Exposés théoriques sous forme de power point du cours de contentieux administratif

Learning material (2010)

L'intégralité des exposés théoriques du cours de contentieux administratif

Exposés théoriques sous forme de power point du cours de fonction publique

Learning material (2010)

Exposition de l'Utopie au Réel

Learning material (1994)

L’Exposition internationale de Liège 1939. Urbanisme et architecture

in Cahiers Nouveaux (Les) (2012), 83

Les expositions d'art sonore: désarçonnantes?

Conference (2009)

Exposure to oestrogen prenatally does not interfere with the normal female-typical development of odour preferences

in Journal of Neuroendocrinology (2007), 19(5), 329-334

The neural mechanisms controlling mate recognition and heterosexual partner preference are sexually differentiated by perinatal actions of sex steroid hormones. We previously showed that the most ... [more ▼]

The neural mechanisms controlling mate recognition and heterosexual partner preference are sexually differentiated by perinatal actions of sex steroid hormones. We previously showed that the most important action of oestrogen during prenatal development is to defeminise and, to some extent, masculinise brain and behaviour in mice. Female mice deficient in alpha-foetoprotein (AFP) due to a targeted mutation in the Afp gene (AFP-KO) do not show any female sexual behaviour when paired with an active male because they lack the protective action of AFP against maternal oestrogens. In the present study, we investigated whether odour preferences, another sexually differentiated trait in mice, are also defeminised and/or masculinised in AFP-KO females due to their prenatal exposure to oestrogens. AFP-KO females of two background strains (CD1 and C57Bl/6j) preferred to investigate male over female odours when given the choice between these two odour stimuli in a Y-maze, and thus remained very female-like in this regard. Thus, the absence of lordosis behaviour in these females cannot be explained by a reduced motivation of AFP-KO females to investigate male-derived odours. Furthermore, the presence of a strong male-directed odour preference in AFP-KO females suggests a postnatal contribution of oestrogens to the development of preferences to investigate opposite-sex odours. [less ▲]

Expresión de la glicoproteína gp53 del virus de la diarrea viral bovina en plantas transgénicas de alfalfa

Poster (2002, September 23)

Expressing female fertility in the Walloon region of Belgium: how to do?

Conference (2009, August)

Since September 2007, the Walloon Region of Belgium has used a genetic evaluation system for pregnancy rate in Holsteins and has participated in 3 of the 5 MACE trait INTERBULL runs for female fertility ... [more ▼]

Since September 2007, the Walloon Region of Belgium has used a genetic evaluation system for pregnancy rate in Holsteins and has participated in 3 of the 5 MACE trait INTERBULL runs for female fertility. In order to define general way of female fertility expression, a principal component analysis was carried out on six published foreign female fertility indexes. Results of were used to compute a direct female fertility index with the INTERBULL international female fertility proofs available on the Walloon scale. An indirect female fertility index was also developed in order to increase reliability of young bulls. Approximate procedure based on selection index was used to combine both indexes in an overall index called combined female fertility index. This index was highly correlated with the direct female fertility index (.96) and the first principal component (.85), therefore it was considered as good expression of female fertility. Moreover, this allowed recovering 4,019 INTERBULL bulls with a publishable female fertility index. [less ▲]

Expression analyses identify MLL as a prominent target of 11q23 amplification and support an etiologic role for MLL gain of function in myeloid malignancies

in Blood (2004), 103(1), 229-235

MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), associated with adverse prognosis and karyotype complexity. Here we ... [more ▼]

MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS), associated with adverse prognosis and karyotype complexity. Here we present detailed results of fluorescence in situ hybridization (FISH) and expression analyses of MLL and 5 selected 11q candidate oncogenes (CBL, DDX6, ETS1, FLI1, and PLZF) in 31 patient samples and one cell line with 11q23 gain. FISH analyses revealed that the 11q23 amplicon invariably encompassed MLL, DDX6, ETS1, and FLI1, whereas expression analyses identified MLL and DDX6 as the most differentially expressed genes among samples with and without 11q23 copy gain or amplification. In MLL-amplified samples, a significant transcriptional up-regulation of MEIS1, PROML1, ADAM10, NKG2D, and ITPA was noted. Further analyses, designed to elucidate a possible role of the 11q overexpressed genes (MLL, DDX6, FLI1, and ETS1) in unselected MDS and AML samples, revealed a significant upregulation of MLL in MDS. Our findings confirm the MLL gene as a prominent target of 11q23 amplification and provide further evidence for an etiologic role for MLL gain of function in myeloid malignancies. In addition, our results indicate that the transcriptional program associated with MLL rearrangements and MLL overexpression displays significant similarities. [less ▲]

Expression and function of the collagen receptor GPVI during megakaryocyte maturation.

in Journal of Biological Chemistry (2001), 276(18), 15316-25

In this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord ... [more ▼]

In this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord blood derived CD34(+) cells. By flow cytometry, using an anti-GPVI monoclonal antibody or convulxin, a GPVI-specific ligand, GPVI was detected only on CD41(+) cells including some CD41(+)/CD34(+) cells, suggesting expression at a stage of differentiation similar to CD41. These results were confirmed at the mRNA level using reverse transcription-polymerase chain reaction. GPVI expression was low during megakaryocytic differentiation but increased in the more mature megakaryocytes (CD41(high)). As in platelets, megakaryocyte GPVI associates with the Fc receptor gamma chain (FcRgamma). The FcR gamma chain was detected at the RNA and protein level at all stages of megakaryocyte maturation preceding the expression of GPVI. The other collagen receptor, alpha(2)beta(1) integrin (CD49b/CD29), had a pattern of expression similar to GPVI. Megakaryocytic GPVI was recognized as a 55-kDa protein by immunoblotting and ligand blotting, and thus it presented a slightly lower apparent molecular mass than platelet GPVI (58 kDa). Megakaryocytes began to adhere to immobilized convulxin via GPVI after only 8-10 days of culture, at a time when megakaryocytes were maturing. At this stage of maturation, they also adhered to immobilized collagen by alpha(2)beta(1) integrin-dependent and -independent mechanisms. Convulxin induced a very similar pattern of protein tyrosine phosphorylation in megakaryocytes and platelets including Syk, FcRgamma, and PLC(gamma)2. Our results showed that GPVI is expressed early during megakaryocytic differentiation but functionally allows megakaryocyte adherence to collagen only at late stages of differentiation when its expression increases. [less ▲]