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See detail2015 ESC Guidelines for the Management of Acute Coronary Syndromes in Patients Presenting Without Persistent ST-segment Elevation.
Roffi, Marco; Patrono, Carlo; Collet, Jean-Philippe et al

in Revista espanola de cardiologia (English ed.) (2015), 68(12), 1125

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See detail2015 ESC Guidelines for the management of infective endocarditis.
Habib, Gilbert; LANCELLOTTI, Patrizio ULg; Antunes, Manuel J. et al

in Revista espanola de cardiologia (English ed.) (2016), 69(1), 69

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See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension : web addenda
GALIE, Nazzareno; HUMBERT, Marc; VACHIERY, Jean-Luc et al

in European Respiratory Journal (2015)

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See detail2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT).
Galie, Nazzareno; Humbert, Marc; Vachiery, Jean-Luc et al

in The European respiratory journal (2015), 46(4), 903-75

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management ... [more ▼]

Guidelines summarize and evaluate all available evidence on a particular issue at the time of the writing process, with the aim of assisting health professionals in selecting the best management strategies for an individual patient with a given condition, taking into account the impact on outcome, as well as the risk-benefit ratio of particular diagnostic or therapeutic means. Guidelines and recommendations should help health professionals to make decisions in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible health professional(s) in consultation with the patient and caregiver as appropriate. [less ▲]

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See detail2015 FMA Annual Meeting
Platania, Federico ULg; Lambert, Marie ULg; Moreno, Manuel

Scientific conference (2015, October)

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally ... [more ▼]

In this paper we develop a novel valuation model and methodology to value a pharmaceutical R&D project based on real options approach. The real options approach enables the possibility of optimally abandon the project before completion whenever the investment cost turns out to be larger than the expected net cash flow stream. On the other hand, the proposed model accounts for two different sources of uncertainty, those are technical and economic risk. This model incor- porates a novel economic state vector where each economic state captures the interaction among different market and economic forces using Fourier series as the particular basis for the economic function space. In this sense, Fourier series are considered as an aggregate of forces playing a relevant role in the process evolution determining the cash flow structure and also allowing us to properly define an economic scenario where the project will be developed. [less ▲]

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See detail21st century Antarctic surface mass balance downscaling from global circulation models
Agosta, Cécile ULg; Favier, Vincent; Genthon, Christophe et al

Poster (2011, October)

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See detail21st century high-resolution downscaling of the Antarctic surface mass balance from global circulation models
Agosta, Cécile ULg; Favier, Vincent; Genthon, Christophe et al

Conference (2011, April)

Most of the IPCC-AR4 Atmospheric Global Circulation Models (AGCM) predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. Present ... [more ▼]

Most of the IPCC-AR4 Atmospheric Global Circulation Models (AGCM) predict an increase of the Antarctic Surface Mass Balance (SMB) during the 21st century that would mitigate global sea level rise. Present accumulation and predicted change are largest at the ice sheet margins because they are driven by snowfall, which mostly comes from warm, moist air arising over the land slopes. The coastal belt is also where complex processes of sublimation, melt and redistribution by the wind occur. Thus, high-resolution modelling (5 to 10 km) is necessary to adequately capture the effects of small-scale variations in topography on the atmospheric variables in this area, but limitations in computing resources prevent such resolution at the scale of Antarctica in full climate models. We present here a downscaling method leading to 10-km SMB resolution for century time-scales over Antarctica. We compute the effect of the fine topography on orographic precipitation and on boundary layer processes that lead to melt and sublimation. We show that the accumulation downscaled from ERA-Interim is in good agreement with field measurements for the last 40 years. We then display the SMB downscaled from LMDZ4 AGCM outputs (~60-km resolution), and show that the downscaling improves the agreement between present modelled and observed SMB. Finally, we present hi-resolution features of the Antarctic SMB evolution during the 21st century downscaled from LMDZ4 and discuss the effect of the resolution on the Antarctic SMB contribution to sea level change. The downscaling model is a powerful tool that will be applied to others climate models for a better assessment of future sea level rise. [less ▲]

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See detail21st century projections of surface mass balance changes for major drainage systems of the Greenland ice sheet
Tedesco, M.; Fettweis, Xavier ULg

in Environmental Research Letters (2012), 7

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins ... [more ▼]

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins of the Greenland ice sheet (GrIS). The regional model is forced with the outputs of three different Earth System Models (CanESM2, NorESM1 and MIROC5) obtained when considering two greenhouse gas future scenarios with levels of CO2 equivalent of, respectively, 850 and >1370 ppm by 2100. Results indicate that the increase in runoff due to warming will exceed the increased precipitation deriving from the increase in evaporation for all basins, with the amount of net loss of mass at the surface varying spatially. Basins along the southwest and north coast are projected to have the highest sensitivity of SMB to increasing temperatures. For these basins, the global temperature anomaly corresponding to a decrease of the SMB below the 1980–99 average (when the ice sheet was near the equilibrium) ranges between +0.60 and +2.16 °C. For the basins along the northwest and northeast, these values range between +1.50 and +3.40 °C. Our results are conservative as they do not account for ice dynamics and changes in the ice sheet topography. [less ▲]

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See detail22nd Annual Conference of the Multinational Finance Society
Platania, Federico ULg; Lambert, Marie ULg; Moreno, Manuel

Scientific conference (2015)

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