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See detailÉloge de l'hétérogénéité des structures d'analyse de textes
Bénel, Aurélien; Lejeune, Christophe ULg; Zhou, Chao

in Document Numérique (2010), 13(2), 41-56

This paper deals with how we used a "knowledge organization system" management infrastructure to build software for researchers involved in text interpretation. Founded on a viewpoints-based model, this ... [more ▼]

This paper deals with how we used a "knowledge organization system" management infrastructure to build software for researchers involved in text interpretation. Founded on a viewpoints-based model, this implementation highlighted the heterogeneity of analyses structures, whether it comes from authors diversity or from automation level. [less ▲]

Detailed reference viewed: 222 (57 ULg)
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See detailL'Eloge de la folie d'Erasme
Adam, Renaud ULg

in Toussaint, Jacques (Ed.) Pulsion(s) : images de la folie du Moyen Age au siècle des Lumières (2012)

Detailed reference viewed: 37 (5 ULg)
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See detailL'éloge de la folie en hôpital de jour: présent du passé et perspectives
Triffaux, Jean-Marc ULg

in Revue des Hôpitaux de Jour Psychiatriques et des Thérapies Institutionnelles (2003)

Detailed reference viewed: 20 (2 ULg)
See detailEloge de Marcel Migeotte (1912-1992)
Biémont, Emile ULg

in Bulletin de la Classe des Sciences. Académie Royale de Belgique (1994), V(6), 271-278

Detailed reference viewed: 5 (2 ULg)
See detailEloge du compromis. Pour une nouvelle pratique démocratique
Nachi, Mohamed ULg

Scientific conference (2008, March)

La place du compromis dans les espaces publics démocratiques

Detailed reference viewed: 11 (1 ULg)
See detailEloge du compromis. Pour une nouvelle pratique démocratique
Nachi, Mohamed ULg

Book published by Academia-Bruylant (2006)

Detailed reference viewed: 33 (0 ULg)
See detailEloge du politiquement correct
Delruelle, Edouard ULg

Conference given outside the academic context (2013)

Detailed reference viewed: 6 (0 ULg)
See detailElogio de Collodi
Curreri, Luciano ULg

in Las aventuras de Pinocho : Historia de un títire (2011)

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See detailElogio di Collodi
Curreri, Luciano ULg

in Le avventure di Pinocchio : Storia di un burattino (2010)

Detailed reference viewed: 17 (0 ULg)
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See detailElongation of telechelic ionomers under shear: a rheological and rheo-optical study
Chassenieux, Christophe; Tassin, Jean-François; Gohy, Jean-François et al

in Macromolecules (2000), 33(5), 1796-1800

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong ... [more ▼]

The behavior under shear of solutions of α,ω-lithium sulfonato polystyrene (α,ω-LiPSS100) in toluene has been investigated by rheo-optics and rheology. Shear-thickening is observed and related to a strong increase of birefringence and a pronounced and rapid alignment of the polymer chains toward the flow direction leading to an important elasticity of the fluids. The draw ratio of the polymer chains under shear has been estimated from the rheo-optical data. When the fraction of loops is taken into account, draw ratios on the order of 4 are calculated in the shear thickening regime. [less ▲]

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See detailElongator - an emerging role in neurological disorders
Nguyen, Laurent ULg; Humbert, Sandrine; Saudou, Frédéric et al

in Trends in Molecular Medicine (2010), 16

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based ... [more ▼]

We are currently facing important challenges to prevent and cure neurological disorders that are becoming a major public health issue in our aging society. Because of the lack of mechanism-based treatments to correct brain malformations or to prevent the progression of cell death in neurodegenerative disorders, most of these pathologies follow a fatal course. Thus, one major objective is to understand the molecular events that underlie these diseases in order to prevent their onset and/or halt their progression. Converging experimental and clinical evidences obtained by our lab and others prompt us to speculate that Elongator may be commonly targeted in different neurological disorders and as such, should represent a strong candidate for research and development efforts to design drug-based therapies. [less ▲]

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See detailElongator controls the migration and differentiation of cortical neurons through acetylation of a tubulin
Creppe, Catherine ULg; Malinouskaya, Lina ULg; Volvert, Marie-Laure ULg et al

in Cell (2009), 136

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which ... [more ▼]

The generation of cortical projection neurons relies on the coordination of radial migration with branching. Here we report that the multi-subunit histone acetyltransferase Elongator complex, which contributes to transcript elongation, also regulates the maturation of projection neurons. Indeed, silencing of its scaffold (Elp1) or catalytic subunit (Elp3) cell-autonomously delays the migration and impairs the branching of projection neurons. Strikingly, neurons defective in Elongator show reduced levels of acetylated alpha tubulin. A direct reduction of alpha tubulin acetylation leads to comparable defects in cortical neurons and suggests that alpha tubulin is a target of Elp3. This is further supported by the demonstration that Elp3 promotes acetylation and counteracts HDAC6-mediated deacetylation of this substrate in vitro. Our results uncover alpha tubulin as a target of the Elongator complex and suggest that a tight regulation of its acetylation underlies the maturation of cortical projection neurons. [less ▲]

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See detailElongator depletion causes defective transcript elongation of genes that regulate cell motility
Close, Pierre ULg; Hawkes, N; Cornez, I et al

Poster (2005, November 15)

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See detailElongator orchestrates cerebral cortical neurogenesis
creppe, catherine; malinouskaya, lina; Volvert, Marie-Laure ULg et al

in Medecine Sciences : M/S (2010)

Pas d'abstract pour cette publication

Detailed reference viewed: 68 (18 ULg)
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See detailElp3 is required for initiation of colon cancer
Ladang, Aurélie ULg; Heukamp, L; Buettner, R et al

Poster (2013, September 18)

Detailed reference viewed: 8 (2 ULg)
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See detailEls problemes de la violència esportiva. 10 anys després de Heysel
Comeron, Manuel ULg; Van Limbergen, Kris

in Revista d’Historia L'Avenç (1997), (211), 25-32

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es ... [more ▼]

Les conductes violentes desenvolupades pels seguidors de futbol, tradicionalment anomenades hooliganismo, estan profundament arrelades en la historia i tenen una difusio geografica molt amplia, es relaciona llavors amb comportaments d'agressio fisica i de vandalisme produïts pels espectadors d'una manifestacio esportiva, mes concretament dels partits de futbol. [less ▲]

Detailed reference viewed: 32 (1 ULg)
See detailEls Terratrèmols de l'any 1373 al Pirineu : Efectes a Espanya i França
Olivera, Carme; Riera, Antoni; Alexandre, Pierre ULg et al

Book published by Servei Geologic de Catalunya (1994)

Detailed reference viewed: 21 (0 ULg)
See detailElsvier, Computers in Industry, Special Issue on Natural Language Processing and Text Analytics in Industry
Ittoo, Ashwin ULg; Bosh, v.d., Antal; Nguyen, Le Minh

Book published by Elsevier (2015)

Detailed reference viewed: 24 (6 ULg)
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See detailElucidating the altered transcriptional programs in breast cancer using independent component analysis
Teschendorff, A. E.; Journee, Michel ULg; Absil, P.-A. et al

in PLoS Computational Biology (2007), 3(8), 1539-1554

The quantity of mRNA transcripts in a cell is determined by a complex interplay of cooperative and counteracting biological processes. Independent Component Analysis ( ICA) is one of a few number of ... [more ▼]

The quantity of mRNA transcripts in a cell is determined by a complex interplay of cooperative and counteracting biological processes. Independent Component Analysis ( ICA) is one of a few number of unsupervised algorithms that have been applied to microarray gene expression data in an attempt to understand phenotype differences in terms of changes in the activation/ inhibition patterns of biological pathways. While the ICA model has been shown to outperform other linear representations of the data such as Principal Components Analysis ( PCA), a validation using explicit pathway and regulatory element information has not yet been performed. We apply a range of popular ICA algorithms to six of the largest microarray cancer datasets and use pathway- knowledge and regulatory- element databases for validation. We show that ICA outperforms PCA and clustering- based methods in that ICA components map closer to known cancer- related pathways, regulatory modules, and cancer phenotypes. Furthermore, we identify cancer signalling and oncogenic pathways and regulatory modules that play a prominent role in breast cancer and relate the differential activation patterns of these to breast cancer phenotypes. Importantly, we find novel associations linking immune response and epithelial - mesenchymal transition pathways with estrogen receptor status and histological grade, respectively. In addition, we find associations linking the activity levels of biological pathways and transcription factors ( NF1 and NFAT) with clinical outcome in breast cancer. ICA provides a framework for a more biologically relevant interpretation of genomewide transcriptomic data. Adopting ICA as the analysis tool of choice will help understand the phenotype - pathway relationship and thus help elucidate the molecular taxonomy of heterogeneous cancers and of other complex genetic diseases. [less ▲]

Detailed reference viewed: 38 (10 ULg)