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See detailEpithelial metaplasia: an inadequate environment for antitumour immunity?
Delvenne, Philippe ULg; Hubert, Pascale ULg; Jacobs, Nathalie ULg

in Trends in Immunology (2004), 25(4), 169-73

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See detailEpithelial supporting cells can differentiate into outer hair cells and Deiters' cells in the cultured organ of Corti
Malgrange, Brigitte ULg; Thiry, Marc ULg; Van De Water, Thomas R. et al

in Cellular and Molecular Life Sciences : CMLS (2002), 59(10), 1744-1757

The organ of Corti is a complex structure containing a single row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs), supported respectively by one row of inner phalangeal cells and ... [more ▼]

The organ of Corti is a complex structure containing a single row of inner hair cells (IHCs) and three rows of outer hair cells (OHCs), supported respectively by one row of inner phalangeal cells and three rows of Deiters' cells. When fetal rat organ of Corti explants are cultured, supernumerary OHCs and supernumerary Deiters' cells are produced, without any additional cell proliferation. Analysis of semi- and ultrathin sections revealed that supernumerary OHCs are produced at the distal edge of the organ of Corti. Quantitative analysis of cell types present in the organ of Corti demonstrates that when the number of OHCs increases: (i) the total number of cells remains constant; (ii) the number of Deiters' cells increases; (iii) the number of tectal cells decreases and of Hensen's cells decreases. Using specific HC markers, i.e. jagged2 (Jag2) and Math1, we showed that in addition to existing OHCs, supernumerary OHCs, tectal cells and Hensen's cells expressed these markers in embryonic day 19 organ of Corti explants after 5 days in vitro. The results of this study suggest that Hensen's cells retain the capacity to differentiate into either tectal cells, which differentiate into OHCs, or into undertectal cells which differentiate into Deiters' cells. [less ▲]

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See detailEpithelial-mesenchymal transition process in human embryonic stem cells cultured in feeder-free conditions.
Ullmann, U.; In'T Veld, P.; Gilles, Christine ULg et al

in Molecular Human Reproduction (2007), 13(1), 21-32

Feeder-free human embryonic stem cell (hESC) culture is associated with the presence of mesenchymal-like cells appearing at the periphery of the colonies. The aim of this study was to identify this early ... [more ▼]

Feeder-free human embryonic stem cell (hESC) culture is associated with the presence of mesenchymal-like cells appearing at the periphery of the colonies. The aim of this study was to identify this early differentiation process. Long-term feeder-free hESC cultures using matrigel and conditioned medium from mouse and from human origin revealed that the appearance of mesenchymal-like cells was similar regardless of the conditioned medium used. Standard characterization confirmed the preservation of hESC properties, but the feeder-free cultures could not be maintained longer than 37 passages. The early differentiation process was characterized in the short term after switching hESCs cultured on feeders to feeder-free conditions. Transmission electron microscopy showed an epithelium-like structure inside the hESC colonies, whereas the peripheral cells revealed the acquisition of a rather mesenchymal-like phenotype. Immunochemistry analysis showed that cells at the periphery of the colonies had a negative E-cadherin expression and a positive Vimentin expression, suggesting an epithelial–mesenchymal transition (EMT). Nuclear staining of ß-catenin, positive N-cadherin and negative Connexin 43 expression were also found in the mesenchymal-like cell population. After RT–PCR analysis, Slug and Snail, both EMT-related transcription factors, were detected as up-regulated in the mesenchymal-like cell population. Taken together, our data suggest that culturing hESCs in feeder-free conditions enhances an early differentiation process identified as an EMT. [less ▲]

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See detailEpithelial-to-Mesenchymal Transition in Hpv-33-Transfected Cervical Keratinocytes Is Associated with Increased Invasiveness and Expression of Gelatinase A
Gilles, Christine ULg; Polette, M.; Piette, Jacques ULg et al

in International Journal of Cancer = Journal International du Cancer (1994), 59(5), 661-6

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on ... [more ▼]

The invasive potential of a set of HPV-33- and HPV-33 + ras-transfected cervical keratinocytes was investigated. These cell lines were previously separated into 2 groups according to their behavior on collagen rafts. Cell lines from the first group reconstituted CINIII-like lesions, whereas cell lines from the second group reconstituted epithelia comparable to micro-invasive carcinomas. They were thus postulated to represent distinct stages of cervical carcinogenesis. The present results have shown that lines from group I, which have conserved an epithelial morphology in monolayer, (i) could not invade matrigel when tested in a modified Boyden chamber assay, (ii) produced solely gelatinase B and (iii) were unable to activate exogenous gelatinase A. On the other hand, lines from group II associated epithelial-to-mesenchymal transition (acquisition of elongated morphology, vimentin positivity) with high in vitro invasive potential and with the ability both to produce and to activate gelatinase A. These results strongly support the hypothesis that the epithelial-to-mesenchymal transition and the associated events might be implicated in the progression to the metastatic phenotype. [less ▲]

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See detailEpithelial-to-mesenchymal transitions and circulating tumor cells.
Bonnomet, A.; Brysse, Anne ULg; Tachsidis, A. et al

in Journal of Mammary Gland Biology & Neoplasia (2010), 15(2), 261-73

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological ... [more ▼]

Epithelial-to-mesenchymal transition (EMT) phenomena endow epithelial cells with enhanced migratory and invasive potential, and as such, have been implicated in many physiological and pathological processes requiring cell migration/invasion. Although their involvement in the metastatic cascade is still a subject of debate, data are accumulating to demonstrate the existence of EMT phenotypes in primary human tumors, describe enhanced metastatic potential of EMT derivatives in animal models, and report EMT attributes in circulating tumor cells (CTCs). The relationships between EMT and CTCs remain largely unexplored, and we review here in vitro and in vivo data supporting a putative role of EMT processes in CTC generation and survival. [less ▲]

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See detailEpithelio-mesenchymal interface and fibronectin in the differentiation of the rat mesonephric and paramesonephric ducts.
Paranko, J.; Pelliniemi, L. J.; Foidart, Jean-Michel ULg

in Differentiation : Research in Biological Diversity (1984), 27(3), 196-204

The distribution of fibronectin and the morphological differentiation of the genital ducts was studied in rat fetuses at ages from 15 to 21 days. Fibronectin was localized with the peroxidase ... [more ▼]

The distribution of fibronectin and the morphological differentiation of the genital ducts was studied in rat fetuses at ages from 15 to 21 days. Fibronectin was localized with the peroxidase-antiperoxidase and avidin-biotin method at the electron- and light-microscope level. In 15-day-old male and female fetuses, fibronectin was localized as a continuous lamella around the mesonephric duct and as a discontinuous lamella around the paramesonephric duct. During the differentiation of the female paramesonephric duct, the fibronectin layer became continuous and remained so after the age of 16 days. The fibronectin layer of the male mesonephric duct remained continuous at all ages. The accumulation of mesenchymal cells on the outer surface of the female mesonephric duct and the concomitant detachment of the fibronectin layer around the duct suggests that mesenchymal regulation plays a role in the regression of the mesonephric duct. In the regressing male paramesonephric duct fibronectin was simultaneously lost in the condensed periductal mesenchyme, the places of epithelio-mesenchymal contact, and the epithelial cytoplasmic protrusions towards the mesenchyme. Ultrastructurally, fibronectin was localized in the basal laminae, on the cell membrane in contact with the extracellular material, and on the surface of the fibrillar and flocculent extracellular material. In addition to auto- and heterophagy, epithelio-mesenchymal interactions seem to play an important role in the regression of the genital ducts, although in different ways in males and females. The present results give additional support to the theory of the possible migration of epithelial cells into the surrounding mesenchyme during the regression of the paramesonephric duct. [less ▲]

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See detailEpithelioid Cell Histiocytoma: A Report of Two Cases
Dezfoulian, Bita ULg; Nikkels, Arjen ULg; Pierard-Franchimont, Claudine ULg et al

in Dermatology : International Journal for Clinical & Investigative Dermatology (1995), 190(4), 349-350

Epithelioid cell histiocytoma is a rarely reported tumor derived from factor-XIIIa-positive dermal dendrocytes. Two additional cases are presented including their clinical, histologic and ... [more ▼]

Epithelioid cell histiocytoma is a rarely reported tumor derived from factor-XIIIa-positive dermal dendrocytes. Two additional cases are presented including their clinical, histologic and immunohistochemical features. [less ▲]

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See detailÉpithètes cultuelles et interprétation philosophique. À propos d'Aphrodite Ourania et Pandémos à Athènes
Pirenne-Delforge, Vinciane ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1988), 57

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See detailÉpithètes cultuelles et interprétation philosophique. À propos d'Aphrodite Ourania et Pandémos à Athènes
Pirenne-Delforge, Vinciane ULg

in Antiquité Classique : Revue Interuniversitaire d'Etudes Classiques (1988), 57

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See detailEpitopes of BLV glycoprotein gp51 recognized by sera infected cattle and sheep
Bruck, Claudine; Portetelle, Daniel ULg; Mammerickx, Marc et al

in Leukemia Research (1984), 8

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See detailEpizootic Rabbit Enteropathy
Licois, D.; Coudert; Marlier, Didier ULg

in Maertens, L.; Coudert, P. (Eds.) Recent advances in rabbits sciences (2007)

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See detailEpizootic rabbit enteropathy inoculum (TEC4) antibiograms and antibiotic fractionation
Huybens, Nathalie ULg; Houeix, Julien ULg; Licois, Dominique et al

in Veterinary Research Communications (2011), 35

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See detailEpizootic rabbit enteropathy: Comparison of PCR-based RAPD fingerprints from virulent and non-virulent samples
Huybens, Nathalie ULg; Houeix, Julien ULg; Licois, Dominique et al

in Veterinary Journal (2011), 190(3), 416-417

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See detailEpizootic spread of emerging Schmallenberg virus in wild cervids, Belgium, fall 2011
Linden, Annick ULg; Desmecht, Daniel ULg; Volpe, Rosario ULg et al

in Emerging Infectious Diseases (2012), 18(12), 2006-2008

The Schmallenberg virus emerged in summer-fall 2011 in North-West Europe. During the fall of 2011, the virus widely spread in red and roe deer populations living about 250 km from the emergence location.

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See detailEpizootiologie des infections à herpèsvirus chez les ruminants sauvages. I. Le virus de la rhinotrachéite infectieuse bovine et les virus antigéniquement apparentés.
Thiry, Etienne ULg; Meersschaert, C.; Pastoret, Paul-Pierre ULg

in Revue d'Elévage et de Médecine Vétérinaire des Pays Tropicaux (1988), 41(2), 113-20

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See detailEpizootológia modrého jazyka (Bluetongue) v Európskej únii
Saegerman, Claude ULg; Berkvens, D.; Mellor, P. S.

in Slovak Veterinary Journal (2008), 23(4), 217-220

Zhrnutie. Modrý jazyk (Bluetongue (BT)) je ochorenie podliehajúce hláseniu, ktoré vyvoláva značné socio-ekonomické znepokojenie a je veľmi závažné v súvislosti s medzinárodným obchodom so zvieratami a ... [more ▼]

Zhrnutie. Modrý jazyk (Bluetongue (BT)) je ochorenie podliehajúce hláseniu, ktoré vyvoláva značné socio-ekonomické znepokojenie a je veľmi závažné v súvislosti s medzinárodným obchodom so zvieratami a živočíšnymi produktmi. Pred rokom 1998, sa BT v Európe považoval za exotické ochorenie. Od roku 1998 až do roku 2005, bolo nepretržite prítomných v Stredomorskej kotline najmenej 6 BT vírusových kmeňov, patriacich do 5 sérotypov (BTV-1, BTV-2, BTV-4, BTV-9, a BTV-16). Od augusta 2006, spôsobuje BTV-8 v severnej Európe závažnú epizoóciu BT. Rozsiahle opätovné prepuknutie a rozšírenie infekcií v severnej Európe spôsobených BTV-8 v priebehu roku 2007 poukazuje na to, že požiadavky na etablovanie BTV môžu byť v tejto oblasti teraz splnené. Okrem toho, radiálne rozšírenie BTV-8 v Európe zvyšuje riziko pre stretnutie sa tohto sérotypu s inými sérotypmi, zvlášť tými, ktoré sa vyskytujú v Stredomorskej kotline, kde aktivita vektora trvá väčšinou počas celého roka. Táto okolnosť zvyšuje riziko pre preskupenie (reassortment) jednotlivých segmentov BTV génu. [less ▲]

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See detailEPOCA/EUR-OCEANS data compilation on the biological and biogeochemical responses to ocean acidification
Nisumaa, A.-M.; Pesant, S.; Bellerby, R.G.J. et al

in Earth System Science Data (2010), 2

The uptake of anthropogenic CO2 by the oceans has led to a rise in the oceanic partial pressure of CO2, and to a decrease in pH and carbonate ion concentration. This modification of the marine carbonate ... [more ▼]

The uptake of anthropogenic CO2 by the oceans has led to a rise in the oceanic partial pressure of CO2, and to a decrease in pH and carbonate ion concentration. This modification of the marine carbonate system is referred to as ocean acidification. Numerous papers report the effects of ocean acidification on marine organisms and communities but few have provided details concerning full carbonate chemistry and complementary observations. Additionally, carbonate system variables are often reported in different units, calculated using different sets of dissociation constants and on different pH scales. Hence the direct comparison of experimental results has been problematic and often misleading. The need was identified to (1) gather data on carbonate chemistry, biological and biogeochemical properties, and other ancillary data from published experimental data, (2) transform the information into common framework, and (3) make data freely available. The present paper is the outcome of an effort to integrate ocean carbonate chemistry data from the literature which has been supported by the European Network of Excellence for Ocean Ecosystems Analysis (EUR-OCEANS) and the European Project on Ocean Acidification (EPOCA). A total of 185 papers were identified, 100 contained enough information to readily compute carbonate chemistry variables, and 81 data sets were archived at PANGAEA – The Publishing Network for Geoscientific & Environmental Data. This data compilation is regularly updated as an ongoing mission of EPOCA. Data access: http://doi.pangaea.de/10.1594/PANGAEA.735138 [less ▲]

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