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See detailDionysos Ômèstès (Plutarque, Thémistocle, 13 ; Antoine, 24)
Lebreton, Sylvain ULg

in Bodiou, Lydie; Mehl, Véronique; Oulhen, Jacques (Eds.) et al Chemin Faisant : Mythes, cultes et société en Grèce ancienne : Mélanges en l'honneur de Pierre Brulé (2009)

À travers l’étude de deux extraits des Vies de Plutarque (Thémistocle, 13 et Antoine, 24), faisant tous deux apparaître un Dionysos Ômèstès, cette contribution tente de donner une appréciation de la ... [more ▼]

À travers l’étude de deux extraits des Vies de Plutarque (Thémistocle, 13 et Antoine, 24), faisant tous deux apparaître un Dionysos Ômèstès, cette contribution tente de donner une appréciation de la fiabilité de cet auteur comme source pour l’étude des épiclèses du polythéisme hellénique. La mise en perspective de ces deux passages au sein de l’œuvre plutarchéenne, mais aussi leur confrontation avec d’autres sources, permettent en effet de déterminer que, dans les deux cas, Plutarque a extrait cette épiclèse de son contexte cultuel originel pour la réintégrer dans un contexte historique tout autre. La mise au jour de ce procédé, soutenue par d’autres exemples, permet in fine d’esquisser des hypothèses et d’autres pistes de recherche sur l’utilisation des épiclèses divines par cet auteur. [less ▲]

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See detailDioxin accumulation in residents around incinerators
Fierens, S.; Mairesse, H.; Hermans, C. et al

in Journal of Toxicology and Environmental Health. Part A (2003), 66(14), 1287-1293

To evaluate the human exposure impact of municipal waste incinerators, dioxin and coplanar polychlorinated biphenyl (PCB) concentrations were determined in blood of 84 subjects who resided approximately ... [more ▼]

To evaluate the human exposure impact of municipal waste incinerators, dioxin and coplanar polychlorinated biphenyl (PCB) concentrations were determined in blood of 84 subjects who resided approximately 18 yr in the vicinity of two old incinerators, one located in a rural area (n = 51) and the other in an industrial area (n = 33). These subjects were compared with 63 controls from an unpolluted area. While no change was found in contaminant levels in residents living around the incinerator in the industrial area, subjects residing around the incinerator in the rural area possessed significantly higher serum levels of dioxins (38 vs. 24 pg TEQ/g fat) and coplanar PCBs (10 vs. 7 pg TEQ/g fat) than controls. These results were confirmed by multiple-regression analysis, showing that residence around the incinerator in the rural area (partial r(2) = .18) was the major contributor to dioxin accumulation followed by age (partial r(2) = .07). A two-way analysis of variance (ANOVA) on age-adjusted dioxin levels revealed a significant interaction between residence around incinerators and the consumption of fat from local origin, especially bovine and poultry products. Although age-adjusted dioxin levels in controls did not vary with local animal fat consumption, concentrations of dioxins in subjects living around the incinerators increased proportionally to their intake of local animal fat, with almost a doubling in subjects with a fat intake higher than 150 gfat/wk. Extrapolation from these data suggests that a significant increase of dioxin body burden is likely to occur only when dioxin emissions exceed 5 ng TEQ/Nm(3), a threshold considerably above most emissions standards currently in force. [less ▲]

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See detailDioxin Analyses in practice
Focant, Jean-François ULg

Learning material (2008)

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See detailDioxin Analyses. The Dogs Bark, but the Caravan Goes on...
Focant, Jean-François ULg

Scientific conference (2014, April 28)

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See detailDioxin analysis in feed: cell-based assay versus mass spectrometry method
Scippo, Marie-Louise ULg; Rybertt, Soledad; Eppe, Gauthier ULg et al

in Accreditation and Quality Assurance (2006), 11(1-2), 38-43

In the determination of contaminants (dioxins, polychlorinated biphenyls, polyaromatic hydrocarbons), cell-based assays are useful methods for screening purposes: they are mainly characterized by high ... [more ▼]

In the determination of contaminants (dioxins, polychlorinated biphenyls, polyaromatic hydrocarbons), cell-based assays are useful methods for screening purposes: they are mainly characterized by high sample throughput and lower costs than the Mass Spectrometry (MS)-based methods. Although cell-based assays can be sensitive enough for the determination of dioxins and related substances in agreement with the presently tolerable limits in food and feed (Regulation No. 2375/2001/EC and Directive 2003/57/EC respectively), their lack of specificity make their use rather questionable in control laboratories. In this paper, we present and compare results obtained from the analysis of a limited number of feed samples by both gas chromatography-high resolution mass spectrometry (GC-HRMS) and cell-based assay (DR-CALUX: dioxin responsive-chemically activated luciferase gene expression) methods. The DR-CALUX screening led to less than 10% false non-compliant and no false compliant results. In addition, there is a good correlation between GC-HRMS and DR-CALUX data. However, these preliminary results have to be confirmed on a larger number of samples to demonstrate that total toxic equivalent (TEQ), including dioxins, furans and dioxin-like polychlorobiphenyls (PCBs) can be monitored in feed and food with a cell-based assay. [less ▲]

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See detailDIOXIN BODY BURDEN AMONG BLOOD DONORS BEFORE AND AFTER THE BELGIAN DIOXIN/PCB INCIDENT
Debacker, Noemi; Sasse, André; Van Wouwe, Nathalie et al

in Organohalogen Compounds (2004)

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See detailDioxin Body Burden of Populations Living in the Vicinity of Two Municipal Solid Waste Incinerators (MSWI) in Belgium
Fierens, S.; mairesse, H.; Focant, Jean-François ULg et al

in Organohalogen Compounds (2001), 52

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See detailDioxin Food Crises and New POPs: Challenges in Analyses
Focant, Jean-François ULg

Conference (2012, September)

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See detailDioxin food crises and new POPs: challenges in analysis
Focant, Jean-François ULg

in Analytical and Bioanalytical Chemistry (2012), 403

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See detailTHE DIOXIN FUNCTION AS A USEFUL TOOL FOR ASSESSING DIOXIN LABORATORY PERFORMANCES IN PROFICIENCY TESTS
Eppe, Gauthier ULg; Van Cleuvenbergen, Rudy; Smastuen Haug, Line et al

in Organohalogen Compounds (2007)

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See detailDioxin levels in European eels, a Belgian study
Focant, Jean-François ULg; Geeraerts, C.; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2010, September)

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See detailDioxin levels in fertilizers from Belgium: Determination and evaluation of the potential impact on soil contamination
Elskens, M; Pussemier, L; Dumortier, P et al

in Science of the Total Environment (2013), 454-455

Dioxins are harmful Persistent Organic Pollutants (POPs) to which humans are exposed mostly via the consumption of animal products. They can enter the food chain at any stage, including crop fertilization ... [more ▼]

Dioxins are harmful Persistent Organic Pollutants (POPs) to which humans are exposed mostly via the consumption of animal products. They can enter the food chain at any stage, including crop fertilization. Fertilizers belong to several categories: synthetic chemicals providing the essential elements (mostly N, P and K) that are required by the crops but also organic fertilizers or amendments, liming materials, etc. Ninety-seven samples of fertilizers were taken in Belgium during the year 2011 and analyzed after a soft extraction procedure for polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and dioxin-like polychlorinated biphenyls (DL-PCBs) using GC-IDHRMS. Only small qualitative differences could be observed between the main fertilizer categories since the PCDD:PCDF:DL-PCB average ratio obtained with the results expressed in WHO 2005-TEQ was often close to 30:30:40 (typically for sewage sludge) or 40:30:30 (typically for compost). The median dioxin levels determined were generally lower than recorded previously and were the highest for sewage sludge and compost (5.6 and 5.5 ng TEQ/kg dry weight (dw), respectively). The levels in other fertilizers were lower including manure for which the median value was only 0.2 ng TEQ/kg dw. Several fertilization scenarios relying on the use of those fertilizers were assessed taking into consideration the application conditions prevailing in Belgium. From this assessment it could be concluded that the contribution of fertilizers to the overall soil contamination will be low by comparison of other sources of contamination such as atmospheric depositions. At the field scale, intensive use of compost and sewage sludge will increase dramatically the dioxin inputs compared with other fertilization practices but this kind of immission to the soil will still be relatively low compared to the dioxin atmospheric depositions. [less ▲]

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See detailDioxin Strategies for the Triple Quadrupole Market
Focant, Jean-François ULg

Scientific conference (2015, March 16)

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See detailDioxin-like compounds in porpoises and seals from the southern North Sea: relationship with biological and ecological factors
Das, Krishna ULg; De Pauw, Edwin ULg; Eppe, Gauthier ULg et al

in Organohalogen Compounds (2008), 70

The North Sea represents a major ecosystem for the harbour porpoise (Phocoena phocoena) and the harbour seal (Phoca vitulina). The grey seal (Halichoerus grypus) occurs more occasionally in the southern ... [more ▼]

The North Sea represents a major ecosystem for the harbour porpoise (Phocoena phocoena) and the harbour seal (Phoca vitulina). The grey seal (Halichoerus grypus) occurs more occasionally in the southern part of the North Sea. Their population over this last decade has experienced major fluctuations likely linked to prey availability and seal epizootics. Despite being banned more than 30 years ago, levels of polychlorinated biphenyls (PCBs) in marine mammals are still of concern due to historical contamination of the North Sea. [less ▲]

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See detailDioxin/polychlorinated biphenyl body burden, diabetes and endometriosis: findings in a population-based study in Belgium
Fierens, S.; Mairesse, H.; Heilier, J. F. et al

in Biomarkers : Biochemical Indicators of Exposure, Response, & Susceptibility to Chemicals (2003), 8(6), 529-534

Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background ... [more ▼]

Dioxins and polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the food chain, which is the main source of human exposure. Their effects on human health at background exposure levels are still poorly understood. Recent epidemiological evidence suggests a possible association between these pollutants and diabetes. We report here the results of a population-based study in Belgium on 257 (142 women and 115 men) environmentally exposed subjects, including 10 cases of endometriosis and nine cases of diabetes. Seventeen 2,3,7,8-polychlorinated dibenzodioxins/dibenzofurans (PCDD/Fs or dioxins), four coplanar PCBs (International Union of Pure and Applied Chemistry [IUPAC] nos 77, 81, 126 and 169) and 12 PCB markers ( IUPAC nos 3, 8, 28, 52, 101, 118, 138, 153, 180, 194, 206 and 209) were quantified in serum fat from fasting blood samples in order to estimate the body burden of these pollutants. Whilst no difference was found between women with endometriosis and their controls, diabetic patients had significantly increased serum levels of dioxins, coplanar PCBs and the 12 PCB markers. After adjustment for age and other covariates, serum total toxic equivalent activity (sum of PCDD/Fs and coplanar PCBs) and 12 PCB marker concentrations in diabetics were 62% (p=0.0005) and 39% (p=0.0067) higher, respectively, than in controls. The risk of diabetes was significantly increased in subjects in the top decile for adjusted concentrations of dioxins (odds ratio 5.1, 95% confidence interval [CI] 1.18-21.7), coplanar PCBs (odds ratio 13.3, 95% CI 3.31-53.2) or 12 PCB markers (odds ratio 7.6, 95% CI 1.58-36.3). These findings warrant further studies to assess the significance of the associations between diabetes and environmental exposure to polychlorinated pollutants. [less ▲]

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See detailDioxin2011 Highlights
Focant, Jean-François ULg

Report (2011)

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See detailLa dioxine, info ou intox? A propos de l'acné de Seveso et de Yushchenko.
Pierard, Gérald ULg; Plomteux, Guy ULg; Denooz, Raphael ULg et al

in Revue Médicale de Liège (2005), 60(1), 18-22

The generic term "dioxin" covers more than 400 chemicals of which less than 30 prove to be toxic. Such compounds are involved in environmental pollutions and in food contaminations. Some selected dioxins ... [more ▼]

The generic term "dioxin" covers more than 400 chemicals of which less than 30 prove to be toxic. Such compounds are involved in environmental pollutions and in food contaminations. Some selected dioxins have also been used as a non-lethal chemical weapon. The assessment of the impact on health needs a precise toxicological identification. Without that basic assessment, a discrepancy may appear between the real risk linked to the exposure and the concerns and fear generated in the population, particularly because in animals the toxic concentrations of dioxins can interfere with some hormonal systems, alter immunity, induce chloracne, and participate in the development of sarcomas, lymphomas and some carcinomas. They may be responsible for some birth defects. [less ▲]

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