Browsing
     by title


0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

or enter first few letters:   
OK
Full Text
Peer Reviewed
See detailEFNS guideline on the treatment of tension-type headache - Report of an EFNS task force.
Bendtsen, L.; Evers, S.; Linde, M. et al

in European Journal of Neurology (2010)

Background: Tension-type headache (TTH) is the most prevalent headache type and is causing a high degree of disability. Treatment of frequent TTH is often difficult. Objectives: To give evidence-based or ... [more ▼]

Background: Tension-type headache (TTH) is the most prevalent headache type and is causing a high degree of disability. Treatment of frequent TTH is often difficult. Objectives: To give evidence-based or expert recommendations for the different treatment procedures in TTH based on a literature search and the consensus of an expert panel. Methods: All available medical reference systems were screened for the range of clinical studies on TTH. The findings in these studies were evaluated according to the recommendations of the EFNS resulting in level A, B or C recommendations and good practice points. Recommendations: Non-drug management should always be considered although the scientific basis is limited. Information, reassurance and identification of trigger factors may be rewarding. Electromyography (EMG) biofeedback has a documented effect in TTH, whilst cognitive-behavioural therapy and relaxation training most likely are effective. Physical therapy and acupuncture may be valuable options for patients with frequent TTH, but there is no robust scientific evidence for efficacy. Simple analgesics and non-steroidal anti-inflammatory drugs are recommended for the treatment of episodic TTH. Combination analgesics containing caffeine are drugs of second choice. Triptans, muscle relaxants and opioids should not be used. It is crucial to avoid frequent and excessive use of analgesics to prevent the development of medication-overuse headache. The tricyclic antidepressant amitriptyline is drug of first choice for the prophylactic treatment of chronic TTH. Mirtazapine and venlafaxine are drugs of second choice. The efficacy of the prophylactic drugs is often limited, and treatment may be hampered by side effects. [less ▲]

Detailed reference viewed: 36 (0 ULg)
Full Text
Peer Reviewed
See detailEFSA's scientific activities and achievements on the risk assessment of genetically modified organisms (GMOs) during its first decade of existence: looking back and ahead.
Devos, Yann; Aguilera, Jaime; Diveki, Zoltan et al

in Transgenic research (2014), 23(1), 1-25

Genetically modified organisms (GMOs) and derived food and feed products are subject to a risk analysis and regulatory approval before they can enter the market in the European Union (EU). In this risk ... [more ▼]

Genetically modified organisms (GMOs) and derived food and feed products are subject to a risk analysis and regulatory approval before they can enter the market in the European Union (EU). In this risk analysis process, the role of the European Food Safety Authority (EFSA), which was created in 2002 in response to multiple food crises, is to independently assess and provide scientific advice to risk managers on any possible risks that the use of GMOs may pose to human and animal health and the environment. EFSA's scientific advice is elaborated by its GMO Panel with the scientific support of several working groups and EFSA's GMO Unit. This review presents EFSA's scientific activities and highlights its achievements on the risk assessment of GMOs for the first 10 years of its existence. Since 2002, EFSA has issued 69 scientific opinions on genetically modified (GM) plant market registration applications, of which 62 for import and processing for food and feed uses, six for cultivation and one for the use of pollen (as or in food), and 19 scientific opinions on applications for marketing products made with GM microorganisms. Several guidelines for the risk assessment of GM plants, GM microorganisms and GM animals, as well as on specific issues such as post-market environmental monitoring (PMEM) were elaborated. EFSA also provided scientific advice upon request of the European Commission on safeguard clause and emergency measures invoked by EU Member States, annual PMEM reports, the potential risks of new biotechnology-based plant breeding techniques, evaluations of previously assessed GMOs in the light of new scientific publications, and the use of antibiotic resistance marker genes in GM plants. Future challenges relevant to the risk assessment of GMOs are discussed. EFSA's risk assessments of GMO applications ensure that data are analysed and presented in a way that facilitates scientifically sound decisions that protect human and animal health and the environment. [less ▲]

Detailed reference viewed: 35 (1 ULg)
See detailEG_Vergabregeln im ÖPNV : Stand und Perspektive
Partsch, Philippe-Emmanuel ULg

in Der Nahverkehr (2008)

Detailed reference viewed: 14 (2 ULg)
Full Text
See detailL'égalité des chances : slogan ou réalité ?
de Landsheere, Gilbert ULg

in Socialisme (1981), 28

Detailed reference viewed: 22 (6 ULg)
See detailEgalité des chances et cohésion sociale
Delruelle, Edouard ULg

Conference given outside the academic context (2011)

Detailed reference viewed: 1 (0 ULg)
Full Text
See detailL'égalité des créanciers: du principe à l'incantation?
Georges, Frédéric ULg

in A.E.D.B.F. (Ed.) Banque et insolvabilité (2007)

Detailed reference viewed: 77 (3 ULg)
Full Text
See detailEgalité et émancipation : enjeux politiques de l'éducation à la philosophie
Herla, Anne ULg

Article for general public (2009)

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailL'égalité et le droit commercial: un rapport à géométrie variable
Thirion, Nicolas ULg

in Revue de Jurisprudence de Liège, Mons et Bruxelles (2002)

Detailed reference viewed: 28 (10 ULg)
Full Text
Peer Reviewed
See detailEGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation.
Du, G.; Willet, K.; Mouithys-Mickalad, Ange ULg et al

in Free Radical Biology & Medicine (1999), 27

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to ... [more ▼]

The present study investigated the protective effects of Ginkgo biloba extract (EGb 761) on rat liver mitochondrial damage induced by in vitro anoxia/reoxygenation. Anoxia/reoxygenation was known to impair respiratory activities and mitochondrial oxidative phosphorylation efficiency. ADP/O (2.57 +/- 0.11) decreased after anoxia/reoxygenation (1.75 +/- 0.09, p < .01), as well as state 3 and uncoupled respiration (-20%, p < .01), but state 4 respiration increased (p < .01). EGb 761 (50-200 microg/ml) had no effect on mitochondrial functions before anoxia, but had a specific dose-dependent protective effect after anoxia/reoxygenation. When mitochondria were incubated with 200 microg/ml EGb 761, they showed an increase in ADP/O (2.09 +/- 0.14, p < .05) and a decrease in state 4 respiration (-22%) after anoxia/reoxygenation. In EPR spin-trapping measurement, EGb 761 decreased the EPR signal of superoxide anion produced during reoxygenation. In conclusion, EGb 761 specially protects mitochondrial ATP synthesis against anoxia/reoxygenation injury by scavenging the superoxide anion generated by mitochondria [less ▲]

Detailed reference viewed: 10 (1 ULg)
Full Text
Peer Reviewed
See detailEGF amplifies the replacement of parvalbumin-expressing striatal interneurons after ischemia.
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULg et al

in Journal of Clinical Investigation (2003), 111(8), 1125-32

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that ... [more ▼]

EGF promotes proliferation and migration of stem/progenitor cells in the normal adult brain. The effect of epidermal growth factor on neurogenesis in ischemic brain is unknown, however. Here we show that intraventricular administration of EGF and albumin augments 100-fold neuronal replacement in the injured adult mouse striatum after cerebral ischemia. Newly born immature neurons migrate into the ischemic lesion and differentiate into mature parvalbumin-expressing neurons, replacing more than 20% of the interneurons lost by 13 weeks after ischemia and representing 2% of the total BrdU-labeled cells. These data suggest that administration of EGF and albumin could be used to manipulate endogenous neurogenesis in the injured brain and to promote brain self-repair. [less ▲]

Detailed reference viewed: 29 (14 ULg)
Peer Reviewed
See detailEGF amplifies the replacement of parvalbumin-expressing striatal neurons after ischemia
Teramoto, Tetsuyuki; Qiu, Jianhua; Plumier, Jean-Christophe ULg et al

Poster (2003)

Detailed reference viewed: 1 (0 ULg)
Full Text
Peer Reviewed
See detailEGF stimulates Pit-1 independent transcription of the human prolactin pituitary promoter in human breast cancer SK-BR-3 cells through its proximal AP-1 response element
Manfroid, Isabelle ULg; Van de Weerdt, Cécile ULg; Baudhuin, Ariane et al

in Molecular & Cellular Endocrinology (2005), 229(1-2), 127-39

Normal and neoplastic human mammary gland cells are targets for the proliferative action of prolactin. These cells also synthesize prolactin, thereby inducing an autocrine/paracrine proliferative loop. We ... [more ▼]

Normal and neoplastic human mammary gland cells are targets for the proliferative action of prolactin. These cells also synthesize prolactin, thereby inducing an autocrine/paracrine proliferative loop. We present the first extensive analysis of the transcriptional regulation of the human prolactin gene (hPRL) in human mammary tumor cells, SK-BR-3. We show that the pituitary promoter is functional in these cells in the absence of the pituitary-specific factor Pit-1. Expression of exogenous Pit-1 or epidermal growth factor (EGF) treatment stimulates the transfected hPRL pituitary promoter and the endogenous hPRL expression. EGF stimulation is mediated by increased synthesis of c-fos and c-jun, resulting in AP-1 binding to the proximal hPRL pituitary promoter. This regulation involves the EGF receptor, possibly ErbB2 that is highly expressed in SK-BR-3 cells, and a PI3K/JNK pathway. The stimulation of hPRL gene transcription by EGF in mammary cells may include hPRL in a complex regulatory network controlling growth of human mammary cells. [less ▲]

Detailed reference viewed: 19 (4 ULg)
Full Text
Peer Reviewed
See detailEGFR activation and signaling in cancer cells are enhanced by the membrane-bound metalloprotease MT4-MMP.
Paye, Alexandra ULg; Truong, Alice ULg; Yip, Cassandre ULg et al

in Cancer research (2014)

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of ... [more ▼]

MT4-MMP (MMP-17) is a GPI-anchored matrix metalloprotease expressed on the surface of cancer cells which promotes tumor growth and metastasis. In this report, we identify MT4-MMP as an important driver of cancer cell proliferation through CDK4 activation and retinoblastoma protein (Rb) inactivation. We also determine a functional link between MT4-MMP and the growth factor receptor EGFR. Mechanistic experiments revealed direct association of MT4-MMP and its positive effects on EGFR phosphorylation in response to TGF- and EGF in cancer cells. Notably, the effects of MT4-MMP on proliferation and EGFR activation did not rely on metalloprotease activity. Clinically, MT4-MMP and EGFR expression were correlated in human triple negative breast cancer specimens. Altogether our results identify MT4-MMP as a positive modifier of EGFR outside-in signaling that acts to cooperatively drive cancer cell proliferation. [less ▲]

Detailed reference viewed: 8 (1 ULg)
Full Text
Peer Reviewed
See detailEgg and meat production performances of two varieties of the local Ardennaise poultry breed: silver black and golden black
Moula, Nassim ULg; Michaux, Charles ULg; Philippe, François-Xavier ULg et al

in Animal Genetic Resources = Resources Génétiques Animales = Recursos Genéticos Animales (2013), 53(2), 57-67

The Ardennaise breed is emblematic of the Belgian poultry diversity. We compared two varieties of the breed, the golden black and the silver black. The comparison encompassed: (i) the morphology of adult ... [more ▼]

The Ardennaise breed is emblematic of the Belgian poultry diversity. We compared two varieties of the breed, the golden black and the silver black. The comparison encompassed: (i) the morphology of adult birds, (ii) the growth, carcass characteristics and meat quality of broilers 22 weeks old, (iii) the laying rate during 52 weeks and the egg quality. Significant differences were observed in the size of mature males and females: body weight, diameter and length of the tarsus, size of the comb and wattles. The two varieties did not differ concerning the carcass and meat quality traits. The golden black has a higher laying rate and a higher yolk / albumen ratio, but lays lighter eggs. It could be interesting to complete this study by molecular markers analysis to evaluate the degree of genetic diversity between the two varieties. [less ▲]

Detailed reference viewed: 41 (16 ULg)
Full Text
Peer Reviewed
See detailEgg and whole-body amino acid profile of African bonytongue (Heterotis niloticus) with an estimation of their dietary indispensable amino acids requirements
Momentcham, Serge-Eric; Wathelet, Bernard ULg; Pouomogne, Victor et al

in Fish Physiology and Biochemistry (2009)

Detailed reference viewed: 18 (2 ULg)
Full Text
Peer Reviewed
See detailEgg Production Performance of the Local Kabyle Hen and its Crossbreeds with ISA-Brown Strain in Semi-Intensive Conditions
Moula, Nassim ULg; Mamadou Tandiang, Diaw; Salhi, Abdellah et al

in International Journal of Poultry Sciences (2013), 12(3), 148-152

A cross between the ISA-Brown industrial strain and an Algerian local (Kabyle) breed was compared with the Algerian local (Kabyle) hen. The comparison during the egg production period was done in ... [more ▼]

A cross between the ISA-Brown industrial strain and an Algerian local (Kabyle) breed was compared with the Algerian local (Kabyle) hen. The comparison during the egg production period was done in individual cages, in a ventilated henhouse without any particular isolation. The same commercial diet has been provided over three time periods (35 to 36 weeks, 50 to 51 weeks and 65 to 66 weeks of age). Egg number and body weight at first egg was significantly lower in the Kabyle local breed. Mortality was almost equal during the breeding period and the egg production periods for the two genotypes. The Kabyle hen eggs, in spite of a weight which was lower (43.70 to 53.37 g according to the age), gave yolk to albumen ratio similar to the ISAKAB cross (0.52 to 0.58 according to age). Finally, the ISAKAB cross was better in terms of egg production and egg quality than the local hen, in test conditions. [less ▲]

Detailed reference viewed: 107 (37 ULg)