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See detailThe effects of testosterone and its metabolites on sexual behavior and morphology in male and female Japanese quail.
Schumacher, M.; Balthazart, Jacques ULg

in Physiology & Behavior (1983), 30(3), 335-9

Adult Japanese quail are sexually dimorphic. Even when implanted with testosterone (T), ovariectomized females fail to copulate and their cloacal glands are smaller than those of males. This may be due to ... [more ▼]

Adult Japanese quail are sexually dimorphic. Even when implanted with testosterone (T), ovariectomized females fail to copulate and their cloacal glands are smaller than those of males. This may be due to a reduced capacity of the females to transform testosterone into active metabolites (estradiol-17 beta and 5 alpha-dihydrotestosterone). Indeed, in the male quail, estradiol-17 beta (E2) activates copulation whereas 5 alpha-dihydrotestosterone (5 alpha-DHT) activates crowing, strutting and the development of the cloacal gland. To test this hypothesis, we studied the effects of in vivo treatments of male and female quail with the different T-metabolites. Forty-one castrated male and female quail were implanted with subcutaneous silastic implants of T, 5 alpha-DHT, E2 and E2 in combination with 5 alpha-DHT. When implanted with these metabolites, females failed to copulate and their cloacal glands remained less developed than those of males. Sexual differences in behavior and morphology thus cannot be entirely explained by sexual dimorphism of the metabolism. [less ▲]

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See detailEffects of testosterone on Reelin expression in the brain of male European starlings
Absil, Philippe ULg; Pinxten, R.; Balthazart, Jacques ULg et al

in Cell & Tissue Research (2003), 312(1), 81-93

Reelin, a large glycoprotein defective in reeler mice, is assumed to determine the final location of migrating neurons in the developing brain. We studied the expression of Reelin in the brain of adult ... [more ▼]

Reelin, a large glycoprotein defective in reeler mice, is assumed to determine the final location of migrating neurons in the developing brain. We studied the expression of Reelin in the brain of adult male European starlings that had been treated or not with exogenous testosterone. Reelin-immunoreactive cells and fibers were widely distributed in the forebrain including areas in and around the song control nucleus, HVC. No labeling was detected in other song control nuclei with the exception of nucleus uvaeformis, which was delineated by a dense cluster of Reelin-immunoreactive perikarya. Reelin is thus expressed in areas incorporating new neurons in adulthood, such as HVC. Reelin expression was sharply decreased by testosterone in HVC, nucleus uvaeformis and dorsal thalamus but not in other brain regions. These results are consistent with the idea that seasonal changes in Reelin expression modulate the incorporation of neurons within HVC. The presence of Reelin in other brain areas that do not incorporate new neurons in adulthood indicates, however, that this protein must play other unrelated roles in the adult brain. Additional studies should now be carried out to determine the specific role played by this protein in the seasonal plasticity of the songbird brain. [less ▲]

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See detailEffects of testosterone propionate on the social behaviour of groups of male comestic ducklings Anas platyrhynchos L.
Balthazart, Jacques ULg; Stevens, M.

in Animal behaviour (1975), 23(4), 926-31

One-month old testosterone-injected ducklings were observed in groups of three males and their social behaviour compared to that of oil-injected control birds. Most elements of adult sexual behaviour and ... [more ▼]

One-month old testosterone-injected ducklings were observed in groups of three males and their social behaviour compared to that of oil-injected control birds. Most elements of adult sexual behaviour and one pattern of aggressive behaviour (chest fight) occurred more frequently in the experimental animals. It was shown that the same hormonal treatment induces different behavioural responses in different animals. Unlike previous studies, no social displays were observed in the testosterone-injected ducklings. Possible explanations of this fact are discussed. [less ▲]

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See detailEffects of the calving number on animal performance, carcass and meat composition in finishing Belgian Blue double-muscled culled females
Cabaraux, Jean-François ULg; Hornick, Jean-Luc ULg; Dotreppe, Olivier ULg et al

in Livestock Production Science (2004), 87(2-3), 161-169

In a 2-year experiment, 66 Belgian Blue (BB) double-muscled culled females have been divided in three groups according to the calving number (heifers-H, cows culled after two calvings-C2 or four calvings ... [more ▼]

In a 2-year experiment, 66 Belgian Blue (BB) double-muscled culled females have been divided in three groups according to the calving number (heifers-H, cows culled after two calvings-C2 or four calvings-C4) and finished on a maize silage-based diet in order to compare animal performance and evolution of carcass and meat characteristics with age. Four females per group were slaughtered on day 0 to assess carcass and meat characteristics of lean animals. The initial and final live weights, the carcass weight and the daily food intake increased with advancing age, while the live weight gain and feed efficiency decreased. The H presented the higher killing-out and muscle proportions and the lower adipose tissue proportion. Their meat was less dark and less red than that of older cows. The lowest protein content and the highest fat content in meat dry matter were found in the C2. In the three groups, the carcass and meat became fatter with finishing process. The amplitude of fat deposition was the highest in C2. It can be concluded that the performance of BB culled females vary with age. The carcass and meat characteristics differ mainly between H and cows, few differences appearing between cows. (C) 2003 Elsevier B.V All rights reserved. [less ▲]

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See detailEffects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study.
Van Gaal, Luc F; Rissanen, Aila M; Scheen, André ULg et al

in Lancet (2005), 365(9468), 1389-97

BACKGROUND: In animal models, cannabinoid-1 receptor (CB1) blockade produces a lean phenotype, with resistance to diet-induced obesity and associated dyslipidaemia. We assessed the effect of rimonabant, a ... [more ▼]

BACKGROUND: In animal models, cannabinoid-1 receptor (CB1) blockade produces a lean phenotype, with resistance to diet-induced obesity and associated dyslipidaemia. We assessed the effect of rimonabant, a selective CB1 blocker, on bodyweight and cardiovascular risk factors in overweight or obese patients. METHODS: patients with body-mass index 30 kg/m2 or greater, or body-mass index greater than 27 kg/m2 with treated or untreated dyslipidaemia, hypertension, or both, were randomised to receive double-blind treatment with placebo, 5 mg rimonabant, or 20 mg rimonabant once daily in addition to a mild hypocaloric diet (600 kcal/day deficit). The primary efficacy endpoint was weight change from baseline after 1 year of treatment in the intention-to-treat population. FINDINGS: Weight loss at 1 year was significantly greater in patients treated with rimonabant 5 mg (mean -3.4 kg [SD 5.7]; p=0.002 vs placebo) and 20 mg (-6.6 kg [7.2]; p<0.001 vs placebo) compared with placebo (-1.8 kg [6.4]). Significantly more patients treated with rimonabant 20 mg than placebo achieved weight loss of 5% or greater (p<0.001) and 10% or greater (p<0.001). Rimonabant 20 mg produced significantly greater improvements than placebo in waist circumference, HDL-cholesterol, triglycerides, and insulin resistance, and prevalence of the metabolic syndrome. The effects of rimonabant 5 mg were of less clinical significance. Rimonabant was generally well tolerated with mild and transient side effects. INTERPRETATION: CB1 blockade with rimonabant 20 mg, combined with a hypocaloric diet over 1 year, promoted significant decrease of bodyweight and waist circumference, and improvement in cardiovascular risk factors. [less ▲]

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See detailThe effects of the construction of Europe on national immigration and refugee policies: the case of Belgium
Martiniello, Marco ULg; Rea, Andrea

in Geddes, A.; Favell, A. (Eds.) The Politics of Belonging: Migrants and Minorities in Contemporary Europe (1999)

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See detailEffects of the Convention on trade negotiations (with Lilian Richieri Hanania)
Vlassis, Antonios ULg

in RICHIERI HANANIA, LILIAN (Ed.) Cultural diversity in international law: Effectiveness and normativity of the 2005 Convention on Diversity of Cultural Expressions (2014)

The UNESCO Convention on the Protection and Promotion of the Diversity of Cultural Expressions (CDCE) was adopted in 2005 and designed to allow States to protect and promote cultural policies. This book ... [more ▼]

The UNESCO Convention on the Protection and Promotion of the Diversity of Cultural Expressions (CDCE) was adopted in 2005 and designed to allow States to protect and promote cultural policies. This book examines the effectiveness of the CDCE and offers ways by which its implementation may be improved to better attain its objectives. The book provides insight in how the normative character of the CDCE may be strengthened through implementation and increasingly recurrent practice based on its provisions. Hailing from various fields of international law, political and social sciences, the book’s contributors work to promote discussions on the practical and legal influence of the CDCE, and to identify opportunities and recommendations for a more effective application. Part One of the book assesses the effectiveness of the CDCE in influencing other areas of international law and the work conducted by other intergovernmental organizations through the recognition of the double nature (cultural and economic) of cultural goods and services. Part Two focuses on the practice of the CDCE beyond the recognition of the specificity of cultural goods and services in international law by addressing the CDCE’s call for greater international cooperation and stronger integration of cultural concerns in development strategies at the national and regional levels. The book will be of great use and interest to academics and practitioners in law, social and political sciences, agents of governmental and international organizations, and cultural sector stakeholders. [less ▲]

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See detailEffects of the Coriolis force on high-order g modes in γ Doradus stars
Bouabid, M.-P.; Dupret, Marc-Antoine ULg; Salmon, Sébastien ULg et al

in Monthly Notices of the Royal Astronomical Society (2013), 429(3), 2500

γ Doradus stars pulsate with high-order gravity modes having typical frequencies which can be comparable to or higher than their rotation frequencies. Therefore, rotation has a non-negligible effect on ... [more ▼]

γ Doradus stars pulsate with high-order gravity modes having typical frequencies which can be comparable to or higher than their rotation frequencies. Therefore, rotation has a non-negligible effect on their oscillation properties. To explore the rotation-pulsation coupling in γ Dor stars, we perform a non-adiabatic study including the traditional approximation of rotation on a grid of spherical stellar models covering the mass range 1.4 < M[SUB]*[/SUB] < 2.1 M[SUB]&sun;[/SUB]. This approximation allows us to treat the effect of the Coriolis force on the frequencies and the stability of high-order g modes. The effect of the Coriolis force depends on the kind of mode considered (prograde sectoral or not) and increases with their periods. As a consequence, we first find that the period spacing between modes is no longer periodically oscillating around a constant value. Secondly, we show that the frequency gap (5-15 cycles day[SUP]-1[/SUP]) arising from stable modes between γ Dor-type high-order g modes and δ Scuti-type modes can be easily filled by g-mode frequencies shifted to higher values by the rotation. Thirdly, we analyse the combined effect of diffusive mixing and the Coriolis force on the period spacings. And finally, we predict a slight broadening of the γ Dor instability strip. [less ▲]

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See detailEffects of the electrode positions on the dynamical behaviour of electrostatically actuated MEMS resonators
Pustan, Marius ULg; Paquay, Stéphane; Rochus, Véronique et al

(2011, April 18)

The influence of the lower electrode positions on the dynamic response of polysilicon MEMS resonators is studied and presented in this paper. The change in the frequency response of investigated MEMS ... [more ▼]

The influence of the lower electrode positions on the dynamic response of polysilicon MEMS resonators is studied and presented in this paper. The change in the frequency response of investigated MEMS resonators as function of the lower electrode positions is measured using a vibrometer analyzer. The decrease in the amplitude and velocity of oscillations if the lower electrode is moved from the beam free-end toward to the beam anchor is experimental monitored. The measurements are performed in ambient conditions in order to characterize the forced-response Q-factor of samples. A decrease of the Q- factor if the lower electrode is moved toward to the beam anchor is experimental determined. Different responses of MEMS resonators may be obtained if the position of the lower electrode is modified. Indeed the resonator stiffness, velocity and amplitude of oscillations are changed. [less ▲]

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See detailEffects of the H(3) receptor inverse agonist thioperamide on cocaine-induced locomotion in mice: role of the histaminergic system and potential pharmacokinetic interactions.
Brabant, Christian ULg; Alleva, Livia ULg; Grisar, Thierry ULg et al

in Psychopharmacology (2009), 202(4), 673-87

RATIONALE: Previous studies have shown that intraperitoneal injections of thioperamide, an imidazole-based H(3) receptor inverse agonist that enhances histamine release in the brain, potentiate cocaine ... [more ▼]

RATIONALE: Previous studies have shown that intraperitoneal injections of thioperamide, an imidazole-based H(3) receptor inverse agonist that enhances histamine release in the brain, potentiate cocaine-induced hyperlocomotion. The present study examined the involvement of the histaminergic system in these effects of thioperamide in mice. MATERIALS AND METHODS: We investigated whether immepip, a selective H(3) agonist, could reverse the potentiating effects of thioperamide. Moreover, the non-imidazole H(3) inverse agonist A-331440 was tested on the locomotor effects of cocaine. Using high-performance liquid chromatography with ultraviolet detection, cocaine plasma concentrations were measured to study potential drug-drug interactions between thioperamide and cocaine. Finally, thioperamide was tested on the locomotor effects of cocaine in histamine-deficient knockout mice in order to determine the contribution of histamine to the modulating effects of thioperamide. RESULTS: Thioperamide potentiated cocaine-induced hyperlocomotion in normal mice, and to a higher extent, in histamine-deficient knockout mice. A-331440 only slightly affected the locomotor effects of cocaine. Immepip did not alter cocaine-induced hyperactivity but significantly reduced the potentiating actions of thioperamide on cocaine's effects. Finally, plasma cocaine concentrations were more elevated in mice treated with thioperamide than in mice that received cocaine alone. CONCLUSIONS: The present results indicate that histamine released by thioperamide through the blockade of H(3) autoreceptors is not involved in the ability of this compound to potentiate cocaine induced-hyperactivity. Our data suggest that thioperamide, at least at 10 mg/kg, increases cocaine-induced locomotion through the combination of pharmacokinetic effects and the blockade of H(3) receptors located on non-histaminergic neurons. [less ▲]

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See detailEffects of the H-3-receptor inverse agonist thioperamide on the psychornotor effects induced by acutely and repeatedly given cocaine in C57BL/6J mice
Brabant, Christian ULg; Quertemont, Etienne ULg; Tirelli, Ezio ULg

in Pharmacology, Biochemistry & Behavior (2006), 83(4), 561-569

Previous studies have shown that histamine H(3) blockers potentiate the psychomotor and rewarding effects of cocaine. The present study examined the influence of thioperamide, an inverse H(3) receptor ... [more ▼]

Previous studies have shown that histamine H(3) blockers potentiate the psychomotor and rewarding effects of cocaine. The present study examined the influence of thioperamide, an inverse H(3) receptor agonist, on the development of psychomotor sensitization and stereotyped activity induced by acute or intermittent cocaine in C57BL/6J mice. In the first experiment, mice were injected i.p. with saline, 10 or 20mg/kg thioperamide and saline or 8mg/kg cocaine, 10min apart, before being tested for their locomotor activity (providing data on the acute effects of thioperamide on cocaine-induced activity). Subsequently, mice were treated in the same manner every other day over six additional sessions. Sensitization was assessed by the responsiveness to a cocaine challenge (8mg/kg, i.p.) given 2 and 14days following the intermittent treatment. In experiments 2 and 3, we tested the effects of thioperamide (10 or 20mg/kg, i.p.) on gnawing and sniffing induced or affected by relatively high doses of cocaine (24 or 32mg/kg, s.c.), the drugs being given 10min apart. In the first experiment, both doses of thioperamide amplified cocaine-induced psychomotor hyperactivity almost on all experimental sessions. However, the histamine inverse agonist did not affect the induction of a psychomotor sensitization. All cocaine-treated mice showed similar levels of sensitized activity 2 and 14days after the intermittent treatments, whether they received thioperamide or not. The second and the third experiments showed that thioperamide did not affect gnawing and sniffing induced by cocaine. Taken together, these results indicate that H(3) receptors clearly contribute to the neurobiological mechanisms of the locomotor component of cocaine-induced psychomotor activation, but less likely to those underlying the development of cocaine behavioral sensitization or the expression of cocaine-induced oro-facial stereotypies. [less ▲]

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See detailEffects of the interaction between habitat properties and disturbance characteristics on the interior/edge ratio.
Bogaert, Jan ULg; Verbeeck, A; Impens, I

in Farina, A (Ed.) Proceedings of the VII International Congress of Ecology (1998)

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See detailEffects of the lenght of the grazing period on animal performances in fattening bulls finished indoor
Dufrasne, Isabelle ULg; Limbourg, Pierre; Gauthier, Sabine et al

in Proceedings of the 45th Annual Meeting of E.A.A.P. (1994)

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See detailThe effects of the mineral phase on C stabilization mechanisms and microbial dynamics along an eroding slope transect
Doetterl, Sebastian; Opgerfelt, Sophie; Cornelis, Jean-Thomas ULg et al

Scientific conference (2013)

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See detailEffects of the MMP inhibitor GM-6001 on emphysema development, infllammation and MMPs activity induced by cadmium in rats
Fievez, Laurence ULg; Kirschvinck, N.; Belleflamme, N. et al

in Fundamental & Clinical Pharmacology (2006), 20

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See detailEffects Of The Nature Of Nitrogen Supplementation On Voluntary Intake, Rumen Parameters And Ruminal Degradation Of Dry Matter In Sheep Fed Oat Silage-Based Diets
Mahouachi, Mokhtar; Haddad, L.; Kayouli, Chedly et al

in Small Ruminant Research (2003), 48(3), 181-187

The effects of nature of nitrogen supplementation on silageDMintake (SDMI), totalDMintake (TDMI), rumen parameters and ruminal degradation of DM of silage and wheat straw were studied using four adult ... [more ▼]

The effects of nature of nitrogen supplementation on silageDMintake (SDMI), totalDMintake (TDMI), rumen parameters and ruminal degradation of DM of silage and wheat straw were studied using four adult Noire de Thibar rams. Silage was made from predominantly oats harvested at milk stage and ensiled without preservative. The silage was offered ad libitum as the sole diet (OS) or supplemented with 450 g DM of iso-nitrogen (25.6 g/kg DM) and iso-energy (0.8 Unité Fourragère Lait: UFL/kg DM) concentrate containing soybean meal (SBM), urea (UR) or poultry litter (PL) as nitrogen supplements. SDMI (g/kgW0.75 × day) and TDMI (g/kgW0.75 × day) were affected (P < 0.001) by the type of supplement and averaged 63.9, 60.1, 54.9, 51.1 and 63.9, 81.4, 74.8, 72.2 for OS, SBM, PL and UR diets, respectively. In comparison with other diets, SBM diet systematically decreased (P < 0.05) the pH of the rumen after the morning feeding and reduced the rumen concentration of total VFA at 1 h after feeding. SBM diet decreased DM disappearance of the oat silage incubated in nylon bags for 72 h (P < 0.05), but not of wheat straw. The three supplements increased the ammonia-N concentrations in the rumen for several hours after feeding in comparison with the OS diet. However, only the SBM diet kept this difference just before the next meal. It is concluded that despite its low nutritive value (0.62 UFL and 108 g crude protein/kg DM), the oat silage is well consumed by the local ruminants accustomed to use poor forages for a long time. In Tunisia, poultry litter may be used as a nitrogen source to supplement the oat silage for sheep. [less ▲]

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See detailEffects of the Nonsteroidal Inhibitor R76713 on Testosterone-Induced Sexual Behavior in the Japanese Quail (Coturnix Coturnix Japonica)
Balthazart, Jacques ULg; Evrard, L.; Surlemont, C.

in Hormones & Behavior (1990), 24(4), 510-31

A new triazole derivative, R76713 (6-[4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H- benzotriazole), was recently shown to inhibit aromatase selectively without affecting other steroid ... [more ▼]

A new triazole derivative, R76713 (6-[4-chlorophenyl)(1H-1,2,4-triazol-1-yl)methyl]-1-methyl-1H- benzotriazole), was recently shown to inhibit aromatase selectively without affecting other steroid-metabolizing enzymes and without interacting with estrogen, progestin, or androgen receptors. This compound was tested for its capacity to intefere with the induction of copulatory behavior by testosterone (T) in castrated Japanese quail (Coturnix coturnix japonica). In a first experiment, R76713 inhibited (range 0.01 to 1 mg/kg) the activation of sexual behavior by T silastic implants and hypothalamic aromatase activity in castrated male quail in a dose-dependent manner. The 5 alpha- and 5 beta- reductases of T were not systematically affected. Stereotaxic implantation of R76713 in the medial preoptic area similarly blocked the behavior activated by systemic treatment with T, demonstrating that central aromatization of androgen is implicated in the activation of behavior. These inhibiting effects of R76713 on behavior were observed when implants were placed in the medial part of the nucleus preopticus medialis, confirming the implication of this brain area in the control of male copulatory behavior. Finally, the behavioral inhibition produced by R76713 could be reversed by simultaneous treatment with a dose of estradiol, which was not behaviorally effective by itself. This suggests that the behavioral deficit induced by the inhibitor was specifically due to the suppression of estrogen production. This also shows that the activation of copulatory behavior probably results from the interaction of androgens and estrogens at the brain level, as the two treatments separately providing these hormonal stimuli (T with the aromatase inhibitor on one hand and a low dose of estradiol on the other hand) had almost no behavioral effects but they synergized to activate copulation when given concurrently. These data confirm the critical role of preoptic aromatase in the activation of reproductive behavior and demonstrate that R76713 is a useful tool for the in vivo study of estrogen-dependent processes. [less ▲]

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