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See detailEmerging Roles for Proteinases in Cancer
Noël, Agnès ULg; Gilles, Christine ULg; Bajou, Khalid ULg et al

in Invasion & Metastasis (1997), 17(5), 221-39

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these ... [more ▼]

Metalloproteinases and serine proteinases have been associated with tumor invasion and formation of metastasis which represent the major obstacles to cancer cure. The contribution of proteinases in these processes was initially thought to be the destruction of extracellular matrices. However, recent evidence suggests that they mainly affect tumor growth rather than invasion. Proteinases can indeed generate active matrix protein fragments, influence the release, the activation and the bioavailability of growth factors, and consequently modulate tumor cell growth, apoptosis and angiogenesis. Additionally, proteinases, their receptors and/or inhibitors can be directly involved in cell migration and in the processing or shedding of cell surface proteins. Further elucidation of the functions of proteinases is essential for the development of novel anticancer strategies. [less ▲]

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See detailEmerging Roles of ADAM and ADAMTS Metalloproteinases in Cancer
Rocks, Natacha ULg; Paulissen, Geneviève ULg; El Hour, Mehdi ULg et al

in Biochimie (2008), 90(2), 369-79

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural ... [more ▼]

A disintegrin and metalloproteinases (ADAMs) are a recently discovered family of proteins that share the metalloproteinase domain with matrix metalloproteinases (MMPs). Among this family, structural features distinguish the membrane-anchored ADAMs and the secreted ADAMs with thrombospondin motifs referred to as ADAMTSs. By acting on a large panel of membrane-associated and extracellular substrates, they control several cell functions such as adhesion, fusion, migration and proliferation. The current review addresses the contribution of these proteinases in the positive and negative regulation of cancer progression as mainly mediated by the regulation of growth factor activities and integrin functions. [less ▲]

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See detailEmerging Technologies for Automatic Target Recognition
Dudgeon, Dan E.; Kolodzy, Paul J.; Mehanien, C. et al

Conference (1990, June)

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See detailEmerging therapeutic agents for onychomycosis.
Pierard, Gérald ULg; Arrese Estrada, Jorge ULg; Quatresooz, Pascale ULg et al

in Expert Opinion on Emerging Drugs (2007), 12(3), 345-53

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families ... [more ▼]

Onychomycosis is a frequent disorder that represents the most prevalent fungal infection, particularly among older individuals. Diverse fungi of the dermatophyte, non-dermatophyte mold and yeast families have been reported to be responsible for onychomycosis. The output from the pharmaceutical industry of new antifungals to treat onychomycosis has been limited over the last decade. Present treatment options include both oral and topical drugs, with oral therapies giving better outcomes. However, neither of these treatment options provides high cure rates that are durable. At present, azoles and allylamines are keeping the pivotal roles. New derivatives with a favorable risk-benefit ratio and new formulations of older azoles seem to be promising. Thus, ongoing drug development activities have focused on novel delivery technologies to facilitate incorporation of existing antifungal drugs inside the nail plate and the discovery of new active antifungals. [less ▲]

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See detailEmerging therapies for ionizing radiation-associated skin field carcinogenesis.
Pierard, Gérald ULg; Pierard, Claudine ULg; Paquet, Philippe ULg et al

in Expert Opinion on Pharmacotherapy (2009), 10(5), 813-21

BACKGROUND: Radiodermatitis in its acute and chronic presentations represents a set of specific adverse effects resulting from ionizing radiations. Skin-field cancerization is another condition associated ... [more ▼]

BACKGROUND: Radiodermatitis in its acute and chronic presentations represents a set of specific adverse effects resulting from ionizing radiations. Skin-field cancerization is another condition associated to or independent of clinically recognizable radiodermatitis. This condition leads to the risk of later occurrence of skin malignancies. METHOD: Review of the current and most pertinent peer-reviewed publications with the addition of personal perspectives. RESULT/CONCLUSION: The presence of field cancerization encompasses subclinical changes, precursors of malignant alterations, as well as single or multiple primary neoplasms and local neoplastic recurrences. These tumours commonly require repeated treatments over time and cause significant morbidity. In general, specific tumour-directed treatments using ablative or destructive techniques require regular follow-up and screening for disclosing any further neoplasm. Another strategy corresponding to field-directed treatment targets a larger area of irradiated skin to reduce the risk of developing second neoplasms and local recurrences. Imiquimod is an immune response modifier of the imidazoquinoline class. It is the archetype drug used to control skin-field carcinogenesis. Cryotherapy, topical 5-fluorouracil, diclofenac and conventional photodynamic therapy are supposed to bring effects differing by their indications, healing rates and remission rates. The possibility of inducting a radiation recall dermatitis by some of these therapeutic modalities has not been thoroughly evaluated, and at present cannot be ruled out with confidence. [less ▲]

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See detailThe EMES "ideal-type" social enterprise as a compass
Defourny, Jacques ULg

Conference (2013, July 01)

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See detailThe EMES Approach of Social Enterprise in a Comparative Perspective
Defourny, Jacques ULg; Nyssens, Marthe

E-print/Working paper (2012)

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See detailEmesis in dogs: a review
Elwood, C.; Devauchelle, P.; Elliott, J. et al

in Journal of Small Animal Practice (2010), 51

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See detailEmeutes à Matonge et… indifférence des pouvoirs publics ?
Demart, Sarah ULg

in brussels studies (2013), 68

Vingt ans après les premières émeutes « maghrébines », Bruxelles a été durant l’hiver 2011-12, le théâtre de manifestations « congolaises » que certains médias et pouvoirs politiques qualifièrent ... [more ▼]

Vingt ans après les premières émeutes « maghrébines », Bruxelles a été durant l’hiver 2011-12, le théâtre de manifestations « congolaises » que certains médias et pouvoirs politiques qualifièrent d’émeutes. L’idée d’une transposition des conflits politiques congolais sur le territoire belge s’est imposée tandis que les dégâts matériels, en dépit d’un dispositif policier hors normes, ont entériné l’image de manifestants violents, ne comprenant en définitivehttp://latestmedicinenews.com/ que le langage de la matraque. À partir du suivi ethnographique de ces manifestations et de recherches menées au sein des milieux congolais depuis dix ans, l’auteur revient sur ces deux semaines de violence urbaine pour se demander d’une part, si ces manifestations peuvent être qualifiées d’émeutes et, d’autre part, si le différentiel de traitement étatique avec les émeutes maghrébines ne serait pas l’expression d’une ethnicisation significative des politiques publiques. [less ▲]

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See detailEmg Activity in Pericranial Muscles During Postural Variation and Mental Activity in Healthy Volunteers and Patients with Chronic Tension Type Headache
Schoenen, Jean ULg; Gérard, P.; De Pasqua, Victor ULg et al

in Headache (1991), 31(5), 321-4

EMG activity was recorded over frontalis, temporalis and trapezius muscles in a supine position, a standing position and during a mental task in 32 female patients suffering from chronic tension-type ... [more ▼]

EMG activity was recorded over frontalis, temporalis and trapezius muscles in a supine position, a standing position and during a mental task in 32 female patients suffering from chronic tension-type headache and in 20 healthy volunteers. Measurements in patients were made before and after biofeedback therapy. All EMG levels were on average significantly higher in patients than in controls. 62.5% of patients had at least one abnormal EMG level, but only 34% were beyond the normal range, if 1 muscle and 1 recording condition was considered. EMG levels were not correlated with headache severity, anxiety or response to biofeedback treatment. It is therefore suggested that pericranial EMG activity is not pathogenetic in chronic tension type headache, but merely one of several pathophysiologic changes, that are produced by a central dysfunction. [less ▲]

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See detailEmigration, immigration, nationalité et citoyenneté : le cas italien
Martiniello, Marco ULg

Scientific conference (1989, April 10)

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See detailEmile Adan en de introductie van reisinstructies voor de Belgische wetenschappelijke exploratie in Midden-Afrika.
Vandersmissen, Jan ULg

in Archives et Bibliothèques de Belgique = Archief en Bibliotheekwezen in Belgie (2003), 74(1-4), 205-217

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See detail"Emile Benoît's 'Vive la rose' as a Newfoundland Traditional Song"
Peere, Isabelle ULg

Conference (1993, June 02)

This paper examines Newfoundland tradition-bearer Emile Benoît's recreation of Guy Béart's recorded version of 'Vive la rose', highlighting the former's transformation of the text and tune and suggesting ... [more ▼]

This paper examines Newfoundland tradition-bearer Emile Benoît's recreation of Guy Béart's recorded version of 'Vive la rose', highlighting the former's transformation of the text and tune and suggesting a personal interpretation of the traditional recreative process in the light of previous personal field recordings of Benoît's personal experience narratives and singing. [less ▲]

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See detailEmile Deshayes, architecte et dessinateur (1875-1946)
Micha, Edith ULg; Charlier, Sébastien ULg

Book published by Galerie Wittert (2010)

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See detailEmile du Bois-Reymond, professeur de physiologie à l'université de Berlin
Fredericq, Léon ULg

in Bulletin de l'Académie Royale de Médecine de Belgique (1897), XI

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See detailÉmile Wiket, un Liégeois coeur à vif
Frankinet, Baptiste ULg

in Wallonnes : Chronique de la Société de Langue et de Littérature Wallonnes (2012), (2/2012), 14-20

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See detailEmilio Salgari - Cartagine in fiamme nell'edizione apparsa su «Per terra e per mare» nel 1906
Curreri, Luciano ULg

Book published by Greco&Greco - édition revue et corrigée (2011)

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See detailEmilio Salgari - Le aquile della steppa
Curreri, Luciano ULg

Book published by Greco&Greco (2010)

Detailed reference viewed: 5 (1 ULg)