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See detailDonner un sens aux données: Le cas de la modélisation de l'information archéologique du site de calakmul (Mexico)
Van Ruymbeke, Muriel ULg; Cervera - Xicotencatl, Ari; Billen, Roland ULg et al

Conference (2011, April 13)

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See detailDonor Advocacy with Special Reference to Belgium
SQUIFFLET, Jean-Paul ULg

in Transplantation Proceedings (2011), 43

Before any published Belgian law, EU Directive, and/or EU Action Plan, the donor <br />advocate was naturally a member of the transplantation team performing living kidney <br />donation. The need of ... [more ▼]

Before any published Belgian law, EU Directive, and/or EU Action Plan, the donor <br />advocate was naturally a member of the transplantation team performing living kidney <br />donation. The need of donor advocacy appeared obvious with liver living donation, which <br />was and is still a risky procedure. Today, it is clear that the donor advocacy must not be <br />limited to living donation but extended to brain-dead and cardiac-dead donation. <br />Nevertheless, its complexity will need experienced persons in the field of organ donation <br />as well as transplantation, while remembering that patients’ first right is the right to donate. [less ▲]

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See detailDonor age as a risk factor in donation after circulatory death liver transplantation in a controlled withdrawal protocol programme.
DETRY, Olivier ULg; DE ROOVER, Arnaud ULg; MEURISSE, Nicolas ULg et al

in The British journal of surgery (2014), 10(7), 784-792

BACKGROUND: Results of donation after circulatory death (DCD) liver transplantation are impaired by graft loss, resulting mainly from non-anastomotic biliary stricture. Donor age is a risk factor in ... [more ▼]

BACKGROUND: Results of donation after circulatory death (DCD) liver transplantation are impaired by graft loss, resulting mainly from non-anastomotic biliary stricture. Donor age is a risk factor in deceased donor liver transplantation, and particularly in DCD liver transplantation. At the authors' institute, age is not an absolute exclusion criterion for discarding DCD liver grafts, DCD donors receive comfort therapy before withdrawal, and cold ischaemia is minimized. METHODS: All consecutive DCD liver transplantations performed from 2003 to 2012 were studied retrospectively. Three age groups were compared in terms of donor and recipient demographics, procurement and transplantation conditions, peak laboratory values during the first post-transplant 72 h, and results at 1 and 3 years. RESULTS: A total of 70 DCD liver transplants were performed, including 32 liver grafts from donors aged 55 years or less, 20 aged 56-69 years, and 18 aged 70 years or more. The overall graft survival rate at 1 month, 1 and 3 years was 99, 91 and 72 per cent respectively, with no graft lost secondary to non-anastomotic stricture. No difference other than age was noted between the three groups for donor or recipient characteristics, or procurement conditions. No primary non-function occurred, but one patient needed retransplantation for artery thrombosis. Biliary complications were similar in the three groups. Graft and patient survival rates were no different at 1 and 3 years between the three groups (P = 0.605). CONCLUSION: Results for DCD liver transplantation from younger and older donors were similar. Donor age above 50 years should not be a contraindication to DCD liver transplantation if other donor risk factors (such as warm and cold ischaemia time) are minimized. [less ▲]

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See detailDonor Age in Liver Transplantation: Donation after Circulatory Death.
DETRY, Olivier ULg

in Journal of the American College of Surgeons (2015), 221(3), 779

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See detailDonor and stem cell source selection
BAUDOUX, Etienne ULg

Learning material (2012)

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See detailDonor lymphocyte infusion to eradicate recurrent host hematopoiesis after allogeneic BMT for sickle cell disease.
Baron, Frédéric ULg; Dresse, Marie-Françoise ULg; Beguin, Yves ULg

in Transfusion (2000), 40(9), 1071-3

BACKGROUND: Donor lymphocyte infusion (DLI) is currently standard therapy for relapse of malignancies after allogeneic BMT. Several observations suggest that both normal and leukemic progenitor cells of ... [more ▼]

BACKGROUND: Donor lymphocyte infusion (DLI) is currently standard therapy for relapse of malignancies after allogeneic BMT. Several observations suggest that both normal and leukemic progenitor cells of host origin constitute effective target cells for donor-derived lymphocytes. To prevent relapse of sickle cell disease (SCD), a child with evidence of decreasing mixed chimerism received DLIs 8 months after allogeneic BMT for SCD. CASE REPORT: A 4-year-old child who was homozygous for SCD underwent a transplantation of bone marrow from his fully HLA-matched sister. Routine detection of sex chromosomes in bone marrow cells evidenced decreasing mixed chimerism, which heralded a probably imminent recurrence of the disease. The patient received two DLIs in graded incremental doses on Days 234 and 267. One month later, he developed grade 2 acute GVHD that responded well to corticosteroids and cyclosporine. RESULTS: DLI resulted in complete donor chimerism within 2 months of the second infusion. Now, 2 years after the second DLI, the patient is in excellent condition, with normal Hb and excellent growth and development. CONCLUSION: This is the first report of successful use of DLI in a patient with probable imminent SCD recurrence after allogeneic BMT. It shows that DLI can displace residual host HPCs in case of recurrence of nonmalignant disease after allogeneic BMT. [less ▲]

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See detailA donor-acceptor substrate of the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61
Zeiger, Allen R; Frère, Jean-Marie ULg; Ghuysen, Jean-Marie ULg et al

in FEBS Letters (1975), 52(2), 221-225

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See detailDe dood van Kain in de Engelsche mysteriespelen van Coventry
Hamélius, Paul ULg

in Volkskunde (1903), 15(3-4), 49-59

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See detailDopa-responsive parkinsonism after acute subdural hematoma.
MAERTENS DE NOORDHOUT, Alain ULg; DAENEN, Frédéric ULg; Bex, Vincent

in European Journal of Neurology (2006), 13(7), 10-1

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See detailLe dopage en cyclisme sur route : un objet d’étude criminologique
Fincoeur, Bertrand ULg

in Guedah, Mohammed (Ed.) Délinquances et changements sociaux des modes de vie et des pratiques d'intervention (2009)

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See detailLe dopage en cyclisme sur route: un objet d'étude criminologique
Fincoeur, Bertrand ULg

Conference (2008, May 11)

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See detailLe dopage
Kaux, Jean-François ULg

Learning material (2015)

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See detailDopamine 'D2-like' receptor agonists in combination with cocaine: absence of interactive effects on locomotor activity.
Tirelli, Ezio ULg; Reggers, Jean ULg; Terry, P.

in Behavioural Pharmacology (1997), 8(2-3), 147-59

This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in ... [more ▼]

This study examined interactions between cocaine and drugs that act as direct agonists at subtypes of "D2-like" dopamine receptors. The drugs 7-OH-DPAT, quinpirole and RU24213 were studied alone and in combination with cocaine for their effects on locomotor activity in non-habituated mice. Locomotor activity was measured by photobeam crossings over 140 min. At the doses given (7-OH-DPAT: 0.006-6.4 mg/kg; quinpirole: 0.001-1 mg/kg; RU24213: 0.008-8 mg/kg) all three direct agonists dose-dependently reduced locomotor activity throughout the test, whereas cocaine (0.6-20 mg/kg) produced dose-related hyperactivity. Next, for each direct agonist, a series of doses was selected (up to threshold behaviourally-active doses) as pretreatments to a sub-maximally stimulant dose of cocaine (15 mg/kg). 7-OH-DPAT and quinpirole did not modulate the effects of cocaine; RU24213 produced, at best, a very modest attenuation of the effects of cocaine. Finally, a series of cocaine doses (below stimulant threshold) was given before a single dose of each direct agonist (the lowest dose to reduce activity significantly). Cocaine did not reliably alter the hypoactivity produced by any of the D2-like agonists. By demonstrating negligible interactions between cocaine and D2-like agonists, the results fail to demonstrate any necessary involvement of D2-like receptors in one of the behavioural effects of cocaine. [less ▲]

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See detailDopamine activates noradrenergic receptors in the preoptic area
Cornil, Charlotte ULg; Balthazart, Jacques ULg; Motte, Patrick ULg et al

in Journal of Neuroscience (2002), 22(21), 9320-9330

Dopamine (DA) facilitates male sexual behavior and modulates aromatase activity in the quail preoptic area (POA). Aromatase neurons in the POA receive dopaminergic inputs, but the anatomical substrate ... [more ▼]

Dopamine (DA) facilitates male sexual behavior and modulates aromatase activity in the quail preoptic area (POA). Aromatase neurons in the POA receive dopaminergic inputs, but the anatomical substrate that mediates the behavioral and endocrine effects of DA is poorly understood. Intracellular recordings showed that 100 muM DA hyperpolarizes most neurons in the medial preoptic nucleus (80%) by a direct effect, but depolarizes a few others (10%). DA-induced hyperpolarizations were not blocked by D1 or D2 antagonists (SCH-23390 and sulpiride). Extracellular recordings confirmed that DA inhibits the firing of most cells (52%) but excites a few others (24%). These effects also were not affected by DA antagonists (SCH-23390 and sulpiride) but were blocked by alpha(2)-(yohimbine) and alpha(1)-(prazosin) noradrenergic receptor antagonists, respectively. Two dopamine-beta-hydroxylase (DBH) inhibitors (cysteine and fusaric acid) did not block the DA-induced effects, indicating that DA is not converted into norepinephrine (NE) to produce its effects. The pK(B) of yohimbine for the receptor involved in the DA- and NE-induced inhibitions was similar, indicating that the two monoamines interact with the same receptor. Together, these results demonstrate that the effects of DA in the POA are mediated mostly by the activation of alpha(2) (inhibition) and alpha(1) (excitation) adrenoreceptors. This may explain why DA affects the expression of male sexual behavior through its action in the POA, which contains high densities of alpha(2)-noradrenergic but limited amounts of DA receptors. This study thus clearly demonstrates the existence of a cross talk within CNS catecholaminergic systems between a neurotransmitter and heterologous receptors. [less ▲]

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See detailDopamine and Dobutamine in the treatment of low cardiac output and hypotension
CREMERS, S; EL ALLAF, D; D'Orio, Vincenzo ULg et al

Conference (1982)

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See detailDopamine and Migraine: A Review of Pharmacological, Biochemical, Neurophysiological, and Therapeutic Data
Mascia, A.; Afra, J.; Schoenen, Jean ULg

in Cephalalgia : An International Journal of Headache (1998), 18(4), 174-82

The dopamine theory of migraine pathogenesis, first proposed by F. Sicuteri in 1977, has attracted renewed interest after an increased frequency of the dopamine D2 receptor (DRD2) gene allele NcoI C was ... [more ▼]

The dopamine theory of migraine pathogenesis, first proposed by F. Sicuteri in 1977, has attracted renewed interest after an increased frequency of the dopamine D2 receptor (DRD2) gene allele NcoI C was found in patients with migraine with aura. [less ▲]

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