Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailDevelopment and assessment of the Osteoporosis Index of Risk (OSIRIS) to facilitate selection of women for bone densitometry
Sedrine, W. B.; Chevallier, T.; Zegels, Brigitte ULg et al

in Gynecological Endocrinology : The Official Journal of the International Society of Gynecological Endocrinology (2002), 16(3), 245-250

A simple questionnaire would be useful to identify individuals most in need of bone mineral density (BMD) testing. We designed a new predictive model and risk assessment instrument based on an extensive ... [more ▼]

A simple questionnaire would be useful to identify individuals most in need of bone mineral density (BMD) testing. We designed a new predictive model and risk assessment instrument based on an extensive review of the literature evaluating risk factors for osteoporosis, and tested its performance in a large cohort of postmenopausal women in whom BMD was measured by dual x-ray absorptiometry. In total, 1303 postmenopausal women from an outpatient osteoporosis clinic participated in this study. The Osteoporosis Index of Risk (OSIRIS) is based on four variables: age, body weight, current hormone replacement therapy use and history of previous low impact fracture. The sensitivity and specificity for an OSIRIS value of +1 were respectively 78.5% and 51.4%. The AUC under the ROC curve of OSIRIS was 0.71. Three categories were arbitrarily created using OSIRIS, with cutoff of +1 and -3. The low risk category (OSIRIS > +1) represented 41% of all women; only 7% of the women in this category had osteoporosis. The prevalence of osteoporosis was very high (66%) among the group at high risk (OSIRIS < -3 representing 15% of all women). The prevalence of osteoporosis was 39% in the intermediate risk group (-3 < OSIRIS < +1, 44% of all women). In conclusion, OSIRIS is a simple index based on four easy-to-collect variables from postmenopausal women, it shows a high degree of accuracy, and performed well for classifying the degree of risk of osteoporosis in western European women of Caucasian lineage. Based on this instrument it is possible to propose a strategy that would initiate treatment in women with very high risk, postpone BMD measurement in women with low risk and limit BMD measurement to women with intermediate risk of osteoporosis, this would spare more than 55% of the densitometry bill compared with a mass screening scenario. [less ▲]

Detailed reference viewed: 21 (2 ULg)
Full Text
Peer Reviewed
See detailDevelopment and characterization of bilayer films of FucoPol and chitosan
Ferreira, A.R.V.; Torres, C.A.V.; Freitas, F. et al

in Carbohydrate Polymers (2016), 147

Detailed reference viewed: 19 (3 ULg)
Full Text
Peer Reviewed
See detailDevelopment and characterization of microsatellite loci in Pericopsis elata (Fabaceae) using a cost-efficient approach
Micheneau, Claire; Dauby, Gilles; Bourland, Nils ULg et al

in American Journal of Botany (2011)

Premise of the study : Microsatellite loci were developed in the endangered Pericopsis elata using a combination of low-cost procedures. Methods and Results : Microsatellite isolation was performed ... [more ▼]

Premise of the study : Microsatellite loci were developed in the endangered Pericopsis elata using a combination of low-cost procedures. Methods and Results : Microsatellite isolation was performed simultaneously on three distinct species through a newly available procedure that associates multiplex microsatellite enrichment and next-generation sequencing, allowing the rapid and low-cost development of microsatellite-enriched libraries through the use of a 1/32nd GS-FLX plate. Genotyping using M13-like label- ing in multiplexed reactions allowed additional cost savings. From 72 primers selected for initial screening, 21 positively amplified P. elata , and 11 showed polymorphism with two to 11 alleles per locus and a mean value of 5.4 alleles per locus. Conclusions : These microsatellite loci will be useful to further investigate the level of genetic variation within and between natural populations of P. elata in Africa. [less ▲]

Detailed reference viewed: 27 (7 ULg)
Full Text
Peer Reviewed
See detailDevelopment and characterization of SSR markers for pomegranate (Punica granatum L.) using an enriched library
Hasnaoui, Nejib ULg; Buonamici, Anna; Sebastiani, Federico et al

in Conservation Genetics Resources (2010), 2

In the present work, we report the development of 11 microstallite markers (SSR) for Punica granatum. Evaluated on a set of 27 pomegranate accessions sampled in Tunisia, they displayed 25 alleles, with ... [more ▼]

In the present work, we report the development of 11 microstallite markers (SSR) for Punica granatum. Evaluated on a set of 27 pomegranate accessions sampled in Tunisia, they displayed 25 alleles, with number of alleles per locus ranging between 1 and 4, and an observed heterozygosity from 0.037 and 0.592. This set of SSR markers can be very useful for studies dealing with genetic diversity assessment of germplasm, with cultivars/varieties fingerprinting and pedigree analysis of this economically important fruit species. [less ▲]

Detailed reference viewed: 58 (3 ULg)
Full Text
See detailDevelopment and comparison of liposomes and nanocapsules as injectable nanocarriers for poorly aqueous soluble drugs
Karim, Reatul ULg; Palazzo, Claudio ULg; Laloy, Julie et al

Poster (2016, December)

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site ... [more ▼]

About 90% of drugs in development phase have poor aqueous solubility. Liposomes and nanocapsules are promising approaches that enable parenteral administration of these drugs with possibilities of site specific delivery. The objective of the study was to develop different liposomes and lipid nanocapsules entrapping a hydrophobic model molecule (apigenin (AG)), and to characterize and compare them as potential injectable nanocarriers (NCs) for drugs with low aqueous solubility. [less ▲]

Detailed reference viewed: 51 (7 ULg)
Peer Reviewed
See detailDevelopment and epidemiological evaluation of a monoclonal ELISA detecting Bovine Viral Diarrhœa Pestivirus antigens in field blood samples of persistently infected cattle
Mignon, Bernard ULg; Dubuisson, J.; Waxweiler, S. et al

in Steven, Edwards (Ed.) ESVV-Proceedings of the second symposium on pestiviruses (1993)

Detailed reference viewed: 10 (7 ULg)
Full Text
Peer Reviewed
See detailDevelopment and evaluation in vitro and in vivo of injectable hydrolipidic gels with sustained-release properties for the management of articular pathologies such as osteoarthritis.
Réeff, Jonathan; Oprenyeszk, Frédéric ULg; Franck, Thierry ULg et al

in International Journal of Pharmaceutics (2015), 490

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the ... [more ▼]

This study aimed to evaluate glycerol monooleate (GMO) as a carrier to develop viscoelastic and injectable sustained-release drug delivery systems. The potential pro- and antioxidant activity of the developed hydrolipidic gels were evaluated by measuring the production of ROS by polymorphonuclear leukocytes (PMNs). In addition, the biocompatibility and effectiveness of two selected gel candidates were evaluated in vivo by evaluating the benefit of a single intraarticular injection of these new treatments in a model of osteoarthritis in rabbits. The in vitro study demonstrated that the carrier F1 did not have a pro-oxidative effect and even protected PMNs against natural auto-activation, regardless of the incorporation of either clonidine chlorhydrate or betamethasone dipropionate. The in vivo study demonstrated that F1 and F1-BDP induced a loss of cartilage quality in comparison to the control and reference groups but that the lesions of cartilage observed were generally mild, with not much full-depth erosion. Moreover, no exacerbating inflammation was observed when considering the synovial membranes and the PGE2 and CRP levels. These results seemed to demonstrate that the sustained-release formulation based on GMO could be well-tolerated after intraarticular injection. Moreover, it could have the potential to prevent inflammatory conditions while sustaining drug activity locally over weeks. [less ▲]

Detailed reference viewed: 33 (3 ULg)
Full Text
See detailDevelopment and Evaluation of a VTOL Observation Platform
Buysschaert, F.; Yacoubi, M.; Alami, A. et al

in Proceedings of the 27th International Congress of the Aerospace Sciences (2010, September)

An aerodynamic study of the ULB-developed ducted rotor MAV using the results of full-scale wind tunnel tests allowed the determination of the platform’s positive speed envelope, power requirements and ... [more ▼]

An aerodynamic study of the ULB-developed ducted rotor MAV using the results of full-scale wind tunnel tests allowed the determination of the platform’s positive speed envelope, power requirements and endurance characteristics for ISA sea level conditions. In this study, the power consumption appears to be majorly depending on the rotor rotational speed, while an increase in horizontal speed results in a duct operating more as a circular wing, also unveiling a power bucket as is the case with conventional helicopters. A positive influence of the ground proximity on the total thrust has been monitored. [less ▲]

Detailed reference viewed: 81 (19 ULg)
Full Text
Peer Reviewed
See detailDevelopment and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.
Rubins, Daniel J.; Melega, William P.; Lacan, Goran et al

in NeuroImage (2003), 20(4), 2100-18

An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were ... [more ▼]

An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were defined on a set of digitized cryosectioned images of the rat brain. For VOI placement, each PET study was registered with a synthetic PET target constructed from the VOI template. Registration was accomplished with an automated algorithm that maximized the mutual information content of the image volumes. The accuracy and precision of this method for VOI placement was determined using datasets from PET studies of the striatal dopamine and hippocampal serotonin systems. Each evaluated PET study could be registered to at least one synthetic PET target without obvious failure. Registration was critically dependent upon the initial position of the PET study relative to the synthetic PET target, but not dependent on the amount of synthetic PET target smoothing. An evaluation algorithm showed that resultant radioactivity concentration measurements of selected brain structures had errors=2% due to misalignment with the corresponding VOI. Further, radioligand binding values calculated from these measurements were found to be more precise than those calculated from measurements obtained with manually drawn regions of interest (ROIs). Overall, evaluation results demonstrated that this atlas-derived VOI method can be used to obtain unbiased measurements of radioactivity concentration from PET studies. Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures. [less ▲]

Detailed reference viewed: 60 (5 ULg)
Full Text
Peer Reviewed
See detailThe development and experimental validation of a reduced ternary kinetic mechanism for the auto-ignition at HCCI conditions, proposing a global reaction path for ternary gasoline surrogates
Machrafi, Hatim ULg; Cavadias, Simeon; Amouroux, Jacques

in Fuel Processing Technology (2009), 90(2), 247-263

To acquire a high amount of information of the behaviour of the Homogeneous Charge Compression Ignition (HCCI) auto-ignition process, a reduced surrogate mechanism has been composed out of reduced n ... [more ▼]

To acquire a high amount of information of the behaviour of the Homogeneous Charge Compression Ignition (HCCI) auto-ignition process, a reduced surrogate mechanism has been composed out of reduced n-heptane, iso-octane and toluene mechanisms, containing 62 reactions and 49 species. This mechanism has been validated numerically in a OD HCCI engine code against more detailed mechanisms (inlet temperature varying from 290 to 500 K, the equivalence ratio from 0.2 to 0.7 and the compression ratio from 8 to 18) and experimentally against experimental shock tube and rapid compression machine data from the literature at pressures between 9 and 55 bar and temperatures between 700 and 1400 K for several fuels: the pure compounds n-heptane, iso-octane and toluene as well as binary and ternary mixtures of these compounds. For this validation, stoichiometric mixtures and mixtures with an equivalence ratio of 0.5 are used. The experimental validation is extended by comparing the surrogate mechanism to experimental data from an HCCI engine. A global reaction pathway is proposed for the auto-ignition of a surrogate gasoline, using the surrogate mechanism, in order to show the interactions that the three compounds can have with one another during the auto-ignition of a ternary mixture. (C) 2008 Elsevier B.V. All rights reserved. [less ▲]

Detailed reference viewed: 57 (1 ULg)
Full Text
Peer Reviewed
See detailDevelopment and experimental validation of an Organic Rankine cycle model
Lemort, Vincent ULg; Quoilin, Sylvain ULg; Cuevas, Critian et al

(2007)

This paper presents both a numerical model of an Organic Rankine Cycle (ORC) and an experimental study carried out on a prototype of such a cycle working with refrigerant HCFC-123, and whose heat sources ... [more ▼]

This paper presents both a numerical model of an Organic Rankine Cycle (ORC) and an experimental study carried out on a prototype of such a cycle working with refrigerant HCFC-123, and whose heat sources consist in two hot air flows. The ORC model s built by connecting different sub-models: the heat exchanger models, a volumetric pump model and a scroll expander model. Measured performances of the ORC prototype are presented and allow the validation of the ORC model. This model is finally used to investigate potential improvements of the prototype. [less ▲]

Detailed reference viewed: 579 (30 ULg)
Full Text
Peer Reviewed
See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULg; Revie, James A.; Paeme, Sabine ULg et al

Conference (2012, August 31)

Detailed reference viewed: 61 (6 ULg)
Full Text
Peer Reviewed
See detailDevelopment and Identification of a Closed-Loop Model of the Cardiovascular System Including the Atria
Pironet, Antoine ULg; Revie, James A.; Paeme, Sabine ULg et al

in Proceedings of the 8th IFAC Symposium on Biological and Medical Systems (2012, August)

Detailed reference viewed: 47 (10 ULg)
Full Text
See detailDevelopment and implementation of a methodology for hybrid fire testing applied to concrete structures with elastic boundary conditions
Sauca, Ana ULg

Doctoral thesis (2017)

Fire tests remain a precious tool to comprehend the behavior of structures under accidental fire conditions. The common practice in fire testing is to isolate the tested element in a furnace in which the ... [more ▼]

Fire tests remain a precious tool to comprehend the behavior of structures under accidental fire conditions. The common practice in fire testing is to isolate the tested element in a furnace in which the mechanical support conditions are maintained constant throughout the test. However, such tests fail to capture the effect of the structure surrounding the element of interest when this effect cannot be realistically modeled by a free or fixed support condition. It has been observed in large-scale tests that the behavior of entire structures under fire is different compared with the behavior observed in traditional tests on isolated elements. This indicates the importance of capturing accurately the boundary conditions between the element and the remainder of the structure when characterizing the behavior of this element in fire. The literature describes a few attempts at performing fire tests under realistic boundary conditions. In the latter, the tests were still performed on isolated elements but the boundary conditions were updated during the test taking into account the characteristics of the remainder structure. This technique, called hybrid testing, represents an appealing solution to test structural elements under realistic boundary conditions. Hybrid testing is a methodology which offers the advantage of testing singular structural elements (or a group of structural elements) named physical substructure PS while at the same time considering the characteristics of the remainder substructure named numerical NS, thus allowing to model realistic boundary conditions. Pioneering work has been done in the seismic field where this technique is now well described, but the implementation of this methodology for structural fire testing raises important challenges due to the specificities of the field. A few hybrid fire tests have been performed in the past on columns and slabs. Their analysis shows that they all use a similar methodology, which is referred to as the first generation method in this work. The objective of the thesis was to develop and implement a hybrid fire testing methodology on a reinforced concrete beam extracted from a moment resisting frame. Initially, it was intended to build on the first generation method, but after its detailed analysis in the development stage it has been observed that the process can be unstable. The value of the stiffness ratio between the numerical substructure and the physical substructures has been identified as critical in governing the stability of the test, dictating whether the hybrid test needs to be applied in displacement control or force control. This is a severe drawback of the first generation method, as the stiffness ratio is unknown and changing during the test; besides different degrees-of-freedom can require different procedures during the test. Therefore, it has been shown that the first generation method should not be applied as it can lead to instability prematurely during the tests. To overcome the drawbacks of the first generation method, the objective was to develop a new technique that leads to interface equilibrium and compatibility while at the same time is unconditionally stable (i.e. independently of the stiffness ratio). Thus a novel methodology was developed and applied to the case of a concrete beam (PS) being part of a concrete moment resisting frame (NS). The novel method makes use of the PS’s stiffness in addition to the NS’s stiffness as it was the case in the first generation method. The stiffness matrix of the PS is unknown during the test therefore the initial tangent stiffness matrix is considered during the calculations. The latter choice influences the value of the time step to be adopted during the test. Every time step the boundary conditions are updated and it will be discussed how the chosen value can influence the results. A predetermined matrix is used to describe the behavior of the NS during the hybrid fire tests. This approach does not capture the nonlinearity of the remainder but at the same time the implementation is relative simple and the negative effect of the time calculation is eliminated. The procedure to compute the predetermined matrix of the NS is presented in this thesis. One possible direction in the future development of hybrid fire testing is to model the NS in the finite element model. The algorithm of the proposed method is developed and implemented in nonlinear finite element software SAFIR in order to perform virtual hybrid fire tests. The same algorithm is translated in order to be implemented by the company in charge of the control system at the CERIB furnace facility. The thesis also presents a traditional fire test that has been performed on the beam, in order to highlight the differences when testing structural element without and with the real boundary conditions. For the hybrid test, three degrees-of-freedom are controlled at the interface. The furnace facility has an important role to perform successful test where the equilibrium and compatibility are ensured and no instability occurs during the test. The impediments encountered during the tests will be discussed along with the recommendation for a successful hybrid fire test. [less ▲]

Detailed reference viewed: 81 (23 ULg)
Full Text
Peer Reviewed
See detailDevelopment and in vitro characterisation of novel bioresorbable and bioactive composite materials based on polylactide foams and Bioglass (R) for tissue engineering applications
Roether, J. A.; Boccaccini, Aldo R.; Hench, L. L. et al

in Biomaterials (2002), 23(18), 3871-3878

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and ... [more ▼]

Bioactive and bioresorbable composite materials were fabricated using macroporous poly(DL-lactide) (PDLLA) foams coated with and impregnated by bioactive glass (Bioglass®) particles. Stable and homogeneous Bioglasss coatings on the surface of PDLLA foams as well as infiltration of Bioglass® particles throughout the porous network were achieved using a slurry-dipping technique in conjunction with pre-treatment of the foams in ethanol. The quality of the bioactive glass coatings was reproducible in terms of thickness and microstructure. Additionally, electrophoretic deposition was investigated as an alternative method for the fabrication of PDLLA foam/Bioglass® composite materials. In vitro studies in simulated body fluid (SBF) were performed to study the formation of hydroxyapatite (HA) on the surface of PDLLA/Bioglass® composites. SEM analysis showed that the HA layer thickness rapidly increased with increasing time in SBF. The high bioactivity of the PDLLA foam/Bioglasss composites indicates the potential of the materials for use as bioactive, resorbable scaffolds in bone tissue engineering. [less ▲]

Detailed reference viewed: 107 (3 ULg)
Full Text
See detailDevelopment and Layout of a ACC-System by means of Evolutionary Algorithms
Christen, Fréderic ULg

Scientific conference (2007, August 22)

Detailed reference viewed: 9 (0 ULg)