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See detailDiabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?
Scheen, André ULg

in Diabètes & Métabolism (2005), 31 Spec No 2

Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function ... [more ▼]

Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function is due to an inevitable consequence of "biological aging" or due to environmental or lifestyle variables. Indeed, increased adiposity/altered fat distribution, decreased fat free mass/abnormal muscle composition, poor dietary habits and physical inactivity all contribute to reduce insulin sensitivity. Insulin resistance in elderly people appears to predominate in skeletal muscle, whereas hepatic glucose output seems to be almost unaffected. Several abnormalities in islet beta-cell and insulin secretion were also pointed out in elderly people such as increased amyloid deposition and decreased amylin secretion, impaired insulin secretion pulsatility, decreased insulin sensitivity of pancreatic beta-cells to insulinotropic gut hormones and diminished insulin response to non-glucose stimuli such as arginine. Controversial results were reported concerning the effects of aging on absolute insulin secretion in response to oral or intravenous glucose. However, insulin secretion appears to decrease with age, with significantly diminished beta-cell sensitivity and acute insulin response to glucose, provided it is analyzed relative to concomitant decreased insulin sensitivity. Thus, there is an interplay between decreased insulin secretion and increased insulin resistance that largely explains the abnormal glucose metabolism seen in elderly. Weight loss, especially reduction of abdominal adiposity, and increased physical activity may contribute to improve insulin sensitivity and glucose tolerance, and prevent the development of type 2 diabetes in elderly people. [less ▲]

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See detailDiabètes secondaires à une endocrinopathie.
Borges-Martins, L.; Betea, Daniela ULg; Daly, Adrian ULg et al

in Revue Médicale de Liège (2005), 60(5-6), 442-447

Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal ... [more ▼]

Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal secretion, which alters insulin secretion or action. It is characterized by the absence of ketosis because of the persistence of endogenous insulin secretion. Diabetes is usually reversible with successful treatment of the underlying endocrine disorder and the correction of hormonal overproduction. Most important endocrine diseases associated with diabetes mellitus are briefly described and the underlying mechanisms of glucose abnormalities are discussed. [less ▲]

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See detailDiabetes: Time for reconciliation between cardiologists and diabetologists.
Scheen, André ULg

in Nature Reviews. Cardiology (2016)

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See detailDiabetogenic coxsackievirus B4 modifies cytokine secretion by human thymic epithelial cells
Brilot, Fabienne; Chehadeh, Wassim; Renard, Chantal et al

in Diabetologia (2000), 43 (Suppl. 1)

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See detailLe Diable et les vierges
Dor, Juliette ULg

in Carruthers, Leo (Ed.) Anges et démons dans la littérature anglaise du Moyen Âge (2002)

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See detail"Les Diables rouges sont-ils instrumentalisés en politique ?"
Verjans, Pierre ULg

Article for general public (2016)

"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de ... [more ▼]

"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de s’abstenir. Ils ne vont pas s’enthousiasmer un drapeau tricolore à la main. Il y a une évidente contradiction entre leur vision flamande avant tout et la diversité et le bilinguisme qu’affichent les Diables." [less ▲]

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See detail"Diabolo-Manques", histoire d'une évaluation
Grignard, Sophie ULg; Vandoorne, Chantal ULg

in Education Santé (2008), (236), 2-3

Cet article présente les grandes lignes d’une brochure, coéditée par l’APES-ULg et par la Maison du Social de la Province de Liège, et intitulée «Diabolo-Manques - Une exploration à la découverte de soi ... [more ▼]

Cet article présente les grandes lignes d’une brochure, coéditée par l’APES-ULg et par la Maison du Social de la Province de Liège, et intitulée «Diabolo-Manques - Une exploration à la découverte de soi - L'évaluation d'un programme de prévention des assuétudes en Province de Liège». Cette brochure d’une vingtaine de pages décrit de façon synthétique et intégrée les différentes phases d’évaluation de ce programme ainsi que leurs résultats. [less ▲]

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See detailDiacerein: Benefits, Risks and Place in the Management of Osteoarthritis. An Opinion-Based Report from the ESCEO
Pavelka, Karel; Bruyère, Olivier ULg; Cooper, Cyrus et al

in Drugs & Aging (2016), 33(2), 75-85

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been ... [more ▼]

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit–risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated [less ▲]

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See detailA diachronic analysis of French ‘à/au travers’ in combination with the preposition ‘de’
Hoelbeek, Thomas ULg

in Neuphilologische Mitteilungen (2015)

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See detailA diachronic analysis of the dynamic of two cities: Kisangani and Lubumbashi (Democratic Republic of Congo): How do the extension and/or of the densification of these cities impact the urban internal and peripheral ecosystems?
Andre, Marie ULg; Mahy, Grégory ULg; Lejeune, Philippe ULg et al

Poster (2014, February 07)

The dynamics of two cities between two years (2002 and 2010 for Kisangani; 2002 and 2008 for Lubumbashi, both part of the Democratic Republic of Congo) have been examined in order to estimate how their ... [more ▼]

The dynamics of two cities between two years (2002 and 2010 for Kisangani; 2002 and 2008 for Lubumbashi, both part of the Democratic Republic of Congo) have been examined in order to estimate how their extension and/or of the densification have impacted the urban internal and peripheral ecosystems. This study singularizes itself from the subjective ones by its quantified and objective approach based on landscape ecology. This discipline assumes that the landscape pattern description is important because, according to its central hypothesis called “pattern-process paradigm”, the ecological processes influence landscape structure and vice versa. Composition metrics, which are commonly used in landscape ecology, describe the pattern among other things in quantifying the presence and the number of patches from the various classes within the landscape. For each city two SPOT 5 images were classified with a oriented-object supervised approach; then built area proportion index, a composition landscape metric, has been evaluated in order to 1) identify the extent of each area (urban, suburban, rural) within the urban-rural gradient, 2) quantify the dynamic of the different areas in the urban-rural gradient during the last decade and 3) quantify the effect of a decade of urban and suburban growth on ecosystems. The similarities and differences between these cities, relevance and gaps in the method have then been identified and discussed. [less ▲]

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See detailDiachronic lexical semantics in Ancient Egyptian–Coptic: The Egyptianness of basic vocabulary in Coptic
Grossman, Eitan; Polis, Stéphane ULg

Conference (2015, November 21)

Coptic, as it comes down to us in written texts, is massively influenced by Greek in the domain of lexicon. The Leipzig-Berlin Dictionary and Database of Greek Loanwords in Coptic project has already ... [more ▼]

Coptic, as it comes down to us in written texts, is massively influenced by Greek in the domain of lexicon. The Leipzig-Berlin Dictionary and Database of Greek Loanwords in Coptic project has already recorded c. 5000 loan word types and c. 60.000 loan word tokens. On this basis, linguists, philologists, and historians often make assumptions about the nature and extent of bilingualism. Some linguists have even proposed that Coptic is a case of ‘code-mixing’ of Egyptian and Greek, which assumes extensive bilingualism among Egyptians in Late Antiquity. In this paper, we tackle this question from another angle, by determining the extent to which Greek influenced Coptic in terms of its *basic vocabulary*. It may be that we can learn more about bilingualism in Late Antique Egypt this way, since overall lexical borrowing need not correlate with lexical borrowing in the domain of basic vocabulary. As a (significant) side effect of this study, we can also describe the rate of replacement of basic vocabulary in Egyptian-Coptic across its 4000 years of attestation, as well as the semantic domains and periods in which lexical replacement was faster or slower. [less ▲]

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