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See detailElevated MMP-12 protein levels in induced sputum from patients with COPD
Demedts, Inge K.; Morel-Montero, A.; Lebecque, S. et al

in Thorax (2006), 61(3), 196-201

Background: Several matrix metalloproteinases ( MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD). In mice, MMP-12 plays a crucial role in the development of ... [more ▼]

Background: Several matrix metalloproteinases ( MMPs) are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD). In mice, MMP-12 plays a crucial role in the development of cigarette smoke induced emphysema. A study was undertaken to investigate the role of MMP-12 in the development of COPD in human smokers. Methods: Induced sputum samples were collected from patients with stable COPD (n = 28), healthy smokers ( n = 14), never smokers ( n = 20), and former smokers ( n = 14). MMP-12 protein levels in induced sputum were determined by ELISA and compared between the four study groups. MMP-12 enzymatic activity in induced sputum was evaluated by casein zymography and by cleaving of a fluorescence quenched substrate. Results: Median (IQR) MMP-12 levels were significantly higher in COPD patients than in healthy smokers, never smokers, and former smokers (17.5 (7.1 - 42.1) v 6.7 (3.9 - 10.4) v 4.2 (2.4 - 11.3) v 6.1 (4.5 - 7.6) ng/ml, p = 0.0002). MMP-12 enzymatic activity was significantly higher in patients with COPD than in controls (4.11 (1.4 - 8.0) v 0.14 (0.1 - 0.2) mu g/ml, p = 0.0002). Conclusion: MMP-12 is markedly increased in induced sputum from patients with stable COPD compared with controls, suggesting a role for MMP-12 in the development of COPD in smokers. [less ▲]

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See detailElevated Plasma Alpha 1-Acid Glycoprotein Levels: Lack of Connection to Resistance to Vecuronium Blockade Induced by Anticonvulsant Therapy
Hans, Pol ULg; Brichant, Jean-François ULg; Pieron, F. et al

in Journal of Neurosurgical Anesthesiology (1997), 9(1), 3-7

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled ... [more ▼]

This study was designed to investigate the relationships among anticonvulsant therapy, plasma alpha 1-acid glycoprotein (AAG) levels, and resistance to vecuronium blockade. Thirty-one patients scheduled for routine neurosurgery were included in the study. The patients were treated (TG; n = 20) with phenytoin (n = 15) and/or carbamazepine (n = 4) and/or phenobarbital (n = 3) for > or = 6 days or were left untreated (UG; n = 11, control group). TG patients were further assigned to one of two subgroups according to the plasma anticonvulsant level measured the day before surgery and found to be within (TGW, n = 10) or below (TGB, n = 10) the therapeutic range. Finally, the 31 patients were divided into two more groups according to their plasma AAG levels: higher than (HAAG, n = 17) or within (NAAG, n = 14) the normal range (25-94 mg dl-1). Anesthesia was induced and maintained with propofol and sufentanil. Muscle relaxation was obtained with vecuronium 0.1 mg kg-1. A train-of-four (TOF) stimulation mode at 2 Hz was applied to the ulnar nerve every 15 s, and neuromuscular transmission was assessed using a TOF-Guard accelograph monitor. Plasma AAG concentrations (means +/- SEM) were 103.7 +/- 7.6 mg dl-1 in TG, 80.7 +/- 6.7 mg dl-1 in UG, 95.9 +/- 13.2 mg dl-1 in TGW, 111.6 +/- 7.6 mg dl-1 in TGB. 114.9 +/- 7.4 mg dl-1 in HAAG, and 71.4 +/- 3.8 mg dl-1 in NAAG groups. The differences in plasma AAG concentrations between UG and TG and between HAAG and NAAG groups were statistically significant. No significant relationship was found between plasma AAG levels and phenytoin concentrations (r = -0.26). The time (mean +/- SEM) to recovery of T1 to 25% of control was significantly shorter in TG (28.2 +/- 1.4 min) than in UG (42.2 +/- 3.1 min) but did not differ significantly according to the plasma anticonvulsant level (27.3 +/- 2.0 min in TGW; 29.1 +/- 1.9 min in TGB) and the plasma AAG level 31.7 +/- 1.9 min in HAAG; 35.3 +/- 3.3 min in NAAG). The time for the TOF ratio to recover to 25% yielded similar profiles and statistical significance levels: TG, 32.9 +/- 2.2 min; UG, 51.2 +/- 4.0 min; TGW, 35.0 +/- 3.9 min; TGB, 30.7 +/- 1.8 min; HAAG, 38.1 +/- 3.1 min; NAAG, 42.0 +/- 4.1 min. We conclude that anticonvulsant therapy induces an increase in plasma AAG independently of the plasma anticonvulsant level. However, duration and recovery of vecuronium blockade do not differ according to plasma AAG levels. Consequently, elevated AAG does not contribute to the resistance to vecuronium blockade induced by anticonvulsants. [less ▲]

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See detailElevation des biomarqueurs cardiaques apres un effort physique intense.
DUGAUQUIER, Christophe ULg; Hanssen, M.; GACH, Olivier ULg et al

in Revue medicale de Liege (2009), 64(7-8), 370-2

We present the case of a patient who felt faint after a strenuous exercise. A coronary angiography was performed because of an elevated level of troponin, but it failed to demonstrat any significant ... [more ▼]

We present the case of a patient who felt faint after a strenuous exercise. A coronary angiography was performed because of an elevated level of troponin, but it failed to demonstrat any significant coronary stenosis. We discuss the effect of strenuous exercise on cardiac biomarkers. Most previous published studies involved young trained populations. The frequency of these abnormalities in older, less trained people is unknown. Moreover, the possible impact of these abnormalities on mid- or long-term outcome is a matter of debate. Seniors practising intensive sport activities should systematically be submitted to a cardiological evaluation. [less ▲]

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See detailElévation faible d’hCG en dehors d’un contexte gravidique : à propos de deux cas et revue de la littérature
DE BACKER, Benjamin ULg; GOFFIN, Frédéric ULg; NISOLLE, Michelle ULg et al

in Annales de Biologie Clinique (2013), 71(4), 496-502

Unexpected finding or persistence of low human chorionic gonadotropin (hCG) levels is not a rare situation. It requires a clinico-biological approach in order to avoid misunderstandings that could lead to ... [more ▼]

Unexpected finding or persistence of low human chorionic gonadotropin (hCG) levels is not a rare situation. It requires a clinico-biological approach in order to avoid misunderstandings that could lead to inappropriate diagnostic or therapeutic attitudes. Beyond pregnancy, persistent low levels of hCG may be associated with various benign and malignant conditions, i.e. quiescent gestational trophoblastic disease (QTD), raised pituitary hCG or false positive elevation caused by circulating heterophile antibodies. We report the cases of two non-pregnant patients with low serum hCG. In the first case, hCG levels raised during several years following a spontaneous abortion. The likelihood of heterophilic antibodies interference was ruled out and extensive clinical investigation excluded the presence of a tumour. The diagnosis was QTD. In the second case, elevated hCG came to light as an incidental finding in a women with chronic renal failure and led the clinicians to question the laboratory. The cause was probably an increase in pituitary hCG consecutive to terminal renal failure. These cases illustrate the importance of understanding the biology of the hCG and the causes of its persistent low elevation, which are reviewed in this article. It is essential to demonstrate clinically the presence of a tumour in order to avoid unnecessary and ineffective chemotherapy and/or hysterectomy. [less ▲]

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See detailElevation of cardiac and oxidative stress biomarkers after a running activity in sedentary subjects
LE GOFF, Caroline ULg; Bury, Thierry ULg; Rodriguez de la Cruz, Carlos ULg et al

in Clinical Chemistry & Laboratory Medicine (2011, May), 49(Special Suppl), 313

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See detailELEVATIONAL PATTERNS OF GENETIC VARIATION IN THE COSMOPOLITAN MOSS BRYUM ARGENTEUM (BRYACEAE)
Pisa, S; Werner, OJ; Vanderpoorten, Alain ULg et al

in American Journal of Botany (2013), 100

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See detailElever les truies gestantes en groupes. Témoignages d'éleveurs
Boudry, Christelle ULg

Article for general public (2009)

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See detailLes élèves apprennent mieux les langues quand ils y croient!
Blondin, Christiane ULg; Goffin, Christelle ULg; Baye, Ariane ULg

Learning material (2014)

Written for the teachers, the short paper shows a few results of ESLC about students' attitudes toward the languages and their competences

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See detailElèves issus de l’immigration et diversité linguistique et culturelle
Lucchini, Silvia ULg

Scientific conference (2010, January 05)

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See detailEleveur autrement? Contribution d'une méthode audiovisuelle réflexive à l'explicitation d'un mode d'existence
Mathieu, Valérie ULg; Stassart, Pierre M ULg

in Eyraud, Corine; Lambert, Guy (Eds.) Filmer le Travail, Films et Travail (2009)

Ce papier se propose d’interroger le rôle que peut avoir un outil audiovisuel dans la production d’un mode d’existence particulier1. Dans notre démarche méthodologique, le chercheur n’est plus un ... [more ▼]

Ce papier se propose d’interroger le rôle que peut avoir un outil audiovisuel dans la production d’un mode d’existence particulier1. Dans notre démarche méthodologique, le chercheur n’est plus un observateur neutre et objectif , il est un apprenant qui, de la rencontre entre son expérience cognitive et l’expérience de vie des acteurs, cherchera comment tient une situation. Mais, plus précisément, comment le chercheur peut –il participer à l’émergence d’un groupe que l’on peut décrire comme se rendant capable d’expliciter ses intérêts sur un mode qui les constituerait éventuellement en affaire publique (Stengers, 2006) ? Cette question nous l’avons posée à travers la possibilité que nous avons entrevue de voir émerger un public (Dewey, 1927) autour de la question de l’élevage « pluri-actif » et du mode d’existence particulier des éleveurs pluri-actifs dans la région gaumaise (au sud de la Belgique). Ceux-ci exercent deux métiers à la fois : ils sont facteur, éducateur ou encore couvreur, et pratiquent l’élevage en plus, « après journée ». Ils nous intéressaient tout particulièrement car, bien que présents dans la région ils sont aussi bien effacés du discours de la profession agricole qu’absents des données statistiques produites par l’administration. [less ▲]

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See detailLes éleveurs d'alpaca du Pérou
Hanzen, Christian ULg; Bay, Daniel ULg

Learning material (2012)

Ce film de 52 minutes réalisé par Daniel Bay sur un scénario de Christian Hanzen présente les divers aspects du projet d'amélioration de la fibre d'alpaca financé par la Coopération Universitaire au ... [more ▼]

Ce film de 52 minutes réalisé par Daniel Bay sur un scénario de Christian Hanzen présente les divers aspects du projet d'amélioration de la fibre d'alpaca financé par la Coopération Universitaire au développement dans le cadre d'une coopération institutionnelle entre les universités de Namur (FUNDPN) et de Louvain (UCL) et l'Université Sans Antonio Abad del Cusco. Cette amélioration implique la caractérisation phénotypique de la fibre d'alpaca mais également l'amélioration des biotechnologies de la reproduction du mâle et de la femelle alpaca. [less ▲]

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See detailEleveurs et consommateurs, que pensent-ils de l'élevage
Bartiaux-Thill, Nicole; Stassart, Pierre M ULg; Lamine, Claire et al

Article for general public (2007)

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See detailThe elicitation of a systemic resistance by Pseudomonas putida BTP1 in tomato involves the stimulation of two lipoxygenase isoforms
Mariutto, Martin ULg; Duby, Franceline ULg; Adam, Akram et al

in BMC Plant Biology (2011), 11

Background Some non-pathogenic rhizobacteria called Plant Growth Promoting Rhizobacteria (PGPR) possess the capacity to induce in plant defense mechanisms effective against pathogens. Precedent studies ... [more ▼]

Background Some non-pathogenic rhizobacteria called Plant Growth Promoting Rhizobacteria (PGPR) possess the capacity to induce in plant defense mechanisms effective against pathogens. Precedent studies showed the ability of Pseudomonas putida BTP1 to induce PGPR-mediated resistance, termed ISR (Induced Systemic Resistance), in different plant species. Despite extensive works, molecular defense mechanisms involved in ISR are less well understood that in the case of pathogen induced systemic acquired resistance. Results We analyzed the activities of phenylalanine ammonia-lyase (PAL) and lipoxygenase (LOX), key enzymes of the phenylpropanoid and oxylipin pathways respectively, in tomato treated or not with P. putida BTP1. The bacterial treatment did not stimulate PAL activity and linoleate-consuming LOX activities. Linolenate-consuming LOX activity, on the contrary, was significantly stimulated in P. putida BTP1-inoculated plants before and two days after infection by B. cinerea. This stimulation is due to the increase of transcription level of two isoforms of LOX: TomLoxD and TomLoxF, a newly identified LOX gene. We showed that recombinant TomLOXF preferentially consumes linolenic acid and produces 13-derivative of fatty acids. After challenging with B. cinerea, the increase of transcription of these two LOX genes and higher linolenic acid-consuming LOX activity were associated with a more rapid accumulation of free 13-hydroperoxy-octadecatrienoic and 13-hydroxy-octadecatrienoic acids, two antifungal oxylipins, in bacterized plants. Conclusion In addition to the discovery of a new LOX gene in tomato, this work is the first to show differential induction of LOX isozymes and a more rapid accumulation of 13-hydroperoxy-octadecatrienoic and 13-hydroxy-octadecatrienoic acids in rhizobacteria mediated-induced systemic resistance. [less ▲]

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