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See detailElogio di Collodi
Curreri, Luciano ULg

in Le avventure di Pinocchio : Storia di un burattino (2010)

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See detailElongation of telechelic ionomers under shear: a rheological and rheo-optical study
Chassenieux, Christophe; Tassin, Jean-François; Gohy, Jean-François et al

in Macromolecules (2000), 33(5), 1796-1800

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong ... [more ▼]

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong increase of birefringence and a pronounced and rapid alignment of the polymer chains toward the flow direction leading to an important elasticity of the fluids. The draw ratio of the polymer chains under shear has been estimated from the rheo-optical data. When the fraction of loops is taken into account, draw ratios on the order of 4 are calculated in the shear thickening regime. [less ▲]

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See detailElongator - an emerging role in neurological disorders
Nguyen, Laurent ULg; Humbert, Sandrine; Saudou, Frédéric et al

in Trends in Molecular Medicine (2010), 16

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based ... [more ▼]

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based treatments to correct brain malformations or to prevent the progression of cell death in neurodegenerative disorders, most of these pathologies follow a fatal course. Thus, one major objective is to understand the molecular events that underlie these diseases in order to prevent their onset and/or halt their progression. Converging experimental and clinical evidences obtained by our lab and others prompt us to speculate that Elongator may be commonly targeted in different neurological disorders and as such, should represent a strong candidate for research and development efforts to design drug-based therapies. [less ▲]

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See detailElongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin
Creppe, Catherine ULg; Malinouskaya, Lina ULg; Volvert, Marie-Laure ULg et al

in Cell (2009), 136

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which ... [more ▼]

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which contributes to transcript elongation, also regulates the maturation of projection neurons. Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. Strikingly, neurons defective in Elongator show reduced levels of acetylated alpha tubulin. A direct reduction of alpha tubulin acetylation leads to comparable defects in cortical neurons and suggests that alpha tubulin is a target of Elp3. This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate in vitro. Our results uncover alpha tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons. [less ▲]

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See detailElongator depletion causes defective transcript elongation of genes that regulate cell motility
Close, Pierre ULg; Hawkes, N; Cornez, I et al

Poster (2005, November 15)

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See detailElongator orchestrates cerebral cortical neurogenesis
creppe, catherine; malinouskaya, lina; Volvert, Marie-Laure ULg et al

in Medecine Sciences : M/S (2010)

Pas d'abstract pour cette publication

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See detailElp3 is required for initiation of colon cancer
Ladang, Aurélie ULg; Heukamp, L; Buettner, R et al

Poster (2013, September 18)

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See detailEls problemes de la violència esportiva. 10 anys després de Heysel
Comeron, Manuel ULg; Van Limbergen, Kris

in Revista d’Historia L'Avenç (1997), (211), 25-32

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es ... [more ▼]

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es relaciona llavors amb comportaments d'agressio fisica i de vandalisme produïts pels espectadors d'una manifestacio esportiva, mes concretament dels partits de futbol. [less ▲]

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See detailEls Terratrèmols de l'any 1373 al Pirineu : Efectes a Espanya i França
Olivera, Carme; Riera, Antoni; Alexandre, Pierre ULg et al

Book published by Servei Geologic de Catalunya (1994)

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See detailElsvier, Computers in Industry, Special Issue on Natural Language Processing and Text Analytics in Industry
Ittoo, Ashwin ULg; Bosh, v.d., Antal; Nguyen, Le Minh

Book published by Elsevier (2015)

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See detailElucidating the altered transcriptional programs in breast cancer using independent component analysis
Teschendorff, A. E.; Journee, Michel ULg; Absil, P.-A. et al

in PLoS Computational Biology (2007), 3(8), 1539-1554

The quantity of mRNA transcripts in a cell is determined by a complex interplay of cooperative and counteracting biological processes. Independent Component Analysis ( ICA) is one of a few number of ... [more ▼]

The quantity of mRNA transcripts in a cell is determined by a complex interplay of cooperative and counteracting biological processes. Independent Component Analysis ( ICA) is one of a few number of unsupervised algorithms that have been applied to microarray gene expression data in an attempt to understand phenotype differences in terms of changes in the activation/ inhibition patterns of biological pathways. While the ICA model has been shown to outperform other linear representations of the data such as Principal Components Analysis ( PCA), a validation using explicit pathway and regulatory element information has not yet been performed. We apply a range of popular ICA algorithms to six of the largest microarray cancer datasets and use pathway- knowledge and regulatory- element databases for validation. We show that ICA outperforms PCA and clustering- based methods in that ICA components map closer to known cancer- related pathways, regulatory modules, and cancer phenotypes. Furthermore, we identify cancer signalling and oncogenic pathways and regulatory modules that play a prominent role in breast cancer and relate the differential activation patterns of these to breast cancer phenotypes. Importantly, we find novel associations linking immune response and epithelial - mesenchymal transition pathways with estrogen receptor status and histological grade, respectively. In addition, we find associations linking the activity levels of biological pathways and transcription factors ( NF1 and NFAT) with clinical outcome in breast cancer. ICA provides a framework for a more biologically relevant interpretation of genomewide transcriptomic data. Adopting ICA as the analysis tool of choice will help understand the phenotype - pathway relationship and thus help elucidate the molecular taxonomy of heterogeneous cancers and of other complex genetic diseases. [less ▲]

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See detailElucidating the structure of genetic regulatory networks: a study of a second order dynamical model on artificial data
Quach, Minh; Geurts, Pierre ULg; d Alché-Buc, Florence

in Proc. of the 14th European Symposium on Artificial Neural Networks (2006)

Learning regulatory networks from time-series of gene expres- sion is a challenging task. We propose to use synthetic data to analyze the ability of a state-space model to retrieve the network structure ... [more ▼]

Learning regulatory networks from time-series of gene expres- sion is a challenging task. We propose to use synthetic data to analyze the ability of a state-space model to retrieve the network structure while varying a number of relevant problem parameters. ROC curves together with new tools such as spectral clustering of local solutions found by EM are used to analyze these results and provide relevant insights. [less ▲]

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See detailElucidation of non-parallel EIA curves
François-Gérard, C.; Gérard, Paul ULg; Rentier, Bernard ULg

in Journal of Immunological Methods (1988), 111(1), 59-65

Quantitative determinations by EIA can be only obtained by reverse regression when linear portions of sample and standard curves are parallel. However, analysis of complex biological fluids often yields ... [more ▼]

Quantitative determinations by EIA can be only obtained by reverse regression when linear portions of sample and standard curves are parallel. However, analysis of complex biological fluids often yields sigmoid curves displaying lower slopes, thus invalidating any quantitative interpretation. We hypothesized that this phenomenon was due to a competition effect between the target (for example an antigen) and related molecules for the binding sites (for example a capture antibody) immobilized onto the solid phase. This has been confirmed experimentally using various target-to-competitor ratios and formulated as a mathematical model. The slope decrease in target detection was related to the proportion of competitor, not in a linear, but in an exponential manner. This mathematical model has been computerized and can be used to correct aberrant sample curves provided the relevant parameters have been previously determined in the same systems. A competition effect should be suspected whenever non-parallel EIA sigmoid slopes are obtained. [less ▲]

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See detailElucidation of the gas vesicle gene clusters in cyanobacteria of the genus Arthrospira (Oscillatoriales, Cyanophyta) and correlation with ITS phylogeny
Miklaszewska, Magdalena; Waleron, Malgorzata; Morin, Nicolas et al

in European Journal of Phycology (2012), 47

The genus Arthrospira comprises filamentous cyanobacteria in which the trichomes form an open helix and contain gas vacuoles. The gas vesicle gene cluster of five Arthrospira strains was amplified by PCR ... [more ▼]

The genus Arthrospira comprises filamentous cyanobacteria in which the trichomes form an open helix and contain gas vacuoles. The gas vesicle gene cluster of five Arthrospira strains was amplified by PCR and sequenced. The genes are organized in one operon, in the order gvpA1–gvpC1–gvpA2–gvpC2–gvpA3–gvpC3–gvpN. In Arthrospira sp. strain PCC 8005, the genes gvpJ, gvpK, gvpV and gvpW were also identified. Each of the three copies of gvpA encodes a protein of 71 amino acids. In the case of gvpC, there are two different length variants. Each of the two shorter genes, gvpC1 and gvpC2, encodes a putative protein of 151 amino acids, while the longer one, gvpC3, codes for a putative protein of 284 residues. The amino acid sequences of GvpC1 and GvpC2 are identical to the N-terminal part of GvpC3. In spite of the presence of stop codons downstream of gvpC1 and gvpC2, the deduced amino acid sequences in these regions are highly similar to the C-terminal part of GvpC3 (residues 160 to 229). The GvpC1, GvpC2 and GvpC3 proteins contain contiguous repeats of 33 amino acids as previously reported for other cyanobacteria. The sequences of the gvpA1, gvpC1, gvpA2 and gvpC2 genes were not found in the genome data of Arthrospira sp. PCC 8005, A. maxima CS-328, and A. platensis NIES-39 as a result of incomplete assembly. The genes gvpN and gvpJ located downstream of gvpC3, encode putative proteins of 394 and 127 amino acids, respectively. The deduced amino acid sequences of gvpK, gvpV and gvpW contain 151, 112 and 227 residues, respectively. The analysis of gvp sequences of five strains of Arthrospira revealed the presence of polymorphic positions, which distinguished the strains in agreement with their previous assignments to ITS clusters I and II. This is the first report of gvp genes in members of the genus Arthrospira. [less ▲]

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See detailLes élus d'origine étrangère à Bruxelles: une nouvelle étape de la participation politique des populations d'origine immigrée
Martiniello, Marco ULg

in Revue Européenne des Migrations Internationales (1998), 14(2), 123-149

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See detailElusive Poets, Fugitive Texts. The Impact of the London Shelley Society in the Low Countries
Steyaert, Kris ULg

in Toremans, Tom; Verschueren, Walter (Eds.) Crossing Cultures. Nineteenth-Century Anglophone Literature in the Low Countries (2009)

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See detailElusiveness of evidence for multifragmentation in 1-GeV proton-nucleus reactions
Mancusi, D.; Boudard, A.; Cugnon, Joseph ULg et al

in Physical Review. C : Nuclear Physics (2011), 84(6),

We use the tools of hybrid intranuclear-cascade/nuclear-deexcitation models to evaluate the sensitivity of several physical observables to the inclusion of a multifragmentation stage in the deexcitation ... [more ▼]

We use the tools of hybrid intranuclear-cascade/nuclear-deexcitation models to evaluate the sensitivity of several physical observables to the inclusion of a multifragmentation stage in the deexcitation chain and assess the need for a multifragmentation model in the quantitative description of p + 56Fe and p + 136Xe reactions at 1-GeV incident energy. We seek clear signatures of multifragmentation by comparing different state-of-the-art deexcitation models coupled with intranuclear-cascade models and by focusing on discriminating observables such as correlations and fragment longitudinal-velocity distributions. None of the considered observables can be unambiguously interpreted as a multifragmentation footprint. The experimental data are best described as originating from sequential binary decays. However, no deexcitation model can reproduce the experimental longitudinal-velocity distributions from 1-GeV p + 136Xe. © 2011 American Physical Society. [less ▲]

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See detailThe elusiveness of multifragmentation footprints in 1-GeV proton-nucleus reactions
Mancusi, D; Boudard, A; Cugnon, Joseph ULg et al

in EPJ Web of Conferences (2012), 31

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See detailL'émancipation du Conseil de la Concurrence? Note sous la décision du Conseil de la concurrence du 26 mai 2009 dans l'affaire Base/BMB
Petit, Nicolas ULg; Provost, Elise ULg

in Tijdschrift voor Belgische Mededinging [=TBM] = Revue de la Concurrence Belge [=RCB] (2010), (2), 89-101

Enième avatar de la bataille juridique opposant les opérateurs alternatifs de communications électroniques à l’ancien monopole public Belgacom1, la décision commentée constitue une première pour Conseil ... [more ▼]

Enième avatar de la bataille juridique opposant les opérateurs alternatifs de communications électroniques à l’ancien monopole public Belgacom1, la décision commentée constitue une première pour Conseil de la concurrence (« le Conseil ») à plus d’un titre : première condamnation de l’opérateur historique, première caractérisation d’un ciseau tarifaire abusif, première décision infligeant une amende aussi élevée en Belgique. Après des années de carence dans l’application des règles de concurrence au secteur des communications électroniques le Conseil parait vouloir renverser la vapeur. Sonne peut-être – comme nous l’avons écrit précédemment – la « fin de la récréation pour l’opérateur historique ». Il faut sans doute s’en féliciter, la Belgique figurant depuis longtemps parmi les mauvais élèves de l’ouverture à la concurrence des industries de réseaux. [less ▲]

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