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Peer Reviewed
See detailEffect of cyclodextrin derivatives on bronchial epithelial cell layer permeability
Belhadj-Salem, Leila; Bosquillon, Cynthia; Delattre, Luc ULg et al

Poster (2007)

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See detailEffect of cyclodextrins on artemisinin stability and in vitro dissolution
Zime-Diawara, Hermine; Gbaguidi, Fernand; Semde, Rasmane et al

in International Journal of Biological and Chemical Sciences (2013), 7(1), 356-365

Artemisinin is extracted from the Asian plant Artemisia annua L. It has been proven to be, with its derivatives, the molecules that have shown so far the most powerful activity on malaria, even in its ... [more ▼]

Artemisinin is extracted from the Asian plant Artemisia annua L. It has been proven to be, with its derivatives, the molecules that have shown so far the most powerful activity on malaria, even in its complicated forms and resistance cases. To resolve the problem of low aqueous solubility of this molecule, the use of cyclodextrins (CDs) was envisaged and gave good results in this topic. However, the impact on its stability and in vitro dissolution, important parameters for drug formulation and evaluation, was not evaluated. In this study, stability in accelerated degradation conditions and in vitro dissolution analysis of artemisinin were performed in comparison with complexes of artemisinin and cyclodextrins. The finding of this work allowed us to suggest that CDs improve the stability of artemisinin, especially when it's in aqueous solution. We also demonstrated the beneficial impact of cyclodextrins on the in vitro dissolution of artmisinin from capsules prepared with rough extracts of A. annua. [less ▲]

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See detailThe Effect of Cyclodextrins on the Aqueous Solubility of a New Mmp Inhibitor: Phase Solubility, 1 H-Nmr Spectroscopy and Molecular Modeling Studies, Preparation and Stability Study of Nebulizable Solutions
Bertholet, Pascal; Guéders, Maud ULg; Dive, Georges ULg et al

in Journal of Pharmacy & Pharmaceutical Sciences : A Publication of the Canadian Society for Pharmaceutical Sciences (2005), 8(2), 164-175

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous ... [more ▼]

PURPOSE: Ro 28-2653 (RO) is a synthetic inhibitor of matrix metalloproteinases (MMPs), which is potentially effective against bronchial remodeling. Given that this molecule has very poor aqueous solubility, different cyclodextrins (CDs) have been tested to increase its solubility. The aim of this study was to prepare and to characterize inclusion complexes between RO and CDs, in order to develop nebulizable solutions. METHODS: The complex formation was investigated by phase solubility studies. (1)H-NMR spectroscopy and molecular modeling studies were carried out to elucidate the structure of the inclusion complex between RO and dimethyl-beta-CD (DIMEB). Nebulizable solutions of RO were developed with CDs and a stability study was performed over 9 months. RESULTS: The phase solubility studies showed that beta-CD and its derivatives form a 1:2 complex with RO, whereas gamma-CD includes RO with a 1:1 stoichiometry and a weak stability constant. T-ROESY spectra showed that DIMEB is able to complex two RO substituents (nitrophenyl and biphenyl groups) with preferential orientations, while molecular modeling demonstrated that the configurations observed with (1)H-NMR are energetically favorable, especially owing to H-bond formation between RO and DIMEB. Two CDs were selected to develop nebulizable solutions of RO and the stability study demonstrated that RO degradation in solution is strongly dependent on the concentration of the 1:2 inclusion complex. CONCLUSIONS: CDs are able to include RO and to improve its aqueous solubility. The beta-CD derivatives can be used to formulate nebulizable solutions of RO, the stability of which depends on the concentration of the 1:2 complex. [less ▲]

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See detailEffect of cyclodextrins on the membrane permeability of liposomes
Piel, Géraldine ULg; Piette, Marie ULg; Barillaro, Valery et al

Poster (2005, November)

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See detailEffect of cyclodextrins on the viability of endothelial cells
Castagne, Delphine ULg; Belhadj Salem, Leila; Delattre, Luc ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2007), 57(1-4), 105-107

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See detailEFFECT OF DATE FLESH FIBER CONCENTRATE ADDITION ON DOUGH PERFORMANCE AND BREAD QUALITY
Borchani,, Chema; Masmoudi, Manel; Besbes, Souhail et al

in JOURNAL OF TEXTURE STUDIES (2011), 42(4), 300-308

Date flesh fiber concentrate (DFFC) of Deglet Nour variety were extracted and incorporated in a bakery product. Dough rheological characteristics showed that water absorption, stability, index quality ... [more ▼]

Date flesh fiber concentrate (DFFC) of Deglet Nour variety were extracted and incorporated in a bakery product. Dough rheological characteristics showed that water absorption, stability, index quality, resistance to deformation increased with the amount of added fiber, whereas degree of softening and extensibility decreased in all levels of fiber. Bread evaluation revealed that DFFC addition caused an increase of bread yield especially for the highest levels, a change of crumb color and an insignificant decrease of bread volume. Breads are subjected to sensory evaluation for odor, taste, crumb color, crumb smoothness and overall acceptability. Significant differences were not found (P > 0.05) between scores for all sensory parameters. [less ▲]

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See detailEffect of deep digital flexor tendon orientation on magnetic resonance imaging signal intensity in isolated equine limbs - The magic angle effect
Busoni, Valeria ULg; Snaps, Frédéric ULg

in Veterinary Radiology & Ultrasound (2002), 43(5, Sep-Oct), 428-430

Ten normal equine isolated limbs were imaged using a knee coil in a 1.5 Tesla magnetic field, with short echo time sequences (TE < 15 ms). Magnetic resonance imaging was performed on each isolated limb in ... [more ▼]

Ten normal equine isolated limbs were imaged using a knee coil in a 1.5 Tesla magnetic field, with short echo time sequences (TE < 15 ms). Magnetic resonance imaging was performed on each isolated limb in different positions, with and without extension of the metacarpophalangeal joint. Deep digital flexor tendon orientation ranged from 20 to 60 degrees in relation to the static magnetic field. Increased intratendinous signal intensity was observed when the angle between the deep digital flexor tendon and the constant magnetic field approached 55 degrees ("magic angle"). The increased signal intensity was independent from extension of the metacarpophalangeal joint. Recognition of the magic angle phenomenon is essential for proper evaluation of magnetic resonance imaging studies of the equine foot. [less ▲]

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See detailEffect of Deferoxamine Mesylate on Freezability of Blood Supplemented Canine Semen
Van Den Berghe, Femke ULg; Rijsselaere, Tom; Van Soom, Ann et al

Poster (2011, September)

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See detailEffect of deferoxamine on the in vitro growth of Mycobacterium tuberculosis and Mycobacterium avium
MELIN, Pierrette ULg; Boelaert, J.; Chbicheb, R. et al

Conference (1997, March)

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See detailThe effect of deforestation on land tenure in Central Africa
Gillet, Pauline ULg; Feintrenie, Laurène; Codina Llavinia, Elisabet et al

Conference (2015, March 23)

The CoForTips project aims at the promotion of better management of the forest of the Congo Basin by presenting to the policy makers plausible scenarios of social and ecological systems evolution. In this ... [more ▼]

The CoForTips project aims at the promotion of better management of the forest of the Congo Basin by presenting to the policy makers plausible scenarios of social and ecological systems evolution. In this paper, we focused on the impact of deforestation on land tenure mutation in Central Africa. Land tenure defines the level of ownership and management experienced by the local population on defined areas (Le Roy et al., 1996). We assume that the rules acting on objects of land tenure evolve from loose land control to privatization and the ability to dispose of resources when we progress on the forest transition curve designed by Mather (1992). We demonstrate that individual land tenure increases along with the deforestation process, and continue along with the reforestation process where this one is a consequence of agricultural plantations on deforested lands. We then draw a theoretical land tenure evolution with variation of population density in relation to forest cover that could be used as an indicator of SES shifting more sensitive than the evolution of forest cover to appreciate forest transition at the SES level and predict the presence and intensity of tipping points. [less ▲]

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See detailThe effect of deforestation rate on land tenure in Central AFrica
Gillet, Pauline ULg; Vermeulen, Cédric ULg; Feintrenie, Laurène

Poster (2014, October)

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See detailEffect of dementia severity and age on posterior cingulate cortex metabolism in Alzheimer's disease
Withofs, Nadia ULg; Salmon, Eric ULg; Hallet, Claude ULg et al

in Journal of Neurology (2007, May), 254(Suppl. 3), 146

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See detailEffect of denosumab treatment in postmenopausal women with osteoporosis: eight-year results from the freedom extension, phase 3 clinical trial
Lewieck, E; Papapoulos, S; Lippuner, K et al

in Endocrine Reviews (2014), 35(3), 22-1

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See detailEffect of dexamethasone on the mean plaque size of bovine herpesvirus 1.
Curvers, V.; Thiry, Etienne ULg; Leroy, Pascal ULg et al

in Annales de Recherches Vétérinaires = Annals of Veterinary Research (1985), 16(1), 80-5

The effect of dexamethasone on infectious bovine rhinotracheitis virus (Bovine herpesvirus 1: BHV 1) was studied by measuring the mean plaque size produced by eight virus strains under two concentrations ... [more ▼]

The effect of dexamethasone on infectious bovine rhinotracheitis virus (Bovine herpesvirus 1: BHV 1) was studied by measuring the mean plaque size produced by eight virus strains under two concentrations of dexamethasone phosphate (0.1 and 1 mM). Dexamethasone induced a significant reduction of the mean plaque size, whatever the strain used. Some differences were noted between the BHV 1 strains studied, depending on the dexamethasone concentration. [less ▲]

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See detailEffect of diazepam on the efficacy of dual-phase FDG PET imaging.
Zhuang, Hongming; Hustinx, Roland ULg; Alavi, Abass

in European Journal of Nuclear Medicine and Molecular Imaging (2006), 33(2), 228-9230

Detailed reference viewed: 24 (2 ULg)
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See detailEffect of diet and bST on mRNA for IGF-I binding proteins (BP)-2 and -3 in dairy cattle
Sharma, B. K.; Vandehaar, M. J.; Tucker, H. A. et al

in Journal of Dairy Science (1997), 80(suppl 1), 176

Detailed reference viewed: 5 (1 ULg)