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See detailAn enhanced version of a bone remodelling model based on the continuum damage mechanics theory.
Mengoni, Marlène ULg; Ponthot, Jean-Philippe ULg

in Computer Methods in Biomechanics & Biomedical Engineering (in press)

The purpose of this work is to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics theory. In their paper, they stated that the evolution ... [more ▼]

The purpose of this work is to propose an enhancement of Doblaré and García's internal bone remodelling model based on the continuum damage mechanics theory. In their paper, they stated that the evolution of the internal variables of the bone microstructure, and its incidence on the modification of the elastic constitutive parameters, may be formulated following the principles of Continuum Damage Mechanics, although no actual damage was considered. The resorption and apposition criteria (similar to the damage criterion) were expressed in terms of a mechanical stimulus. However, the resorption criterion is lacking a dimensional consistency with the remodelling rate. We here propose an enhancement to this resorption criterion, insuring the dimensional consistency while retaining the physical properties of the original remodelling model. We then analyse the change in the resorption criterion hypersurface in the stress space for a 2D analysis. We finally apply the new formulation to analyse the structural evolution of a 2D femur. This analysis gives results consistent with the original model but with a faster and more stable convergence rate. [less ▲]

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See detailAn Enhanced Version of Timed LOTOS and its Application to a Case study
Léonard, Luc; Leduc, Guy ULg

in Tenney, R. L.; Amer, P. D.; Uyar, M. U. (Eds.) FORMAL DESCRIPTION TECHNIQUES, VI (1993, October)

We propose here ET-LOTOS, a timed extension of LOTOS. It is an enhancement of Timed LOTOS that we presented at FORTE 92. We show how some simple modifications allow us to improve the expressiveness of our ... [more ▼]

We propose here ET-LOTOS, a timed extension of LOTOS. It is an enhancement of Timed LOTOS that we presented at FORTE 92. We show how some simple modifications allow us to improve the expressiveness of our former formalism. To assess ET-LOTOS, we apply it to the specification of a small case study. Finally, we show how the semantics of ET-LOTOS could be modified to easily define more powerful operators, if one ever had to. [less ▲]

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See detailEnhanced vortex pinning by a composite antidot lattice in a superconducting Pb film
Silhanek, Alejandro ULg; Van Look, L.; Jonckheere, R. et al

in Physical Review. B : Condensed Matter (2005), 72(1),

The use of artificial defects is known to enhance the superconducting critical parameters of thin films. In the case of conventional superconductors, regular arrays of submicron holes (antidots ... [more ▼]

The use of artificial defects is known to enhance the superconducting critical parameters of thin films. In the case of conventional superconductors, regular arrays of submicron holes (antidots) substantially increase the critical temperature T-c(H) and critical current I-c(H) for all fields. Using electrical transport measurements, we study the effect of placing an additional small antidot in the unit cell of the array. This composite antidot lattice consists of two interpenetrating antidot square arrays with a different antidot size and the same lattice period. The smaller antidots are located at the centers of the cells of the large antidots array. We show that the composite antidot lattice can trap a higher number of flux quanta per unit cell inside the antidots compared to a reference antidot film without the additional small antidots. As a consequence, the field range in which an enhanced critical current is observed is considerably expanded. Finally, the possible stable vortex lattice patterns at several matching fields are determined by molecular-dynamics simulations. [less ▲]

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See detailEnhanced vortex trapping by a composite antidot lattice in a superconducting Pb film
Silhanek, Alejandro ULg; Van Look, L.; Jonckheere, R. et al

in Physica C: Superconductivity (2007), 460

Using electrical transport measurements, we study a composite antidot lattice consisting of two interpenetrating antidot square arrays with a different antidot size and the same lattice period. We show ... [more ▼]

Using electrical transport measurements, we study a composite antidot lattice consisting of two interpenetrating antidot square arrays with a different antidot size and the same lattice period. We show that placing an additional small antidot in the unit cell of the array a higher number of flux quanta per unit cell can be trapped inside the antidots, compared to a reference antidot film without the additional small antidots. As a consequence, the field range in which an enhanced critical current is observed is considerably expanded. (c) 2007 Elsevier B.V. All rights reserved. [less ▲]

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See detailEnhancement and parametric analysis of a model of a drilling assembly equipped with a rotary steerable system
Huynen, Alexandre ULg

Master's dissertation (2010)

Demand in products derived from crude oil and the decrease of the gas and petroleum reserves have been boosting the petroleum industry to always beat back the limit between reserves and resources ... [more ▼]

Demand in products derived from crude oil and the decrease of the gas and petroleum reserves have been boosting the petroleum industry to always beat back the limit between reserves and resources, explaining why the interest for directional drilling has been growing up during the last several decades. Nowadays, rotary steerable systems are so efficient that they are becoming the benchmark for the industry. More than one million feet of well-bore are drilled every year using this technology. The drilling industry handles dimensions and times that cover several order of magnitude. The time scale ranges from seconds for the bit revolution to days for the drilling of a well, while the length scale ranges from hundredth of millimetres for the penetration parameters of a bit in a rock formation to kilometres for the length of a drillstring. This makes the drilling industry such an unfamiliar field which confronts engineers to unconventional challenges. This complexity may explain why, despite the substantial resources of the oil industry, direc- tional drilling processes are still misapprehended. Indeed, the industry continues to rely on trial and error to control the direction of an oil well. Nevertheless, relatively recent theories try to com- prehend the directional behaviour of a drilling assembly in order to predict, with relative success, the geometry of the borehole drilled. Mathematical models of the near-bit region of the drillstring already exist. However the literature covers especially drilling assembly equipped with a push- the-bit system. The main purpose of the second part of this work is to develop a mathematical model of a drilling assembly equipped with a point-the-bit system. This one is an enhancement of the Mathematical Model of the Near-Bit Region of an Advancing Drilling System developed by Detournay (2007). The model is composed of three interacting components: (i) the equations governing the geometrical evolution of the borehole, (ii) the laws that link the kinematical bit-rock penetration variables to the forces on the bit, and (iii) the relationships between the forces on the bit and the loads on the drillstring. The third part of this work presents the results of a parametric analysis of this mathematical model. The parametric analysis, led in the framework of planar borehole trajectories and stationary solutions, focus on the the borehole curvature and distinguishes the two configurations of the BHA: with and without rotary steerable system. Finally, a brief case study of a commercialised point-the-bit system is presented in the fourth part. The goal of this last section is to validate the mathematical model developed and highlight the limitations of this one. Some commonly accepted thoughts are also approached. [less ▲]

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See detailEnhancement effects in exclusive ππ and ρπ production in γ* γ scattering
Courtoy, Aurore ULg; Noguera, S.

in Physics Letters B (2009), 675(1), 38-42

The exclusive ππ and ρπ production in hard γ* γ scattering in the forward kinematical region where the virtual photon is highly off-shell is studied using the γ → π- Transition Distribution Amplitudes ... [more ▼]

The exclusive ππ and ρπ production in hard γ* γ scattering in the forward kinematical region where the virtual photon is highly off-shell is studied using the γ → π- Transition Distribution Amplitudes obtained in realistic models for the pion. For ρπ production we confirm the previous estimates before QCD evolution. Nevertheless, once evolution is taken into account this cross section grows one order of magnitude. In the case of ππ production we have evaluated the cross section including the pion pole contribution. We observe that this contribution is responsible for an enhancement of two orders of magnitude with respect to the cross section evaluated without the pion pole term. © 2009 Elsevier B.V. All rights reserved. [less ▲]

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See detailEnhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea resistance by gy gamma-irradiation or drug pretreatment in rat hepatoma cells
Habraken, Yvette ULg; Laval, Françoise

in Cancer Research (1991), 51(4), 499-503

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See detailEnhancement of bovine leukemia virus-induced syncytia formation by di- and tripeptides.
Voneche, V.; Callebaut, I.; Lambrecht, B. et al

in Virology (1993), 192(1),

Short hydrophobic peptides were previously shown to inhibit infectivity of para- and orthomyxoviruses. We tested the ability of a series of di- and tripeptides to interfere with cell fusion induced by ... [more ▼]

Short hydrophobic peptides were previously shown to inhibit infectivity of para- and orthomyxoviruses. We tested the ability of a series of di- and tripeptides to interfere with cell fusion induced by bovine leukemia virus (BLV). Peptides containing a hydrophobic contribution and/or a positive net charge strongly enhanced syncytia formation induced by BLV on CC81 indicator cells. The size of the multinucleated cells was strongly increased (up to 10-fold) in the presence of the enhancer peptides whereas no effect was observed on the indicator cells in the absence of BLV. The peptides thus amplified the fusion process initiated by BLV envelope glycoproteins. The effect was dose-dependent at concentrations ranging from 20 to 640 microM and did not result from an increased expression of BLV proteins. The peptides did not compete with anti-gp51 monoclonal antibodies for the recognition of eight well-defined epitopes of gp51. We consequently hypothesize that the enhancer peptides interact with the membrane of BLV-producing cells and/or indicator cells and propose a model based on molecular modeling. [less ▲]

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See detailEnhancement of in-situ Transformation of M2C Eutectics Carbides during High Temperature Heat Treatment on a HSS and a Semi-HSS Grades
Tchuindjang, Jérôme Tchoufack ULg; Sinnaeve, Mario; Lecomte-Beckers, Jacqueline ULg

Poster (2011, September)

Alloys of the complex system Fe-Si-C-Cr-C-X, where X is a strong carbide forming-element are well known to exhibit interesting mechanical properties, including wear and abrasion resistances. Such a ... [more ▼]

Alloys of the complex system Fe-Si-C-Cr-C-X, where X is a strong carbide forming-element are well known to exhibit interesting mechanical properties, including wear and abrasion resistances. Such a tribological behavior is mainly due to the presence of carbides especially those obtained during the solidification route and that are known as primary or eutectic carbides. It may therefore be interesting to determine the relative stability of primary carbides when considering thermal and thermomechanical treatments performed at a temperature high enough to allow either the homogenization of the matrix or the occurrence of a desired grain size. This thermal stage is often required to produce tailored microstructures that can lead to improved mechanical properties. In this work a series of thermal treatments performed on samples originated form casting foundry parts were done. Raw materials are both HSS and semi-HSS grades used in application where wear resistance is needed. Thermo- Calc® (TC) simulations and Differential Thermal Analysis (DTA) were performed to determine the crystallization behavior and the subsequent solid state transformations of the studied alloys respectively in equilibrium and in non equilibrium conditions. Light and Scanning Electron Microscopies were done together with hardness measurements in order to enhance metallurgical features of the heat treated samples. Image analysis yielded the determination of carbides volume fractions. It appears from microstructural analyses and carbides quantification that Mo-rich eutectic carbides undergo in situ phase transformations during heat treatments. In fact Mo-rich M2C carbides transform themselves into MC, M6C and M3C, through a so-called budding phenomenon. Such a phenomenon is the evidence of a preferential migration of some atoms that escape from the parent M2C carbide to diffuse further away from their initial site with increasing time and temperature. The stable or metastable nature of eutectic carbides is also discussed from DTA and TC results, as M2C carbides found in both as-conditions and DTA samples were not predicted by equilibrium conditions. [less ▲]

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See detailEnhancement of lysozyme stability and activity by polyamines
Powroznik, Brigitte; Gharbi, Myriam ULg; Dandrifosse, Guy ULg et al

in Biochimie (2004), 86(9-10, Sep-Oct), 651-656

Spermine, a low molecular weight polyamine, administered orally to suckling rats induces the maturation of the small intestine. In this organ, lysozyme is an important component of the innate immunity. In ... [more ▼]

Spermine, a low molecular weight polyamine, administered orally to suckling rats induces the maturation of the small intestine. In this organ, lysozyme is an important component of the innate immunity. In this report, we analysed the binding of spermine to lysozyme and its effect on thermal inactivation of the protein by spectroscopy techniques. The activity of the enzyme was analysed in presence of spermine by lysoplate technique. We studied the effects of spermine ingestion by suckling rats on intestinal lysozyme activity and gene expression. We reported that spermine binds to lysozyme and increases in vitro the thermal stability and the activity of the protein. When administered orally to suckling rats, spermine increases the lysozyme activity in jejunum, but not in ileum. This increase is not due to a modification of the gene expression. The observed effects lead us to postulate that spermine could be used in some mammals as a promoter of the innate immunity. (C) 2004 Elsevier SAS. All rights reserved. [less ▲]

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See detailEnhancement of metastatic potential of murine and human melanoma cells by laminin receptor peptide G: attachment of cancer cells to subendothelial matrix as a pathway for hematogenous metastasis.
Taraboletti, G.; Belotti, D.; Giavazzi, R. et al

in Journal of the National Cancer Institute (1993), 85(3), 235-40

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly ... [more ▼]

BACKGROUND: Stable anchorage of circulating cancer cells to the vasculature is a critical step in the formation of hematogenous metastases. Although the basement membrane glycoprotein laminin clearly plays a crucial role in this event, the exact interactive pathways among cancer cells, laminin, and the vessel wall have not been elucidated. In a previous study, we identified synthetic peptide G, which contains the laminin-binding domain of the 67-kd laminin receptor and which inhibits tumor cell adhesion to endothelial cells. PURPOSE: To assess the role of the interaction between laminin and the 67-kd laminin receptor in hematogenous metastasis formation, we studied the effect of peptide G on melanoma cell behavior in vivo and in vitro. METHODS: The effect of peptide G and control peptides was studied in vivo on lung retention and colonizing potential of murine (B16BL6) and human (A2058) melanoma cells injected intravenously in C57BL/6 and nude mice, respectively. In addition, their effect on cell adhesion and chemotaxis to laminin and on binding of iodine 125-labeled laminin to cells was studied in vitro. RESULTS: In vivo, pretreatment of cells with peptide G resulted in a two- to 10-fold significant increase in the number of experimental lung metastases. A significant relative increase in lung retention of peptide G-treated tumor cells was observed 48 hours after injection, although after 4 hours a partial reduction was observed. In vitro, peptide G significantly increased laminin binding and cancer cell adhesion to laminin and subendothelial matrix, whereas chemotaxis to laminin was significantly inhibited. CONCLUSIONS: Peptide G differentially affected the biological response of cancer cells to laminin. In vitro, it increased laminin binding and cell adhesion to laminin and subendothelial matrix, whereas it inhibited cell chemotaxis to laminin. In vivo, the overall effect of peptide G was an augmentation of lung metastasis. IMPLICATIONS: Our findings suggest that direct adhesion of tumor cells to the subendothelial matrix is a main pathway for hematogenous metastases and that tumor cell-matrix interaction may be more relevant than tumor cell-endothelial cell attachment in this process. [less ▲]

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See detailEnhancement of MSH2-MSH3-mediated mismatch repair recognition by the yeast MLH1-PMS1 complex
Habraken, Yvette ULg; Sung, Patrick; Prakash, Louise et al

in Current Biology (1997), 7(10), 790-3

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See detailEnhancement of nuclear receptor transcriptional signalling.
Renkawitz, Rainer; Kaltschmidt, Christian; Leers, Joerg et al

in Journal of Steroid Biochemistry & Molecular Biology (1996), 56(1-6 Spec No), 39-45

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which ... [more ▼]

Glucocorticoids and thyroid hormones induce complex responses in about every mammalian tissue. These effects are mediated by the transcription factor function of the corresponding nuclear receptors, which in most cases achieve the observed regulatory strength in synergy with other factors. Here we describe the functional interaction of the glucocorticoid receptor (GR) with liver-specific transcription factors, the functional synergy of GR with the thyroid hormone receptor (TR), the synergizing sub-domains of the TR, and finally the direct interaction of the GR with other proteins. [less ▲]

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See detailEnhancement of ray tracing method for radiative heat transfer with new isocell quasi-monte carlo technique and application to EUI space instrument
Jacques, Lionel ULg; Masset, Luc ULg; Kerschen, Gaëtan ULg

in Proceedings of the 10th International Conference on Heat Transfer, Fluid Mechanics and Thermodynamics, HEFAT2014 (2014, July)

Monte Carlo ray tracing method for thermal analysis. The rationale for this research is the speed-up of radiative heat transfer computation with the Finite Element Method, widely used in mechanical ... [more ▼]

Monte Carlo ray tracing method for thermal analysis. The rationale for this research is the speed-up of radiative heat transfer computation with the Finite Element Method, widely used in mechanical engineering especially for space structure design but not yet often for thermal analysis of these structures. Based on Nusselt’s analogy, the ray direction sampling is done by sampling the unit disc to derive the ray directions. Stratified sampling is applied to the unit disc that is divided into cells or strata into which random points are generated. The isocell method relies on cells that have the particularity of presenting almost the same area and shape. This enhances the uniformity of the generated quasi-random sequence of ray directions and leads to faster convergence. The isocell method is associated with different surface sampling to derive REFs. The method is benchmarked against ESARAD, the standard ray tracing engine of the thermal analysis software used in the European aerospace industry. Various geometries are used. In particular, one entrance baffle of the Extreme Ultraviolet Imager (EUI) instrument developed at the Centre Spatial de Liège in Belgium is presented. The EUI instrument of the Solar Orbiter European Space Agency mission and will be launched in a 0.28 perihelion orbit around the Sun in 2018. [less ▲]

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See detailEnhancement of ray tracing method for radiative heat transfer: application to EUI space instrument
Jacques, Lionel ULg; Masset, Luc ULg; Kerschen, Gaëtan ULg

in Proceedings of the 15th International Heat Transfer Conference, IHTC-15 (2014, August)

The finite element method (FEM) is widely used in mechanical engineering, in particular for space structure design. However, FEM is not yet often used for thermal engineering of space structures where the ... [more ▼]

The finite element method (FEM) is widely used in mechanical engineering, in particular for space structure design. However, FEM is not yet often used for thermal engineering of space structures where the lumped parameter method is still dominant. Radiative exchange factors (REFs), used to calculate radiative thermal exchanges in space, are usually computed through Monte Carlo ray tracing. Due to the large number of elements composing a FE model, the computation of the REFs is prohibitively expensive. The isocell method aims at reducing the computational effort of the REFs with FEM, by decreasing the number of rays required to achieve a given accuracy. Based on Nusselt’s analogy, the ray direction sampling is carried out by sampling the unit disc to derive the ray directions. The isocell method is a special case of stratified sampling. It divides the unit disc into cells of almost same area and shape from which random points are generated. This enhances the uniformity of the ray directions and leads to faster convergence. This isocell method is associated with different surface sampling to derive the REFs. The method is benchmarked against ESARAD, the standard thermal analysis ray tracing engine used in the European aerospace industry. One entrance baffle of the Extreme Ultraviolet Imager (EUI) instrument developedat the Centre Spatial de Liège in Belgium is used as benchmarking case. Solar Orbiter is an European Space Agency mission to be launched in a Sun-centered 0.28 perihelion orbit. [less ▲]

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See detailThe Enhancement of Secondary Succession by Western Lowland Gorillas (Gorilla gorilla gorilla) in a Moist Tropical Forest of Southeast Cameroon
Petre, Charles-Albert ULg; Haurez, Barbara ULg; Tagg, Nikki et al

in Folia Primatologica : International Journal of Primatology = Internationale Zeitschrift für Primatologie = Journal international de Primatologie (2013), 84

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See detailEnhancement of selectivity and resolution in the enantioseparation of uncharged compounds using mixtures of oppositely charged cyclodextrins in capillary electrophoresis.
Abushoffa, Adel M; Fillet, Marianne ULg; Servais, Anne-Catherine ULg et al

in Electrophoresis (2003), 24(3), 343-50

The enantiomeric separation of some nonsteroidal anti-inflammatory drugs (NSAIDs) was investigated in capillary electrophoresis (CE) using dual systems with mixtures of charged cyclodextrin (CD ... [more ▼]

The enantiomeric separation of some nonsteroidal anti-inflammatory drugs (NSAIDs) was investigated in capillary electrophoresis (CE) using dual systems with mixtures of charged cyclodextrin (CD) derivatives. A significant enhancement of selectivity and resolution could be achieved in the enantioseparation of these analytes in their uncharged form by the simultaneous addition of two oppositely charged CD derivatives to the background electrolyte. The combination of the single-isomer cationic CD, permethyl-6-monoamino-6-monodeoxy-beta-CD (PMMAbetaCD) and the single-isomer polyanionic CD, heptakis-6-sulfato-beta-cyclodextrin (HSbetaCD) in a pH 2.5 phosphoric acid-triethanolamine buffer, was designed and employed for the enantioseparation of profens. The improvement in selectivity and resolution can be attributed to the fact that the two CDs, which lead to independent and enantioselective complexation with the analyte enantiomers, have not only opposite effects on the electrophoretic mobility of these compounds but also opposite affinity patterns towards the enantiomers of these compounds. Binding constants for these enantiomers with each CD were determined using linear regression approach, in order to be able to predict the effect of the concentrations of the two CDs on enantiomeric selectivity and resolution in such dual systems. [less ▲]

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See detailEnhancement of steroid receptor-mediated transcription for the development of highly responsive bioassays
Willemsen, Philippe; Scippo, Marie-Louise ULg; Maghuin-Rogister, Guy ULg et al

in Analytical and Bioanalytical Chemistry (2005), 382(4), 894-905

We have previously generated several transformed human mammary cell lines for the detection of steroid receptor-mediated activities and used these cell lines to detect and characterize steroid hormone ... [more ▼]

We have previously generated several transformed human mammary cell lines for the detection of steroid receptor-mediated activities and used these cell lines to detect and characterize steroid hormone (ant)agonistic compounds. In this report, we describe the specific optimization procedures used to enhance receptor-mediated transcription through the human glucocorticoid, progesterone and androgen receptors, respectively. Sodium arsenite-induced chemical stress leads to a substantial and specific increase in the glucocorticold receptor-mediated transcription, resulting in maximal stimulations of more than 2000-fold by the agonist dexamethasone. Similarly, a combined treatment with forskolin (an activator of adenylate cyclase) and trichostatin A (an inhibitor of histone deacetylases) leads to a synergistic enhancement of progesterone or androgen stimulation, resulting in a maximal induction of more than 200-fold or about 100-fold, respectively. The enhanced responses to specific steroids are mediated by the corresponding nuclear receptor. We show that by using these enhanced transcriptional stimulation protocols, it is possible to detect lower amounts of steroid hormones without substantially affecting the relative biological activities of various agonists. Finally, the application of these enhanced reporter cell assays to real biological samples from meat-producing animals is evaluated, and some validation parameters are presented. [less ▲]

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