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Peer Reviewed
See detailDetection of early sympathetic cardiovascular neuropathy by squatting test in NIDDM.
Marfella, R.; Salvatore, T.; Giugliano, D. et al

in Diabetes Care (1994), 17(2), 149-51

OBJECTIVE--To determine the role of the squatting test in the detection of early sympathetic neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Three ... [more ▼]

OBJECTIVE--To determine the role of the squatting test in the detection of early sympathetic neuropathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS--Three groups of nonsmoking, nonobese subjects were studied: 10 healthy subjects, 10 NIDDM patients without autonomic neuropathy (AN), and 10 NIDDM patients with AN defined by the presence of a pathological deep-breathing value. All subjects were given three postural tests: lying-to-standing, sitting-to-standing, and squatting test. Heart rate (HR) and finger arterial pressure were recorded with a noninvasive technique. RESULTS--Blood pressure (BP) fall (expressed as decremental area) was not significantly different among the groups at standing up after sitting or lying. By contrast, a significantly greater BP drop occurred in NIDDM patients with AN (1,123 +/- 245 mm2) compared with NIDDM patients without AN (460 +/- 232 mm2) or normal subjects (429 +/- 138 mm2, P < 0.001). The HR increase after all the orthostatic maneuvers was smaller in diabetic patients with AN (P < 0.01) compared with that recorded in other groups. Significant correlations were observed between BP fall after squatting and either the expiration:inspiration ratio at deep breathing (r = -0.77, P < 0.001) or the duration of diabetes (r = 0.76, P < 0.001). CONCLUSIONS--The intrinsic orthostatic load of the squatting test, which is greater than conventional postural maneuvers, makes the squatting test an easy and useful test to detect early orthostatic dysregulation in NIDDM. [less ▲]

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See detailDetection of Echinococcus multilocularis in wild boars in France using PCR techniques against larval form
Boucher, J. M.; Hanosset, R.; Augot, D. et al

in Veterinary Parasitology (2005), 129(3-4), 259-266

Recently, new data have been collected on the distribution and ecology of Echinococcus multilocularis in European countries. Different ungulates species such as pig, goat, sheep, cattle and horse are ... [more ▼]

Recently, new data have been collected on the distribution and ecology of Echinococcus multilocularis in European countries. Different ungulates species such as pig, goat, sheep, cattle and horse are known to host incomplete development of larval E. multilocularis. We report a case of E. multilocularis portage in two wild boars from a high endemic area in France (Department of Jura). Histological examination was performed and the DNA was isolated from hepatic lesions then amplified by using three PCR methods in two distinct institutes. Molecular characterisation of PCR products revealed 99% nucleotide sequence homology with the specific sequence of the U1 sn RNA gene of E. multilocularis, 99 and 99.9% nucleotide sequence homology with the specific sequence of the cytochrome oxydase gene of Echinococcus genus and 99.9% nucleotide sequence homology with a genomic DNA sequence of Echinococcus genus for the first and the second wild boar, respectively. (c) 2004 Elsevier B.V. All rights reserved. [less ▲]

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See detailDetection of exozodiacal dust: a step toward Earth-like planet characterization with infrared interferometry
Defrere, Denis ULg

Doctoral thesis (2009)

The existence of other habitable worlds and the possible development of life elsewhere in the Universe have been among mankind's fundamental questions for thousands of years. These interrogations about ... [more ▼]

The existence of other habitable worlds and the possible development of life elsewhere in the Universe have been among mankind's fundamental questions for thousands of years. These interrogations about our origins and place in the Universe are today at the dawn of being answered in scientific terms. The key year was 1995 with the discovery of the first extrasolar planet orbiting around a solar-type star. About 400 extrasolar planets are known today and the possibility to identify habitable worlds and even life among them largely contributes to the growing interest about their nature and properties. However, characterizing planetary systems is a very difficult task due to both the huge contrast and the small angular separation between the host stars and their environment. New techniques have emerged during the past decades with the purpose of tackling these fantastic observational challenges. In that context, infrared interferometry is a very promising technique, since it provides the required angular resolution to separate the emission of the star from that of its environment. This dissertation is devoted to the characterization of extrasolar planetary systems using the high angular resolution and dynamic range capabilities of infrared interferometric techniques. The first part of the present work is devoted to the detection with current interferometric facilities of warm dust within the first few astronomical units of massive debris discs around nearby stars. In order to extend the imaging of planetary systems to fainter discs and to extrasolar planets, we investigate in a second step the performance of future space-based nulling interferometers and make a comparison with ground-based projects. Finally, the third part of this work is dedicated to the impact of exozodiacal discs on the performance of future life-searching space missions, the goal being to characterize extrasolar planets with sizes down to that of the Earth. [less ▲]

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See detailDetection of eye movements specific to drowsiness and their relation with subjective assessment of sleepiness in PVT: A cognitive ergonomic approach
Blavier, Adelaïde ULg; Montagnino, Cédric; Wertz, Jérôme ULg et al

Conference (2014, February 24)

Drowsiness is one of the major factors explaining accidents, particularly in traffic accidents but also in work situations with serious consequences (e.g. medicine). The drowsiness may be assessed by ... [more ▼]

Drowsiness is one of the major factors explaining accidents, particularly in traffic accidents but also in work situations with serious consequences (e.g. medicine). The drowsiness may be assessed by diverse measures that vary from physiological and unconscious data (e.g. EEG) to subjective and conscious evaluation. In their daily life, people are used to evaluate their drowsiness by subjective assessment and research observes a great inter-individual variation in this evaluation. Moreover, the subjective evaluation is dependent on the situation and the risk perceived by the person (e.g., new versus usual situations, simple versus complex environments, etc.). In this theoretical context, our purpose was to investigate the links between 1) objective performance (reaction time) measured by a psychomotor vigilance task (PVT), 2) data from eye movements and 3) subjective assessment of drowsiness (measured with Karolinska Sleepiness Scale, KSS). 12 persons, aged from 20 to 56, participated individually. They were asked to respect a 60% sleep deprivation during the night before the experiment and to not drink any energy drinks the day of the experiment. The experiment was conducted between 1 and 3 PM after a heavy lunch in order to increase the circadian effect. Moreover, the temperature of the room was 25° in order to increase drowsiness. Each participant was asked to perform 4 PVT. However, although 100% of participants performed the first two PVT, only 66% were able to perform the third PVT and only 33% of participants performed the fourth and last PVT. Our results showed an effect of time on objective performance, eye movements and subjective assessment of drowsiness in PVT 1 and 2: significant increase of reaction time, increase of eye closure and perclos, reduction of pupil diameter and increase of subjective drowsiness estimation (KSS). Only the frequency and duration of blinks remained constant across time. In PVT 3 and 4, data from eye movements and objective performance (reaction time) did not vary anymore across the time. Only the subjective estimation of drowsiness (KSS) continued to increase. Furthermore, subjective estimation of drowsiness was differently correlated with eye movements and objective performance across the PVT; it was significantly correlated with reaction time (PVT 1,2,3), blink frequency and duration (PVT 1,2,3), perclos (PVT 1,2,3,4), eye closure (PVT 2,3), pupil diameter (PVT 1,2,3,4). These results are discussed and integrated in an ergonomic approach in order to analyze the links between objective performance, eye movements and subjective assessment of drowsiness. [less ▲]

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Peer Reviewed
See detailDetection of eye movements specific to drowsiness and their relation with subjective assessment: A cognitive ergonomic approach.
Blavier, Adelaïde ULg; Montagnino, Cédric; Wertz, Jérôme ULg et al

Poster (2014, May 27)

Drowsiness is one of the major factors explaining accidents, particularly in traffic accidents but also in work situations with serious consequences (e.g. medicine). The drowsiness may be assessed by ... [more ▼]

Drowsiness is one of the major factors explaining accidents, particularly in traffic accidents but also in work situations with serious consequences (e.g. medicine). The drowsiness may be assessed by diverse measures that vary from physiological and unconscious data (e.g. EEG) to subjective and conscious evaluation. In their daily life, people are used to evaluate their drowsiness by subjective assessment and research observes a great inter-individual variation in this evaluation. Moreover, the subjective evaluation is dependent on the situation and the risk perceived by the person (e.g., new versus usual situations, simple versus complex environments, etc.). In this theoretical context, our purpose was to investigate the links between 1) objective performance (reaction time) measured by a psychomotor vigilance task (PVT), 2) data from eye movements and 3) subjective assessment of drowsiness (measured with Karolinska Sleepiness Scale, KSS). 12 persons, aged from 20 to 56, participated individually. They were asked to respect a 60% sleep deprivation during the night before the experiment and to not drink any energy drinks the day of the experiment. The experiment was conducted between 1 and 3 PM after a heavy lunch in order to increase the circadian effect. Moreover, the temperature of the room was 25° in order to increase drowsiness. Each participant was asked to perform 4 PVT. However, although 100% of participants performed the first two PVT, only 66% were able to perform the third PVT and only 33% of participants performed the fourth and last PVT. Our results showed an effect of time on objective performance, eye movements and subjective assessment of drowsiness in PVT 1 and 2: significant increase of reaction time, increase of eye closure and perclos, reduction of pupil diameter and increase of subjective drowsiness estimation (KSS). Only the frequency and duration of blinks remained constant across time. In PVT 3 and 4, data from eye movements and objective performance (reaction time) did not vary anymore across the time. Only the subjective estimation of drowsiness (KSS) continued to increase. Furthermore, subjective estimation of drowsiness was differently correlated with eye movements and objective performance across the PVT; it was significantly correlated with reaction time (PVT 1,2,3), blink frequency and duration (PVT 1,2,3), perclos (PVT 1,2,3,4), eye closure (PVT 2,3), pupil diameter (PVT 1,2,3,4). These results are discussed and integrated in an ergonomic approach in order to analyze the links between objective performance, eye movements and subjective assessment of drowsiness. [less ▲]

Detailed reference viewed: 55 (10 ULg)
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See detailDetection of food antigens in dog foods used as elimination diets
Ricci, Rebecca; Granato, A; Palagiano, C et al

in Castrillo, Carlos (Ed.) Congress Proceedings 15th Congress ESVCN (2011, September)

Detailed reference viewed: 42 (4 ULg)
See detailDetection of foodborne pathogenic bacteria by Multiplex real time PCR
China, B.; Carpeaux, R.; Daube, Georges ULg

Poster (2002, June 20)

Detailed reference viewed: 9 (0 ULg)
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See detailDetection of forest fragmentation gradients and intensities.
Bogaert, Jan ULg; Salvador-Van Eysenrode, David; Van Hecke, Piet et al

in Maudsley, M; Marshall, J. (Eds.) Heterogeneity in Landscape Ecology: Pattern and Scale (1999)

Detailed reference viewed: 16 (6 ULg)
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See detailDetection of frequency spacings in the young O-type binary HD 46149 from CoRoT photometry
Degroote, P.; Briquet, Maryline ULg; Auvergne, M. et al

in Astronomy and Astrophysics (2010), 519

<BR /> Aims: Using the CoRoT space based photometry of the O-type binary HD 46149, stellar atmospheric effects related to rotation can be separated from pulsations, because they leave distinct signatures ... [more ▼]

<BR /> Aims: Using the CoRoT space based photometry of the O-type binary HD 46149, stellar atmospheric effects related to rotation can be separated from pulsations, because they leave distinct signatures in the light curve. This offers the possibility of characterising and exploiting any pulsations seismologically. <BR /> Methods: Combining high-quality space based photometry, multi-wavelength photometry, spectroscopy and constraints imposed by binarity and cluster membership, the detected pulsations in HD 46149 are analyzed and compared with those for a grid of stellar evolutionary models in a proof-of-concept approach. <BR /> Results: We present evidence of solar-like oscillations in a massive O-type star, and show that the observed frequency range and spacings are compatible with theoretical predictions. Thus, we unlock and confirm the strong potential of this seismically unexplored region in the HR diagram. The CoRoT space mission was developed and is operated by the French space agency CNES, with participation of ESA's RSSD and Science Programmes, Austria, Belgium, Brazil, Germany, and Spain.Based on observations made with the ESO telescopes at La Silla Observatory under the ESO Large Programme LP182.D-0356.Based on observations made with the Mercator Telescope, operated on the island of La Palma by the Flemish Community, at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica de Canarias. [less ▲]

Detailed reference viewed: 32 (6 ULg)
See detailDetection of fruit trees viroids and epidemiological characteristics of the disease caused by Peach Latent Mosaic Viroid in Tunisia
Fekih Hassen, I.; Roussel, S.; Kummert, J. et al

Conference (2004)

Detailed reference viewed: 16 (1 ULg)
See detailDetection of fruit trees viroids and epidemiological characteristics of the disease caused by peach latent mosaic viroid in tunisia
Fekih Hassen, Imene; Roussel, Sophie; Kummert, Jean et al

Conference (2005)

Detailed reference viewed: 16 (1 ULg)
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See detailDetection of glucocorticoid bioactivity in bovine urine samples using a reporter gene assay
Connolly, Lisa; Cai, Kai; Van Der Heiden, Edwige ULg et al

in Analytica Chimica Acta (2009), 637

The illegal use of anabolic substances in the meat producing industry is an ongoing problem due to the continual production of new synthetic compounds and/or the practice of lowlevel cocktail ... [more ▼]

The illegal use of anabolic substances in the meat producing industry is an ongoing problem due to the continual production of new synthetic compounds and/or the practice of lowlevel cocktail administration to avoid detection by the surveillance schemes of EU member states National Plan surveillance systems. We present a highly sensitive reporter gene assay and sample extraction procedure based on a two step solid phase extraction and high performance liquid chromatography, developed for the detection of glucocorticoid abuse in bovine urine. The assay is capable of detecting compounds with glucocorticoid bioactivity and is extremely sensitive with an EC50 of 0.79 ngmL−1 for dexamethasone. New or unknown compounds with glucocorticoid bioactivity and low-level cocktail mixtures are detectable by this assay. Cross-reactivity data for a range of 11 -hydroxyglucocorticoids has been provided. This assay shows low interference from the 11-keto prohormones and other steroidal hormones. The assay may be suitable for application in other matrices such as hair. In conclusion this screening assay offers advantages over existing analytical techniques. [less ▲]

Detailed reference viewed: 52 (12 ULg)
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See detailDetection of glucocorticoid bioactivity in bovine urine samples using a reporter gene assay
Connolly, Lisa; Kai, C.; Van Der Heiden, Edwige ULg et al

in Proceedings of the Euroresidue VI Conference (2008)

Detailed reference viewed: 8 (0 ULg)
Peer Reviewed
See detailDetection of Ground Movements on the Mt. Etna Volcano using the Global Positioning System
Bruyninx, Carine; Warnant, René ULg

in Acta Vulcanologica (1995), 7(1), 27-33

Detailed reference viewed: 11 (0 ULg)
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See detailDetection of Heavy Metal Elements in Fume by Laser-Induced Breakdown Spectroscopy
Lin, Zhaoxiang; Li, Jie ULg; Liu, Linmei et al

in Chinese Journal of Lasers (2008), 35(12), 338-340

Detailed reference viewed: 22 (0 ULg)
See detailDetection of High molecular mass for MALDI Imaging and Profiling
Franck, Julien; Longuespée, Rémi ULg; Bonnel, David et al

Conference (2009)

Detailed reference viewed: 9 (0 ULg)
See detailDetection of High molecular mass for MALDI Imaging and Profiling
Franck, Julien; Longuespée, Rémi ULg

Conference (2009, September)

Detailed reference viewed: 12 (0 ULg)
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See detailDetection of Hoxa1 Expression in Human Breast Cancer
Chariot, Alain ULg; Castronovo, Vincenzo ULg

in Biochemical and Biophysical Research Communications (1996), 222(2), 292-7

Homeodomain-containing proteins are transcription factors that regulate the coordinated expression of multiple genes involved in development, differentiation and malignant transformation. To better ... [more ▼]

Homeodomain-containing proteins are transcription factors that regulate the coordinated expression of multiple genes involved in development, differentiation and malignant transformation. To better understand the role played by these proteins in breast cancer cells, we demonstrate, using semi-quantitative RT-PCR experiments, that progestin induces HOXA1 mRNAs in MCF7 cells. This is the first evidence of regulation of a HOX gene by steroids. Moreover, we detected HOXA1 expression in a variety of human breast cancer lesions, suggesting that HOXA1 may be required for the establishment of breast cancer cells phenotype. We propose that HOXA1 gene could be one of the orchestrators that regulate breast epithelial cell differentiation and that alteration of HOXA1 expression could play a role in breast cancer progression. [less ▲]

Detailed reference viewed: 94 (8 ULg)