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See detailEmerging Hyphenated Analytical Techniques for POP’s
Focant, Jean-François ULg

Conference (2011, March)

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See detailEmerging hyphenated analytical techniques for POPs
Focant, Jean-François ULg

in Organohalogen Compounds (2008), 70

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See detailEmerging Hyphenated Analytical Techniques for POPs'
Focant, Jean-François ULg

Conference (2011, January)

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See detailEmerging International Standards : If a dream could come true
Michel, Quentin ULg

Conference (2008, September 25)

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See detailEmerging International Standards : If a dream could come true
Michel, Quentin ULg

Conference (2009, May 27)

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See detailEmerging Models of Social Enterprise in Eastern Asia: a Cross-Country Analysis
Defourny, Jacques ULg; Kim, Shin-Yang

in Social Enterprise Journal (2011), vol. 7(1), 86-111

We first examine the socio-economic contexts in which new public policies and new NPOs’ initiatives were launched to offer innovative solutions to current challenges, especially unemployment. Interactions ... [more ▼]

We first examine the socio-economic contexts in which new public policies and new NPOs’ initiatives were launched to offer innovative solutions to current challenges, especially unemployment. Interactions between Eastern Asia and Western regions (EU, US) are also analysed as to experiments and conceptions of social enterprise. In order to identify major convergences and divergences across countries in Eastern Asia, we rely on country studies presented in this issue as well as on a broad literature, related more specifically to the development and roles of NPOs and co-operatives in this region. Five major models of social enterprise with specific dynamics can be identified in Eastern Asia. State influence and driving forces linked to public policies make these models rather different from the typical US social enterprise; as for the role of civil society, it seems weaker than in Western contexts but is growing significantly. Co-operative movements also play a significant role in shaping some social enterprise models. Finally, two conditions identified as critical for the development of social economy organisations – a "condition of necessity" and a "condition of shared destiny" - seem to be valid in Eastern Asia as well, provided they are properly reinterpreted. The present analysis, just like the other four papers in this issue, is a result of a joint research project of the EMES European Research Network and East-Asian researchers. Country studies were conducted along common broad guidelines, and they were discussed and revised at various stages, which insured a fairly good level of comparability. Moreover, this seems to be the first systematic comparative analysis on social enterprise involving all industrialised countries in Eastern Asia. [less ▲]

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See detailEmerging pathogenic mechanisms in human myxomatous mitral valve: lessons from past and novel data.
Hulin, Alexia; Deroanne, Christophe ULg; Lambert, Charles ULg et al

in Cardiovascular Pathology (2013), 22

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See detailEmerging Patterns of Depoliticization and Engagement to Inform the Future of Science and Technology Studies: A Case Study in Nanotechnologies
Thoreau, François ULg

Conference (2009)

In this paper, we address the issue of the future of a particular field of research in social science: Science and Technology Studies (STS). Although this is a very young research field, its history is ... [more ▼]

In this paper, we address the issue of the future of a particular field of research in social science: Science and Technology Studies (STS). Although this is a very young research field, its history is already diverse and its evolutions are fastly moving on. Its rapid expansion and its characteristic feature of crossing disciplinary boundaries are making it an interesting case to study, which takes a particular place in the overall history – and future – of social changes. As we shall indicate, STS have an increasing committment for the resolution of sociotechnical controversies. In this paper, we problematise this particular position by underlying the implicit politics of STS research and how they will shape the future of that particular field. Our approach is threefold. First, we give a brief overview of the history of the field and we point out the main evolutions since the developement of the Social Construction of Technology approach (SCOT) in the 1980s that long influenced the field. By doing so, we underline the epistemological critical tradition that gave the field some of its particularities that we address. We show how this tradition brought important insights of “political” nature within the development of the field. Second, our ambition is to highlight new patterns of evolution of the STS field, emphasizing the trends towards both a greater depoliticisation and a more engaged research. By “depoliticisation”, we intend to analyse the dynamics of institutionalisation of the field which adopts resources and tools to legitimate itself among the social scientific community. By “engaged” research, we will explore the evolutions of the STS field as inherently political. The field does have an implicit statement in favor of changing social order and an increasing willingness to actually influence that social change. In that respect, research projects in STS often have underlying politics, as we shall demonstrate. Third, we give a concrete example of these new patterns occuring, relying on the growing importance of nanotechnologies, both in the STS literature and research projects. We consider this case study to be intertwined with the development of STS as a field of research. In that sense, we stress that nanotechnologies happened to be a powerful tool for legitimation for the STS community. Therefore, we — as STS scholars — suggest instrumentalizing the interest we have in nanotechnologies in order to observe the evolutions of our field of research. Then, nanotechnologies will constitute an interesting ground to perform a test that will show depoliticisation and engagement as patterning the STS field. [less ▲]

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See detailThe emerging role of class II histone deacetylases.
Fischle, Wolfgang; Kiermer, Véronique; Dequiedt, Franck ULg et al

in Biochemistry & Cell Biology (2001), 79(3), 337-48

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in all eukaryotes. Several histone acetyltransferases have been identified that ... [more ▼]

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in all eukaryotes. Several histone acetyltransferases have been identified that act as transcriptional coactivators. In contrast, histone deacetylases (HDACs) are part of transcriptional corepressor complexes. Based on their similarity to known yeast factors, the human HDACs are grouped into three classes. Class I HDACs are similar to the yeast transcriptional repressor yRPD3, while class II HDACs are related to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated in cell differentiation and development, and many molecular details are emerging that shed light on class II HDAC function and regulation. We discuss the biological role of these factors in the context of physiological processes. [less ▲]

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See detailThe Emerging Role of Exercise Testing and Stress Echocardiography in Valvular Heart Disease
Picano, Eugenio; Pibarot, Philippe; Lancellotti, Patrizio ULg et al

in Journal of the American College of Cardiology (2009), 54(24), 2251-60

Exercise testing has an established role in the evaluation of patients with valvular heart disease and can aid clinical decision making. Because symptoms may develop slowly and indolently in chronic valve ... [more ▼]

Exercise testing has an established role in the evaluation of patients with valvular heart disease and can aid clinical decision making. Because symptoms may develop slowly and indolently in chronic valve diseases and are often not recognized by patients and their physicians, the symptomatic, blood pressure, and electrocardiographic responses to exercise can help identify patients who would benefit from early valve repair or replacement. In addition, stress echocardiography has emerged as an important component of stress testing in patients with valvular heart disease, with relevant established and potential applications. Stress echocardiography has the advantages of its wide availability, low cost, and versatility for the assessment of disease severity. The versatile applications of stress echocardiography can be tailored to the individual patient with aortic or mitral valve disease, both before and after valve replacement or repair. Hence, exercise-induced changes in valve hemodynamics, ventricular function, and pulmonary artery pressure, together with exercise capacity and symptomatic responses to exercise, provide the clinician with diagnostic and prognostic information that can contribute to subsequent clinical decisions. Nevertheless, there is a lack of convincing evidence that the results of stress echocardiography lead to clinical decisions that result in better outcomes, and therefore large-scale prospective randomized studies focusing on patient outcomes are needed in the future. [less ▲]

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See detailThe emerging role of lysine acetylation of non-nuclear proteins
Close, Pierre ULg; Creppe, Catherine; Gillard, Magali ULg et al

in Cellular and Molecular Life Sciences : CMLS (2010), 67(8), 1255-1264

Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports ... [more ▼]

Lysine acetylation is a post-translational modification that critically regulates gene transcription by targeting histones as well as a variety of transcription factors in the nucleus. More recent reports have also demonstrated that numerous proteins located outside the nucleus are also acetylated and that this modification has profound consequences on their functions. This review describes the latest findings on the substrates acetylated outside the nucleus and on the acetylases and deacetylates that catalyse these modifications. Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders. [less ▲]

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See detailEmerging Roles for Proteinases in Cancer
Noël, Agnès ULg; Gilles, Christine ULg; Bajou, Khalid ULg et al

in Invasion & Metastasis (1997), 17(5), 221-39

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these ... [more ▼]

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these processes was initially thought to be the destruction of extracellular matrices. However, recent evidence suggests that they mainly affect tumor growth rather than invasion. Proteinases can indeed generate active matrix protein fragments, influence the release, the activation and the bioavailability of growth factors, and consequently modulate tumor cell growth, apoptosis and angiogenesis. Additionally, proteinases, their receptors and/or inhibitors can be directly involved in cell migration and in the processing or shedding of cell surface proteins. Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies. [less ▲]

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See detailEmerging Roles of ADAM and ADAMTS Metalloproteinases in Cancer
Rocks, Natacha ULg; Paulissen, Geneviève ULg; El Hour, Mehdi ULg et al

in Biochimie (2008), 90(2), 369-79

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural ... [more ▼]

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural features distinguish the membrane-anchored ADAMs and the secreted ADAMs with thrombospondin motifs referred to as ADAMTSs. By acting on a large panel of membrane-associated and extracellular substrates, they control several cell functions such as adhesion, fusion, migration and proliferation. The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions. [less ▲]

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See detailEmerging Technologies for Automatic Target Recognition
Dudgeon, Dan E.; Kolodzy, Paul J.; Mehanien, C. et al

Conference (1990, June)

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See detailEmerging therapeutic agents for onychomycosis.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Expert Opinion on Emerging Drugs (2007), 12(3), 345-53

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families ... [more ▼]

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families have been reported to be responsible for onychomycosis. The output from the pharmaceutical industry of new antifungals to treat onychomycosis has been limited over the last decade. Present treatment options include both oral and topical drugs, with oral therapies giving better outcomes. However, neither of these treatment options provides high cure rates that are durable. At present, azoles and allylamines are keeping the pivotal roles. New derivatives with a favorable risk-benefit ratio and new formulations of older azoles seem to be promising. Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals. [less ▲]

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See detailEmerging therapies for ionizing radiation-associated skin field carcinogenesis.
Pierard, Gérald ULg; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in Expert Opinion on Pharmacotherapy (2009), 10(5), 813-21

BACKGROUND: Radiodermatitis in its acute and chronic presentations represents a set of specific adverse effects resulting from ionizing radiations. Skin-field cancerization is another condition associated ... [more ▼]

BACKGROUND: Radiodermatitis in its acute and chronic presentations represents a set of specific adverse effects resulting from ionizing radiations. Skin-field cancerization is another condition associated to or independent of clinically recognizable radiodermatitis. This condition leads to the risk of later occurrence of skin malignancies. METHOD: Review of the current and most pertinent peer-reviewed publications with the addition of personal perspectives. RESULT/CONCLUSION: The presence of field cancerization encompasses subclinical changes, precursors of malignant alterations, as well as single or multiple primary neoplasms and local neoplastic recurrences. These tumours commonly require repeated treatments over time and cause significant morbidity. In general, specific tumour-directed treatments using ablative or destructive techniques require regular follow-up and screening for disclosing any further neoplasm. Another strategy corresponding to field-directed treatment targets a larger area of irradiated skin to reduce the risk of developing second neoplasms and local recurrences. Imiquimod is an immune response modifier of the imidazoquinoline class. It is the archetype drug used to control skin-field carcinogenesis. Cryotherapy, topical 5-fluorouracil, diclofenac and conventional photodynamic therapy are supposed to bring effects differing by their indications, healing rates and remission rates. The possibility of inducting a radiation recall dermatitis by some of these therapeutic modalities has not been thoroughly evaluated, and at present cannot be ruled out with confidence. [less ▲]

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See detailThe EMES "ideal-type" social enterprise as a compass
Defourny, Jacques ULg

Conference (2013, July 01)

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