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See detailDistribution of nerve fibres in bovine and human mucosal associated lymphoid tissues
Defaweux, Valérie ULg; Dorban, G.; Antoine, Nadine ULg et al

Poster (2006, October)

Prion cell tropism varies significantly among animal species, depending on both the agent strain and host-specific factors. For example, prions show high lymphotropism in scrapie infected sheep and vCJD ... [more ▼]

Prion cell tropism varies significantly among animal species, depending on both the agent strain and host-specific factors. For example, prions show high lymphotropism in scrapie infected sheep and vCJD, but little, if any, in sCJD or BSE. In particular, the BSE strain is associated with significant PrP-res accumulation in tonsils, spleen and appendix in humans, whereas it is largely confined to the nervous system in infected cattle. Therefore, at least in the case of BSE and vCJD, it appears that host properties can influence the accumulation of the infectious agent in lymphoid organs. Mature FDC play an important role in prion pathogenesis, since neuroinvasion following peripheral challenge is significantly impaired in their absence. The proximity between these FDC and sympathetic nerve endings is known to affect the speed of prion neuroinvasion. In this study, we analysed the mucosal innervation and the interface between nerve fibres and FDC in bovine and human tonsils and in ileal and jejunal bovine Peyer’s patches using a panel of antibodies observed by confocal microscopy. Since differences in the innervation of lymphoid organs depending on age have been reported, we analysed three categories of bovine ages (new born calves, calves less than 12 months old and bovines older than 24 months) and two categories of human ages (patients less than 5 years old and patients older than 25 years). In both species, hypothetical ways of innervation by-passing germinal centre could be postulated: nerve fibres are widely distributed in antigens/cells traffic area (the lamina propria, the interfollicular zone, the suprafollicular dome in Peyer’s patches and the lymphoepithelial area in tonsils). We pointed out that, only in ileal and jejunal Peyer’s patches and in tonsils of bovines older than 24 months, nerve fibres are observed to be in contact with FDC. In contrast, in human tonsils, no nerve fibres established contact with FDC, whatever the age. Thus, innervation of germinal centres can be said to be an age-dependent dynamic process in bovines and a weak innervation of the secondary lymphoid organs could thus be a rate-limiting step to neuroinvasion in humans. This variation could influence the way of neuroinvasion and thus, the differences of susceptibility of bovines and humans to the BSE agent. [less ▲]

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See detailDistribution of nucleic acids in cell nuclei by molecular immunocytochemistry
Thiry, Marc ULg; Vandelaer, Marc; Goessens, Guy ULg

Poster (1993)

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See detailDistribution of particulate trace elements in the Northeastern Atlantic
Dauby, Patrick ULg; Baeyens, Willy; Biondo, Renzo ULg et al

in Progress in Belgian Oceanographic Research (1993)

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See detailDistribution of pCO2 in the frontal zone of the Indian sector of the Southern Ocean during spring and summer
Delille, Bruno ULg; Kostianoy, A.; FRankignoulle, M.

Poster (2000, July)

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See detailDistribution Of Peach Latent Mosaic Viroid In Commercial Orchards Of Peach In The North Of Tunisia
Hassen, If.; Massart, Sébastien ULg; Roussel, S. et al

in Journal of Phytopathology (2007), 155(7-8), 403-408

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See detailDistribution of plankton parameters in the north eastern North Sea in relation to vertical physical structures
Veeschkens, Christine; Belkhiria, Sami; Goffart, Anne ULg et al

in Bulletin de la Société Royale des Sciences de Liège (1994), 63(1-2), 65-88

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See detailDistribution of POC, PON and particulate Al, Cd, Cr, Cu, Pb, Ti, Zn and deltaC13 in the English Channel and adjacent areas
Dauby, Patrick ULg; Frankignoulle, Michel; Gobert, Sylvie ULg et al

in Oceanologica Acta (1994), 17(6), 643-657

Detailed reference viewed: 58 (9 ULg)
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See detailDistribution of polluting trace metals along a toposequence in a contaminated suburban field
Dere, Christelle ULg; Cornu, Sophie; Lamy, Isabelle et al

Poster (2002, August)

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See detailDistribution of potential bluetongue vectors on Belgium farms
Zimmer, Jean-Yves ULg; Haubruge, Eric ULg; Francis, Frédéric ULg et al

in Veterinary Record : Journal of the British Veterinary Association (2008), 162(21), 700

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See detailDistribution of Reelin and its cytoplasmic signaling protein, DAB-1 in the forebrain of male canaries
Boseret, Géraldine ULg; Ball, G. F.; Balthazart, Jacques ULg

in Hormones & Behavior (2005, June), 48(1), 90

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See detailDistribution of scheelite in magnesian skarns at Traversella (Piemontse Alps, Italy) and Costabonne ( Eastern Pyrénées, France) : Nature of the associated magmatism and influence of fluid composition
Dubru, Michel; Vander Auwera, Jacqueline ULg; van Marcke de Lummen, Guy et al

in Boissonnas, Jean; Omenetto, P. (Eds.) Mineral Deposits within the Ruropean Community (1988)

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See detailDistribution of serotypes of clinical group B streptococci isolated in Belgium: a decade review
MELIN, Pierrette ULg; De Mol, Patrick ULg

in LISSSD Board (Ed.) Abstract book (2008, June)

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See detailDistribution of somatogenic and lactogenic receptors in pregnant cow
Beckers, Jean-François ULg; Wouters-Ballman, P; Ectors, F

Conference (1988)

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See detailDistribution of sputum cellular phenotype in a large asthma cohort: predicting factors for eosinophilic vs neutrophilic inflammation.
SCHLEICH, FLorence ULg; Manise, Maïté ULg; Sele, Jocelyne et al

in BMC Pulmonary Medicine (2013), 13(1), 11

ABSTRACT: BACKGROUND: Phenotyping asthma according to airway inflammation allows identification of responders to targeted therapy. Induced sputum is technically demanding. We aimed to identify predictors ... [more ▼]

ABSTRACT: BACKGROUND: Phenotyping asthma according to airway inflammation allows identification of responders to targeted therapy. Induced sputum is technically demanding. We aimed to identify predictors of sputum inflammatory phenotypes according to easily available clinical characteristics. METHODS: This retrospective study was conducted in 508 asthmatics with successful sputum induction recruited from the University Asthma Clinic of Liege. Receiver-operating characteristic (ROC) curve and multiple logistic regression analysis were used to assess the relationship between sputum eosinophil or neutrophil count and a set of covariates. Equations predicting sputum eosinophils and neutrophils were then validated in an independent group of asthmatics. RESULTS: Eosinophilic (>=3%) and neutrophilic (>=76%) airway inflammation were observed in 46% and 18% of patients respectively. Predictors of sputum eosinophilia >=3% were high blood eosinophils, FENO and IgE level and low FEV1/FVC. The derived equation was validated with a Cohen's kappa coefficient of 0.59 (p < 0.0001). ROC curves showed a cut-off value of 220/mm3 (AUC = 0.79, p < 0.0001) or 3% (AUC = 0.81, p < 0.0001) for blood eosinophils to identify sputum eosinophilia >=3%. Independent predictors of sputum neutrophilia were advanced age and high FRC but not blood neutrophil count. CONCLUSION: Eosinophilic and paucigranulocytic asthma are the dominant inflammatory phenotypes. Blood eosinophils provide a practical alternative to predict sputum eosinophilia but sputum neutrophil count is poorly related to blood neutrophils. [less ▲]

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See detailDistribution of surface carbon dioxide and air-sea exchange in the English Channel and adjacent areas
Borges, Alberto ULg; Frankignoulle, Michel

in Journal of Geophysical Research (2003), 108(C5),

In the present paper we report the distribution of the partial pressure of CO2 (pCO2) in surface waters along 13 transects in the English Channel, covering the four seasons. The spatial and temporal ... [more ▼]

In the present paper we report the distribution of the partial pressure of CO2 (pCO2) in surface waters along 13 transects in the English Channel, covering the four seasons. The spatial and temporal variability of pCO2 is controlled by a complex combination of primary production (from May to June), degradation of organic matter, temperature change, and freshwater inputs. Preliminary air-sea CO2 exchange computations suggest that the Channel is not a major sink of atmospheric CO2 and is probably neutral from the point of view of atmospheric coupling. This is mainly related to a relatively low export and/or burial of organic carbon and intense benthic calcification. [less ▲]

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See detailDistribution of surface carbon dioxide and air-sea exchange in the upwelling system off the Galician coast
Borges, Alberto ULg; Frankignoulle, Michel

in Global Biogeochemical Cycles (2002), 16

Data on the distribution of the partial pressure of CO2 (pCO2) were obtained during six cruises off the Galician coast, a region characterized by a seasonal upwelling. The values of pCO2 over the ... [more ▼]

Data on the distribution of the partial pressure of CO2 (pCO2) were obtained during six cruises off the Galician coast, a region characterized by a seasonal upwelling. The values of pCO2 over the continental shelf are highly variable and range between 265 and 415 matm during the upwelling season and between 315 and 345 matm during the downwelling season. Both the continental shelf and off-shelf waters behave as significant net sinks of atmospheric CO2. The computation of the air-sea fluxes of CO2 over the continental shelf yields a net influx in the range of 2.3 (±0.6) to 4.7 (±1.0) mmol C m 2 d 1 during the upwelling season and 3.5 (±0.8) to 7.0 (±1.5) mmol C m 2 d 1 on an annual basis. During the upwelling season and on an annual basis, although the observed air-sea gradients of CO2 over the continental shelf are significantly stronger than those in off-shelf waters, the computed air-sea CO2 fluxes are not significantly different because of the important incertitude introduced in the calculations by the estimated error on wind speed measurements. The presence of upwelling filaments increases the influx of atmospheric CO2 in the off-shelf waters. During summer, important short-term variations of pCO2 are observed that are related to both upwelling and temperature variations. During winter the cooling of water causes important undersaturation of CO2 related to the effect of temperature on the dissolved inorganic carbon equilibrium constants. [less ▲]

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See detailDistribution of surface water partial CO2 pressure in the English Channel and in the Southern Bight of the North Sea
Frankignoulle, Michel; Bourge, Isabelle; Canon, Christine ULg et al

in Continental Shelf Research (1996), 16

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See detailDistribution of temperature in steel and composite beams and joints under natural fire
Hanus, François; Franssen, Jean-Marc ULg

Conference (2011, April 29)

Parametric numerical analyses have been performed with SAFIR for the temperature distribution in steel and composite beams and joints subjected to natural fires. A simple model has been derived to ... [more ▼]

Parametric numerical analyses have been performed with SAFIR for the temperature distribution in steel and composite beams and joints subjected to natural fires. A simple model has been derived to calculate the temperature development in the upper flange of the steel section supporting a concrete slab. This model takes into account, not only the heat transfer with the surounding hot gases, but also the heat transfer 1) by conduction with the lower part of the section through the web and 2) with the supported concrete slab. [less ▲]

Detailed reference viewed: 45 (0 ULg)