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See detailE.C. Treaty & European Citizenship. Regional Integration and Cultural Diversity: the case of european citizenship
Carlier, Jean-Yves ULg

in Foblets; Dundes Renteln, Alison; Gaudreault-Desbiens, Jean-François (Eds.) Cultural Diversity and the Law. State Responses from (2010)

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See detailE.coli prpoS::gfp strain as biosensor of glucose heterogeneity inside industrial bioreactors
Brognaux, Alison ULg; Delvigne, Frank ULg; Thonart, Philippe ULg

Poster (2010, December 08)

• OBJECTIVE: Escherichia coli is a microorganism widely used in the industry for the production of recombinant proteins. The performances obtained at the laboratory level are not reproducible at a large ... [more ▼]

• OBJECTIVE: Escherichia coli is a microorganism widely used in the industry for the production of recombinant proteins. The performances obtained at the laboratory level are not reproducible at a large scale. Actually, the mixing operation is not efficient enough: gradients of glucose and oxygen appear when operating in fed-batch mode (addition of glucose during the culture). These gradients cause adverse impacts on the production of biomass and recombinant protein. The aim of this work is to use the microbial population as biocaptor of the encoutered stress inside heterogeneous industrial bioreactors to better scale-up and regulate these reactors. • MATERIALS AND METHODS: A plasmid carrying a stress promoter followed by the coding sequence of the Green Fluorescent Protein (GFP) is introduced in the bacterial host (in our case, the strain E. coli K12 will be considered as a model organism). When the cell is submitted to given stress condition, GFP synthesis is induced and accumulated into the cytoplasm, leading to the increase of the cell's fluorescence. Flow cytometry detection is used in order to quantify the fluorescence at the single cell level. Obtained results are frequency histograms of fluorescenceintensity in the microbial population • RESULTS: The rpoS gene is a gene of the general stress response, mainly induced at the entrance to stationary phase (during a lack of glucose). The tracking of the GFP fluorescence linked to the activation / repression of the rpoS promoter gives good results. Indeed, there is appearance of a segregation at the level of the GFP content among the microbial population. The intensity of the segregation, as well as its time of appearance during the culture can be related to the bioreactor mixing efficiency. • CONCLUSION: prpoS::gfp strains can be used as biosensors of the heterogeneity of glucose encountered inside industrial reactors. • POTENTIAL APPLICATIONS & KEY BENEFITS: These strains could be used to validate a fed-batch regulation (addition of glucose) at the industrial level. [less ▲]

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See detailE.coli virulence factors
Mainil, Jacques ULg

Conference (2011)

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See detailE.T.A. Hoffmann und das Experiment
Küpper, Achim ULg

Scientific conference (2013, May 30)

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See detailE.T.A. Hoffmann: Das Majorat. Rezension
Küpper, Achim ULg

E-print/Working paper (2004)

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See detailE1 Transitions of Astrophysical Interest in Neutral Oxygen
Hibbert, A.; Biémont, Emile ULg; Godefroid, M. et al

in Journal of Physics : B Atomic Molecular & Optical Physics (1991), 24

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See detailEACTS guidelines for the use of patient safety checklists.
Clark, SC; Dunning, J; Alfieri, OR et al

in European Journal of Cardio - Thoracic Surgery (2012), 41(5), 993-1004

The Safety Checklist concept has been an integral part of many industries that face high-complexity tasks for many decades and in industries such as aviation and engineering checklists have evolved from ... [more ▼]

The Safety Checklist concept has been an integral part of many industries that face high-complexity tasks for many decades and in industries such as aviation and engineering checklists have evolved from their very inception. Investigations of the causes of surgical deaths around the world have repeatedly pointed to medical errors that could be prevented as an important cause of death and disability. As a result, the World Health Organisation developed and evaluated a three-stage surgical checklist in 2007 demonstrating that complications were significantly reduced, including surgical infection rates and even mortality. Together with the results from other large cohort studies into the utility of the surgical checklist, many countries have fully implemented the use of surgical checklists into routine practice. A key factor in the successful implementation of a surgical checklist is engagement of the staff implementing the checklist. In surgical specialties such as our own it was quickly seen that there were many important omissions in the generic checklist that did not cover issues particular to our specialty, and thus the European Association for Cardio-Thoracic Surgery embarked on a process to create a version of the checklist that might be more appropriate and specific to cardiothoracic surgery, including checks on preparations for excessive bleeding, perfusion arrangements and ICU preparations, for example. The guideline presented here summarizes the evidence for the surgical checklist and also goes through in detail the changes recommended for our specialty. [less ▲]

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See detailEACVI/HFA Cardiac Oncology Toxicity Registry in breast cancer patients: rationale, study design, and methodology (EACVI/HFA COT Registry)-EURObservational Research Program of the European Society of Cardiology.
Lancellotti, Patrizio ULg; Anker, Stefan D.; Donal, Erwan et al

in European Heart Journal - Cardiovascular Imaging (2015)

The goal of adjuvant anti-cancer therapies is cure with limited or no side effects, in particular long-term side effects with negative impact on quality of life. In the palliative setting disease control ... [more ▼]

The goal of adjuvant anti-cancer therapies is cure with limited or no side effects, in particular long-term side effects with negative impact on quality of life. In the palliative setting disease control, quality of life and overall survival are important end points. Partly due to improvements in treatment, the population of cancer survivors is large and growing. However, anti-cancer drug-related cardiotoxicity (ADRC) is the leading cause of treatment-associated mortality in cancer survivors. It is one of the most common post-treatment problems among 5- to 10-year survivors of adult cancer. This is particularly true for breast cancer, the most common cancer in women. The EACVI/HFA COT registry is designed for comprehensive data collection and evaluation of the current European practice in terms of diagnosis and management of ADRC in breast cancer patients. The COT registry will be carried out in two continuing phases, the pilot study phase involving 13 countries followed by the long-term registry in which all the 56 ESC countries will be invited to participate. With the COT registry, several critical information will be obtained: on predisposing factors for the development of ADRC, the rate of subclinical LV dysfunction and its transition to overt heart failure, the clinical impact and outcome of ADRC. [less ▲]

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See detailL'EAD à l'Université de Liège, Le dispositif d'accompagnement du LabSET
Lecomte, Béatrice ULg

Scientific conference (2005)

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See detailEAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography.
Lang, Roberto M.; Badano, Luigi P.; Tsang, Wendy et al

in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography (2012), 25(1), 3-46

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See detailEAE/ASE recommendations for image acquisition and display using three-dimensional echocardiography.
Lang, Roberto M.; Badano, Luigi P.; Tsang, Wendy et al

in European Heart Journal - Cardiovascular Imaging (2012), 13(1), 1-46

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See detailEANA European Astrobiology workhop, Program and abstracts
Javaux, Emmanuelle ULg; Dehant, Véronique; Muller, Christian

Book (2009)

EANA Euroepan Astrobiology workhop, Program and abstracts, Brussels 12-14 oct 2009

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See detailEAO Summer Camp Session
LAMBERT, France ULg

Conference (2012, October 11)

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See detailEarlier onset of delta-retrovirus-induced leukemia after splenectomy.
Florins, ARNAUD-FRANCOIS ULg; Reichert, Michal; Asquith, Becca et al

in PLoS ONE (2009), 4(9), 6943

Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts ... [more ▼]

Infection by delta-retroviruses such as human T-lymphotropic virus type 1 (HTLV-1) and bovine leukemia virus (BLV) is mostly asymptomatic. Indeed, only a minority (<5%) of delta-retrovirus infected hosts will develop either lymphoproliferative or neurodegenerative diseases after long latency periods. In fact, the host immune response is believed to tightly control viral replication but this assumption has not been definitely proven in vivo. Here, we provide direct experimental evidence demonstrating that integrity of the spleen is required to control pathogenesis. In the BLV model, we show that asplenia decreases efficiency of the immune response and induces an imbalance in cell dynamics resulting in accelerated onset of leukemia. These observations enlighten a potential threat in splenectomized HTLV-1 carriers and justify a regular preventive evaluation. [less ▲]

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See detailEarlier onset of tumoral anglogenesis in matrix metalloproteinase-19-deficient mice
Jost, M.; Folgueras, A. R.; Frerart, F. et al

in Cancer Research (2006), 66(10), 5234-5241

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during ... [more ▼]

Among matrix metalloproteinases (MMP), MMP-19 displays unique structural features and tissue distribution. In contrast to most MMPs, MMP-19 is expressed in normal human epidermis and down-regulated during malignant transformation and dedifferentiation. The contribution of MMP-19 during tumor angiogenesis is presently unknown. In an attempt to give new insights into MMP-19 in vivo functions, angiogenic response of mutant mice lacking MMP-19 was analyzed after transplantation of murine malignant PDVA keratinocytes and after injection of Matrigel supplemented with basic fibroblast growth factor. In situ hybridization and immunohistochemical analysis revealed that MMP-19 is produced by host mesenchymal cells but not by endothelial capillary cells or CD11b-positive inflammatory cells. Based on a new computer-assisted method of quantification, we provide evidence that host MMP-19 deficiency was associated with an increased early angiogenic response. In addition, increased tumor invasion was observed in MMP-19-/- mice. We conclude that, in contrast to most MMPs that promote tumor progression, MMP-19 is a negative regulator of early steps of tumor angiogenesis and invasion. These data highlight the requirement to understand the individual functions of each MMP to improve anticancer strategies. [less ▲]

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See detailThe earlier the smaller the better for natalizumab-associated PML: in MRI vigilance veritas ?
PHAN BA, Remy ULg; Belachew, Shibeshih ULg; Outteryck, Olivier et al

in Neurology (2012), 79

Natalizumab-associated progressive multifocal leukoencephalopathy (N-PML) in multiple sclerosis (MS) is due to CNS infection by the opportunistic JC virus (JCV). As of december 2011, 193 confirmed cases ... [more ▼]

Natalizumab-associated progressive multifocal leukoencephalopathy (N-PML) in multiple sclerosis (MS) is due to CNS infection by the opportunistic JC virus (JCV). As of december 2011, 193 confirmed cases of N-PML have been observed, giving rise to an overall risk of approximately 0,202%. N-PML pathogenesis remains partially elusive although risk factors have now been clearly delineated. In patients with prior JCV infection detected by serum anti-JCV antibodies, duration of therapy and prior use of immunosuppressants (IS) increase the risk of N-PML. The clinical outcome of MS patients who developed N-PML was highly variable, ranging from asymptomatic case to varying degrees of neurological disability or even death. It was also observed in real life setting that the earlier N-PML was diagnosed and treated, the better was the clinical outcome. Clinical vigilance is now considered as the established cornerstone of PML risk-management algorithm. Here we present early MRI features of 4 out of 8 N-PML cases, which were observed in Wallonia-Brussels and Northern France in more than 4 years of post-marketing utilization of natalizumab for both regions. We are not aware of the specific context and outcome of the 4 other N-PML cases, which were diagnosed and treated in other centers. The reported cases emphasize that (i) N-PML can have a long presymptomatic course while still being clearly detectable with MR imaging, (ii) N-PML can have a benign outcome provided it is diagnosed and treated early, (iii) a clinically symptomatic N-PML may be a further advanced infection with a poorer prognosis, and (iv) periodic brain MR scans, particularly in high risk situations, are likely to provide earlier detection of N-PML and better outcomes. [less ▲]

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See detailThe earliest Eocene mammal fauna of the Erquelinnes Sand Member near the French-Belgian border
Missiaen, P.; Quesnel, F.; Dupuis, C. et al

in Geologica Belgica (2013), 16(4), 262-273

The earliest Eocene Erquelinnes site was discovered in 1880, but its mammal fauna has been frequently ignored. This paper provides the first detailed overview of the Erquelinnes mammals since 1929. The ... [more ▼]

The earliest Eocene Erquelinnes site was discovered in 1880, but its mammal fauna has been frequently ignored. This paper provides the first detailed overview of the Erquelinnes mammals since 1929. The new faunal list doubles the known diversity at Erquelinnes to a total of 16 species, now also including amphilemurids, hyaenodontids, mesonychids, louisinids, equids and diacodexeids. The majority of the Erquelinnes species is also present in the earliest Eocene Dormaal MP7 reference fauna, with as most notable exceptions the presence of a potentially dwarfed specimen of Dissacus, and of two perissodactyl taxa at Erquelinnes. The ceratomorph perissodactyl Cymbalophus cuniculus is also known from the earliest Eocene of England, but a specimen identified as cf. Sifrhippus sandrae is closely similar to contemporaneous primitive North American equids. This specimen represents the oldest unambiguous European equid and highlights faunal similarities between Europe and North America during this time interval. Faunal differences between Erquelinnes and Dormaal seem mostly due to depositional differences, and the Erquelinnes fauna represents a typical earliest Eocene fauna, closely similar to other MP7 and PEI faunas in Europe. [less ▲]

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See detailThe earliest seed plants from Gondwana: palaeogeographical and evolutionary implications based on Tournaisian (Mississippian) records from Argentina
Prestianni, C.; Rustán, J.J.; Balseiro, D. et al

Conference (2014, September)

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See detailEarliest Taeniate Bisaccates from the Amazon basin are not older than Westphalian.
Loboziak, S; Melo, J.H.G.; Dino, R et al

in Geobios (1997), 30(4), 467-474

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