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Peer Reviewed
See detailDiagnostic performance of the thirty-four hour dexamethasone suppression test
Ansseau, Marc ULg; Doumont, Arlette; Cerfontaine, Jean-Luc et al

in Psychoneuroendocrinology (1985), 10

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See detailDiagnostic pitfall in antenatal manifestations of CPT II deficiency.
BOEMER, François ULg; DEBERG, Michelle ULg; SCHOOS, Roland ULg et al

in Clinical genetics (2015)

Carnitine palmitoyltransferase II (CPT2) deficiency is a rare inborn error of mitochondrial fatty acid metabolism associated with various phenotypes. Whereas most patients present with postnatal signs of ... [more ▼]

Carnitine palmitoyltransferase II (CPT2) deficiency is a rare inborn error of mitochondrial fatty acid metabolism associated with various phenotypes. Whereas most patients present with postnatal signs of energetic failure affecting muscle and liver, a small subset of patients presents antenatal malformations including brain dysgenesis and neuronal migration defects. Here, we report recurrence of severe cerebral dysgenesis with Dandy-Walker malformation in three successive pregnancies and review previously reported antenatal cases. Interestingly, we also report that acylcarnitines profile, tested retrospectively on the amniotic fluid of last pregnancy, was not sensitive enough to allow reliable prenatal diagnosis of CPT2 deficiency. Finally, because fetuses affected by severe cerebral malformations are frequently aborted, CPT2 deficiency may be underestimated and fatty acid oxidation disorders should be considered when faced with a fetus with Dandy-Walker anomaly or another brain dysgenesis. [less ▲]

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See detailLe diagnostic pour les politiques de gestion de la diversité
Cornet, Annie ULg; zannad, hedia; Stone, Peter

Scientific conference (2014)

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See detailDiagnostic préalable à un contrat d'axe sur la ligne SNCB 40 Liège-Guillemins - Visé. Etude du potentiel de l'outil contrat d'axe en Wallonie et de la densification des gares de la ligne 40
Wilmotte, Pierre-François ULg

Master's dissertation (2016)

Le travail vise à alimenter la réflexion menée par le consortium Pluris - Trame - B. Bianchet à propos de l'élaboration d'un Schéma de Développement Territorial (SDT) pour l'arrondissement de Liège : d ... [more ▼]

Le travail vise à alimenter la réflexion menée par le consortium Pluris - Trame - B. Bianchet à propos de l'élaboration d'un Schéma de Développement Territorial (SDT) pour l'arrondissement de Liège : d'une part, étudier le potentiel des quartiers de gare en région liégeoise et, d'autre part, à voir si l'outil des "Contrats d'axe", développés en France, pourrait être pertinent dans le cadre wallon. La recherche a été appliquée à un axe ferroviaire de la région de Liège. [less ▲]

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See detailDiagnostic precision of PET imaging and functional MRI in disorders of consciousness: a clinical validation study
Stender, Johan; Gosseries, Olivia ULg; Bruno, Marie-Aurélie ULg et al

in Lancet Neurology (2014)

Background: Bedside clinical examinations can have high rates of misdiagnosis of unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The diagnostic and prognostic usefulness ... [more ▼]

Background: Bedside clinical examinations can have high rates of misdiagnosis of unresponsive wakefulness syndrome (vegetative state) or minimally conscious state. The diagnostic and prognostic usefulness of neuroimaging-based approaches has not been established in a clinical setting. We did a validation study of two neuroimaging-based diagnostic methods: PET imaging and functional MRI (fMRI). Methods: For this clinical validation study, we included patients referred to the University Hospital of Liège, Belgium, between January, 2008, and June, 2012, who were diagnosed by our unit with unresponsive wakefulness syndrome, locked-in syndrome, or minimally conscious state with traumatic or non-traumatic causes. We did repeated standardised clinical assessments with the Coma Recovery Scale—Revised (CRS—R), cerebral 18F-fluorodeoxyglucose (FDG) PET, and fMRI during mental activation tasks. We calculated the diagnostic accuracy of both imaging methods with CRS—R diagnosis as reference. We assessed outcome after 12 months with the Glasgow Outcome Scale—Extended. Findings: We included 41 patients with unresponsive wakefulness syndrome, four with locked-in syndrome, and 81 in a minimally conscious state (48=traumatic, 78=non-traumatic; 110=chronic, 16=subacute). 18F-FDG PET had high sensitivity for identification of patients in a minimally conscious state (93%, 95% CI 85—98) and high congruence (85%, 77—90) with behavioural CRS—R scores. The active fMRI method was less sensitive at diagnosis of a minimally conscious state (45%, 30—61) and had lower overall congruence with behavioural scores (63%, 51—73) than PET imaging. 18F-FDG PET correctly predicted outcome in 75 of 102 patients (74%, 64—81), and fMRI in 36 of 65 patients (56%, 43—67). 13 of 42 (32%) of the behaviourally unresponsive patients (ie, diagnosed as unresponsive with CRS—R) showed brain activity compatible with (minimal) consciousness (ie, activity associated with consciousness, but diminished compared with fully conscious individuals) on at least one neuroimaging test; 69% of these (9 of 13) patients subsequently recovered consciousness. Interpretation: Cerebral 18F-FDG PET could be used to complement bedside examinations and predict long-term recovery of patients with unresponsive wakefulness syndrome. Active fMRI might also be useful for differential diagnosis, but seems to be less accurate. Funding: The Belgian National Funds for Scientific Research (FNRS), Fonds Léon Fredericq, the European Commission, the James McDonnell Foundation, the Mind Science Foundation, the French Speaking Community Concerted Research Action, the University of Copenhagen, and the University of Liège. [less ▲]

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See detailDiagnostic précoce de gestation chez les différentes espèces animales
Delahaut, Philippe; Beckers, Jean-François ULg; Ectors, Francis ULg

in Annales de Médecine Vétérinaire (1978)

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See detailDiagnostic précoce de la maladie d'Alzheimer : la tâche RI-48
Adam, Stéphane ULg

Scientific conference (2005, September 07)

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See detailDiagnostic précoce de la maladie d'Alzheimer: Importance de l'optimisation de l'encodage
Adam, Stéphane ULg

Scientific conference (2009, October 27)

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See detailLe diagnostic précoce des cancers de la peau est primordial
PIERARD, Gérald ULg; ANDRE, J.; BROCHEZ, L. et al

Book published by bioderma (2009)

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See detailLe diagnostic précoce des troubles du comportement externalisé est-il fiable ? Mise à l’épreuve d’une procédure multi informateurs et multi méthodes
Roskam, Isabelle; Stievenart, Marie ULg; Meunier, Jean-Christophe et al

in PRATIQUES PSYCHOLOGIQUES (2011), 17

Cette contribution questionne la fiabilité du diagnostic précoce des troubles du comportement externalisé chez l’enfant. Les données concernant le comportement de 118 enfants ont été collectées par ... [more ▼]

Cette contribution questionne la fiabilité du diagnostic précoce des troubles du comportement externalisé chez l’enfant. Les données concernant le comportement de 118 enfants ont été collectées par questionnaires et observation auprès de leurs parents, leurs enseignants et les cliniciens lors du recrutement et après 12 mois. Les résultats montrent des variations importantes dans le nombre d’enfants atteignant un seuil clinique selon l’informateur et la méthode considérés. Une méthode combinant les évaluations des informateurs pour obtenir un diagnostic valide est éprouvée. Les résultats plaident en faveur d’une procédure multi-informateurs et multiméthodes dont les implications sont discutées sur le plan clinique et de la recherche. [less ▲]

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See detailDiagnostic précoce du rejet de l'allogreffe pancréatique: intérêt du dosage de l'amylasurie.
Meurisse, Michel ULg; Defraigne, Jean-Olivier ULg; Defechereux, Thierry et al

in Revue Médicale de Liège (1989), XLIV(11), 388-395

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See detailDiagnostic strategy for identifying avian pathogenic Escherichia coli based on four patterns of virulence genes
Schouler, C; Schaeffer, B; Brée, A et al

in Journal of Clinical Microbiology (2012), 50(5), 1673-1678

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See detailDiagnostic territorial de la Wallonie (2011)
Cawoy, Valérie; Droeven, Emilie ULg; Grandjean, Martin et al

Book published by Service Public de Wallonie (2011)

A l’aube de l’actualisation du SDER, la CPDT a reçu la mission de dresser le diagnostic territorial de la Wallonie. Cette publication présente ce diagnostic et s’articule en trois grandes parties. La ... [more ▼]

A l’aube de l’actualisation du SDER, la CPDT a reçu la mission de dresser le diagnostic territorial de la Wallonie. Cette publication présente ce diagnostic et s’articule en trois grandes parties. La première partie aborde six défis majeurs pour l'avenir - le défi démographique, le défi climatique, le défi énergétique, le défi de la compétitivité, le défi de la cohésion sociale et le défi de la mobilité- et envisage dans une approche prospective comment le territoire sera impacté par ces changements. La seconde partie du diagnostic vise à estimer les besoins spatiaux des grands secteurs occupant et dynamisant le territoire. Une analyse fine permet de dégager ces besoins sur la base des structures héritées mais aussi d’extrapoler les enjeux de leur adaptation aux grands défis. Dans la troisième partie, le diagnostic se penche sur l’intégration des besoins sectoriels à l’espace wallon. L’examen des dimensions spatiales permet de conclure le diagnostic de manière transversale et territoriale. La première dimension concerne l'insertion de la Wallonie dans l’Europe des Régions et dégage les principaux enjeux vis-à-vis des projets européens et des régions voisines. Une autre dimension a pour objet la structure spatiale interne de la Wallonie et interroge ses pôles et ses aires de pertinences. Enfin, le diagnostic examine la question des spécificités et des relations entre villes et campagnes en Wallonie. [less ▲]

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See detailDiagnostic tests of bovine leukemia. Comparison between an hematological test and the serological diagnosis.
Mammerickx, Marc; Portetelle, Daniel ULg; Kettmann, Richard ULg et al

in European Journal of Cancer (1976), 12

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See detailThe diagnostic utility of folate receptor autoantibodies in blood
Sequeira, JM; RAMAEKERS, Vincent ULg; Quadros, EV

in Clinical Chemistry & Laboratory Medicine (2013), 51(3), 545-54

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See detailThe diagnostic value of equine rectal and duodenal biopsies.
Tossens, Morgane; Borde, Laura ULg; Amory, Hélène ULg et al

in Journal of Veterinary Internal Medicine (2012), 26(2), 430-431

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See detailDiagnostic Value of Exercise Electrocardiography and Angina after Coronary Artery Stenting. Benestent Study Group
Legrand, Victor ULg; Raskinet, B.; Laarman, G. et al

in American Heart Journal (1997), 133(2), 240-8

To determine whether metallic stent implantation within a coronary artery modifies the accuracy of angina or exercise test results in predicting stenosis, we studied 172 patients assigned to stent ... [more ▼]

To determine whether metallic stent implantation within a coronary artery modifies the accuracy of angina or exercise test results in predicting stenosis, we studied 172 patients assigned to stent implantation and 153 patients assigned to balloon angioplasty enrolled in the Benestent trial comparing de novo stenting with conventional balloon angioplasty. Sensitivity and specificity curves were constructed for the prediction of percentage diameter stenosis and minimal lumen diameter. Receiver-operator curves were constructed for comparison of diagnostic accuracy. Identical exercise load and duration were achieved in the two groups, despite a better angiographic result in patients treated with a stent. Similarly, the diagnostic accuracy of clinical symptoms or exercise test results as a function of the angiographic results were similar in patients with and patients without a stent. The intersection points of the sensitivity and specificity curves for recurrent angina or ST-segment depression were 72% to 77%. The corresponding cut-off points for percentage diameter stenosis were, respectively, 52% and 50% for patients with and without a stent (1.35 and 1.50 mm for minimal lumen diameter). We conclude that the presence of an intracoronary stent does not affect the diagnostic accuracy of recurrent angina or exercise-induced ST depression in predicting residual stenosis. We also conclude that exercise tolerance is similar after balloon angioplasty, with or without stenting, despite a better angiographic outcome in the group receiving a stent, suggesting a minimal threshold beyond which the patient is no longer at risk for ischemia during exercise. [less ▲]

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See detailDiagnostic value of interleukine-6, transforming growth factor-beta 1 and vascular endothelial growth factor in malignant pleural effusions.
Duysinx, Bernard ULg; Corhay, Jean-Louis ULg; Hubin, Laurent et al

in Respiratory Medicine (2008), 102(12), 1708-14

STUDY OBJECTIVES: We evaluate the accuracy of pleural interleukine-6 (IL-6), transforming growth factor-beta 1 (TGF-beta1), and vascular endothelial growth factor (VEGF) levels for differentiating benign ... [more ▼]

STUDY OBJECTIVES: We evaluate the accuracy of pleural interleukine-6 (IL-6), transforming growth factor-beta 1 (TGF-beta1), and vascular endothelial growth factor (VEGF) levels for differentiating benign from malignant pleural exudates. PATIENTS AND METHODS: Levels of IL-6, TGF-beta1, and VEGF were measured by ELISA in 103 patients with non neutrophilic (<50%) exudative pleurisy including both benign and malignant effusions. Pleurisies were split into benign and malignant according to the pathological diagnosis. RESULTS: Thirty-nine benign (seven infections; 32 inflammatory diseases) and 64 malignant (34 extrathoracic tumors; 25 lung cancers; five mesotheliomas) pleural exudates were diagnosed by thoracoscopy. Pleural reticulo-monocyte count, protein Light's ratio and lactic dehydrogenase Light's ratio were significantly higher in malignant than in benign effusions (p<0.05, p<0.001 and p<0.001, respectively). The median (range) level of VEGF was significantly higher in malignant than in benign effusions (664.50 pg/ml [10-40,143] vs 349 pg/ml [10-8888]) (p<0.05). VEGF levels correlated with pleural LDH (r=0.41, p<0.0001), glucose (r=-0.30, p<0.01) and red cell count (r=0.57, p<0.0001). No significant difference was found between malignant and benign effusions with respect to IL-6 (26.8 ng/ml [1.8-421] vs 18.4 ng/ml [0.45-400], respectively) and TGF-beta1 (1079 pg/ml [18-6206] vs 1123 pg/ml [34-5447]) levels. ROC analysis between benign and malignant pleurisies for VEGF showed an area under the curve of 619 (p=0.03) with a value of 382 pg/ml as the best threshold for distinguishing benign from malignant effusions. CONCLUSIONS: Malignant effusions may enhance the release of VEGF in pleural space and its measurement may help in the diagnosis of malignant effusion. [less ▲]

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