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See detailDifferent Mechanisms of Extracellular Matrix Remodeling by Fibroblasts in Response to Human Mammary Neoplastic Cells
Noël, Agnès ULg; Munaut, Carine ULg; Nusgens, Betty ULg et al

in Invasion & Metastasis (1993), 13(2), 72-81

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties ... [more ▼]

Human breast tumors are often associated with a fibrotic reaction termed desmoplasia. Tumor cells may indirectly modulate the composition of the extracellular matrix by influencing fibroblast properties. They may also directly interact with collagen fibrils leading to retraction of the matrix. We have studied in vitro the influence of various human mammary tumor cells on the proliferation rate of normal human fibroblasts and on their level of collagen synthesis, as well as their release of collagenase activity. Interactions between neoplastic cells and collagen matrix were investigated by incorporation of tumor cells in collagen gels (lattices) and measurement of their retraction. All cells tested (HBL100, SW613, SA52, MDA-MB-231, MCF7, MCF7/6, MCF7 ras, BT20 and T47D) were able to modulate the composition of the extracellular matrix by one or several of the mechanisms investigated. Our results also demonstrate an opposite regulation of collagen and collagenase production. The effects on the collagen metabolism and on fibroblast proliferation are probably mediated by soluble cytokines since they are reproduced by incubating the fibroblasts in the presence of medium conditioned by tumor cells. The desmoplastic reaction may thus result from different mechanisms dependent upon tumor cell types. [less ▲]

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See detailDifferent mechanoregulatory models predict different patterns of tissue differentiation
Geris, Liesbet ULg; Van Oosterwyck, Hans; Duyck, Joke et al

in Middleton, J.; Jones, M. L.; Shrive, N. (Eds.) Proceedings of the 6th international symposium on Computer Methods in Biomechanics and Biomedical Engineering (2005)

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See detailDifferent methods for spatial interpolation of rainfall data for operational hydrology and hydrological modeling at watershed scale: a review
Ly, Sarann ULg; Charles, Catherine ULg; Degré, Aurore ULg

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2013), 17(2), 392-406

Watershed management and hydrological modeling require data related to the very important matter of precipitation, often measured using raingages or weather stations. Hydrological models often require a ... [more ▼]

Watershed management and hydrological modeling require data related to the very important matter of precipitation, often measured using raingages or weather stations. Hydrological models often require a preliminary spatial interpolation as part of the modeling process. The success of spatial interpolation varies according to the type of model chosen, its mode of geographical management and the resolution used. The quality of a result is determined by the quality of the continuous spatial rainfall which ensues from the interpolation method used. The objective of this article is to review the existing methods for interpolation of rainfall data that are usually required in hydrological modeling. We review the basis for the application of certain common methods and geostatistical approaches used in interpolation of rainfall. Previous studies have highlighted the need for new research to investigate ways of improving the quality of rainfall data and ultimately, the quality of hydrological modeling. [less ▲]

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See detailDifferent modes of food restriction and compensatory growth in double-muscled Belgian Blue bulls: plasma metabolites and hormones
Cabaraux, Jean-François ULg; Kerrour, M.; Van Eenaeme, Christian ULg et al

in Animal Science (2003), 77

The effects of different sequences of food restriction and fattening have been studied on plasma metabolites and hormones in double-muscled Belgian Blue bulls. Twenty animals were divided into five groups ... [more ▼]

The effects of different sequences of food restriction and fattening have been studied on plasma metabolites and hormones in double-muscled Belgian Blue bulls. Twenty animals were divided into five groups. The first group (control, CG) was given, ad libitum, a fattening diet based on sugar-beet pulp. In G2 and G3, fattening was interrupted after 103 and 187 days, respectively, by a period of food restriction lasting about 2 months during which the animals received a maintenance ration. They were finished with the same diet as CG. The last two groups, G4 and G5, received a limited amount of the restriction diet to support 0.5 and 0 kg gain per day, respectively, for 4 months, before being fattened as CG. Plasma glucose, alpha-amino nitrogen, non-esterified fatty acids, urea, creatinine, thyroxine (T4), 3, 3', 5'-tri-iodothyroxine (T3), and insulin-like growth factor-1 (IGF-1) were measured in blood samples taken every 2 weeks. Plasma GH and insulin profiles were measured in serial blood samples obtained at three different times during growth. Animals that showed compensatory growth had lower plasma urea, associated with high levels of T3, T4 and IGF-1. Animals from G2 and G3 failed to show compensatory growth. In Belgian Blue bulls, compensatory growth is markedly affected when food restriction is severe or fattening interrupted. [less ▲]

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See detailThe different origins of high- and low-ionization broad emission lines revealed by gravitational microlensing in the Einstein cross
Braibant, Lorraine ULg; Hutsemekers, Damien ULg; Sluse, Dominique ULg et al

in Astronomy & Astrophysics (2016), 592

We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high ... [more ▼]

We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high- and low-ionization broad emission lines. We combine visible and near-infrared spectra of the four images of the lensed quasar and detect a large-amplitude microlensing effect distorting the high-ionization CIV and low-ionization Hα line profiles in image A. While microlensing only magnifies the red wing of the Balmer line, it symmetrically magnifies the wings of the CIV emission line. Given that the same microlensing pattern magnifies both the high- and low-ionization broad emission line regions, these dissimilar distortions of the line profiles suggest that the high- and low-ionization regions are governed by different kinematics. Since this quasar is likely viewed at intermediate inclination, we argue that the differential magnification of the blue and red wings of Hα favors a flattened, virialized, low-ionization region whereas the symmetric microlensing effect measured in CIV can be reproduced by an emission line formed in a polar wind, without the need of fine-tuned caustic configurations. [less ▲]

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See detailDifferent patterns of insulin resistance in relatives of type 1 diabetic patients with retinopathy or nephropathy
Hadjadj, S.; Pean, F.; Pean, F. et al

in Diabetes Care (2004), 27(11), 2661-2668

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin ... [more ▼]

OBJECTIVE- Insulin resistance may be a risk factor for diabetic microangiopathy, which may have a familial component. We carried out a family-based study to determine which components of the insulin resistance syndrome are associated with diabetic retinopathy and nephropathy in type 1 diabetes. RESEARCH DESIGN AND METHODS- The Genesis France-Belgium Study is a multicenter binational study designed to investigate the genetic factors involved in the microvascular complications of type 1 diabetes using a family-based design. Probands were type 1 diabetic patients with diabetic retinopathy (classified as background, preproliferative, or proliferative) and possibly diabetic nephropathy (absent, incipient, established, or advanced). The insulin resistance score of their first-degree relatives was calculated according to their BMI and history of arterial hypertension, lipid disorders, and type 2 diabetes. RESULTS- The insulin resistance score of relatives was positively correlated with the albumin excretion rate (P = 0.0009) and fasting plasma glucose (P = 0.0003) and HbA(1c) (P < 0.0001) concentrations. This score was higher in the relatives of probands with than in those without diabetic nephropathy (P = 0.0370). Similarly, it was higher in relatives of subjects with proliferative diabetic retinopathy than in those of probands without, even after controlling for subjects with versus without diabetic nephropathy (P = 0.0379). However, the components of the insulin resistance score in relatives differed according to the severity of diabetic retinopathy or nephropathy in the probands. Obesity and history of arterial hypertension were most common in relatives of probands with proliferative diabetic retinopathy, whereas obesity and history of lipid disorders were most common in the relatives of probands with diabetic nephropathy. CONCLUSIONS- Familial insulin resistance segregates with diabetic complications: lipid disorders and obesity segregate with diabetic nephropathy, whereas arterial hypertension and obesity segregate with diabetic retinopathy. [less ▲]

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See detailDifferent periods of feed restriction before compensatory growth in Belgian Blue bulls: II. Plasma metabolites and hormones
Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg; Diez, Marianne ULg et al

in Journal of Animal Science (1998), 76(1), 260-271

Plasma metabolites and hormones were studied in 16 double-muscled Belgian Blue bulls maintained at low growth (.5 kg/d) for 114 (G2), 243 (G3), or 419 (G4) d (low growth period, LGP) before fattening ... [more ▼]

Plasma metabolites and hormones were studied in 16 double-muscled Belgian Blue bulls maintained at low growth (.5 kg/d) for 114 (G2), 243 (G3), or 419 (G4) d (low growth period, LGP) before fattening (rapid growth period, RGP). Animals from the control group (CG) were fed a diet high in energy and protein. The animals from G2, G3, and G4 were fed a restricted amount of a diet low in energy and protein during LGP and the same diet as CG during RGP. Plasma glucose, alpha-amino nitrogen (AAN), NEFA, urea, creatinine, thyroxine (T4), 3,3',5'-triiodothyronine (T3), and IGF-I were measured in blood samples taken fortnightly. Plasma GH and insulin (I) profiles were measured in serial blood samples obtained at three times during growth. The RGP was characterized by an initial compensatory growth, by higher plasma glucose, AAN, and urea levels, and by lower plasma NEFA and creatinine levels. Plasma GH concentration decreased after refeeding. Plasma T4 increased linearly during refeeding, as opposed to T3, which showed a different profile in each group. Plasma IGF-I showed a curvilinear increase during RGP and reached a plateau after 3 mo in each compensating group. In G4, changes of plasma metabolites and hormones differed often distinctly from G2 or G3. During refeeding, higher nutrient supply improved the functionality of the somatotropic axis and increased the concentration of anabolic hormones, allowing rapid muscle deposition. However, animals underfed the longest period behaved differently from the other groups, possibly because they reached a more complete sexual maturity. [less ▲]

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See detailDifferent phases of water transfer during rock drying
Prime, Noémie ULg; Housni, Zakarya; Fraikin, Laurent ULg et al

Conference (2013, September 10)

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See detailDifferent regimes of nucleation of superconductivity in mesoscopic superconductor/ferromagnet hybrids
Schildermans, N.; Aladyshkin, A Yu; Silhanek, Alejandro ULg et al

in Physical Review. B : Condensed Matter (2008), 77(21),

The competition between two regimes of the nucleation of superconductivity is investigated experimentally and theoretically in a mesoscopic disk-shaped superconductor/ferromagnet hybrid. By changing the ... [more ▼]

The competition between two regimes of the nucleation of superconductivity is investigated experimentally and theoretically in a mesoscopic disk-shaped superconductor/ferromagnet hybrid. By changing the magnetic state of a multilayered Co/Pt disk one can reversibly affect the magnetic-field dependence of the critical temperature T(c)(H) of an Al layer. We demonstrate that an enhancement of the magnetic field near the edge of the out-of-plane magnetized disk either stimulates the nucleation of superconductivity at the disk perimeter due to the field compensation effect or prevents it due to edge magnetic barrier (for relatively low parallel to H parallel to values). As a consequence, the presence of such magnetic-field pattern makes it possible to eliminate boundary effects for mesoscopic superconducting samples. Switching from one nucleation regime to another while sweeping H leads to an abrupt change of the slope of the T(c)(H) envelope. [less ▲]

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See detailDifferent responses of bees and hoverflies to land use in an urban–rural gradient show the importance of the nature of the rural land use
Verboven, Hans; Uyttenbroeck, Roel ULg; Brys, Rein et al

in Landscape & Urban Planning (2014), 126

Most studies focusing on the effects of urban land use on pollinators have compared urban sites with one type of rural site. However, there is a lot of variation in the amount of natural habitats or ... [more ▼]

Most studies focusing on the effects of urban land use on pollinators have compared urban sites with one type of rural site. However, there is a lot of variation in the amount of natural habitats or intensive agriculture in rural areas. The position of urban areas within that continuum in terms of pollinator communities remains unclear. In this work, we studied bee and hoverfly communities (abundance, diversity, and species composition) in three site types along two river systems crossing urban areas, rural areas dominated by agriculture (termed rural-agricultural) and rural areas with high amounts of semi-natural land use (termed rural-natural). Pollinators were caught in August 2011. Abundance and diversity were highest in rural-natural sites for both taxonomic groups. Our data also indicate that hoverflies and bees responded differently to the surrounding land use, with bee abundance and diversity only significantly reduced in rural-agricultural sites but not in urban sites, and hoverfly abundance and diversity only significantly reduced in urban sites but not in rural-agricultural sites. The observed differences in the response of pollinators point out the importance of incorporating different types of rural land use and clearly defining the rural end of an urban–rural gradient in getting a clear view on how urban land use affects a specific pollinator group. Year-round sampling of these pollinators would, however, probably enable a more accurate view on these responses. [less ▲]

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See detailDifferent retroviruses show different susceptibilities to 2-deoxy-D-glucose.
Thiry, Lise; Sprecher-Goldberger, S.; Cogniaux-Leclercq, J. et al

in Gallo, R. C.; Stehelin, D.; Varnier, O. (Eds.) Retroviruses and human pathology (1985)

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See detailDifferent techniques to study the conformation of surfactins at interfaces
Deleu, Magali ULg; Gallet, Xavier; Brasseur, Robert et al

Poster (2001)

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See detailDifferent treatments of linseed of culled cows and young bulls
Robaye, Vincent ULg; Dotreppe, Olivier ULg; Cabaraux, Jean-François ULg et al

in 58th Annual Meeting of the European Association for Animal Production (2007)

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See detailDifferent universality classes for SOC in models driven by extremal dynamics
Vandewalle, Nicolas ULg; Ausloos, Marcel ULg

in Europhysics Letters [=EPL] (1997), 37(1), 1-6

We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree ... [more ▼]

We investigate a simple growth model. The model considers the growth of trees driven by extremal dynamics. Self-organized criticality (SOC) exhibited by the model is discussed. We point out that this tree-like model does not seem to belong to any already studied SOC universality class. This is shown through a discussion of the dynamics and the so-called gap equation which does not hold here. [less ▲]

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See detailDifférentes estimations du libre parcours moyen en acoustique des salles : influence sur l’estimation de l’énergie acoustique par un modèle de diffusion
Foy, Cédric; Billon, Alexis ULg; Valeau, Vincent et al

Conference (2006, April)

La plupart des outils de prévision en acoustique des salles sont basés sur le principe du tir de rayons. La précision des résultats dépend alors du nombre de rayons choisi, nécessairement important quand ... [more ▼]

La plupart des outils de prévision en acoustique des salles sont basés sur le principe du tir de rayons. La précision des résultats dépend alors du nombre de rayons choisi, nécessairement important quand la géométrie simulée est grande et/ou disproportionnée, ce qui implique alors des temps de calcul élevés. Pour ce type de géométrie, une méthode alternative, basée sur la résolution numérique d’une équation de diffusion, permet en revanche de réaliser des prévisions acoustiques au prix d’un coût numérique modeste. Ce modèle repose en particulier sur un coefficient de diffusion caractérisant la pièce. Ce coefficient est théoriquement proportionnel au libre parcours moyen (LPM) du local considéré, vérifiant classiquement l’expression 4V/S (V étant le volume de la salle, S la surface des parois). Il est souvent admis que cette valeur est valide pour une salle de dimensions homogènes et dans le cas d’un champ réverbéré diffus. Néanmoins, dans la présente étude nous montrons que pour des locaux particulièrement allongés ou plats, l’atténuation sonore, directement dépendante du coefficient de diffusion, est surestimée par ce modèle. Il en est de même pour des locaux dont la loi de réflexion aux parois s’écarte d’une loi de Lambert. Ainsi, afin d’améliorer les performances du modèle de diffusion, la solution envisagée consiste d’une part, à réaliser un calcul numérique préliminaire du LPM et d’autre part, à considérer les approches analytiques alternatives du LPM rencontrées dans la littérature. La méthode numérique retenue est basée sur le suivi de particules sonores, et permet d’établir le LPM à partir de l’ensemble des distances de collision entre deux parois, pour des conditions de réflexion quelconques. Les résultats de ces approches analytiques et numériques sont présentés en terme d’atténuation sonore pour un local plat et un local allongé, et sont comparés à ceux issus d’autres méthodes numériques. [less ▲]

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See detailDifférentes facettes de la maladie de type Alzheimer
Salmon, Eric ULg

in Revue Médicale de Liège (2008), 63

Les maladies de type Alzheimer sont fréquentes. Les efforts réalisés en recherche clinique pour en améliorer le diagnostic précoce sont justifiés par les espoirs de traitements étiologiques. Dès à présent ... [more ▼]

Les maladies de type Alzheimer sont fréquentes. Les efforts réalisés en recherche clinique pour en améliorer le diagnostic précoce sont justifiés par les espoirs de traitements étiologiques. Dès à présent cependant, un diagnostic précoce est justifié par la possibilité de ralentir les conséquences symptomatiques de la maladie. Bien que l’évolution extrêmement variable soit fort préoccupante pour le patient et son entourage, l’objectif thérapeutique est d’adapter les conditions de vie aux capacités du patient (et de ses proches) et de maintenir une qualité de vie optimale. [less ▲]

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See detailLes différentes fonctions de la résolution de problèmes sont-elles présentes dans l’enseignement primaire en Communauté française de Belgique ?
Demonty, Isabelle ULg; Fagnant, Annick ULg

in Dorier, J-L.; Coutat, S. (Eds.) Enseignement des mathématiques et contrat social : enjeux et défis pour le 21 e siècle – Actes du colloque EMF2012 (2012)

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