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See detailEarly gene expression in human lymphocytes after gamma-irradiation-a genetic pattern with potential for biodosimetry.
Turtoi, Andrei ULg; Brown, Ian; Oskamp, Dominik et al

in International Journal of Radiation Biology (2008), 84(5), 375-87

PURPOSE: Identification of early radiation response genes (ERG) in human lymphocytes after gamma-irradiation by using the whole-human-genome DNA-microarrays and the evaluation of their possible role in ... [more ▼]

PURPOSE: Identification of early radiation response genes (ERG) in human lymphocytes after gamma-irradiation by using the whole-human-genome DNA-microarrays and the evaluation of their possible role in rapid radiation biodosimetry by applying real-time quantitative polymerase chain reaction (RT-qPCR) methodology for validation in a small group of human individuals. MATERIALS AND METHODS: Whole blood from a healthy human donor was exposed at 37 degrees C to 137Cs gamma-radiations (absorbed dose: 1-4 Gy). Fifteen minutes following irradiation the lymphocytes were isolated from the blood (for 2 h at 20 degrees C) and their gene expression was investigated using the DNA-microarrays. Subsequently, 14 genes were selected and validated using the TaqMan probes based upon the RT-qPCR assay within a group of 6 human donors. RESULTS: A dose-related relative change in quantitative gene expression using the DNA-microarray assay was demonstrated in 24 of 102 genes. Up-regulation of expression was observed in 15 genes: CD69 (CD69 molecule), CDKN1A (cyclin-dependent kinase inhibitor 1A), EGR1 (early growth response 1), EGR4 (early growth response 4), FLJ35725 (chromosome 4 ORF 23), hCG2041177 (hCG - human Celera Genome), hCG1643466.2, IFN-gamma (interferon-gamma), ISG20L (interferon stimulated exonuclease gene 20 kDa - like 1), c-JUN (jun oncogene), MDM2 (mouse double minute 2), MUC5B (mucine), PLK2 (polo-like kinase 2), RND1 (rho-family GTPase 1) and TNFSF9 (tumour necrosis factor superfamily member 9). Down-regulation of expression was found in the remaining nine genes: GRIK3 (glutamate receptor ionotropic kainate 3), hCG1985174, hCG1998530, hCG2038519, OCLN (occludin), RPL10A (ribosomal protein L10a), SERHL2 (serine hydrolase-like 2), SGK3 (serum/glucocorticoid regulated kinase 3) and STARD13 (START domain containing 13). CONCLUSION: A significant correlation between absorbed radiation dose and change in relative gene expression was particularly evident for EGR1, EGR4, IFN-gamma, c-JUN and TNFSF9 (p < or = 0.05). Results warrant the further investigation of these ERG as potential biodosimetric markers. [less ▲]

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See detailEarly HFOV parameters and respiratory outcome in RDS newborns less than 32 weeks of gestational age
Battisti, Oreste ULg; Kalenga, M.; François, A. et al

Conference (1998)

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See detailEarly history of extended irreversible thermodynamics (1953-1983): an exploration beyond local equilibrium and classical transport theory
Lebon, Georgy ULg; Jou, david

in European Physical Journal H. Historical Perspectives on Contemporary Physics (2014), 5(23),

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See detailEarly homeostatic disturbances of human growth and maturation by endocrine disrupters
Bourguignon, Jean-Pierre ULg; Parent, Anne-Simone ULg

in Current Opinion in Pediatrics (2010), 22(4), 470-477

We attempt to delineate and integrate aspects of growth and development that could be affected by endocrine disrupters [endocrine-disrupting compounds (EDC)], an increasing public health concern. RECENT ... [more ▼]

We attempt to delineate and integrate aspects of growth and development that could be affected by endocrine disrupters [endocrine-disrupting compounds (EDC)], an increasing public health concern. RECENT FINDINGS: Epidemiological and experimental data substantiate that fetal and early postnatal life are critical periods of exposure to endocrine disrupters, with possible transgenerational effects. The EDC effects include several disorders of the reproductive system throughout life (abnormalities of sexual differentiation, infertility or subfertility and some neoplasia) and disorders of energy balance (obesity and metabolic syndrome). The mechanisms are consistent with the concept of 'developmental origin of adult disease'. They could involve cross-talk between the factors controlling reproduction and those controlling energy balance, both in the hypothalamus and peripherally. SUMMARY: Due to ubiquity of endocrine disrupters and lifelong stakes of early exposure, individual families should be provided by pediatricians with recommendations following the precautionary principle, that is prevention or attenuation of conditions possibly detrimental to health before the evidence of such adverse effects is complete and undisputable. [less ▲]

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See detailEarly identification of inner pillar cells during rat cochlear development.
Thelen, Nicolas ULg; Breuskin, Ingrid ULg; Malgrange, Brigitte ULg et al

in Cell & Tissue Research (2009), 337(1), 1-14

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far from being elucidated. Here, we examine its spatio-temporal development ... [more ▼]

Although the structure of the auditory organ in mature mammals, the organ of Corti, is clearly established, its development is far from being elucidated. Here, we examine its spatio-temporal development in rats from embryonic day 16 (E16) to E19 by using cytochemical and immunocytochemical methods at the light- and electron-microscope levels. We demonstrate that the organ of Corti develops from a non-proliferating cell zone that is located in the junctional region between two edges of the dorsal epithelium of the cochlear duct. We also reveal that the first cells to develop in this zone are the inner pillar cells, a particular type of non-sensory supporting cell, which arise in the base of the cochlear duct at the boundary between the two ridges at E16. Cell differentiation in this prosensory region continues according to a base-to-apex gradient; the inner hair cells appear in the greater epithelial ridge at E17 and the outer hair cells in the lesser epithelial ridge at E18. At E19, the various cell types of the organ of Corti are in place. Finally, we show that unlike the development of all the supporting cell types of the organ of Corti, the development of inner pillar cells within the prosensory domain seems not to involve Notch1 activation. These results highlight the central role that the inner pillar cells probably play in the development of the organ of Corti. [less ▲]

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See detailEarly Implant placement in socket preservations: 12-month results of a prospective case series.
DETHIER, Frédéric ULg; LECLOUX, Geoffrey ULg; ROMPEN, Eric ULg et al

Poster (2012, June)

Objectives: The aim of this study was to evaluate the clinical and histological outcomes of implant placed after socket preservation procedures in the esthetic zone. Implant survival rate and biological ... [more ▼]

Objectives: The aim of this study was to evaluate the clinical and histological outcomes of implant placed after socket preservation procedures in the esthetic zone. Implant survival rate and biological complications were recorded during a follow-up period of 1 year. Materials and methods: A series of 12 patients needing the replacement of a single tooth in the esthetic zone were included in the present study. The hopeless teeth were extracted atraumatically, the sockets were filled with bovine hydroxyapatite (0.25-1mm particles) and the sites were covered with a saddled connective tissue graft. After a healing period of 3 months, biopsies were retrieved in the socket preservation sites and implants were placed. The patients were followed for a period of 1 year. Results: The etiologies of tooth loss were : endodontic (9), caries (1), periodontal (1), and traumatic (1). A total of 12 implants (10 incisors, 2 premolars) were placed on 12 patients (6 men / 6 women) aged from 24 to 61 (42,3 – 11,91). All implant reached an adequate primary stability (> 20N/cm2). 7 out of 12 implants were immediately restored with a temporary crown, and the définitive restorations were successfully placed in all cases. After a follow-up period of 1 year, all implants fulfilled strict success criteria for dental implants with regard to osteointegration, including the absence of peri-implant radiolucency, implant mobility, suppuration, and pain and no further complications occurred. Out of 12 sites only 7 biopsies were retrieved for histological analyses. New bone was found in the apical third of the socket in every specimen, in the mid-third in only 3 specimen and no bone was found in any of the spécimen in the more cervical third of the socket. Conclusion: The results from this prospective case series suggest that early implant placement in extraction socket site seems to display good clinical outcomes despite the incomplete bone regeneration in the socket at 3 months. [less ▲]

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See detailEarly inbreeding depression and pollen competition in Calluna vulgaris (L.) Hull
Mahy, Grégory ULg; Jacquemart, Anne Laure

in Annals of Botany (1999), 83

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See detailEarly infantile cardiomyopathy and liver disease: a multisystemic disorder caused by congenital lipodystrophy.
Debray, François-Guillaume ULg; Baguette, Christel; Colinet, Stephanie et al

in Molecular genetics and metabolism (2013), 109(2), 227-9

Congenital generalized lipodystrophy is a rare inherited multisystemic disorder associated with disturbances of adipocyte functions. We report a young boy presenting at age 1 month with liver disease and ... [more ▼]

Congenital generalized lipodystrophy is a rare inherited multisystemic disorder associated with disturbances of adipocyte functions. We report a young boy presenting at age 1 month with liver disease and severe hypertrophic cardiomyopathy. Despite this multisystemic involvement and contrasting with a cachectic appearance, the anthropometric parameters showed marked overgrowth (+4 DS), leading to diagnosis of congenital lipodystrophy, which was confirmed by the presence of the new homozygous c.259C>T (p.Gln87*) mutation in the AGPAT2 gene. Early infantile cardiomyopathy should be considered as a specific endophenotype in Berardinelli-Seip Congenital Lipodystrophy syndrome. [less ▲]

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See detailEarly inflammation in the airways of a cystic fibrosis foetus
Verhaeghe, C.; Delbecque, Katty ULg; de Leval, Laurence ULg et al

in Journal of Cystic Fibrosis (2007), 6(4), 304-308

In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic ... [more ▼]

In cystic fibrosis patients, inflammation is often considered to be secondary to chronic infections. In the present study, we show increased levels of pro-inflammatory proteins in the lungs of a cystic fibrosis foetus compared to the lungs of two normal foetuses. Our findings suggest therefore the existence of an early intrinsic pro-inflammatory state in cystic fibrosis airways. (C) 2006 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved. [less ▲]

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See detailEarly Jezirah 3b Pottery from Tell Beydar, Selected Inventories from latest excavation campaigns
Mas, Juliette ULg; Gavagnin, Katia

in Bieliński, P; Gawlikowski, M; Koliński, R (Eds.) et al Proceedings of the 8th International Congress on the Archaeology of the Ancient Near East, 30 April – 4 May 2012, University of Warsaw, Volume 2: Excavation and Progress Reports, Posters (2014)

Since 1992, excavations at Tell Beydar have offered the opportunity to explore an urban centre of the Upper Khabur region. The extensive exploration of the EJZ 3b levels gave us access to the urbanism and ... [more ▼]

Since 1992, excavations at Tell Beydar have offered the opportunity to explore an urban centre of the Upper Khabur region. The extensive exploration of the EJZ 3b levels gave us access to the urbanism and the architecture of the city as well as its material culture, especially the pottery. The assemblages presented in this paper were exclusively found directly on the floors of various buildings (of a public, domestic, religious, offi- cial nature) and inside a grave. Most of these inventories consist of complete vessels discovered either intact or smashed but restorable. The aim of this paper is to investigate if, or to what extent, the intra-site distribution of the morphological repertoire of Beydar IIIb ceramic is related to its context of use. [less ▲]

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See detailEarly Jezirah 3b Pottery from Tell Beydar. Selected Inventories from latest excavation campaigns
Mas, Juliette ULg; Gavagnin, Katia

Conference (2012, April)

Since 1992, excavations at Tell Beydar have offered the opportunity to explore an urban centre of the Upper Khabur region. The extensive exploration of the EJZ 3b levels gave us access to the urbanism and ... [more ▼]

Since 1992, excavations at Tell Beydar have offered the opportunity to explore an urban centre of the Upper Khabur region. The extensive exploration of the EJZ 3b levels gave us access to the urbanism and the architecture of the city as well as its material culture, especially the pottery. The assemblages presented in this paper were exclusively found directly on the floors of various buildings (of a public, domestic, religious, offi- cial nature) and inside a grave. Most of these inventories consist of complete vessels discovered either intact or smashed but restorable. The aim of this paper is to investigate if, or to what extent, the intra-site distribution of the morphological repertoire of Beydar IIIb ceramic is related to its context of use. [less ▲]

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See detailEarly land plant evolution: a tremendous success story.
Gerrienne, Philippe ULg

Conference (2009)

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See detailEarly land plant spore assemblages from the Late Silurian of Skane, Sweden
Mehlqvist, K.; Vajda, V.; Steemans, Philippe ULg

in Geologiska Föreningens i Stockholm Förhandlingar (2012), 134(2), 133-144

A palynological study based on sedimentary rocks (mainly calcareous siltstones and mudstones with minor carbonate beds) from the upper Silurian Öved-Ramsåsa Group in the Klinta 1 and Bjärsjölagård 2 ... [more ▼]

A palynological study based on sedimentary rocks (mainly calcareous siltstones and mudstones with minor carbonate beds) from the upper Silurian Öved-Ramsåsa Group in the Klinta 1 and Bjärsjölagård 2 drillcores, Skåne, Sweden, reveals a rich assemblage of well-preserved spores produced by early land plants. Thirty-four spore taxa belonging to 19 genera, including the new species Scylaspora klintaensis sp. nov., were identified. The palynoflora is characterized by cryptospores and trilete spores. The dominant spore species are the cryptospores Gneudnaspora plicata followed by Gneudnaspora divellomedia. Based on the presence of biostratigraphically important spore species such as Hispanaediscus lamontii, Artemopyra radiata, Emphanisporites neglectus, Synorisporites cf. libycus and Synorisporites tripapillatus, the age of the studied strata is interpreted to be of a Late Silurian age. Although the palynological assemblages are strongly dominated by miospores and other land plant fragments, marine microfossils are also present and the sedimentary succession is interpreted to have been deposited in a nearshore marine environment. [less ▲]

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See detailEarly land plants from Paraná Basin (Brazil) - Paleogeographic implications
Gerrienne, Philippe ULg; Steemans, Philippe ULg; Pereira, E. et al

Conference (2000)

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See detailThe early land plants from the Armorican Massif: sedimentological and palynological considerations on age and environment
Strullu-Derrien, Christine; Ducassou, Céline; Ballèvre, Michel et al

in Geological Magazine (2010), 147(6), 830-843

Detailed reference viewed: 75 (8 ULg)
See detailEarly life evolution, habitats and biosignatures. Astrobiology and Habitability workshop
Javaux, Emmanuelle ULg; Marshall, Craig

Conference (2006, June)

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See detailEarly Llandovery cryptospores and miospores from central Saudi Arabia
Steemans, Philippe ULg; Higgs, K. T.; Wellman, C. H. et al

Conference (1998)

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See detailEarly maturation of gonadotropin-releasing hormone secretion and sexual precocity after exposure of infant female rats to estradiol or dichlorodiphenyltrichloroethane
Rasier, Gregory; Parent, Anne-Simone ULg; Gerard, Arlette ULg et al

in Biology of Reproduction (2007), 77(4), 734-742

An increase in the frequency of pulsatile gonadotropin-releasing hormone (GnRH) secretion in vitro and a reduction in LH response to GnRH in vivo characterize hypothalamic-pituitary maturation before ... [more ▼]

An increase in the frequency of pulsatile gonadotropin-releasing hormone (GnRH) secretion in vitro and a reduction in LH response to GnRH in vivo characterize hypothalamic-pituitary maturation before puberty in the female rat. In girls migrating for international adoption, sexual precocity is frequent and could implicate former exposure to the insecticide dichlorodiphenyltrichloroethane (DDT), since a long-lasting DDT derivative has been detected in the serum of such children. We aimed at studying the effects of early transient exposure to estradiol (E 2) or DDT in vitro and in vivo in the infantile female rat. Using a static incubation system of hypothalamic explants from 15-day-old female rats, a concentration- and time-dependent reduction in GnRH interpulse interval (IPI) was seen during incubation with E 2 and DDT isomers. These effects were prevented by antagonists of alpha-amino-3-hydroxy-5-methyl-isoxazole-4 propionic acid (AMPA)/kainate receptors and estrogen receptor. Also, o,p '-DDT effects were prevented by an antagonist of the aryl hydrocarbon orphan dioxin receptor (AHR). After subcutaneous injections of E, or o,p '-DDT between Postnatal Days (PNDs) 6 and 10, a decreased GnRH IPI was observed on PND 15 as an ex vivo effect. After DDT administration, serum LH levels in response to GnRH were not different from controls on PIND 15, whereas they tended to be lower on PND 22. Subsequently, early vaginal opening (VO) and first estrus were observed together with a premature age-related decrease in LH response to GnRH. After prolonged exposure to E 2 between PNDs 6 and 40, VO occurred at an earlier age, but first estrus was delayed. We conclude that a transient exposure to E 2 or o,p '-DDT in early postnatal life is followed by early maturation of pulsatile GnRH secretion and, subsequently, early developmental reduction of LH response to GnRH that are possible mechanisms of the subsequent sexual precocity. The early maturation of pulsatile GnRH secretion could involve effects mediated through estrogen receptor and/or AHR as well as AMPA/kainate subtype of glutamate receptors. [less ▲]

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See detailEarly Middle Ordovician evidence for land plants in Argentina (eastern Gondwana)
Rubinstein, C. V.; Gerrienne, Philippe ULg; de la Puente, G. S. et al

in New Phytologist (2010), 188

Detailed reference viewed: 129 (18 ULg)