with the combination therapy than with the vehicle. Differences between the treatment groups using objective noninvasive assessments were also significantly (p < 0.01) in favor of the combination therapy. The squamometry X measurements showed 47, 67 and 74% improvements with the combination gel after 1, 2 and 3 weeks, respectively. The corresponding values with the placebo gel were 34, 46 and 53%, respectively. The erythema index was almost completely reduced to normal at week 2 of treatment in contrast with about 50% reduction with the unmedicated vehicle. None of the patients reported any side effects. CONCLUSION: The combination of ketoconazole with desonide in an anhydrous gel is well tolerated and proves to be significantly more effective than the vehicle for treating facial seborrheic dermatitis. The fast response to treatment and the limited additional improvement between weeks 2 and 3 of the treatment suggest that this combination product may be efficacious with once daily applications for 2 weeks. These data call for expanded studies comparing each single compound, the vehicle and the combination therapy. [less ▲]

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