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Peer Reviewed
See detailDesign of mesoporous carbon fibers from a poly(acrylonitrile) based block copolymer by a simple templating compression moulding process
Thomassin, Jean-Michel ULg; Debuigne, Antoine ULg; Jérôme, Christine ULg et al

in Polymer (2010), 51(14), 2965-2971

Mesoporous carbon fibers were prepared by controlled pyrolysis of poly(vinyl acetate)-b-poly(acrylonitrile) (PVAc-b-PAN) copolymer located inside a cylindrical nanoporous template. A melt-compression ... [more ▼]

Mesoporous carbon fibers were prepared by controlled pyrolysis of poly(vinyl acetate)-b-poly(acrylonitrile) (PVAc-b-PAN) copolymer located inside a cylindrical nanoporous template. A melt-compression method was developed to help the penetration of the infusible copolymer inside the template without the use of any solvent that ensures the formation of completely filled fibers instead of nanotubes. The influence of the composition of the PVAc-b-PAN copolymer and the heating rate during pyrolysis on the porous morphology of the fibers was studied by transmission electron microscopy (TEM). [less ▲]

Detailed reference viewed: 141 (7 ULg)
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See detailDesign of microstructures using stress-based topology optimization
Collet, Maxime ULg; Bruggi, Matteo; Noël, Lise ULg et al

Conference (2016, August 22)

This paper aims at designing microstructures using stress-based topology optimization. Most of the developments so far have been made for compliance design in various field of applications as reflected in ... [more ▼]

This paper aims at designing microstructures using stress-based topology optimization. Most of the developments so far have been made for compliance design in various field of applications as reflected in the literature. The emergence of the new additive manufacturing techniques allows to consider porous material, such as lattice structures for instance, which ca be used for the design of structural components subject to various solicitations. Those components must account for the stress level to prevent failure everywhere in the microstructures and by extension the whole structure itself. This work proposes to design such microstructures using topology optimization with limitation on the stress level within the microstructures before printing the result. The homogenization technique is used to determine the equivalent material properties. The issues and perspectives are also discussed. [less ▲]

Detailed reference viewed: 110 (10 ULg)
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See detailDesign of Microswitch Systems Avoiding Stiction due to Surface Contact
Wu, Ling ULg; Noels, Ludovic ULg; Rochus, Véronique et al

in Proulx, Tom (Ed.) MEMS and Nanotechnology, Volume 2 (2011)

Stiction which results from contact between surfaces is a major failure mode in micro electro-mechanical systems (MEMS). Increasing restoring forces using high spring constant allows avoiding stiction but ... [more ▼]

Stiction which results from contact between surfaces is a major failure mode in micro electro-mechanical systems (MEMS). Increasing restoring forces using high spring constant allows avoiding stiction but leads to an increase of the actuation voltage so that the switch’s efficiency is threatened. A statistical rough surfaces interaction model, based on Maugis’ and Kim’s formulations is applied to estimate the adhesive forces in MEMS switches. Based on the knowledge of these forces, the proper design range of the equivalent spring constant, which is the main factor of restoring force in MEMS switches, can be determined. The upper limit of equivalent spring constant depends mainly on the expected actuator voltage and on the geometric parameters, such as initial gap size and thickness of dielectric layer. The lower limit is assessed on the value of adhesive forces between the two contacting rough surfaces. It mainly depends on the adhesive work of contact surfaces and on the surfaces’ roughness. In order to study more complicated structures, this framework will be used in a multiscale model: resulting unloading micro adhesive contact-distance curves of two rough surfaces will be used as contact forces in a finite-element model. In this paper the extraction of these curves for the particular case of gold to gold micro-switches is pursued. [less ▲]

Detailed reference viewed: 106 (24 ULg)
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See detailDesign of Microswitch Systems Avoiding Stiction due to Surface Contact
Wu, Ling ULg; Noels, Ludovic ULg; Rochus, Véronique ULg et al

in SEM 2010 Annual Conference & Exposition on Experimental and Applied Mechanics (2010)

Stiction which results from contact between surfaces is a major failure mode in micro electro-mechanical systems (MEMS). Increasing restoring forces using high spring constant allows avoiding stiction but ... [more ▼]

Stiction which results from contact between surfaces is a major failure mode in micro electro-mechanical systems (MEMS). Increasing restoring forces using high spring constant allows avoiding stiction but leads to an increase of the actuation voltage so that the switch’s efficiency is threatened. A statistical rough surfaces interaction model, based on Maugis’ and Kim’s formulations is applied to estimate the adhesive forces in MEMS switches. Based on the knowledge of these forces, the proper design range of the equivalent spring constant, which is the main factor of restoring force in MEMS switches, can be determined. The upper limit of equivalent spring constant depends mainly on the expected actuator voltage and on the geometric parameters, such as initial gap size and ,thickness of dielectric layer. The lower limit is assessed on the value of adhesive forces between the two contacting rough surfaces. It mainly depends on the adhesive work of contact surfaces and on the surfaces’ roughness. In order to study more complicated structures, this framework will be used in a multiscale model: resulting unloading micro adhesive contact-distance curves of two rough surfaces will be used as contact forces in a finite-element model. In this paper the extraction of these curves for the particular case of gold to gold micro-switches is pursued. [less ▲]

Detailed reference viewed: 184 (44 ULg)
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See detailDesign of Movable Weirs and Storm Surge Barriers
Rigo, Philippe ULg; Abdelnour, R.; Bulckaen, D. et al

in PIANC 2006, 31ème Congrès de l’PIANC (Article 031) (2006, May)

Detailed reference viewed: 97 (3 ULg)
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See detailDesign of movables Weirs and Storm Surge Barriers
Rigo, Philippe ULg; Abdelnour, R.; Bulckaen, D. et al

Book published by PIANC - INCOM (2006)

State of of in the dsign of movable weirs and storm surge barriers

Detailed reference viewed: 635 (28 ULg)
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See detailDesign of Muong Chuoi, Kinh-Lo and Thu-Bo Barriers (report Jan 2011)
Rigo, Philippe ULg

Report (2011)

Consulting activities for the water level control for flood protection of HCMC area Design of Muong Chuoi, Kinh-Lo and Thu-Bo Barriers ICMB-9, HCMC, Vietnam

Detailed reference viewed: 81 (1 ULg)
See detailDesign of nanoobjects endowed with specific properties
Willet, Nicolas ULg; Qiu, Hongjin; Rieger, Jutta ULg et al

Conference (2004, March)

Detailed reference viewed: 8 (4 ULg)
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See detailDesign of new delivery systems for therapeutic proteins based on calcium carbonate microspheres
Ramalapa, Bathabile ULg; Crasson, Oscar ULg; Vandevenne, Marylène ULg et al

Poster (2015, December 10)

There exists a constant need for delivery systems that are biocompatible, offer bioactives protection from premature degradation and allow for targeted delivery and controlled release. Calcium carbonate ... [more ▼]

There exists a constant need for delivery systems that are biocompatible, offer bioactives protection from premature degradation and allow for targeted delivery and controlled release. Calcium carbonate (CaCO3) is one such system that has gained great favour for employment in the biomedical field due to possibilities of controlling size, morphology and crystalline forms of particles by tuning the synthesis conditions. CaCO3 has demonstrated ability to increase safety, stability and overall efficiency of protein therapeutics. The aim of the present work was to assess the significance of polysaccharide-protein complexes in enhancing the encapsulation of proteins in CaCO3 microspheres. A Chitin Binding Domain (ChBD), reported to have affinity for hyaluronic acid, was inserted on β-lactamase enzyme to develop a chimeric protein. The chimeric protein retained the activity of the enzyme and the binding properties and was encapsulated in CaCO3 microspheres by a super critical CO2 (ScCO2) process using hyaluronic acid as a templating agent. The particles were characterised in terms of size, zeta potential, morphology and protein loading. The results obtained confirmed the affinity of the ChBD to hyaluronic acid towards the production of stable, vaterite microparticles. Protein assays demonstrated that the ChBD enhanced the encapsulation of protein by up to 10 fold. Confocal images also suggested high encapsulation of the chimeric protein compared to native protein. Thus the production of polysaccharide-protein complexes seems effective in enhancing the encapsulation of proteins in CaCO3 microparticles using the ScCO2 process. Moreover this method will further be used to enhance encapsulation of therapeutic proteins such as growth factors for bone and cartilage regeneration. [less ▲]

Detailed reference viewed: 72 (5 ULg)
See detailDesign of new multifunctional nanocarriers for protein delivery
Parilti, Rahmet ULg; Alaimo, David; Grignard, Bruno ULg et al

Poster (2015, March 23)

Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. However, efficient encapsulation and delivery of therapeutic proteins in targeted ... [more ▼]

Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. However, efficient encapsulation and delivery of therapeutic proteins in targeted manner still present challenges. This project aims to develop a novel one-pot strategy to obtain nanoparticles able to carry proteins in their core, as well as bearing targeting and/or imaging agents on their surface. In addition to this objective, polymerizations will be carried out in supercritical carbon dioxide (scCO2), which confers environmentally benign features to the process. [less ▲]

Detailed reference viewed: 14 (3 ULg)
See detailDesign of new multifunctional nanocarriers for protein delivery
Parilti, Rahmet ULg; Jérôme, Christine ULg; Howdle, Steven M. et al

Conference (2015, May 18)

Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. However, efficient encapsulation and delivery of therapeutic proteins in targeted ... [more ▼]

Polymeric nanoparticles have been extensively investigated for their biomedical applications especially as drug carriers. However, efficient encapsulation and delivery of therapeutic proteins in targeted manner still present challenges. This project aims to develop a novel one-pot strategy to obtain nanoparticles able to carry proteins in their core, as well as bearing targeting and/or imaging agents on their surface. In addition to this objective, polymerizations are carried out in supercritical carbon dioxide (scCO2), which confers environmentally benign features to the process. Dispersion polymerizations of hydrophilic monomer 2-hydroxyethyl methacrylate (HEMA) in are carried out in scCO2 in the presence of an initiator, cross-linker and CO2-philic photoclevable stabilizer. Upon exposure to UV light, the o-nitrobenzyl junctions present at the surface of the particles are cleaved, thus providing water dispersible hydrogels. Spherical monodisperse nanoparticles were successfully synthesized in scCO2 with two different conditions. Milder reaction conditions were achieved by using 2,2'-Azobis(4-methoxy-2,4-dimethyl valeronitrile (V70) as an initiator which opens up the platform for one-pot protein encapsulation in scCO2. [less ▲]

Detailed reference viewed: 141 (14 ULg)
Peer Reviewed
See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J.-M. et al

in Journal de Pharmacie de Belgique (1998), 53

Detailed reference viewed: 10 (0 ULg)
Peer Reviewed
See detailDesign of new potential hypoglycemic drugs
Masereel, B.; De Tullio, Pascal ULg; Dogne, J. M. et al

Poster (1997, May)

Detailed reference viewed: 10 (0 ULg)
See detailDesign of new reprocessable shape-memory materials
Defize, Thomas ULg; Riva, Raphaël ULg; Thomassin, Jean-Michel ULg et al

Poster (2017, May 04)

Detailed reference viewed: 10 (2 ULg)
See detailDesign of new stealthy and pH-sensitive polymer micelles for potential solid tumor targeting
Van Butsele, Kathy

Doctoral thesis (2008)

Detailed reference viewed: 87 (30 ULg)
See detailDesign of novel copolymers by cobalt-mediated radical polymerization of N-vinyl amides
Debuigne, Antoine ULg

Conference (2012, September 21)

Detailed reference viewed: 21 (6 ULg)