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See detailDevelopmental defects in zebrafish for classification of EGF pathway inhibitors.
Pruvot, Benoist ULg; Curé, Yoann ULg; Djiotsa, Joachim et al

in Toxicology and Applied Pharmacology (2014), 274

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See detailDevelopmental differences in ethanol-induced sensitization using postweanling, adolescent, and adult Swiss mice
Quoilin, Caroline ULg; Didone, Vincent ULg; Tirelli, Ezio ULg et al

in Psychopharmacology (2012), 219

Rationale: The maturing adolescent brain has been suggested to be more sensitive than the adult brain to ethanol-induced neuroadaptations. In animal studies, sensitization to the stimulant effects of ... [more ▼]

Rationale: The maturing adolescent brain has been suggested to be more sensitive than the adult brain to ethanol-induced neuroadaptations. In animal studies, sensitization to the stimulant effects of ethanol is used to study the vulnerability to chronic ethanol-induced neurobehavioral alterations. Objectives: The aim of the present study was to systematically characterize age-dependent changes in the development and expression of the sensitization to the stimulant effects of a range of ethanol doses in female Swiss mice. Three ages were studied: 21-day-old mice (postweanlings), 35-day-old mice (adolescents), and 63-day-old mice (adults). Methods: Postweanling, adolescent, and adult mice were daily injected with saline or various ethanol doses (1.5 to 4 g/kg) for 7 days. They were then tested for acute and sensitized locomotor activity. Results: Postweanling and adolescent mice were more sensitive than adult mice to the acute stimulant effects of ethanol. In adult mice, daily injections of ethanol at doses between 2.5 and 4 g/kg led to significant sensitization. Higher ethanol doses (3.5 and 4 g/kg) were required to induce sensitization in postweanling and adolescent mice. However, younger mice showed ethanol sensitization of higher magnitude. Conclusions: Young mice develop very strong ethanol sensitization at doses that mimic binge drinking in humans. These results might explain why early ethanol drinking during adolescence is related to a higher prevalence of subsequent alcohol disorders. [less ▲]

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See detailDevelopmental differences in the procedural learning of a perceptual-motor skill
Lejeune, Caroline ULg; Catale, Corinne ULg; Merbah, Sarah ULg et al

Poster (2011, May 27)

It is generally admitted that procedural learning is efficient early in childhood. However, few studies have brought empirical data confirming this assumption, and many questions remain regarding the ... [more ▼]

It is generally admitted that procedural learning is efficient early in childhood. However, few studies have brought empirical data confirming this assumption, and many questions remain regarding the cognitive mechanisms that sustain procedural learning in children. The aim of our study was to investigate whether perceptual-motor procedural learning was present to the same extent in 7-, 10-year-old children and in adults. We also examined the role of executive functions, working memory, general intelligence, and motor ability during the learning process. A total of 76 subjects divided into 3 age-groups were tested. The task included 4 blocks of 3 trials during which each subject had to trace the contour of a triangle with an inverted computer mouse. Analyses show an important difference between groups in the initial phase of the learning process. They also reveal that executive functions intervene during the first learning phase, which might explain the observed age effect. In addition, results show significant but different learning effects for the procedural task: while the improvement was equivalent between 10-year-olds and adults, 7-year-old children showed a greater learning slope than the other groups; despite their slowness during the first blocks, younger children showed an equivalent performance at the end of the learning phase. These results suggest that, if executive processes are important during the first learning steps, they are not a “necessary condition” for motor skill learning to occur. The role of compensatory strategies sustaining learning in younger children is discussed. [less ▲]

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See detailDevelopmental disturbance of access to biographical information and people's names: A single-case study
Van der Linden, Martial ULg; Brédart, Serge ULg; Schweich, M.

in Journal of the International Neuropsychological Society (1995), 1(6), 589-595

The paper describes the case of a person (GB) without any clinical evidence of cerebral disease who showed a specific impairment in the retrieval of biographical information, including names, about famous ... [more ▼]

The paper describes the case of a person (GB) without any clinical evidence of cerebral disease who showed a specific impairment in the retrieval of biographical information, including names, about famous people. This deficit appeared while GB scored normally in different long-term memory tasks, and in object naming tasks. Moreover, he showed no impairment in the structural encoding and the recognition of faces. His specific impairment is interpreted both in terms of Bruce and Young's (1986) functional model of person recognition and in terms of the more recent Burton et al. (1990) interactive activation version of the Bruce and Young model. [less ▲]

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See detailDevelopmental evolution in the distribution of radial glial fiber growth cones in the murine cerebral wall
Takahashi, T.; Misson, Jean-Paul ULg; Caviness, V. S.

in Neuroscience (1989)

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See detailDevelopmental Invariance in Implicit Sequence Learning
Lejeune, Caroline ULg; Wansard, Murielle ULg; Meulemans, Thierry ULg

Poster (2014, April 05)

This study was intended to test the age invariance hypothesis on implicit learning abilities using the serial reaction time paradigm and focusing on the comparison of second-order conditional (SOC ... [more ▼]

This study was intended to test the age invariance hypothesis on implicit learning abilities using the serial reaction time paradigm and focusing on the comparison of second-order conditional (SOC) sequences of two different lengths (8 and 12 elements). A total of 128 participants from 4 age groups (4 years, 7 years, 10 years, and adults) were tested. The results showed significant and similar learning effects in 4-, 7-, and 10-year-old children, as well as adults. The learning effect was more pronounced for the 8-element sequence than for the 12-element sequence for all age groups, suggesting that the shorter sequence was better learned than the longer one. In addition, the degree of explicit sequence awareness was comparable between age groups and sequence lengths. These results, showing that 4-year-old children are able to learn 8- and 12-element-long SOC sequences as well as adults, provide further support for the hypothesis that implicit learning abilities are developmentally invariant. [less ▲]

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See detailDevelopmental Neurobiology and the physiopathology of brain injury
Moonen, Gustave ULg; Delrée, Paul; Leprince, Pierre ULg et al

in Stein, Don; Sabel, Bernhard (Eds.) Pharmacological approaches to the treatment of brain and spinal cord injury (1988)

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See detailDevelopmental profiles of GFAP-positive astrocytes in sheep cerebellum
Salouci, Moustafa ULg; Antoine, Nadine ULg; Shikh Al Sook, Mohamad Khir ULg et al

in Veterinary Research Communications (2014)

Astroglial account for the largest glial population in the brain and play a variety of vital functions in the development of the central nervous system (CNS). An immunohistochemical study was performed in ... [more ▼]

Astroglial account for the largest glial population in the brain and play a variety of vital functions in the development of the central nervous system (CNS). An immunohistochemical study was performed in 19 ovine foetuses ranging from two to five months of gestation, one newborn lamb and three adult sheep. Using the anit-glial fibrillary acidic protein (GFAP) marker, several variations were found in the degree of GFAP positive (GFAP+) astrocyte distribution between the different zones in the cerebellum of sheep during brain development. Our study indicates that the first appearance of astrocytes from restricted zones in the cerebellum occurs around the eighth week of gestation. Bergmann cells were found to be present from around the 15th week of gestation onwards. Our findings suggest that the maturation of astrocytes begins in the caudal parts of the cerebellum, developing from their initial ventral regions to spread first to dorsal regions radially within the white matter, then followed by the more rostral parts of the cerebellum. Astrocytes were also found to proliferate in the vermis before appearing in the cerebellar hemispheres. [less ▲]

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See detailDevelopmental profiles of GFAP-positive astrocytes in sheep cerebellum
Salouci, Moustafa ULg; Antoine, Nadine ULg; Shikh Al Sook, Mohamad Khir ULg et al

Poster (2015, July 16)

Astroglial cells make up the largest glial population in the brain and play a variety of vital functions in the development of the CNS. Defects in the development of these cells may induce various ... [more ▼]

Astroglial cells make up the largest glial population in the brain and play a variety of vital functions in the development of the CNS. Defects in the development of these cells may induce various neurodegenerative disorders and result in neural disease. The aim of this study is to investigate the normal development of astrocytes in sheep in various zones of the cerebellum during the different stages of gestation. 19 ovine fetuses, one lamb in the first postnatal week and three adult sheep. Sections of the cerebellum were embedded in paraffin and processed for immunohistochemistry for GFAP. The current study indicates that the first appearance of astrocytes occurs around the 8th week of gestation from restricted zones in the cerebellum. Bergmann cells were present around the 15th week of gestation. Our findings suggest that the maturation of astrocytes begins in the caudal parts of the cerebellum from their initial ventral regions to dorsal regions radially within the white matter followed by the more rostral parts of the cerebellum and that the astrocytes proliferate in the vermis before the cerebellar hemispheres. Our study provide a bases for future studies focusing on the pathological changes in the CNS of both human and sheep. [less ▲]

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See detailDevelopmental regulation of beta-carboline-induced inhibition of glycine-evoked responses depends on glycine receptor beta subunit expression
Mangin, Jean-Marie; Nguyen, Laurent ULg; Gougnard, Catherine et al

in Molecular Pharmacology (2005), 67(5), 1783-1796

In this work, we show that beta-carbolines, which are known negative allosteric modulators of GABA A receptors, inhibit glycine-induced currents of embryonic mouse spinal cord and hippocampal neurons. In ... [more ▼]

In this work, we show that beta-carbolines, which are known negative allosteric modulators of GABA A receptors, inhibit glycine-induced currents of embryonic mouse spinal cord and hippocampal neurons. In both cell types, beta-carboline-induced inhibition of glycine receptor (GlyR)-mediated responses decreases with time in culture. Single-channel recordings show that the major conductance levels of GlyR unitary currents shifts from high levels (>= 50 pS) in 2 to 3 days in vitro (DIV) neurons to low levels (< 50 pS) in 11 to 14 DIV neurons, assessing the replacement of functional homomeric GlyR by heteromeric GlyR. In cultured spinal cord neurons, the disappearance of beta-carboline inhibition of glycine responses and high conductance levels is almost complete in mature neurons, whereas a weaker decrease in beta-carboline-evoked glycine response inhibition and high conductance level proportion is observed in hippocampal neurons. To confirm the hypothesis that the decreased sensitivity of GlyR to beta-carbolines depends on beta subunit expression, Chinese hamster ovary cells were permanently transfected either with GlyR alpha 2 subunit alone or in combination with GlyR beta subunit. Single-channel recordings revealed that the major conductance levels shifted from high levels (>= 50 pS) in GlyR-alpha 2-transfected cells to low levels (< 50 pS) in GlyR-alpha 2-containing cells. Consistently, both picrotoxinand beta-carboline-induced inhibition of glycine-gated currents were significantly decreased in GlyR-alpha 2-transfected cells compared with GlyR-alpha 2-containing cells. In summary, we demonstrate that the incorporation of beta subunits in GlyRs confers resistance not only to picrotoxin but also to beta-carbolineinduced inhibition. Furthermore, we also provide evidence that hippocampal neurons undergo in vitro a partial maturation process of their GlyR-mediated responses. [less ▲]

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See detailDevelopmental Regulation of Neuroligand-Induced Responses in Cultured Oligodendroglia
Belachew, Shibeshih ULg; Malgrange, Brigitte ULg; Rigo, Jean-Michel et al

in Neuroreport (1998), 9(6), 973-80

Using whole-cell patch-clamp techniques, we show that oligosphere-derived oligodendrocyte progenitor cells (OP) display GABA-, glutamate-, 5-HT-, glycine- and acetylcholine-gated inward currents. When OP ... [more ▼]

Using whole-cell patch-clamp techniques, we show that oligosphere-derived oligodendrocyte progenitor cells (OP) display GABA-, glutamate-, 5-HT-, glycine- and acetylcholine-gated inward currents. When OP differentiate into oligodendrocytes (ODC), the amplitude of peak currents elicited by saturating concentrations of these transmitters decreases except for 5-HT. Intracellular Ca2+ concentration changes induced by microperfusion of glutamate, 5-HT, TRH, met-enkephalin and substance P were monitored using a fluo-3-based calcium imaging system. When OP cells differentiate into ODC, a global decrease of the proportion of responding cells is observed. During type-2 astrocytes commitment, this proportion decreases for 5-HT, TRH- and metenkephalin stimulations whereas it remains constant for substance P and glutamate. These data demonstrate a development regulation of neurotransmitter- and neuropeptide-induced responses within the oligodendroglial lineage. [less ▲]

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See detailDevelopmental regulation of the composite CAG promoter activity in the murine T lymphocyte cell lineage.
Baup, D.; Moser, M.; Schurmans, Stéphane ULg et al

in Genesis (New York, N.Y. : 2000) (2009), 47

Promoter selection is of utmost importance for the study of in vivo gene function using transgenic models. In the present study, we have analyzed the expression of the GFP marker under the control of the ... [more ▼]

Promoter selection is of utmost importance for the study of in vivo gene function using transgenic models. In the present study, we have analyzed the expression of the GFP marker under the control of the composite CAG promoter in the lymphoid compartment of several transgenic mouse strains. Despite the ability of the CAG promoter to drive gene expression in almost all tissues examined to date, its activity appears to be developmentally regulated within the T lymphocyte cell lineage. In particular, CD4 and CD8-expressing, thymic immature T cells displayed lower levels of the GFP marker when compared with both bone marrow precursors and mature circulating T cells, suggesting a transient downregulation of CAG activity during T cell development. Alternative promoters may therefore be preferred for the study of T cell development in vivo using a transgenic approach. [less ▲]

Detailed reference viewed: 93 (15 ULg)
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See detailDevelopmental role of thymic neuroendocrine-related self-peptides
Geenen, Vincent ULg

Conference (1997, June)

Detailed reference viewed: 6 (0 ULg)
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See detailDevelopments in digital transducers for vehicle control and telemetric instrumentation
Lewis, Christopher P.; Kraft, Michaël ULg; Hesketh, Thomas G.

in Intelligent autonomous vehicles 1995 (1995)

Detailed reference viewed: 17 (0 ULg)
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See detailDevelopments in finite element simulations of continuous casting
Castagne, Sylvie; Pascon, Frédéric ULg; Blès, Guilhem et al

in Journal de Physique IV (2004), 120

Two complementary approaches of steel continuous casting modelling using the finite element code LAGAMINE have been developed in the M&S Department. We propose here a description of the context in which ... [more ▼]

Two complementary approaches of steel continuous casting modelling using the finite element code LAGAMINE have been developed in the M&S Department. We propose here a description of the context in which the study started, then a description of both macroscopic and mesoscopic approaches. The first one describes the whole continuous casting process, from the free surface in the mould and through the entire machine, including thermal and mechanical behaviour of the steel. The second approach focuses on the prediction of cracks and is developed at the grain scale. Some results are also presented for both models. [less ▲]

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See detailDevelopments in finite element simulations of continuous casting
Castagne, S.; Pascon, Frédéric ULg; Bles, G. et al

in Proceedings of the 2nd International Conference on Thermal Process Modelling and Computer Simulations (ICTPMCS) (2003)

Two complementary approaches of steel continuous casting modelling using the finite element code LAGAMINE have been developed in the M&S Department. We propose here a description of the context in which ... [more ▼]

Two complementary approaches of steel continuous casting modelling using the finite element code LAGAMINE have been developed in the M&S Department. We propose here a description of the context in which the study started, then a description of both macroscopic and mesoscopic approaches. The first one describes the whole continuous casting process, from the free surface in the mould and through the entire machine, including thermal and mechanical behaviour of the steel. The second approach focuses on the prediction of cracks and is developed at the grain scale. Some results are also presented for both models. [less ▲]

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See detailDevelopments in the pharmacotherapeutic management of osteoporosis
Close, Pierre; Neuprez, A.; Reginster, Jean-Yves ULg

in Expert Opinion on Pharmacotherapy (2006), 7(12), 1603-1615

During the last two decades, several medications have been granted a marketing authorisation for the management of osteoporosis. Bisphosphonates are the most widely prescribed drugs in this area ... [more ▼]

During the last two decades, several medications have been granted a marketing authorisation for the management of osteoporosis. Bisphosphonates are the most widely prescribed drugs in this area, worldwide. Alendronate and risedronate are given daily or weekly and have demonstrated their ability to reduce fracture rates at the spine and hip. Ibandronate has demonstrated spine antifracture efficacy with intervals between closings greater than weekly. New developments in this class include intravenous administration of ibandronate or zoledronate, once every three months or once yearly. Raloxifene, a selective estrogen-receptor modulator, reduces spine fractures and, in post-hoc analyses, non-spine fractures in high-risk subjects. New selective estrogen-receptor modulators, including lasofoxifene, bazedoxifene and arzoxifene, are expected to demonstrate antifracture efficacy at the hip level, whilst retaining the extra-skeletal benefits (such as in the breast) that are obtained with raloxifene. The peptides from the parathyroid hormone family are potent stimulators of bone formation. Teriparatide (1 - 34 amino acid fragment of the parathyroid hormone) reduces spine and non-spine fractures, an effect that is sustained for up to 30 months after the withdrawal of treatment. The intact hormone (1 -84 amino acids) showed similar results on spine fractures, and more data are requested to evaluate its effect on non-spine or hip fractures. Strontium ranelate is suggested to be the first medication to uncouple bone formation from bone resorption. It has shown antifracture efficacy at all sites in a large number of postmenopausal women. New developments include: denosumab, an antibody against receptor activator of NF-kappa B ligand (RANKL); a cytokine that is responsible for osteoclastogenesis; and inhibitors of cathepsin K, a cysteine protease that is involved in the cleavage of collagen. [less ▲]

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See detailThe Developments of Cold-rolled TRIP-assisted Multiphase Steels. Al-alloyed TRIP-assisted Multiphase Steels
Jacques, Pascal J.; Girault, Etienne; Mertens, Anne ULg et al

in ISIJ International (2001), 41(9), 1068-1074

The influence of heat-treating conditions on the retention of carbon-enriched austenite of TRIP-assisted multiphase steel grades containing different amounts of silicon and/or aluminium is investigated ... [more ▼]

The influence of heat-treating conditions on the retention of carbon-enriched austenite of TRIP-assisted multiphase steel grades containing different amounts of silicon and/or aluminium is investigated. The ensuing mechanical properties resulting from the TRIP effect are also scrutinised. The bainite transformation kinetics was followed by dilatometry whereas a detailed characterisation of the microstructures led to the construction off transformation maps giving the volume fractions of the different phases and the carbon content of the austenite. The role of silicon and aluminium additions (i)on the retention of austenite by partial bainite transformation and (ii) on the mechanical properties is enlightened. A strong influence of the solid-solution strengthening effect of silicon is highlighted. Aluminium seems to be an effective alloying element for the retention of austenite in TRIP-aided steels even if lower strength levels can be attained. A mixed Al-Si TRIP-aided steel seems to be a very good compromise between the processing needs, the required mechanical properties and the industrial constraints. [less ▲]

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See detailDéveloppement : la course à la compétitivité
Lebailly, Philippe ULg; Gobillon, L.

Article for general public (2003)

Detailed reference viewed: 13 (2 ULg)