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See detailEffect of zolpidem in chronic disorders of consciousness: a prospective open-label study.
Thonnard, Marie ULg; Gosseries, Olivia ULg; Demertzi, Athina ULg et al

in Functional Neurology (2014)

Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty ... [more ▼]

Zolpidem has been reported as an "awakening drug" in some patients with disorders of consciousness (DOC). We here present the results of a prospective openlabel study in chronic DOC patients. Sixty patients (35±15 years; 18 females; mean time since insult ± SD: 4±5.5 years; 31 with traumatic etiology) with a diagnosis of vegetative state/unresponsive wakefulness syndrome (n=28) or minimally conscious state (n=32) were behaviorally assessed using the Coma Recovery Scale-Revised (CRS-R) before and one hour after administration of 10 mg of zolpidem. At the group level, the diagnosis did not change after intake of zolpidem (p=0.10) and CRS-R total scores decreased (p=0.01). Twelve patients (20%) showed improved behaviors and/or CRS-R total scores after zolpidem administration but in only one patient was the diagnosis after zolpidem intake found to show a significant improvement (functional object use), which suggested a change of diagnosis. However, in this patient, a double-blind placebo-controlled trial was performed in order to better specify the effects of zolpidem, but the patient, on this trial, failed to show any clinical improvements. The present open-label study therefore failed to show any clinically significant improvement (i.e., change of Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study diagnosis) in any of the 60 studied chronic DOC patients. [less ▲]

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See detailEffect of ß-Cyclodextrin Derivatives on Bronchial Epithelial Cell Layer Permeability
Bosquillon, C; Belhadj Salem, L; Hernandez, E et al

in Delivery to the lung (2006), 17

Cyclodextrins have been identified as promising adjuvants for pulmonary drug delivery. However, concerns regarding possible adverse effects on the respiratory epithelium may limit their development in ... [more ▼]

Cyclodextrins have been identified as promising adjuvants for pulmonary drug delivery. However, concerns regarding possible adverse effects on the respiratory epithelium may limit their development in inhaled products. Concentrations (10-50 mM) of three ß-cyclodextrin derivatives, randomly methylated ß-cyclodextrin (RAMEB), hydroxypropyl-ß-cyclodextrin (HPßCD) and Kleptose® CRYSMEB, were applied to human respiratory epithelial (Calu-3) cell layers and effects on permeability were evaluated by 14C-mannitol permeability and transepithelial electrical resistance (TEER) measurements. Each cyclodextrin produced a concentration-dependent increase in mannitol flux which was associated with a drop in TEER. Increases in mannitol flux were the highest after exposure to RAMEB and were not apparent until a 50-60% reduction in TEER was reached. Disrupted cell layers recovered to their initial TEER value in less than 24 h except after exposure to high concentrations of RAMEB. Perturbations of the Calu-3 cell layers were shown to be dependent on cyclodextrin concentration, as well as chemical derivatisation, and were reversible in all but the most severe cases. [less ▲]

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See detailEffect of β-cyclodextrin and its derivatives on caveolae disruption, relationships with their cholesterol extraction capacities
Castagne, Delphine ULg; Evrard, Brigitte ULg; Nusgens, Betty ULg et al

in Journal of Inclusion Phenomena and Macrocyclic Chemistry (2010), 67

Endothelial cells (HUVEC) were treated with b-cyclodextrin (b-CD) and hydroxypropylated or methylated derivatives solutions to confirm their lack of affinity with phospholipids and their specificity ... [more ▼]

Endothelial cells (HUVEC) were treated with b-cyclodextrin (b-CD) and hydroxypropylated or methylated derivatives solutions to confirm their lack of affinity with phospholipids and their specificity towards cholesterol. Further studies were performed on bovine aortic endothelial cells to assess the effect of b-CDs (mainly methylated derivatives) on membrane microdomains (lipid rafts or caveolae), by detecting the caveolae marker caveolin-1 in fractions of sucrose gradients. A displacement from the lighter to the heavier fractions, characteristic of caveolae disruption, was observed using CDs. The strongest effect was obtained with dimethyl-b-CD, for which an accumulation of caveolin-1 was observed in the bottom of the gradient. Crysmeb and trimethyl-b-CD seemed to have the weaker effects as a significative amount of caveolin-1 was still detected in the light fraction corresponding to caveolae. b-CD and CDs having a degree of methylation a bit lower than 2 showed intermediate effects. The results of the present study on microdomains seem in good correlation with the cell cholesterol extraction capacities of CDs previously determined. [less ▲]

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See detailEffect of “diagnosis threat” in clinical setting
Fresson, Megan ULg; Dardenne, Benoît ULg; Meulemans, Thierry ULg

Poster (2014, November 14)

Objective. When reminded of their neurological history, mild traumatic brain injured (TBI) students underperform on neuropsychological tests (Suhr & Gunstad, 2002). To date, this “diagnosis threat” (DT ... [more ▼]

Objective. When reminded of their neurological history, mild traumatic brain injured (TBI) students underperform on neuropsychological tests (Suhr & Gunstad, 2002). To date, this “diagnosis threat” (DT) phenomenon has mainly been studied with a non-clinical and high-functioning population (university students). The aim of this study was twofold: to study this phenomenon with neurological patients and to examine the mechanisms responsible for underperformance. Method. Patients (18-55 years-old) who had sustained a TBI or a stroke were recruited from ambulatory and hospitalized cares, and then assigned to one of three conditions : Patients attention was drawn on (1) their neurological disease and the neuropsychological components of the upcoming tasks (DT group) ; (2) their intact sensory capacities and the sensorial components of the tasks (Neutral group); or (3) their better cognitive abilities compared to Alzheimer disease patients (Stereotype boost group). After these instructions, patients carried out cognitive tasks and completed questionnaires. Results. Preliminary analyses (n=18) showed that, on the z-score of executive functioning, the DT group performed worse than both the neutral group (p=.03) and the stereotype boost group (p=.05), but did not differ for the attentional and memory scores. Instructions also had an impact on cognitive self-efficacy, with the neutral group demonstrating greater score than the negative one (p=.08). Furthermore, the self-efficacy score tended to correlate with the score of executive functioning (r=.37). Conclusions. Results show that the DT phenomenon has an impact on cognitive performances in clinical setting, at least on executive functions, which are usually demonstrated to be the most sensitive to stereotype effects. [less ▲]

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See detailEffect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.
MacDonald, Thomas M; Reginster, Jean-Yves ULg; Littlejohn, Thomas W et al

in Journal of Hypertension (2008), 26(8), 1695-702

OBJECTIVES: Nonsteroidal anti-inflammatory drugs vary in their impact on blood pressure and the effect of lumiracoxib 100 mg once daily has not been studied previously. To examine whether lumiracoxib 100 ... [more ▼]

OBJECTIVES: Nonsteroidal anti-inflammatory drugs vary in their impact on blood pressure and the effect of lumiracoxib 100 mg once daily has not been studied previously. To examine whether lumiracoxib 100 mg once daily would result in lower 24-h mean systolic ambulatory blood pressure than ibuprofen 600 mg three times daily in osteoarthritis patients with controlled hypertension, a 4-week, randomized, double-blind, parallel-group study was conducted in 79 centres in nine countries. METHODS: Hypertensive osteoarthritis patients of 50 years at least whose office blood pressure was less than 140/90 mmHg on stable antihypertensive treatment were randomized to lumiracoxib (n = 394) 100 mg once daily or ibuprofen 600 mg three times daily (n = 393) and 24-h ambulatory blood pressure monitoring was performed at baseline and end of study. The primary outcome measure was a comparison of the change in 24-h mean systolic ambulatory blood pressure from baseline to week 4. Secondary analyses included other blood pressure-related endpoints and efficacy (pain) measurements. RESULTS: Compared with baseline, the 24-h mean systolic ambulatory blood pressure (least square mean) decreased in lumiracoxib-treated patients (-2.7 mmHg) and increased in ibuprofen-treated patients (+2.2 mmHg) at 4 weeks, estimated difference -5.0 mmHg (95% confidence interval -6.1 to -3.8) in favour of lumiracoxib. The 24-h mean diastolic ambulatory blood pressure changes were -1.5 mmHg (lumiracoxib), +0.5 mmHg (ibuprofen), difference -2.0 mmHg (95% confidence interval -2.7 to -1.3). Efficacy results were comparable. CONCLUSIONS: Treatment with lumiracoxib 100 mg once daily resulted in clinically significant lower blood pressure compared with ibuprofen 600 mg three times daily in osteoarthritis patients with well controlled hypertension. [less ▲]

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See detailEffect on bone turnover markers of once-yearly intravenous infusion of zoledronic acid versus daily oral risedronate in patients treated with glucocorticoids.
Devogelaer, Jean-Pierre; Sambrook, Philip; Reid, David M et al

in Rheumatology (Oxford, England) (2013), 52(6), 1058-69

Objective. Long-term glucocorticoid use is accompanied by rapid bone loss; however, early treatment with bisphosphonates prevents bone loss and reduces fracture risk. The aim of this study was to examine ... [more ▼]

Objective. Long-term glucocorticoid use is accompanied by rapid bone loss; however, early treatment with bisphosphonates prevents bone loss and reduces fracture risk. The aim of this study was to examine the effects of two bisphosphonates, i.v. zoledronic acid (ZOL) versus oral risedronate (RIS), on bone turnover markers (BTMs) in subjects with glucocorticoid-induced osteoporosis (GIO).Methods. Patients were randomly stratified according to the duration of pre-study glucocorticoid therapy [prevention subpopulation (ZOL, n = 144; RIS, n = 144) </=3 months, treatment subpopulation (ZOL, n = 272; RIS, n = 273) >3 months]. Changes in beta-C-terminal telopeptides of type 1 collagen (beta-CTx), N-terminal telopeptide of type I collagen (NTx), procollagen type 1 N-terminal propeptide (P1NP) and bone-specific alkaline phosphatase (BSAP) from baseline were measured on day 10 and months 3, 6 and 12.Results. At most time points, there were significantly greater reductions (P < 0.05) in the concentrations of serum beta-CTx, P1NP and BSAP and urine NTx in subjects on ZOL compared with RIS in both males and females of the treatment and prevention subpopulations. In pre- and post-menopausal women, there were significantly greater reductions in the concentrations of BTMs with ZOL compared with RIS. At 12 months, ZOL had significantly greater reductions compared with RIS (P < 0.05) for beta-CTx, P1NP, BSAP and NTx levels, independent of glucocorticoid dose.Conclusions. Once-yearly i.v. infusion of ZOL 5 mg was well tolerated in different subgroups of GIO patients. ZOL was non-inferior to RIS and even superior to RIS in the response of BTMs in GIO patients.Trial registration: ClinicalTrials.gov, http://clinicaltrials.gov, NCT00100620. [less ▲]

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See detailThe effect on bone turnover of monofluorophosphate (MFP) combined with raloxifene (RLX) as compared to MFP alone in postmenopausal women with low bone mass
Stepan, J.; Payer, J.; Resch, H. et al

in Osteoporosis International (2002), 13(S1), 54

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See detailEffect on KATP channel activation properties and tissue selctivity of the nature of the substituent in the 7- and the 3-position of 4H-1,2,4-benzothiadiazine
Boverie, S.; Antoine, M.-H.; Somers, F. et al

in Journal of Medicinal Chemistry (2005), 48

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See detailEffect on single annual infusion of zoledronic acid (5mg) on lumbar spine bone mineral density versus daily oral risedronate (5mg) in subgroups of patients receiving glucocorticoid therapy.
Roux, Christian; Fashola, T.; Reid, D. et al

in Osteoporosis International (2009, March), 20(Suppl.1), 7-8

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See detailThe Effect on Systemic and Pulmonary Circulations in the Resuscitation of Asphyxiated Newborn Piglets with 21%, 50% or 100% Oxygen
Haase, Erika; Stevens, Jonathan; Rigo, Vincent ULg et al

in Pediatric Research (2003, April), 53(4 Part 2/2), 354

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See detailEffect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide
Boverie, S.; Antoine, M. H.; Becker, B. et al

Poster (2000, September)

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See detailEffect on the pancreatic endocrine system of 3-alkylamino-7-chloro-4H-1,2,4-benzothiadiazine 1,1-dioxides structurally related to diazoxide
Boverie, S.; Antoine, M.-H.; Becker, B. et al

in Pflügers Archiv : European Journal of Physiology (2000), 439

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See detailEffecten van internationale overnames op aandelenrendementen
Adriaanse, F.; Corhay, Albert ULg; Tourani-Rad, Alireza

in Maandblad voor Accountancy en Bedrijfseconomie [=MAB] (1996), 70(3), 123-132

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See detailEffectifs des populations, répartition et statut du petit nacré, Issoria lathonia L., sur les terrains calaminaires du bassin de la Vesdre (province de Liège, Belgique) (Lepidoptera: Nymphalidae)
Ertz, Damien; Graitson, Eric ULg

in Linneana Belgica : Revue Belge d'Entomologie (2001), 18(2), 87-92

La recherche d'issoria lathonia sur l'ensemble des terrains calaminaires du bassin de la Vesdre a permis de mettre en évidence la présence de ce papillon sur tous les sites où sa plante-hôte, viola ... [more ▼]

La recherche d'issoria lathonia sur l'ensemble des terrains calaminaires du bassin de la Vesdre a permis de mettre en évidence la présence de ce papillon sur tous les sites où sa plante-hôte, viola calaminaria, est bien représentée. Un seul site offre actuellement, avec plus de 1000 individus, une population stable de cette espèce. L'hypothèse de l'existence d'une métapopulation est avancée. La protection des terrains calaminaires semble capitale pour le maintien de populations permanentes d'I. lathonia dans cette région. [less ▲]

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See detailEffective arterial elastance as an index of pulmonary arterial load
Morimont, Philippe ULg; Lambermont, Bernard ULg; Ghuysen, Alexandre ULg et al

in European Journal of Heart Failure, Supplements (2007), 6

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See detailEffective arterial elastance as an index of pulmonary vascular load.
Morimont, Philippe ULg; Lambermont, Bernard ULg; Ghuysen, Alexandre ULg et al

in American Journal of Physiology - Heart and Circulatory Physiology (2008), 294(6), 2736-42

The aim of this study was to test whether the simple ratio of right ventricular (RV) end-systolic pressure (Pes) to stroke volume (SV), known as the effective arterial elastance (Ea), provides a valid ... [more ▼]

The aim of this study was to test whether the simple ratio of right ventricular (RV) end-systolic pressure (Pes) to stroke volume (SV), known as the effective arterial elastance (Ea), provides a valid assessment of pulmonary arterial load in case of pulmonary embolism- or endotoxin-induced pulmonary hypertension. Ventricular pressure-volume (PV) data (obtained with conductance catheters) and invasive pulmonary arterial pressure and flow waveforms were simultaneously recorded in two groups of six pure Pietran pigs, submitted either to pulmonary embolism (group A) or endotoxic shock (group B). Measurements were obtained at baseline and each 30 min after injection of autologous blood clots (0.3 g/kg) in the superior vena cava in group A and after endotoxin infusion in group B. Two methods of calculation of pulmonary arterial load were compared. On one hand, Ea provided by using three-element windkessel model (WK) of the pulmonary arterial system [Ea(WK)] was referred to as standard computation. On the other hand, similar to the systemic circulation, Ea was assessed as the ratio of RV Pes to SV [Ea(PV) = Pes/SV]. In both groups, although the correlation between Ea(PV) and Ea(WK) was excellent over a broad range of altered conditions, Ea(PV) systematically overestimated Ea(WK). This offset disappeared when left atrial pressure (Pla) was incorporated into Ea [Ea * (PV) = (Pes - Pla)/SV]. Thus Ea * (PV), defined as the ratio of RV Pes minus Pla to SV, provides a convenient, useful, and simple method to assess the pulmonary arterial load and its impact on the RV function. [less ▲]

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See detailEffective cobalt mediation of the radical polymerization of vinyl acetate in suspension
Debuigne, Antoine ULg; Caille, Jean-Raphaël; Detrembleur, Christophe ULg et al

in Angewandte Chemie (International ed. in English) (2005), 44(22), 3439-3442

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See detailEffective cobalt-mediated radical coupling (CMRC) of poly(vinylacetate) and poly(N-vinylpyrrolidone) (co)polymer precursors
Debuigne, Antoine ULg; Poli, Rinaldo; De Winter, Julien et al

in Macromolecules (2010), 43(6), 2801-2813

Cobalt-mediated radical coupling (CMRC) is successfully applied to poly(vinyl acetate) (PVAc) and poly(N-vinylpyrrolidone) (PNVP) precursors for the first time. The coupling process is based on addition ... [more ▼]

Cobalt-mediated radical coupling (CMRC) is successfully applied to poly(vinyl acetate) (PVAc) and poly(N-vinylpyrrolidone) (PNVP) precursors for the first time. The coupling process is based on addition of isoprene onto polymer chains preformed by controlled radical polymerization with cobalt complexes (CMRP). The extents of coupling were high (>90%) to moderate (75-80%) for PVAc and PNVP precursors, respectively. Effects of the length of the polymer precursors and conditions used in the polymerization step on the coupling efficiency are discussed. Mass spectrometry (MS) and nuclear magnetic resonance (NMR) analyses conducted on the coupling products demonstrate the preferential insertion of two isoprene units in the final polymers. The CMRC mechanistic proposal, supported by DFT calculations, is based on this microstructure feature. Finally, illustration of the macromolecular engineering potential of this technique is given by the preparation of symmetrical PVAc-b-PNVP-b-PVAc triblock copolymers starting from the corresponding PVAc-b-PNVP-[Co] diblock copolymer. [less ▲]

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See detailEffective concentrations of garlic distillate (Allium sativum) for the control of Tetranychus urticae (Tetranychidae)
Attia, Sabrine; Grissa, Kaouthar Lebdi; Mailleux, Anne-Catherine et al

in Journal of Applied Entomology (2011)

The two-spotted spider mite, Tetranychus urticae Koch, is a worldwide pest that feeds on a large variety of plant families. Because its resistance to acaricides is spreading rapidly, the development of ... [more ▼]

The two-spotted spider mite, Tetranychus urticae Koch, is a worldwide pest that feeds on a large variety of plant families. Because its resistance to acaricides is spreading rapidly, the development of new biological control tactics for population management is crucial. Plant extracts, such as garlic extract (Allium sativum Linn.), may represent viable alternatives, because they are currently considered to be minimum-risk pesticides. Although garlic is known for its acaricidal properties, the extract concentration that provides the most efficient control has not yet been precisely determined. In this study, we conducted a series of laboratory experiments to determine the susceptibility of adult females to different concentrations of garlic extract. Fresh garlic cloves were steam-distilled and sprayed using a Potter spray tower. Mortality and fecundity were measured upon treatment with garlic extract concentrations ranging from 0.46 to 14.4 mg/l. Female mortality increased with concentration, with LD50 and LD90 values of 7.49 and 13.5 mg/l, respectively. Reduced fecundity was previously observed at concentrations of 0.36 and 0.74 mg/l. The chemical composition of the Allium sativum distillate was characterized by reversed-phase high-performance liquid chromatography coupled with photodiode array detection, GC/MS and Fast GC-FID against an authentic standard (Standard, Bioextract).Vinyl dithiin, diallyl disulphide, diallyl trisulphide and methyl allyl trisulphide were identified based on their mass spectra. Sesquiterpenoids were identified by their retention index. [less ▲]

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