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See detailDéveloppement de nouveaux bioproduits générant une valeur ajoutée
Richel, Aurore ULg

Scientific conference (2013, May 30)

Detailed reference viewed: 37 (12 ULg)
See detailDéveloppement de nouveaux marqueurs neuroradiologiques de la maladie de Parkinson par reconnaissance de motifs
Himri, Khadidja ULg; Depierreux, Frédérique ULg; GARRAUX, Gaëtan ULg

Poster (2015, January 27)

Background and objectives: Automatic classification of Parkinson’s disease (PD) versus healthy controls (HC) based on structural MRI has so far focused on unimodal approaches. However, this method is ... [more ▼]

Background and objectives: Automatic classification of Parkinson’s disease (PD) versus healthy controls (HC) based on structural MRI has so far focused on unimodal approaches. However, this method is subject to a poor temporal and spatial resolution leading to low classification accuracy. To overcome this limitation we propose to integrate different modalities by generating a single decision function based on a multi-kernel method, exploiting the complementary information it offers. We predict that the integration of multiple modalities produces greater classification enhancement. Materials and methods: 3Tesla MRI was acquired in 42 patients with PD and 42 age and gender matched healthy controls. We relied on Unified Parkinson’s Disease Rating Scale (UPDRS) for evaluating the clinical status. We used structural and quantitative maps of T1, T2*, proton density (PD), magnetization transfer (MT), Multi-parameter (MT magnetization transfer, proton density (A), Iron Deposit (R2 *), mixing water content, iron, and the fraction of macromolecules tissues (R1) at 1 × 1 × 1 mm3 resolution. We identified cortical and subcortical brain regions (cortex, putamen, globus pallidus, substantia nigra), and cortical grey matter. We applied existing classification algorithms in the field of neuroscience using a classification algorithm based on Support Vector Machines (SVMs) [1], executed using the Pattern Recognition for Neuroimaging Toolbox (PRoNTo) [2]. The processes of classification was the following, data were mean centered and leave one subject out cross-validation was performed, making the test set independent from the training set. Analyses were restricted to voxels where all subjects had non-zero values. Statistical significance of the classifications was tested using permutation testing (1000 permutations) with random assignment of group class to the input image. Subsequently, we combined different modalities (MT, A, R1, R2) and identified the combination giving the highest sensitivity and sensibility in PD classification. As classifier we used support vector machines that are inspired by statistical learning theory Vladimir Vapnik and Multiple Kernel Learning approach, introduced by Lanckriet [3],[4]. Our approach can be seen as an analogue of MKL with SVMs. Conclusion & Future work: Identification of brain areas with affected intensity in the Parkinson’s group compared to Healthy Controls in single modalities using pronto is helpful. However, the subsequent multi-kernel approach utilizes unimodal information in a combined fashion so that emergent information is obtained, transcending effectiveness unimodal approaches. In conclusion, our findings suggest that combining different imaging modalities and different regions of interest increase classification accuracy significantly. These results are promising for objective diagnosis in medical practice. [less ▲]

Detailed reference viewed: 128 (9 ULg)
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See detailDéveloppement de nouvelles méthodes de marquage au fluor-18 pour peptides et oligonucléotides en vue de leur études par tomographie par émission de positons
Flagothier, Jessica ULg

Doctoral thesis (2014)

Positron Emission Tomography is a highly sensitive imaging technique currently available in nuclear medicine for diagnostic. In regard to his physical and nuclear characteristics, fluorine-18 appears ... [more ▼]

Positron Emission Tomography is a highly sensitive imaging technique currently available in nuclear medicine for diagnostic. In regard to his physical and nuclear characteristics, fluorine-18 appears often as the radionuclide of choice for the preparation of short-lived positron-emitter radiotracers for PET studies. The fluorine-18 labelling reaction for biomolecules requires very mild conditions. The current method for highly efficient fluorine-18 labelling of biomolecules is the conjugation of a [18F]prosthetic group with a reactive function on the organic compound. During this thesis, two techniques were developed to label biomolecules via a [18F]prosthetic group: the first one to label tyrosine-containing peptides and the second one to label a siRNA. The first part of this work present the synthesis of the [18F]F-PTAD which is a agent for specific radiolabelling of tyrosine. [18F]F-PTAD was coupled with a tyrosine with a global radiochemical yield (synthesis, coupling, purification) of 20% (DC) and the synthesis lasts 2h30. During the second part of this work, two alkyne-bearing linkers were synthesized. These linkers were ligated with siRNA and then reacted with azide-bearing [18F]prosthetic group via a Huisgen cycloaddition reaction. The [18F]siRNA is then obtained with an global radiochemical yield of 12% (DC) and the synthesis lasts 2h00. In conclusion, two methods for labeling biomolecules have been developed. [less ▲]

Detailed reference viewed: 301 (21 ULg)
Peer Reviewed
See detailLe développement de partenariats multilingues. Une expérience aux dimensions européennes en Communauté française de Belgique
Campolini, L.; Jucquois, G.; Flamini, F. et al

in Annales d'Etudes Européennes de l'Université Catholique de Louvain (2001), 5

Detailed reference viewed: 22 (1 ULg)
See detailDéveloppement de procédés sol-gel de fabrication de matériaux de batterie
Eskenazi, David ULg

Doctoral thesis (2016)

Différents procédés, installations et moyens d'analyse ont été développés pour la fabrication de matériaux de batterie Li-ion par procédé sol-gel. Leur objectif est de faciliter l'utilisation industrielle ... [more ▼]

Différents procédés, installations et moyens d'analyse ont été développés pour la fabrication de matériaux de batterie Li-ion par procédé sol-gel. Leur objectif est de faciliter l'utilisation industrielle de ces matériaux. Il s'agit d'un réacteur continu de fabrication de xérogels de carbone sous forme de billes, d'un réacteur de nitruration de phosphates, et d'une technique d'analyse thermique couplée à de la spectrométrie de masse. [less ▲]

Detailed reference viewed: 28 (1 ULg)
Peer Reviewed
See detailDéveloppement de sondes chimiques pour la microscopie à force atomique et application aux surfaces de polyoléfines
Duwez, Anne-Sophie ULg; Dingyzli, T.; Jonas, A. et al

Conference (1999, March 29)

Detailed reference viewed: 11 (0 ULg)
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See detailLe développement de starters lactiques : de la cellule au produit fini
Thonart, Philippe ULg; Kouakou, P.; Dortu, C. et al

Conference (2009, November 02)

Detailed reference viewed: 53 (14 ULg)
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Peer Reviewed
See detailDéveloppement de systèmes spatiaux d'aide à la décision en environnement: applications de l'Outil Geo-Environnemental d'Aide a la Décision (OGEAD) valorisant les données sols.
Engels, Patrick ULg; Bock, Laurent ULg; Hecq, P. et al

in Biotechnologie, Agronomie, Société et Environnement = Biotechnology, Agronomy, Society and Environment [=BASE] (2004), 8(2),

Detailed reference viewed: 21 (5 ULg)
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See detailDéveloppement de techniques d'identification d'odeurs dans l'environnement
Nicolas, Jacques ULg; Romain, Anne-Claude ULg; Wiertz, Véronique et al

Report (1998)

Different techniques of evaluation of environmental odours were analysed and tested. More particularly, gas chromatography/mass spectrometry and electronic nose were investigated on 5 environmental ... [more ▼]

Different techniques of evaluation of environmental odours were analysed and tested. More particularly, gas chromatography/mass spectrometry and electronic nose were investigated on 5 environmental sources : printing house, compost area, waste water treatment plant, coach building and slaughter house. It is shown that electronic nose is a promising instrument able to identify qualitatively the odour type and to provide a global indicator of the odour level. [less ▲]

Detailed reference viewed: 46 (10 ULg)
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See detailDéveloppement des filières Jatropha décentralisées au Sénégal
Terren, Marieke ULg; Saverys, S.; Jacquet de Haverskercke, P et al

Poster (2009)

Detailed reference viewed: 55 (11 ULg)
Peer Reviewed
See detailLe développement des fonctions du langage en vue d’une meilleure intégration linguistique: le cas des Italiens de Belgique
Lucchini, Silvia ULg

in Cahiers de l'institut de linguistique de Louvain (1995), 21(1-2), 149-156

Detailed reference viewed: 15 (1 ULg)
See detailLe developpement des methodes de lutte biologique en agriculture et horticulture
Jijakli, Haissam ULg

Conference (2010, January)

Detailed reference viewed: 24 (3 ULg)
See detailLe développement du français oral comme prévention des difficultés scolaires des enfants italiens de Bruxelles
Lucchini, Silvia ULg

in Actes du colloque “Le français et les immigrés (1990)

Detailed reference viewed: 11 (2 ULg)