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See detailERT/Table ronde des industriels européens
Geuens, Geoffrey ULg

in Durand, Pascal (Ed.) Les Nouveaux Mots du Pouvoir. Abécédaire critique (2007)

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See detailles éruptions cutanées chez l'enfant
Battisti, Oreste ULg

Learning material (2009)

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See detail“… eine Erweiterung des Wortes in Ausdruck und Wirkung auf emotionaler, sinnlicher und sogar intellektueller Ebene“ Der Komponist Hans Schanderl im Interview mit Vera Viehöver
Viehöver, Vera ULg

in Viehöver, Vera; Nörtemann, Regina (Eds.) Kolmar übersetzen. Studien zum Problem der Lyrikübertragung (2013)

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See detailErysipelothrix rhusiopathiae infection in stranded harbour porpoise (Phocoena phocoena) and harbour seal (Phoca vitulina)
Boseret, Géraldine ULg; Jauniaux, Thierry ULg; Mainil, Jacques ULg

in anton, erken (Ed.) Proceedings of the 4th scientific meeting of the European Association of Zoo and Wildlife Veterinarians and 5th meeting of the European Wildlife Disease Assocation : Heidelberg, Germany 2002 / editor Anton ERKEN. (2002, May 08)

An adult female harbour porpoise (Phocoena phocoena ) and a juvenile male harbour seal have been found dead on a Belgian beach in autumn 2001. The two bodies were in good condition (CC = 2). Pure and ... [more ▼]

An adult female harbour porpoise (Phocoena phocoena ) and a juvenile male harbour seal have been found dead on a Belgian beach in autumn 2001. The two bodies were in good condition (CC = 2). Pure and abundant growth of a small rod-shaped, Gram-labile bacterium was obtained aerobically and anaerobically on Columbia bloodagar from the heart blood, the mouth, the pharynx, the lungs, the intestine and the anus of the porpoise, and from the intestine, the pharynx, the mouth, the nose and the anus of the seal. The colonies were surrounded by a narrow zone of a-hemolysis. The catalase- and peroxydase-tests gave negative results. Rapid ID 32 Strepto (Biomérieux, France) sugar tests applied on porpoise’s heart blood, lungs and intestine, and on seal’s intestine and pharynx identified this isolate to Erysipelothrix rhusiopathiae. Erysipelothrix rhusiopathiae is not reported as a common cause of infection and death in wild cetaceans and wild pinnipeds in opposite to respectively captive dolphins and sea lions. Nevertheless, E. rhusiopathiae can be considered as the cause of death of the stranded harbour porpoise as it was present in heart blood and internal organs, and the seal was carrying the bacterium with lesions of enteritis which could be associated with E. rhusiopathiae infectio [less ▲]

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See detailL'erytheme necrolytique migrateur.
Dandrifosse, J. F.; Dandrifosse, A. C.; Pierard, Gérald ULg et al

in Revue Médicale de Liège (1998), 53(12), 778-83

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to ... [more ▼]

Necrolytic migratory erythema (NME) is generally associated with glucagonoma. It waxes and wanes by successive relapses and remissions. The clinical and microscopical diagnosis is complex. In addition to glucagonoma treatments, the administration of corticoids, aminoacids, zinc or essential fatty acids can be helpful. There exist several etiological hypotheses for NME. These are based on modifications of pancreatic enzyme activities and on variations of aminoacids, fatty acids, zinc or glucagon concentrations. [less ▲]

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See detailThe erythrocyte sodium - potassium cotransport in hypertensive patients: advantages and limitations
Krzesinski, Jean-Marie ULg; Rorive, Georges ULg

in Clinical and Experimental Hypertension. Part A, Theory and Practice (1985), A7(4), 553-572

The Na-K cotransport activity was measured in erythrocytes of 123 normotensive and 92 hypertensive patients, using the methodology described by Dagher and Garay. Large overlap of the values obtained in ... [more ▼]

The Na-K cotransport activity was measured in erythrocytes of 123 normotensive and 92 hypertensive patients, using the methodology described by Dagher and Garay. Large overlap of the values obtained in the two populations is observed, in such a way this laboratory test cannot be applied for the discrimination between primary and secondary hypertension. Moreover, the abnormalities described for the Na-K cotransport do not appear specific for primary hypertension. In this study, the influence of hypertensive heredity, but also obesity on this cotransport system could not be demonstrated. However, this transport activity is significantly decreased in patients with chronic renal failure, during treatment with oestro-progestatives or during the oestrogenic phase of the menstrual cycle. These data strongly suggest that the cotransport activity could be modified not only by the hypertensive familial predisposition but also by environmental and hormonal influences. [less ▲]

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See detailErythrocyte Sodium-Potassium activities, plasma natriuretic activity, and peripheral vascular resistances during hemodialysis or hemofiltration
Krzesinski, Jean-Marie ULg; Godon, J. P.; Rorive, Georges ULg

in Journal of Clinical Hypertension (1985), 3

The effect of hemodialysis (acetate buffer) or hemofiltration on blood pressure, heart rate, peripheral vascular resistances, red blood cells ionic fluxes, and plasma natriuretic activity has been studied ... [more ▼]

The effect of hemodialysis (acetate buffer) or hemofiltration on blood pressure, heart rate, peripheral vascular resistances, red blood cells ionic fluxes, and plasma natriuretic activity has been studied in six male patients treated for end-stage renal disease. The hemodynamic response to these two modes of treatment markedly differs. Whereas, peripheral resistances increase and heart rate is not affected during hemofiltration , a decrease in blood pressure, tachycardia, and vasodilation is observed during hemodialysis. However , in both therapeutic approaches, red blood cell ouabain-sensitive sodium-potassium pump activity increases in a similar way, and the plasmatic natriuretic activity decreases, whereas the vascular response to norepinephrine is reduced. All of these changes were strongly correlated to the amount of fluid removed. The natriuretic activity may thus play a role in the regulation of blood pressure and hemodynamic adjustments to fluid removal in chronic renal failure between two dialyses, but its action is not predominent during the dialysis session itself. [less ▲]

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See detailThe Erythrocyte/Brain Glucose Transporter (Glut1) May Adopt A Two-Channel Transmembrane Alpha/Beta Structure.
Ducarme, P.; Rahman, M.; Lins, Laurence ULg et al

in Journal of Molecular Modeling (1996), 2(2), 27-45

There are two models of topology for the membrane domains of the erythrocyte/brain facilitative glucose transporter, GLUT1. The first is composed of 12 membrane-spanning a-helices, the second of 16 ... [more ▼]

There are two models of topology for the membrane domains of the erythrocyte/brain facilitative glucose transporter, GLUT1. The first is composed of 12 membrane-spanning a-helices, the second of 16 membrane-spanning b-strands. We have used Jähnig’s and Eisenberg’s methods to identify possible transmembrane segments (10 spanning a-helices and 4 b-strands). The topology proposed is more consistent with available experimental data from FTIR, CD and mapping experiment than the previous models . We suggest that GLUT1 might form two channels, one of which is responsible for glucose transport. This agrees with the theoretical and experimental arguments. Finally, an analysis of the mutation periodicity and of the mean hydrophobicity for the GLUT family is provided in order to evaluate the packing of the protein in the membrane. Keywords: [less ▲]

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See detailErythromycin time-kill activity on activated sludge
Louvet, Jean-Noël ULg; Heliun, Yannick; Potier, Olivier et al

Conference (2009)

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See detailErythromycin toxicity on activated sludge
Louvet, Jean-Noël ULg; Giammarino, Cinzia; Potier, Olivier et al

Conference (2009, March 12)

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See detailL’érythropoïèse tardive : une mort avortée ?
Courtois, Geneviève; Vandekerchove, julie; Dussiot, Michael et al

in Hématologie (2007), 13(6), 400-408

La survie et la prolifération des progéniteurs et précurseurs érythroïdes se trouvent sous le contrôle de l’érythropoïétine (Epo), qui est le principal régulateur de l’érythropoïèse. La différenciation ... [more ▼]

La survie et la prolifération des progéniteurs et précurseurs érythroïdes se trouvent sous le contrôle de l’érythropoïétine (Epo), qui est le principal régulateur de l’érythropoïèse. La différenciation érythroïde s’effectue sous la dépendance du facteur de transcription GATA-1 qui active l’expression des gènes de différenciation et de survie. La production des globules rouges est finement régulée par l’inhibition ou au contraire par l’induction de l’apoptose des progéniteurs et des précurseurs érythroïdes. La baisse du taux d’Epo circulante ou l’induction de la voie Fas aboutissent à l’activation de la caspase-3 qui entraîne la protéolyse de GATA-1, l’arrêt de maturation et l’apoptose des érythroblastes immatures. Nous avons montré qu’une activation transitoire de la caspase-3 par la voie mitochondriale est indispensable à la maturation érythroïde. Dans ce contexte, la protéine chaperonne hsp70 joue un rôle majeur en protégeant GATA-1 du clivage par la caspase-3. La différenciation terminale est caractérisée par une réduction progressive du volume cellulaire et du noyau associée à une condensation de la chromatine. Ces changements morphologiques présentent certaines similitudes avec ceux observés dans les cellules en cours d’apoptose. L’énucléation s’effectue ensuite au sein d’îlots érythroblastiques constitués d’un macrophage central étroitement associé par des molécules d’adhérence à des érythroblastes en cours de maturation. La membrane de l’érythroblaste perd progressivement son affinité pour le macrophage alors que le noyau reste fixé, ce qui permet l’énucléation et la phagocytose du noyau par le macrophage. Les réticulocytes ainsi formés vont compléter leur maturation en perdant leurs organelles et en remodelant leur membrane. Nos études suggèrent que le devenir des précurseurs érythroïdes (apoptose versus différenciation) est déterminé par le choix des cibles clivées par les caspases. Si la fonction du clivage de certaines protéines telles que la lamine B ou acinus est bien connue, l’identité et la fonction des autres cibles clivées par les caspases au cours de la maturation terminale restent à déterminer. [less ▲]

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See detailErythropoiesis
Beguin, Yves ULg

in Gasche, C. (Ed.) Anemia in inflammatory bowel disease (2008)

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See detailErythropoiesis after nonmyeloablative stem-cell transplantation is not impaired by inadequate erythropoietin production as observed after conventional allogeneic transplantation.
Baron, Frédéric ULg; Fillet, Georges ULg; Beguin, Yves ULg

in Transplantation (2002), 74(12), 1692-6

BACKGROUND: It is now well established that after conventional allogeneic hematopoietic stem-cell transplantation (HSCT), erythropoietic recovery is impaired because erythropoietin (Epo) production ... [more ▼]

BACKGROUND: It is now well established that after conventional allogeneic hematopoietic stem-cell transplantation (HSCT), erythropoietic recovery is impaired because erythropoietin (Epo) production remains inadequate for prolonged periods of time. However, erythropoietic reconstitution after nonmyeloablative SCT (NMSCT) has never been characterized. METHODS: Twelve patients received a nonmyeloablative conditioning regimen consisting of 2 Gy total body irradiation (TBI) alone (n=6), 2 Gy TBI and fludarabine (n=3), or cyclophosphamide and fludarabine (n=3), followed by transplantation of allogeneic peripheral blood stem cells. Graft-versus-host-disease (GvHD) prophylaxis was carried out with mycophenolate mofetil (from day -1 to day 28) plus cyclosporine (from day -1 to day 120 or longer in case of chronic GvHD). Erythropoiesis was quantitated by soluble transferrin receptor (sTfR) levels, and the adequacy of Epo production was evaluated by the observed-to-predicted Epo ratio (O/P Epo). RESULTS: Mean sTfR levels decreased following the conditioning regimen but remained well within the normal range throughout the posttransplant period. The O/P Epo ratio presented an initial surge quite similar to that observed after conventional conditioning. Thereafter, the O/P Epo ratio normalized rapidly, and Epo levels remained adequate during the whole observation period. CONCLUSION: Contrarily to what is observed after myeloablative transplant, Epo levels remained adequate after NMSCT, resulting in normal erythropoiesis. These results suggest that the administration of erythropoietin therapy (rHuEpo) could be less effective after NMSCT than after conventional allogeneic transplant. [less ▲]

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See detailErythropoiesis and erythropoietin in multiple myeloma.
Beguin, Yves ULg

in Leukemia & Lymphoma (1995), 18(5-6), 413-21

In this review, the pathophysiology and treatment of the anemia of multiple myeloma will be examined. While the anemia of cancer has multiple causes, an important component is labeled the "anemia of ... [more ▼]

In this review, the pathophysiology and treatment of the anemia of multiple myeloma will be examined. While the anemia of cancer has multiple causes, an important component is labeled the "anemia of chronic disease" which is characterized by the combination of a shortened erythrocyte survival with failure of the bone marrow to increase red cell production in compensation. Depressed erythropoiesis is itself related to a combination of factors, including impaired availability of storage iron, inadequate erythropoietin response to anemia, and overproduction of cytokines which are capable of inhibiting erythropoiesis. These cytokines are involved in the retention of iron in the reticuloendothelial system, gastrointestinal tract and hepatocytes, may interfere with erythropoietin production by the kidney, and may exert direct inhibitory effects on erythroid precursors. While overproduction of several such cytokines, including IL-6, IL-1 and TNF-alpha, has been definitely demonstrated in multiple myeloma patients, it is still unclear whether they are directly involved in the pathogenesis of the anemia which develops. Although several mechanisms, such as hemodilution, bleeding, and decreased red cell survival operate, the anemia is mostly caused by defective erythropoietic activity. This in turn is partly explained by inadequate erythropoietin (Epo) production even in some patients without renal impairment. Based on measurements of serum erythropoietin and transferrin receptor, the distinction between marrow unresponsiveness to normal Epo stimulation and deficient Epo production is important for the treatment of the anemia of multiple myeloma with recombinant human Epo. Higher doses would probably be necessary if adequate Epo production is present, whereas only replacement therapy with lower doses may be sufficient when Epo production has been shown to be inappropriate. [less ▲]

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See detailErythropoiesis and renal transplant pregnancy.
Magee, L. A.; von Dadelszen, P.; Darley, J. et al

in Clinical Transplantation (2000), 14(2), 127-35

OBJECTIVE: To examine erythropoiesis in renal transplant pregnancies. METHODS: Retrospective cohort study of 30 renal transplant cases and 30 age, smoking and parity-matched healthy controls with normal ... [more ▼]

OBJECTIVE: To examine erythropoiesis in renal transplant pregnancies. METHODS: Retrospective cohort study of 30 renal transplant cases and 30 age, smoking and parity-matched healthy controls with normal index pregnancy. Retrospective chart review and assay of frozen antenatal serum (for serum erythropoietin concentration [serum EPO]), transferrin receptor protein [TfR], ferritin, folate and B12) were performed. The linear regression equation for normal pregnancy controls was used to calculate predicted [serum EPO] and the observed/predicted (O/P) log [serum EPO] was plotted. The relationship between [serum EPO] and haemoglobin (Hb) among transplant cases was considered to be different from that among controls if the slope of the O/P log [serum EPO] versus Hb regression was significantly different from zero. RESULTS: The transplant (14 cadaveric) to conception interval was (median [range]) 33.5 [4, 189] months. Immunosuppressants were azathioprine (n = 25), cyclosporine (n = 22) and/or prednisone (n = 25). Cases were more often primiparous (20 vs. 7 [controls]; p = 0.01), had pre-existent hypertension (20 vs. 0 [controls]; p < 0.001), developed new/increased hypertension or pre-eclampsia (28 vs. 0 [controls]; p < 0.001) and an antenatal rise in creatinine (14 vs. 2 [controls]; p < 0.001). In early pregnancy, cases had similar EPO (15.2 [2.6, 84.6] vs. 15.7 [6.4, 41.0] [controls] U/L) but lower Hb (101 [65, 129] vs. 116 [106, 150] g/L; p < 0.001). Twenty-two (73%) cases had Hb < 100 g/L (vs. 4 [controls]; p < 0.0001); Hb was comparable at 6 wk postpartum. With advancing gestational age (GA), Hb remained stable and serum EPO increased in both groups. The slope of the O/P log [serum EPO] versus Hb for transplant cases was significantly different from zero within both the 17-28 wk (slope +/- SEM: 0.010 +/- 0.002; p < 0.0001) and the 29-42 wk GA categories (0.006 +/- 0.003; p = 0.02). Cases showed smaller rises in serum TfR (change 481 [- 1471, 2780]) vs. 1119 [- 698, 4195] [controls] ng/mL; p = 0.005). CONCLUSIONS: Anaemia frequently complicates renal transplant pregnancies, in which serum EPO is inappropriately low and the rate of erythropoiesis blunted. [less ▲]

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See detailErythropoiesis in acromegaly : effect of GH or IGF-1 ? Data from the LAS (Liege Acromegaly Survey)
PETROSSIANS, Patrick ULg; Zacharieva, S; Chanson, P et al

in Journal für Klinische Endokrinologie und Stoffwechsel (2012, September), 5(3), 45

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