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Peer Reviewed
See detailDemonstration of the expression of CD95 ligand transcript and protein in human placenta
Zorzi, Willy ULiege; Thellin, Olivier ULiege; Coumans, Bernard ULiege et al

in Placenta (1998), 19(4), 269-277

Tolerance of the fetal allograft enables the human conceptus to implant itself into the maternal uterus and survive and grow there. This tolerance phenomenon remains largely obscure, notably because it ... [more ▼]

Tolerance of the fetal allograft enables the human conceptus to implant itself into the maternal uterus and survive and grow there. This tolerance phenomenon remains largely obscure, notably because it appears to be controlled by multiple mechanisms. CD95 ligand (CD95-L), which can trigger death of CD95-positive cells by apoptosis, may participate in inducing anti-fetus-sensitized CD95-positive T lymphocytes to enter apoptosis. Using immunohistochemistry (first trimester and term placentae), FAGS assays (term placenta) and RT-PCR assays (term placenta), the presence of CD95-L protein and mRNA has been shown in crude placental tissue preparations and isolated placental cells. Among the latter, CD95-L expression was detected in trophoblastic cells, fetal blood cells (mRNA only) and also the Hofbauer macrophages. No CD95-L was detected in fibroblasts or fetal endothelial cells. Thus trophoblastic cells, Hofbauer macrophages, and perhaps also fetal blood cells could form a sequential barrier blocking maternal activated defence cells bearing CD95 molecules. (C) 1998 W. B. Saunders Company Ltd. [less ▲]

Detailed reference viewed: 56 (10 ULiège)
Peer Reviewed
See detailDemonstration of the pituitary expression of the human GH-V gene as assessed by a competitive hybridization technique.
Scippo, Marie-Louise ULiege; Frankenne, F.; Igout, Ahmed ULiege et al

in Proceedings of the 72nd Annual Meeting of the Endocrine Society (1990)

Detailed reference viewed: 5 (0 ULiège)
See detailDemonstration of the two-way nesting in the Gulf of Lions
Vandenbulcke, Luc ULiege; Barth, Alexander ULiege; Ben Bouallegue, Z. et al

Conference (2003, September)

Detailed reference viewed: 6 (1 ULiège)
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See detailDémonstration pratique de l'existence de la nutation diurne
Folie, François ULiege

in Comptes Rendus de l'Académie des Sciences. Série 2, Sciences de la Terre et des Planètes (1886), 103

Introduction of a François Folie’s note about the existence of diurnal nutation of the world’s axis. Nutation that can be sensitive if the globe consists of a fluid core and a solid crust.

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See detailDémonstration pratique de l'existence de la nutation diurne par M. Niesten : rapport de F. Folie
Folie, François ULiege

in Bulletins de l'Académie Royale des Sciences, des Lettres et des Beaux-Arts de Belgique (1887), 3e série, t. 13(4), 398-404

The author establishes a report on the Mr. Niesten’s thesis on the practical demonstration of the diurnal nutation existence.

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See detailDemonstrationof somatogenic receptors in bovine corpus luteum: conjectural effect of trophic hormone on follicular growth and development.
Beckers, Jean-François ULiege; Wouters-Ballman, P.; Viviers-Donnay, I. et al

Poster (1989, September 09)

Detailed reference viewed: 17 (2 ULiège)
See detailDémystifier la consultation démence
Adam, Stéphane ULiege

Conference given outside the academic context (2008)

Detailed reference viewed: 19 (0 ULiège)
Peer Reviewed
See detailDemystifying Comprehensive GC
Focant, Jean-François ULiege

Conference (2013, October)

Detailed reference viewed: 22 (0 ULiège)
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Peer Reviewed
See detailDemystifying ethnic/sex differences in kidney function: is the difference in (estimating) glomerular filtration rate or in serum creatinine concentration?
Pottel, Hans; Hoste, Liesbeth; DELANAYE, Pierre ULiege et al

in Clinica Chimica Acta (2012), 413(19-20), 1612-17

BACKGROUND: The recent evaluation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating the glomerular filtration rate (GFR) in multiple ethnicities has raised the ... [more ▼]

BACKGROUND: The recent evaluation of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation for estimating the glomerular filtration rate (GFR) in multiple ethnicities has raised the question on how well this equation performs for African-American and Asian subjects. There is no doubt that serum creatinine (Scr) concentration differs between ethnicities and sexes. We show that creatinine-based equations for white populations may be inaccurate for estimating GFR in other ethnic/gender groups, especially in populations from Asia. METHODS: This study presents a mathematical analysis of the CKD-EPI-equation complemented with a literature review of median and reference values for IDMS-standardized Scr-concentrations for multiple ethnicities. RESULTS: The study shows that at equal eGFR-CKD-EPI-values, the ratio of Scr between females and males equals 0.79 and between other ethnicities/sexes and white males is constant too. From this information, it is possible to calculate mean Scr-values that correspond very well with literature values directly obtained from Scr-distributions in healthy white males and females and in black males, but the discrepancy is larger for other populations. CONCLUSIONS: Our results confirm the criticism that has been raised for using the CKD-EPI-equation for these ethnicities. An alternative eGFR-model is proposed based on a population-normalized Scr that needs further validation. [less ▲]

Detailed reference viewed: 69 (0 ULiège)
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See detailLa dénazification du Reichsmark
Robelin, Cyril ULiege

Article for general public (2007)

Histoire de la dénazification du Reichsmark et du passage au Deutschemark (1945-1948)

Detailed reference viewed: 17 (0 ULiège)
Peer Reviewed
See detailDenCity: Zero Energy Light Weight Construction Households for Urban Densification
Amer, Mohamed ULiege; Attia, Shady ULiege

in Rencontres Universitaires de Génie Civil de l'AUGC (2016, May 25)

This paper is a part of an ongoing research in the field of sustainable urban densification through providing innovative solutions for zero energy light weight construction. The focus aim of this research ... [more ▼]

This paper is a part of an ongoing research in the field of sustainable urban densification through providing innovative solutions for zero energy light weight construction. The focus aim of this research is to identify the gaps in the construction solutions for roof stacking, to feed in the innovation pipeline of the European construction landscape in the coming years. This paper presents a comprehensive review of different case studies and efforts in the field of roof raising and its repetition potentials. Based on a structured review, 8 different cases from three different European countries were sorted, placing a variety of methods in comparison with each other. The main contribution of this review lies in the analyses of the existing information in this field and the classification of the different validated methods and approaches that has been used. Finally, despite the existing challenges, it was found that the concept of roof stacking can be widely spread and applied in different contexts. Future research is going to investigate possible solution and to formulate structured scientific approaches to widen its application. [less ▲]

Detailed reference viewed: 71 (23 ULiège)
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See detailDenCity: Zero Energy Lightweight Construction Households for Urban Densification
Amer, Mohamed ULiege; Attia, Shady ULiege

Scientific conference (2016, April 27)

Belgium, like many European Countries, has a serious challenge in the housing sector. The Federal planning bureau estimates the increase of the population by one million inhabitants by 2030, which ... [more ▼]

Belgium, like many European Countries, has a serious challenge in the housing sector. The Federal planning bureau estimates the increase of the population by one million inhabitants by 2030, which represent 600,000 additional family requiring accesses to new housing facilities. There is a significant housing shortage for individual, single parent families, seniors and students. Population ageing (mainly due to increase life expectancy) combined with a constant grow rate of individuals living in collective households, leads to a substantial increase of demand of collective households. Furthermore, the stringent European performance environmental regulations for the building sector require that by 2020, all new construction are zero or nearly zero energy, (equivalent to 15 kWh/m2/year), with 60% efficient on-site coverage by renewable energy. The shortage of vacant land and the increasing energy performance requirements is pushing the idea of urban densification and zero energy construction households. [less ▲]

Detailed reference viewed: 80 (38 ULiège)
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Peer Reviewed
See detailDendermonde, a city on two rivers: reflections about the projects d’amenagement after the First World War
Rapalo, Maria Chiara ULiege

in i Quaderni di Careggi - UNISCAPE (2015, September 28)

The First World War as well as being cause to destruction, was also an occasion of renewal for many residential areas, which exploited the post-war reconstruction to change their urban layout. It was the ... [more ▼]

The First World War as well as being cause to destruction, was also an occasion of renewal for many residential areas, which exploited the post-war reconstruction to change their urban layout. It was the time when in Europe new approaches to architecture and urban planning were being discussed, based on the aesthetics. Meanwhile, in the Belgian context, the debate on the Art de Bâtir by C. Sitte began to consolidate, and, simultaneously, the first institutions of sites protection were born. Termonde, a settlement dating from the eleventh century, occupies a geographically strategic place of the Belgian territory: located north of the country, not far from the Dutch border and perfectly in the center of the triangle Ghent-Antwerp-Brussels, the city has always been one of the economy hubs in the nation. The Dendermonde industry has historically implanted in the urban area - crossed by the two rivers Escaut and Dendre - exploiting all the resources for industrial production. Despite the ravages of war and the many floods, thanks to government targeted actions, the city still managed to occupy a place of first importance in Flanders intensive industrialization, representing a crucial point of the 'water railway' which, starting from French Flanders and passing through Ghent and Antwerp, comes up to Germany. The objective of the study is to examine the situation of Dendermonde in the thirties of the twentieth century, by analyzing, in particular - on the basis of historical iconography of the early decades of the twentieth century and some local projects d’amenagement presented soon after the First World War up to the Concours pour l’urbanization de Termonde (1935) - measures, suggestions and reflections on the theme of conservation and redevelopment of the river landscape, in compliance with the historical archaeological persistence, geo-natural and landscape features of the town. In particular, we are going to examine the proposed interventions on the two streams of Dendermonde which aimed primarily at enhancing the ancient center. The projects related to the two rivers involved diversion, interception or slowdown operations. These transformations brought substantial changes to the urban features and to the natural historical landscape, thus altering the identity of places, and by deleting certain environmental values, or historical and aesthetic, without subtracting the character sometimes typically industrial, otherwise picturesque of the northern Europe ancient city. [less ▲]

Detailed reference viewed: 20 (1 ULiège)
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Peer Reviewed
See detailDendrimer-like star block and amphiphilic copolymers by combination of ring opening and atom transfer radical polymerization
Hedrick, James L.; Trollsas, Mikael; Hawker, Craig Jon et al

in Macromolecules (1998), 31(25), 8691-8705

A new type of macromolecular architecture, denoted as dendrimer-like star block copolymers, is reported. These block copolymers are described by a radial geometry where the different generations or layers ... [more ▼]

A new type of macromolecular architecture, denoted as dendrimer-like star block copolymers, is reported. These block copolymers are described by a radial geometry where the different generations or layers are comprised of high molecular weight polymer emanating from a central core. A hexahydroxyl functional core was used as an initiator for the “living” ring opening polymerization (ROP) of ε-caprolactone producing a hydroxyl terminated six arm star polymer with controlled molecular weight and narrow polydispersities (PD < 1.1). Capping these chain ends with dendrons containing activated bromide moieties produced “macro-initiators” for atom transfer radical polymerization (ATRP). Methyl methacrylate was polymerized from these “macro-initiators” in the presence of an organometallic promoter to produce the requisite dendrimer-like star polymers. High molecular weight was obtained with low polydispersities (<1.2). Alternatively, amphiphilic character could be introduced by designing the different layers or generations to be either hydrophobic or hydrophilic. For example, methyl methacrylate (MMA) with either hydroxyethyl methacrylate (HEMA) or methacrylate functional ethylene oxide macromonomers (EO) were polymerized from these “macro-initiators” to provide a hydrophilic outer layer. The use of macromolecular building blocks allows rapid attainment of high polymer in a limited number of steps with purification between transformation requiring only polymer precipitation. [less ▲]

Detailed reference viewed: 102 (12 ULiège)
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Peer Reviewed
See detailDendritic cell differentiation and immune tolerance to insulin-related peptides in Igf2-deficient mice
Hansenne, Isabelle ULiege; Renard-Charlet, C.; Greimers, Roland ULiege et al

in Journal of Immunology (Baltimore, Md. : 1950) (2006), 176(8), 4651-4657

There is some evidence that insulin-like growth factor 2 (IGF-2) may intervene in the control of T cell differentiation. To further study the immunoregulatory function of this growth factor, we analyzed ... [more ▼]

There is some evidence that insulin-like growth factor 2 (IGF-2) may intervene in the control of T cell differentiation. To further study the immunoregulatory function of this growth factor, we analyzed the immune system of Igf2(-/-) mice. Phenotypically, some immunological parameters such as lymphoid organ morphology and cellularity were unaltered in Igf2(-/-) mice, but an increase of CD8(+) cells and a decrease of B220(+) cells were observed in spleen. In vitro, the development of bone marrow-derived dendritic cells was affected by the absence of Igf2 expression. After maturation, a higher percentage of immature dendritic cells was observed in Igf2(-/-) population, together with a secondary decrease in allogenic T cell proliferation. Activation of T cells was also affected by the lack of expression of this growth factor. The profile of B cell response in mutant mice immunized with IGF-2 evidenced a T-dependent profile of anti-IGF-2 Abs that was absent in Igf2(+/+) mice. The influence of IGF-2 upon tolerance to insulin was also assessed in this model, and this showed that IGF-2 also intervenes in tolerance to insulin. The presence of a T-dependent response in Igf2-deficient mice should allow cloning of specific "forbidden" T CD4(+) lymphocytes directed against IGF-2, as well as further investigation of their possible pathogenic properties against insulin family. [less ▲]

Detailed reference viewed: 36 (5 ULiège)
Peer Reviewed
See detailDendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma
Henry, E.; Desmet, C. J.; Garzé, V. et al

Poster (2007)

Detailed reference viewed: 15 (1 ULiège)
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Peer Reviewed
See detailDendritic cells genetically engineered to express IL-10 induce long-lasting antigen-specific tolerance in experimental asthma.
Henry, E.; Desmet, Christophe ULiege; Garze, V. et al

in Journal of Immunology (2008), 181(10), 7230-7242

Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary immune responses, including tolerogenic responses. We have genetically engineered bone marrow-derived DCs to ... [more ▼]

Dendritic cells (DCs) are professional APCs that have a unique capacity to initiate primary immune responses, including tolerogenic responses. We have genetically engineered bone marrow-derived DCs to express the immunosuppressive cytokine IL-10 and tested the ability of these cells to control experimental asthma. A single intratracheal injection of OVA-pulsed IL-10-transduced DCs (OVA-IL-10-DCs) to naive mice before OVA sensitization and challenge prevented all of the cardinal features of airway allergy, namely, eosinophilic airway inflammation, airway hyperreactivity, and production of mucus, Ag-specific Igs, and IL-4. OVA-IL-10-DCs also reversed established experimental asthma and had long-lasting and Ag-specific effects. We furthermore showed, by using IL-10-deficient mice, that host IL-10 is required for mediating the immunomodulatory effects of OVA-IL-10-DCs and demonstrated a significant increase in the percentage of OVA-specific CD4(+)CD25(+)Foxp3(+)IL-10(+) regulatory T cells in the mediastinal lymph nodes of OVA-IL-10-DC-injected mice. Finally, adoptive transfer of CD4(+) mediastinal lymph node T cells from mice injected with OVA-IL-10-DCs protected OVA-sensitized recipients from airway eosinophilia upon OVA provocation. Our study describes a promising strategy to induce long-lasting Ag-specific tolerance in airway allergy. [less ▲]

Detailed reference viewed: 78 (15 ULiège)