Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
See detailDisorders of consciousness
Thibaut, Aurore ULg

Scientific conference (2013, January)

Detailed reference viewed: 12 (3 ULg)
See detailDisorders of consciousness
Vanhaudenhuyse, Audrey ULg

Conference (2012)

Detailed reference viewed: 15 (2 ULg)
Full Text
Peer Reviewed
See detailDisorders of consciousness after acquired brain injury: the state of the science
Giacino, Joseph T; Fins, Joseph J; Laureys, Steven ULg et al

in Nature Reviews Neurology (2014)

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain ... [more ▼]

The concept of consciousness continues to defy definition and elude the grasp of philosophical and scientific efforts to formulate a testable construct that maps to human experience. Severe acquired brain injury results in the dissolution of consciousness, providing a natural model from which key insights about consciousness may be drawn. In the clinical setting, neurologists and neurorehabilitation specialists are called on to discern the level of consciousness in patients who are unable to communicate through word or gesture, and to project outcomes and recommend approaches to treatment. Standards of care are not available to guide clinical decision-making for this population, often leading to inconsistent, inaccurate and inappropriate care. In this Review, we describe the state of the science with regard to clinical management of patients with prolonged disorders of consciousness. We review consciousness-altering pathophysiological mechanisms, specific clinical syndromes, and novel diagnostic and prognostic applications of advanced neuroimaging and electrophysiological procedures. We conclude with a provocative discussion of bioethical and medicolegal issues that are unique to this population and have a profound impact on care, as well as raising questions of broad societal interest. [less ▲]

Detailed reference viewed: 105 (8 ULg)
See detailDisorders of consciousness and neuroimaging techniques
Charland-Verville, Vanessa ULg; Demertzi, Athina ULg; VANHAUDENHUYSE, Audrey ULg et al

Scientific conference (2013, January)

Detailed reference viewed: 6 (0 ULg)
Full Text
Peer Reviewed
See detailDisorders of consciousness: Are we ready for a paradigm shift? - Authors' reply
Jox, RJ; Bernat, JL; Laureys, Steven ULg et al

in Lancet (2013), Vol 12

Detailed reference viewed: 20 (2 ULg)
See detailDisorders of consciousness: Belgium Federal Project
Thibaut, Aurore ULg

Scientific conference (2013, January)

Detailed reference viewed: 9 (0 ULg)
See detailDisorders of consciousness: Belgium Federal Project
Vanhaudenhuyse, Audrey ULg

Conference (2012)

Detailed reference viewed: 16 (0 ULg)
Full Text
See detailDisorders of consciousness: coma, vegetative and minimally conscious states
Gosseries, Olivia ULg; Vanhaudenhuyse, Audrey ULg; Bruno, Marie-Aurélie ULg et al

in D. Cvetkovic & I. Cosic (Ed.) States of Consciousness: Experimental Insights into Meditation, Waking, Sleep and Dreams (2011)

Detailed reference viewed: 55 (3 ULg)
Full Text
Peer Reviewed
See detailDisorders of consciousness: further pathophysiological insights using motor cortex transcranial magnetic stimulation.
Lapitskaya, Natallia; Coleman, Martin R.; Nielsen, Joergen Feldbaek et al

in Progress in Brain Research (2009)

Transcranial magnetic stimulation (TMS) is a noninvasive means of investigating the function, plasticity, and excitability of the human brain. TMS induces a brief intracranial electrical current, which ... [more ▼]

Transcranial magnetic stimulation (TMS) is a noninvasive means of investigating the function, plasticity, and excitability of the human brain. TMS induces a brief intracranial electrical current, which produces action potentials in excitable cells. Stimulation applied over the motor cortex can be used to measure overall excitability of the corticospinal system, somatotopic representation of muscles, and subsequent plastic changes following injury. The facilitation and inhibition characteristics of the cerebral cortex can also be compared using the modulatory effect of a conditioning stimulus preceding a test stimulus. So called paired-pulse protocols have been used in humans and animals to assess GABA (gamma-amino-butyric acid)-ergic function and may have a future role directing therapeutic interventions. Indeed, repetitive magnetic stimulation, where intracranial currents are induced by repetitive stimulation higher than 1 Hz, has been shown to modulate brain responses to sensory and cognitive stimulation. Here, we summarize information gathered using TMS with patients in coma, vegetative state, and minimally conscious state. Although in the early stages of investigation, there is preliminary evidence that TMS represents a promising tool by which to elucidate the pathophysiological sequelae of impaired consciousness and potentially direct future therapeutic interventions. We will discuss the methodology of work conducted to date, as well as debate the general limitations and pitfalls of TMS studies in patients with altered states of consciousness. [less ▲]

Detailed reference viewed: 93 (5 ULg)
Full Text
Peer Reviewed
See detailDisorders of consciousness: Moving from passive to resting state and active paradigms
Bruno, Marie-Aurélie ULg; Soddu, Andrea ULg; Demertzi, Athina ULg et al

in Cognitive Neuroscience (2010), 1(1), 193203

Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e ... [more ▼]

Following coma, some patients will recover wakefulness without signs of consciousness (i.e., vegetative state) or may show nonreflexive movements but with no ability for functional communication (i.e., minimally conscious state). Currently, there remains a high rate of misdiagnosis of the vegetative state. The increasing use of fMRI and EEG tools permits the clinical characterization of these patients to be improved. We first discuss “resting metabolism” and “passive activation” paradigms, used in neuroimaging and evoked potential studies, which merely identify neural activation reflecting “automatic” processing—that is, occurring without the patient’s willful intervention. Secondly, we present an alternative approach consisting of instructing subjects to imagine well-defined sensorymotor or cognitive-mental actions. This strategy reflects volitional neural activation and, hence, witnesses awareness. Finally, we present results on blood-oxgen-level-dependent “default mode network”/resting state studies that might be a promising tool in the diagnosis of these challenging patients. [less ▲]

Detailed reference viewed: 61 (10 ULg)
See detailDisorders of consciousness: new advances in neuroimaging techniques
Soddu, Andrea ULg; Bruno, Marie-Aurélie ULg; VANHAUDENHUYSE, Audrey ULg et al

in Zanotti, Bruno (Ed.) Vegetative State (in press)

Detailed reference viewed: 38 (1 ULg)
Full Text
See detailDisorders of consciousness: what do we know?
Chatelle, Camille ULg; Laureys, Steven ULg; Schnakers, Caroline ULg

in Dehaene, Stanislas; Christen, Yves (Eds.) Characterizing Consciousness: From Cognition to the Clinic? (2011)

Detailed reference viewed: 4 (1 ULg)
Full Text
Peer Reviewed
See detailDisorders of consciousness: What's in a name?
Gosseries, Olivia ULg; Bruno, Marie-Aurélie ULg; Chatelle, Camille ULg et al

in NeuroRehabilitation (2011), 28

Following a coma, some patients may “awaken” without voluntary interaction or communication with the environment. More than 40 years ago this condition was coined coma vigil or apallic syndrome and later ... [more ▼]

Following a coma, some patients may “awaken” without voluntary interaction or communication with the environment. More than 40 years ago this condition was coined coma vigil or apallic syndrome and later became worldwide known as “persistent vegetative state”. About 10 years ago it became clear that some of these patients who failed to recover verbal or nonverbal communication did show some degree of consciousness – a condition called “minimally conscious state”. Some authors questioned the usefulness of differentiating unresponsive “vegetative” from minimally conscious patients but subsequent functional neuroimaging studies have since objectively demonstrated differences in residual cerebral processing and hence, we think, conscious awareness. These neuroimaging studies have also demonstrated that a small subset of unresponsive “vegetative” patients may show unambiguous signs of consciousness and command following inaccessible to bedside clinical examination. These findings, together with negative associations intrinsic to the term “vegetative state” as well as the diagnostic errors and their potential effect on the treatment and care for these patients gave rise to the recent proposal for an alternative neutral and more descriptive name: unresponsive wakefulness syndrome. We here give an overview of PET and (functional) MRI studies performed in these challenging patients and stress the need for a separate ICD9CM diagnosis code and MEDLINEMeSH entry for “minimally conscious state” as the lack of clear distinction between vegetative state/unresponsive wakefulness syndrome and minimally conscious state may encumber scientific studies in the field of disorders of consciousness. [less ▲]

Detailed reference viewed: 107 (2 ULg)
Full Text
See detailDisorders of lambs thyroid by a glucosinolate metabolite: the 5-vinyl-l,3-oxazolidine-2-thione (5-VOT)
Mabon, N.; Mandiki, S.; Bister, J.-L. et al

Conference (2003)

The impact of 5-VOT on thyroid was studied in two lambs. They received ad libitum water, hay and concentrates without rapeseed from ten days of age till weaning (65 days of age). At 85 days of age, one of ... [more ▼]

The impact of 5-VOT on thyroid was studied in two lambs. They received ad libitum water, hay and concentrates without rapeseed from ten days of age till weaning (65 days of age). At 85 days of age, one of them was fed with the same diet but mixed with 100g/d of a rapeseed containing high level of progoitrin: 71.4µmol/g DM (variety Jet Neuf). Blood samples were taken fortnightly for the determination of TSH (Thyroid Stimulating Hormone), T3 (Tri-iodothyronin) and T4 (thyroxin) plasma concentrations. [less ▲]

Detailed reference viewed: 21 (1 ULg)
Full Text
Peer Reviewed
See detailDisorders of mitochondrial function
Debray, François-Guillaume ULg; Lambert, M.; Mitchell, G. A.

in Current Opinion in Pediatrics (2008), 20(4), 471-482

Detailed reference viewed: 11 (1 ULg)
Peer Reviewed
See detailDisorganization of cell-cell junctions regulates vimentin expression during tumor invasion-associated EMT.
Gilles, Christine ULg; Polette, M; Mestadgt, M et al

Conference (2003, October 05)

Detailed reference viewed: 11 (0 ULg)
Full Text
See detailDispa-SET 2.0: unit commitment and power dispatch model
Hidalgo González, Ignacio; Quoilin, Sylvain ULg; Zucker, Andreas

Report (2014)

Most analyses of the future European energy system conclude that in order to achieve energy and climate change policy goals it will be necessary to ramp up the use of renewable energy sources. The ... [more ▼]

Most analyses of the future European energy system conclude that in order to achieve energy and climate change policy goals it will be necessary to ramp up the use of renewable energy sources. The stochastic nature of those energies, together with other sources of short- and long-term uncertainty, already have significant impacts in current energy systems operation and planning, and it is expected that future energy systems will be forced to become increasingly flexible in order to cope with these challenges. Therefore, policy makers need to consider issues such as the effects of intermittent energy sources on the reliability and adequacy of the energy system, the impacts of rules governing the curtailment or storage of energy, or how much backup dispatchable capacity may be required to guarantee that energy demand is safely met. Many of these questions are typically addressed by detailed models of the electric power sector with a high level of technological and temporal resolution. This report describes one of such models developed by the JRC's Institute for Energy and Transport: Dispa-SET 2.0, a unit commitment and dispatch model of the European power system aimed at representing with a high level of detail the short-term operation of large-scale power systems. The new model is an updated version of Dispa-SET 1.0, in use at the JRC since 2009. [less ▲]

Detailed reference viewed: 68 (4 ULg)
Peer Reviewed
See detailDisparités au sein du système éducatif en Communauté française de Belgique
Lafontaine, Dominique ULg

in Eduquer et former. Théories et pratiques (1995), 7

Detailed reference viewed: 13 (0 ULg)
Full Text
Peer Reviewed
See detailLes disparités et les dynamiques territoriales. Introduction méthodologique
Merenne-Schoumaker, Bernadette ULg

in Bulletin de la Société Géographique de Liège (1994), (30), 5-14

This paper considers three kinds of methodological problems in the field of territorial dynamics and disparities. First of all, the definition of the concepts of disparity, dynamics and territory ... [more ▼]

This paper considers three kinds of methodological problems in the field of territorial dynamics and disparities. First of all, the definition of the concepts of disparity, dynamics and territory; secondly, the choice of spatial analysis levels, temporal limits and indicators and finally research into explanations. These are always very complicated and pratical despite the contribution of the major regional development theories and the new inquiries of regional science in the field of perceptions, networks and actors' roll. [less ▲]

Detailed reference viewed: 1037 (3 ULg)