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See detailDesign of polymeric dispersants for waterborne coatings
Creutz, Serge; Jérôme, Robert ULg; Kaptijn, G. M. P. et al

in Journal of Coatings Technology (1998), 70(883), 41-46

Detailed reference viewed: 26 (4 ULg)
See detailDesign of polyphosphoester coplymers as scaffolds for tissue engineering applications
Shah, Urmil ULg; Ergül, Zeynep ULg; Jérôme, Christine ULg

Poster (2017, May 04)

Polymers with repeating phosphoester linkages in the backbone are biodegradable and emerged as a promising class of novel biomaterials. In contrast to polyesters, the pentavalency of the phosphorus atom ... [more ▼]

Polymers with repeating phosphoester linkages in the backbone are biodegradable and emerged as a promising class of novel biomaterials. In contrast to polyesters, the pentavalency of the phosphorus atom offers a large diversity of structures and as a consequence a wide range of properties for these materials. This study aims at taking profit of this easy functionalization to synthesize a series of degradable polymers of precisely tailored properties especially elasticity, hydrophilicity and functionality. We aim at developing a set of degradable materials in which only elasticity is varied keeping unchanged other parameters such as hydrophilicity, which remains quite a challenge. For that purpose, we have synthesized by organocatalyzed ring-opening polymerization,random di- and terpolymers between various cyclic phosphoesters bearing a short side-chain (hydrophilic), a longer side-chain (hydrophobic) and an unsaturated side-chain (butenyl)able to cross-link under UV irradiation. Playing on the composition of these copolymers, the cross-linking density and the hydrophilicity can be tuned quite independently. In the future, these materials will be used as model scaffolds to study the growth and differentiation of stem cells. [less ▲]

Detailed reference viewed: 30 (5 ULg)
See detailDesign of polyphosphoester-based drug delivery systems by efficient thiol-ene reaction
Riva, Raphaël ULg; Vanslambrouck, Stéphanie; Ergül, Zeynep ULg et al

Poster (2017, May 23)

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, polyphosphoesters (PPE) are appealing polymers for biomedical applications. In contrast to ... [more ▼]

Thanks to their biocompatibility, biodegradability and their structure similar to natural biomacromolecules, polyphosphoesters (PPE) are appealing polymers for biomedical applications. In contrast to polyesters, PPE properties and functionality are easily tuned via the chemical nature of the lateral chains. To enhance the drug loading capacity of PPE-based micelles used as carriers for the delivery of poorly soluble drugs, an efficient strategy to increase the lipophilicity of the PPE block of polyethylene oxide (PEO)-b-PPE amphiphilic copolymers has been investigated. A PEO-b-PPE copolymer bearing pendant vinyl groups along the PPE block was synthesized and then modified by thiol-ene click reaction with thiols bearing either a long linear alkyl chain (dodecyl) or a tocopherol moiety. Ketoconazole was used as model for hydrophobic drugs. Comparison of the loading contents and release profiles with PEO-b-PPE bearing shorter pendant groups is presented evidencing the key role of the structure of the pendant group on the PPE backbone. Finally, the low cytotoxicity of these novel PEO-b-PPE copolymers was also demonstrated. The tocopherol derivative was evidenced as particularly promising for drug delivery systems. [less ▲]

Detailed reference viewed: 21 (3 ULg)
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See detailDesign of Pt/carbon xerogel catalysts for PEM fuel cells
Job, Nathalie ULg; Lambert, Stéphanie ULg; Zubiaur, Anthony ULg et al

in Catalysts (2015), 5

Detailed reference viewed: 37 (6 ULg)
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See detailDesign of Pt/carbon xerogel catalysts for PEM fuel cells
Job, Nathalie ULg; Lambert, Stéphanie ULg; Zubiaur, Anthony ULg et al

Conference (2014, July)

Detailed reference viewed: 20 (0 ULg)
See detailDesign of pulsed extraction columns based on lab-sacle experiments with a small number of drops
Groß-Hardt, E; Henschke, M; Klinger, S et al

Conference (2002)

Detailed reference viewed: 3 (0 ULg)
See detailDesign of reprocessable poly(ɛ-caprolactone)-based shape-memory materials
Defize, Thomas ULg

Doctoral thesis (2017)

Shape-memory polymers (SMPs) are remarkable materials able to switch from a temporary shape to their initial permanent shape by crossing a thermal transition, e.g. glass or melting transition. Efficient ... [more ▼]

Shape-memory polymers (SMPs) are remarkable materials able to switch from a temporary shape to their initial permanent shape by crossing a thermal transition, e.g. glass or melting transition. Efficient shape-memory effect is notably observed for chemically cross- linked semi-crystalline polymers. Chemical networks of semi-crystalline poly(ε-caprolactone) (PCL) are widely studied for the development of SMPs especially when biomedical applications are foreseen. As these SMPs are irreversibly cross-linked material, their (re)processing is quite limited since they cannot be molten or solubilized after cross-linking. This prevents any recycling. Thereby, using reversible cross-linking reactions allowing the formation or cleavage of the network upon a selected stimulus raise tremendous interest for the development of smart SMPs. Chemically cross-linked but remarkably (re)processable shape-memory polymers (SMP) were designed by crosslinking poly(ε-caprolactone) (PCL) stars via reversible cycloaddition reactions. The thermo-reversible Diels-Alder (DA) reaction between furan and maleimide was investigated to crosslink the PCL matrix. However, the relatively low retro DA temperature of the furan-maleimide adducts led to some inelastic deformation during shape memory tensile cycles. In order to get rid of this drawback, two alternative approaches were investigated, i.e. the substitution of the DA reaction firstly by the efficient triazolinedione click chemistry, especially the very fast and reversible Alder-ene reaction of 1,2,4-triazoline-3,5- dione (TAD) with indole compounds and secondly by a photo-reversible reaction, typically the photo-induced (2+2) cycloaddition of coumarins. With these networks, the typical shape memory properties of PCL networks (high fixity and recovery ratios) were preserved while upon an external (light or stress) stimulus, the PCL network can be (re)processed efficiently. [less ▲]

Detailed reference viewed: 10 (3 ULg)
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See detailDesign of reversibly core cross-linked micelles sensitive to reductive environment
Cajot, Sébastien ULg; Lautram, N.; Passirani, Catherine et al

in Journal of Controlled Release (2011), 152(1), 30-36

Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in ... [more ▼]

Azido-functional amphiphilic macromolecules based on a biodegradable aliphatic polyester (poly-epsilon-caprolactone, PCL) and a bioeliminable hydrophilic poly(ethylene oxide) (PEO) block have been used in order to build micellar drug delivery systems. Such azido groups being able to react by alkyne-azide 1,3 Huisgens cycloaddition (a click reaction) have been used further in order to cross-link the micelles via redox-sensitive disulfide bridges. This reversible cross-linking allows to prevent micelles dissociation at high dilution upon injection and to trigger their dissociation in more reductive environment, such as the cytosol. Copolymers having three different architectures, i.e. able to crosslink either the core or the shell of core-shell-corona system have been used to investigate their micellization, cross-linking and cross-linking reversibility. The stealthiness of these micelles crosslinked in the hydrophobic segment has also been studied in vitro. [less ▲]

Detailed reference viewed: 113 (34 ULg)
See detailDesign of reversibly disulfide core cross-linked polymer micelles
Cajot, Sébastien ULg; Schol, Daureen ULg; Danhier, F. et al

Poster (2011, November 21)

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block ... [more ▼]

Over the last decade, polymer micelles attracted an increasing interest in drug pharmaceutical research because they could be used as efficient drug delivery systems. Micelles of amphiphilic block copolymers are supramolecular core-shell type assemblies of tens of nanometers in diameter. An accumulation of polymer nanocarriers to solid tumours is possible due to the EPR effect. Even if micelles get a high stability in aqueous media, the dissociation of micelles is not always preserved when they are injected in the blood compartment. This work aims at reporting on the design of reversibly cross-linked micelles based on PEO-b-PCL copolymers by introducing disulfide bridges in the micelle core to provide higher stability. Different kinds of macromolecular architectures are employed to study their impact on the micelles and their biological behavior. These new functional copolymers were all successfully micellized, reversibly cross-linked and are stealthy, which show the efficiency of the developed cross-linking process and offer a set of nanocarriers to be tested further, as shown on the first biological tests. [less ▲]

Detailed reference viewed: 84 (6 ULg)
See detailDesign of reversibly disulfide core cross-linked polymer micelles
Cajot, Sébastien ULg; Schol, Daureen ULg; Danhier, F. et al

Poster (2011, December 07)

Detailed reference viewed: 36 (11 ULg)
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See detailDesign of River Navigation weirs and Flood Protection Barriers
Rigo, Philippe ULg; Sarghiuta, Radu; Herbillon, Vincent ULg et al

in 78th ICOLD Annual Meeting - Hanoi 2010 (2010, May 23)

The aim of the WG (Working Group) was to conduct a comprehensive review (state-of-the-art) of the modern technologies, design tools and recent research used to design and build structures controlling ... [more ▼]

The aim of the WG (Working Group) was to conduct a comprehensive review (state-of-the-art) of the modern technologies, design tools and recent research used to design and build structures controlling water level and flow in rivers, waterways and ports (for navigation & flood protection). The WG considered regulatory structures such as: - Gates controlling water level and flow in rivers (even non navigable) and waterways (lifting gate, tilting gate, radial gate, sector, etc.; designed in one piece or with an upper flap). These are referred to as WEIRS. - Gates controlling water level and flow in estuaries with regards to high tides and storms (lifting gate, articulated, tilting, rolling, floating, sliding, etc.). These structures are referred to as BARRIERS. [less ▲]

Detailed reference viewed: 181 (9 ULg)
See detailDesign of smart polymer micelles for pH triggered drug delivery systems
Jérôme, Christine ULg

Conference (2009, April 02)

Detailed reference viewed: 24 (9 ULg)
See detailDesign of smart SPM probes by electrografting
Gabriel, Sabine ULg; Jérôme, Christine ULg; Duwez, Anne-Sophie ULg

Conference (2007, May 11)

Detailed reference viewed: 36 (4 ULg)
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See detailDesign of statistical measures for the assessment of image segmentation schemes
Van Droogenbroeck, Marc ULg; Barnich, Olivier ULg

in International Conference on Computer Analysis of Images and Patterns (CAIP 2005) (2005)

Image segmentation is discussed for years in numerous papers, but assessing its quality is mainly dealt with in recent works. Quality assessment is a primary concern for anyone working towards better ... [more ▼]

Image segmentation is discussed for years in numerous papers, but assessing its quality is mainly dealt with in recent works. Quality assessment is a primary concern for anyone working towards better segmentation tools. It both helps to objectively improve segmentation techniques and to compare performances with respect to other similar algorithms. In this paper we use a statistical framework to propose statistical measures capable to describe the performances of a segmentation scheme. All the measures rely on a ground-truth segmentation map that is supposed to be known and that serves as a reference when qualifying the results of any segmentation tool. We derive the analytical expression of several transition probabilities and show how to calculate them. An important conclusion from our study, often overlooked, is that performances can be content dependent, which means that one should adapt a measure to the content of an image. [less ▲]

Detailed reference viewed: 243 (14 ULg)
See detailDesign of stealth nanoparticles for drug delivery based on new amphiphilic copolymers
Rieger, Jutta ULg; Passirani, Catherine; Dubois, Philippe et al

Conference (2006, May 18)

Detailed reference viewed: 43 (2 ULg)
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See detailDesign of Steel Connections according ENV 1993-1
Jaspart, Jean-Pierre ULg

in Proceedings of the IABSE Congress on Structural Engineering in Consideration of Economy, Environment, Energy, Workshop on Structural Connections and Assembly Techniques (1996)

Detailed reference viewed: 49 (0 ULg)
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See detailDesign of steel I-girders in bending and shear stiffened by one or two trapezoidal longitudinal stiffeners
Thomas, G.; Degée, Hervé ULg; Maquoi, René ULg et al

in Proceedings of the 5th Conference on Advances in Steel Structures (2007)

Present paper focuses on the design of stiffened plates under bending and shear that are used in steel or composite bridges. Special attention is paid to situations involving one or two stiffeners, where ... [more ▼]

Present paper focuses on the design of stiffened plates under bending and shear that are used in steel or composite bridges. Special attention is paid to situations involving one or two stiffeners, where Eurocode 3 Part 1.5 provides specific rules. First, the paper describes briefly the FEM numerical models used in parametric studies. Then, comparisons between results obtained respectively from numerical simulations and from application of the code clauses are presented. Also, some proposals for improved rules are made. [less ▲]

Detailed reference viewed: 38 (2 ULg)