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See detailEN1198-5 training : computation examples
Cerfontaine, Benjamin ULg

Conference given outside the academic context (2011)

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See detailEnabling Access to Diverse Bioactive Molecules Through Enyne Metathesis Concepts
Dragutan, Ileana; Dragutan, Valerian; Demonceau, Albert ULg et al

in Current Organic Chemistry (2013), 17(22), 2678-2720

This paper surveys recent advances in valorization of transition-metal-catalyzed enyne metathesis as key events in the total synthesis of naturally occurring compounds of biological and medicinal ... [more ▼]

This paper surveys recent advances in valorization of transition-metal-catalyzed enyne metathesis as key events in the total synthesis of naturally occurring compounds of biological and medicinal importance. Special attention is devoted to methodologies based on dienyne ring-closing metathesis (RCM) applied in tandem and sequential processes, on relay ring-closing metathesis (RRCM), ring-rearrangement metathesis (RRM), enyne cross-metathesis (CM) and enyne skeletal bond reorganization, all proceeding under metalcarbenes (Ru or Mo alkylidenes) or metal-salts (Pd or Pt) catalysis. The high potential of these procedures in constructing versatile scaffolds as essential structural cores of a diversity of bioactive natural products is highlighted. Inventive functionalizations by non-metathesis transformations intervening in the total synthesis of the targeted natural compounds, prior to (Michael addition, Wittig olefination, allylation etc.) or after (Diels-Alder cycloaddion, Heck and Suzuki-Miyaura reactions, Dess-Martin oxidation, dihydroxylation, epoxidation etc.) the pivotal metathesis step have also been included. [less ▲]

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See detailEnacting political games in organizational transformation projects: panoptic vs polyphonic styles of management
Pichault, François ULg

Conference (2011, July)

Resistance to change and micro-politics around change processes have been studied by many social scientists. In the managerial field, numerous authors plead for the adoption of participative methods in ... [more ▼]

Resistance to change and micro-politics around change processes have been studied by many social scientists. In the managerial field, numerous authors plead for the adoption of participative methods in order to overcome such phenomena but few of them seriously document the way in which the so-called “human factor” may be really taken into consideration in the management of change projects. Is there a direct relation between the managerial ability to cope with power games and the final results of a change project? Does a participatory strategy necessarily lead to a successful change? What are the conditions under which the enactment of micropolitics may contribute to an effective organizational transformation? We will here focus on change processes occurring in the public sphere: the NPM school of thought led to a large range of organizational reforms in which the civil servants’ engagement and motivation appear to play a crucial role. Our research questions will be discussed through the presentation of two cases studies of Belgian public organizations concerned with the implementation of an electronic document management system (DMS). The first case is located in the Federal Police department while the second occurs in a regional administration. Both are issued from action-researches undertaken with my research team during the last decade. They have been selected in order to contrast the different ways in which power games and end-users resistances may be enacted by senior management. They will help us to distinguish two management styles and to explore their respective impact on the change process itself. [less ▲]

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See detailEnantiomer separation of N-protected amino acids by non-aqueous capillary electrophoresis and high-performance liquid chromatography with tert.-butyl carbamoylated quinine in either the background electrolyte or the stationary phase
Piette, Véronique; Lammerhofer, M.; Lindner, W. et al

in Journal of Chromatography. A (2003), 987(1-2), 421-427

A non-aqueous CE method was developed for evaluating the chiral discrimination potential of cinchona alkaloids and different kinds of carbamoylated derivatives of quinine and quinidine type chiral ... [more ▼]

A non-aqueous CE method was developed for evaluating the chiral discrimination potential of cinchona alkaloids and different kinds of carbamoylated derivatives of quinine and quinidine type chiral selectors towards acidic analytes, in particular a series of various Bz (benzoyl), DNB (3,5-dinitrobenzoyl) and DNZ (3,5-dinitrobenzyloxycarbonyl) amino acid derivatives. In this study, the enantioselectivity values obtained in non-aqueous CE with tert-butyl carbamoylated quinine as chiral additive have been compared with the values found for the same series of selectands in HPLC using the same selector immobilized onto silica as chiral stationary phase. Similarly to the background electrolyte used in CE an ethanol-methanol mixture (60:40, v/v) containing 100 mM octanoic acid and 12.5 mM ammonia has been selected as HPLC mobile phase. Under these conditions, a good correlation (r=0.954) between the enantioselectivities observed with the two techniques has been obtained. Thus the non-aqueous CE method can be applied as a screening tool for the rapid evaluation of the chiral discrimination potential of a large set of newly developed chiral selectors derived from quinine and related alkaloids. (C) 2002 Elsevier Science B.V. All rights reserved. [less ▲]

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See detailEnantiomeric separation of acidic and basic drugs by capillary electrophoresis using neutral and anionic cyclodextrins
Fillet, Marianne ULg; Bechet, I.; Schomburg, G. et al

in Journal de Pharmacie de Belgique (1996), 51

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See detailEnantiomeric separation of acidic compounds using single-isomer amino cyclodextrin derivatives in nonaqueous capillary electrophoresis
Fradi, Inès; Servais, Anne-Catherine ULg; Pedrini, Matteo et al

in Electrophoresis (2006), 27(17), 3434-3442

The enantiomeric separation of a series of acidic pharmaceuticals (mostly nonsteroidal anti-inflammatory drugs) has been investigated in NACE systems using single-isomer amino beta-CD derivatives. The ... [more ▼]

The enantiomeric separation of a series of acidic pharmaceuticals (mostly nonsteroidal anti-inflammatory drugs) has been investigated in NACE systems using single-isomer amino beta-CD derivatives. The first part of this study consisted of the selection of the basic experimental conditions to separate efficiently the enantiomers of acidic drugs. Several parameters, such as the nature of the ionic BGE components, were studied and a methanolic solution of ammonium acetate containing the cationic CD was selected as BGE. A D-optimal design with 20 experimental points was then applied and the nature and concentration of the CD were found to have a significant effect on the enantiomeric resolution for all studied compounds. Resolution (R(s)) values were always higher with 6-monodeoxy-6-mono(3-hydroxy)propylamino-beta-CD (PA-beta-CD) compared to those obtained with 6-monodeoxy-6-mono(2-hydroxy)propylamino-beta-CD (IPA-beta-CD). However, the latter led to shorter migration times. Generic NACE conditions were then selected by means of the multivariate approach in order to obtain the highest R(s) values in a minimum amount of time. Finally, dependence of separation selectivity, resolution, as well as mobility difference on chiral selector concentration was discussed and binding constants with PA-beta-CD were estimated for the two enantiomers of one of the model compounds, suprofen in these NACE systems. [less ▲]

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See detailEnantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives.
Piette, Véronique; Fillet, Marianne ULg; Lindner, W. et al

in Biomedical Chromatography : BMC (2000), 14(1), 19-21

Enantiomeric separation of amino acid derivatives by non-aqueous capillary electrophoresis using quinine and related compounds as chiral additives.

Detailed reference viewed: 16 (0 ULg)