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See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galie, Nazzareno; Humbert, Marc; Vachiery, Jean-Luc et al

in The European respiratory journal (2015), 46(4), 903-75

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management ... [more ▼]

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk-benefit ratio of particular diagnostic or therapeutic means. Guidelines and recommendations should help health professionals to make decisions in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. [less ▲]

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See detail2015 FMA Annual Meeting
Platania, Federico ULg; Lambert, Marie ULg; Moreno, Manuel

Scientific conference (2015, October)

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally ... [more ▼]

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally abandon the project before completion whenever the investment cost turns out to be larger than the expected net cash flow stream. On the other hand, the proposed model accounts for two different sources of uncertainty, those are technical and economic risk. This model incor- porates a novel economic state vector where each economic state captures the interaction among different market and economic forces using Fourier series as the particular basis for the economic function space. In this sense, Fourier series are considered as an aggregate of forces playing a relevant role in the process evolution determining the cash flow structure and also allowing us to properly define an economic scenario where the project will be developed. [less ▲]

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See detail21st century Antarctic surface mass balance downscaling from global circulation models
Agosta, Cécile ULg; Favier, Vincent; Genthon, Christophe et al

Poster (2011, October)

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See detail21st century high-resolution downscaling of the Antarctic surface mass balance from global circulation models
Agosta, Cécile ULg; Favier, Vincent; Genthon, Christophe et al

Conference (2011, April)

Most of the IPCC-AR4 Atmospheric Global Circulation Models (AGCM) predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. Present ... [more ▼]

Most of the IPCC-AR4 Atmospheric Global Circulation Models (AGCM) predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. Present accumulation and predicted change are largest at the ice sheet margins because they are driven by snowfall, which mostly comes from warm, moist air arising over the land slopes. The coastal belt is also where complex processes of sublimation, melt and redistribution by the wind occur. Thus, high-resolution modelling (5 to 10 km) is necessary to adequately capture the effects of small-scale variations in topography on the atmospheric variables in this area, but limitations in computing resources prevent such resolution at the scale of Antarctica in full climate models. We present here a downscaling method leading to 10-km SMB resolution for century time-scales over Antarctica. We compute the effect of the fine topography on orographic precipitation and on boundary layer processes that lead to melt and sublimation. We show that the accumulation downscaled from ERA-Interim is in good agreement with field measurements for the last 40 years. We then display the SMB downscaled from LMDZ4 AGCM outputs (~60-km resolution), and show that the downscaling improves the agreement between present modelled and observed SMB. Finally, we present hi-resolution features of the Antarctic SMB evolution during the 21st century downscaled from LMDZ4 and discuss the effect of the resolution on the Antarctic SMB contribution to sea level change. The downscaling model is a powerful tool that will be applied to others climate models for a better assessment of future sea level rise. [less ▲]

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See detail21st century projections of surface mass balance changes for major drainage systems of the Greenland ice sheet
Tedesco, M.; Fettweis, Xavier ULg

in Environmental Research Letters (2012), 7

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins ... [more ▼]

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins of the Greenland ice sheet (GrIS). The regional model is forced with the outputs of three different Earth System Models (CanESM2, NorESM1 and MIROC5) obtained when considering two greenhouse gas future scenarios with levels of CO2 equivalent of, respectively, 850 and >1370 ppm by 2100. Results indicate that the increase in runoff due to warming will exceed the increased precipitation deriving from the increase in evaporation for all basins, with the amount of net loss of mass at the surface varying spatially. Basins along the southwest and north coast are projected to have the highest sensitivity of SMB to increasing temperatures. For these basins, the global temperature anomaly corresponding to a decrease of the SMB below the 1980–99 average (when the ice sheet was near the equilibrium) ranges between +0.60 and +2.16 °C. For the basins along the northwest and northeast, these values range between +1.50 and +3.40 °C. Our results are conservative as they do not account for ice dynamics and changes in the ice sheet topography. [less ▲]

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See detail22nd Annual Conference of the Multinational Finance Society
Platania, Federico ULg; Lambert, Marie ULg; Moreno, Manuel

Scientific conference (2015)

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See detailThe 24-h recall instrument for home nursing to measure the activity profile of home nurses:development and psychometric testing
De Vliegher, Kristel; Aaertgeerts, Bert; Declercq, Anja et al

in Primary Health Care Research & Development (2014)

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See detail24-hour glucose profiles during continuous or oscillatory insulin infusion. Demonstration of the functional significance of ultradian insulin oscillations.
Sturis, J.; Scheen, André ULg; Leproult, R. et al

in Journal of Clinical Investigation (1995), 95(4), 1464-71

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in ... [more ▼]

Under basal and stimulated conditions, normal insulin secretion oscillates with periods in the ultradian 100-150-min range. To test the hypothesis that oscillatory insulin delivery is more efficient in reducing blood glucose levels than continuous administration, nine normal young men were each studied on two occasions during a 28-h period including a period of polygraphically recorded sleep. Endogenous insulin secretion was suppressed by somatostatin, a constant intravenous glucose infusion was administered, and exogenous insulin was infused either at a constant rate or in a sinusoidal pattern with a period of 120 min. The mean glucose level over the 28-h period was 0.72 +/- 0.31 mmol/liter lower when insulin was infused in an oscillatory pattern than when the rate of infusion was constant (P < 0.05). The greater hypoglycemic effect of oscillatory versus constant infusion was particularly marked during the daytime, with the difference averaging 1.04 +/- 0.38 mmol/liter (P < 0.03). Serum insulin levels tended to be lower during oscillatory than constant infusion, although the same amount of exogenous insulin was administered under both conditions. Ultradian insulin oscillations appear to promote more efficient glucose utilization. [less ▲]

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See detailA 24-month Study Evaluating the Efficacy and Safety of Denosumab for the Treatment of Men With Low Bone Mineral Density: Results From the ADAMO Trial.
Langdahl, Bente L.; Teglbjaerg, Christence S.; Ho, Pei-Ran et al

in The Journal of clinical endocrinology and metabolism (2015), 100(4), 1335-1342

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men ... [more ▼]

Context: One in 4 men in the US aged >50 will suffer an osteoporosis-related fracture. Less data are available on osteoporosis treatment in men than women. Objective: Evaluate denosumab therapy in men with low BMD. Design: Phase 3 study with two treatment periods: a previously reported 12-month double-blind, placebo-controlled phase and a 12-month open-label phase. Setting: Multicenter in North America and Europe. Participants: 228 men entered the open-label phase and 219 completed the study. Intervention: Men from the original denosumab (long-term) and placebo (crossover) groups received denosumab 60 mg SC every 6 months. Main Outcome Measures: BMD, serum C-telopeptide (sCTX), and safety. Results: During the open-label phase, continued BMD increases occurred with long-term denosumab treatment (2.2% lumbar spine; 0.9% total hip; 1.3% femoral neck; 1.3% trochanter; and 0.2% 1/3 radius), resulting in cumulative 24-month gains from baseline of 8.0%, 3.4%, 3.4%, 4.6%, and 0.7%, respectively (all P<0.01). The crossover group showed BMD gains after 12 months of denosumab treatment similar to the long-term denosumab group during the first treatment year. Significant reductions in sCTX were observed following denosumab administration. Adverse events rates were similar between groups and no new safety signals identified. Conclusions: In men with low BMD, denosumab treatment for a second year continued to increase BMD, maintained reductions in bone resorption, and was well tolerated. BMD increased in men initiating denosumab during the second year. These effects were similar to those previously seen in postmenopausal women with osteoporosis and men with prostate cancer on androgen deprivation therapy. [less ▲]

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See detailThe 24th Chapter of the Tattvasamgraha : Refutation of the Mîmâmsâ Doctrine of Vedapaurusheyatva
Verpoorten, Jean-Marie ULg

in Dwivedi, R.C. (Ed.) Studies in Mîmâmsâ.Dr.Mandan Mishra Felicitation Volume (1994)

Ce chapitre de 725 strophes a été écrit par Śāntarakṣita (725-783 de n.è.) et commenté par son élève Kamalaśīla (740-795 de n.è.). Il traite d’un topos de la pensée indienne : l’éternité et ... [more ▼]

Ce chapitre de 725 strophes a été écrit par Śāntarakṣita (725-783 de n.è.) et commenté par son élève Kamalaśīla (740-795 de n.è.). Il traite d’un topos de la pensée indienne : l’éternité et l’infaillibilité du Veda. Cette double thèse est défendue par le mīmāṃsaka contre le bouddhiste dans les śloka’s 2084-2131, portion qui emprunte de nombreux versets au Ślokavārttika de Kumārila. Le présent article suit le débat en précisant les références à Kumārila. Les sujets traités sont : -la nature du son, son éternité et son contact avec l’oreille, -l’apauruṣeyatā du Veda, càd l’absence de tout auteur, humain ou divin, à cette œuvre -le rejet de ce postulat par le bouddhiste qui tient le Veda comme une œuvre humaine et donc faillible. L’autorité morale du Veda découle des ex)plications de ses exégètes humains, comme Manu, Vyāsa -même débat à propos des injonctions fondatrices du rituel védique, par ex. « que celui qui désire le ciel sacrifie » -débat sur la nature du mot. Contrairement à ce que prétend la Mīmāṃsā, ni le mot, ni les lettres ne sont permanents sous peine de ne plus pouvoir exprimer la diversité de la condition humaine et de rendre toute erreur impossible -la connexion mot-chose, selon le bouddhisme, n’est pas innée mais conventionnelle. Même les mots-clès de la Mīmāṃsā (comme ‘ciel’, ‘sacrifice’) sont arbitraires . -la phrase n’est pas non plus éternelle. Tous ces débats qui peuvent apparaître excentriques, reflètent l’antagonisme entre la vision instantanéiste de la réalité typique du bouddhisme et la primauté de la permanence défendue par l’orthodoxie brahmanique. [less ▲]

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See detail25 Years ago - Yannick Bruynoghe
Sacré, Robert ULg

in Soul Bag (1983), (94), 27-28

Interview de Yannick Bruynoghe + photo

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See detail25 novembre 2015 : cent ans de Relativité
De Rop, Yves ULg

E-print/Working paper (2015)

La théorie proposée par Einstein au début du XXe siècle porte bien mal son nom; car si, historiquement, l'accent fut mis d'abord sur la relativité de certaines notions (en particulier, la mesure de l ... [more ▼]

La théorie proposée par Einstein au début du XXe siècle porte bien mal son nom; car si, historiquement, l'accent fut mis d'abord sur la relativité de certaines notions (en particulier, la mesure de l'intervalle de temps écoulé entre deux événements donnés), on a compris par la suite qu'elle reposait plus fondamentalement sur l'existence de quantités absolues, c'est-à-dire, dont la mesure est identique pour tous les observateurs, quel que soit leur état de repos ou de mouvement. Ces quantités sont inconnues de la mécanique de Newton, laquelle ne reconnaît qu'un seul invariant : le temps. Ce texte cherche à retracer, avec un minimum de formalisme, comment s'est imposé un nouveau cadre géométrique pour la physique, dominé par cette exigence d'invariance des mesures spatio-temporelles et intégrant une description révolutionnaire de la gravitation. [less ▲]

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See detail25 years of environmental expertise in Wallonia
Peters, Arnaud ULg; Defechereux, Olivier ULg; Dachouffe, Michel et al

in Paya Pérez, Ana; Pelaez Sanchez, Sara; Van Liedekerke, Marc (Eds.) Remediated Sites and Brownfields. Success Stories in Europe (2015)

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See detail25-OH vitamin D deficiencies and secondary hyperparathyroidism in elderly women living at home or in nursing/retirement homes
DEROISY, Rita ULg; Zheng, XS; Pirenne, H et al

in Osteoporosis International (1996), 6(S1), 119

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See detail25-OH vitamin D levels in healthy ambulatory postmenopausal women
DEROISY, Rita ULg; Albert, Adelin ULg; Zheng, SX et al

in Osteoporosis International (1996), 6(S1), 119

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See detail2500 years record of trace element metal in the Misten peat bog (Hautes Fagnes), Belgium
Allan, Mohammed ULg; Fagel, Nathalie ULg; Le Roux, Gael et al

Poster (2011, April 08)

The Misten peat bog provides a record of atmospheric deposition in the Hautes Fagnes Plateau (East Belgium). A composite 185cm core (W01/01b) was studied for its trace metal content (TM) and its lead ... [more ▼]

The Misten peat bog provides a record of atmospheric deposition in the Hautes Fagnes Plateau (East Belgium). A composite 185cm core (W01/01b) was studied for its trace metal content (TM) and its lead isotopic signature. The peat bog accumulation allows following the history of atmospheric TM deposition during the last 2500 years. TM enrichment factors coupled with a continuous decrease in 206Pb/204Pb, 207Pb/204Pb,208Pb/204Pb isotopic ratios from 494-732AD to1969-1977 AD evidence the increasing importance of TM released by anthropogenic activities. The highest concentrations of TM are found near the surface of the bog; at depths from 30 to 19 cm. Historical records of Cu, Zn, As, Sb, and Pb atmospheric flux during the Industrial Revolution and pre-industrial periods were derived. Maximum fluxes (up to 7.3, 89, 2.4, 1.5, and 116 mg.m-2.y-1, respectively) occurred in peat layers dated from 1619-1877AD to 1992-2000AD, reflecting anthropogenic emissions from diverse sources such as mining, coal combustion, and emissions from the use of leaded gasoline. The TM enrichment factors also increased significantly during the Industrial Revolution until a reduction at the end of the 70’S due to the progressive abolition of the leaded gasoline. [less ▲]

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