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See detailDevelopment of disease : bacterial toxins and their interaction with host cells
Mainil, Jacques ULg

Scientific conference (2005)

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See detailDevelopment of Driver Assistance Systems by Use of SiL and HiL Techniques in the Traffic Flow Simulation Program PELOPS
Breuer, K.; Christen, Fréderic ULg

(2002, October 07)

In this article methods are shown to use software in the loop (SIL) and hardware in the loop (HIL) techniques in connection with the microscopic traffic flow simulation program PELOPS. With some ... [more ▼]

In this article methods are shown to use software in the loop (SIL) and hardware in the loop (HIL) techniques in connection with the microscopic traffic flow simulation program PELOPS. With some application examples the use of these methods are depicted. In this context the ossibilities of such coupled simulation tools in development of driver assistance systems are presented. An outlook is given to future enhancements of the described HIL techniques to control for example test benches or assess real vehicles in virtual traffic. [less ▲]

Detailed reference viewed: 47 (0 ULg)
See detailDevelopment of duplex RT-PCR tests for the routine detection of latent and ILAR viruses in fruit trees
Roussel, S.; Kummert, J.; Dutrecq, O. et al

Poster (2004)

Detailed reference viewed: 5 (1 ULg)
See detailDevelopment of duplex RT-PCR tests for the routine detection of latent and ILAR viruses in fruit trees
Roussel, S.; Kummert, J.; Dutrecq, O. et al

Conference (2004)

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See detailDevelopment of educational info capsules proposing instructional strategies aiming to deal with overweight and obese students
Cloes, Marc ULg; LEBRETHON, Marie-Christine ULg; Feron, Isaline

Conference (2014, February 13)

Irwin et al. (2003) pointed out the principles that quality PE teachers should incorporate into their pedagogical practice in order to take into account the increasing number of overweight and obese ... [more ▼]

Irwin et al. (2003) pointed out the principles that quality PE teachers should incorporate into their pedagogical practice in order to take into account the increasing number of overweight and obese students in their classes. Fighting against obesity is so complex that no simple solution can be proposed. It means that the development of specific tools providing PE teachers with new instructional strategies inspired from public health is needed (Prusak et al., 2011). Inclusion of overweight students into PE can be linked with a social ecological model (Li & Rukavina, 2012). Even if PE teachers are able to develop and implement specific instructional strategies, it seems that they need support from health experts (Cloes et al., 2013). Internet, continuing professional development activities, and educational info capsules were identified as the preferred supports to be used by the practitioners (Cloes et al., 2014). The aims of this study were to produce and validate three pedagogical capsules focusing on specific concerns of PE teachers as well as to analyze the procedure of validation. Using an extensive analysis of the literature, the researchers first identified theoretical and practical resources to be mobilized in the understanding and development of solutions for the selected problems: (1) Students’ lack of awareness about the risks of overweight and obesity; (2) Constraints associated with the motor/physical disabling; (3) Parents’ lack of awareness about PA impact on health. The capsules were then submitted to 11 experts (health specialists, health educators, psychologists, PE teachers) who had to analyze the documents. They acknowledged the content and form of the capsules. Minor changes were requested in order to finalize them. The proposed evaluation sheet was also validated but face-to-face assessment was recommended. Dissemination of the existing capsules as well as development of additional ones should be the next steps of this project. [less ▲]

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See detailDevelopment of edumetrical indices for the analysis of the spectral quality of higher education standardized tests
Gilles, Jean-Luc ULg

in 11th Biennal Conference of the European Association for Research on Learning and Instruction - Multiple Perspectives on Effective Learning Enviroments - Abstracts (2005)

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See detailDevelopment of electrospun chitosan scaffold for wound dressing application
Aqil, Abdelhafid ULg; Tchemtchoua, Victor; Colige, Alain ULg et al

Poster (2011, November 28)

Wound dressing is one of the most promising medical applications for chitosan, due to its adhesive nature, together with some biological properties including bacteriostatic and fungistatic properties that ... [more ▼]

Wound dressing is one of the most promising medical applications for chitosan, due to its adhesive nature, together with some biological properties including bacteriostatic and fungistatic properties that help in faster wound healing. In this work we propose a chitosan biomimetic scaffolds and methods for modulating their intrinsic properties such as rigidity, elasticity, resistance to mechanical stress, porosity, biodegradation and absorbance of exudates. Therefore, the chitosan scaffold comprising at least two fused layers, wherein the advantage of a first fused layer composed of a chitosan electrospun nanofiber membrane are oxygen-permeability, high porosity, variable pore-size distribution, high surface to volume ratio, and most importantly, morphological similarity to natural extracellular matrix in skin, which promote cell adhesion migration and proliferation. The advantages of a second fused layer comprising a porous chitosan support layer are improving mechanical property, good absorption capacities to remove excess exudates and good water and gas exchange. Moreover, the scaffold was characterized by (i) a good adhesion between the porous and nanofiber layers, (ii) a tuneable porosity of the nanofiber layer by tuning the distance between the nanofibers, (iii) a stable nanofibers and porous morphology even when immersed in water. Finally, the scaffolds have shown tremendous promise as a wound dressing, in tissue engineering. The three main human cell types fibroblasts, endothelial cells and keratinocytes was cultured in vitro on electrospun nanofibers scaffold. Properties of electrospun chitosan scaffold and chitosan sponges obtained by lyophilization were also compared in vivo, in order to evaluate importance of the 3D-architecture of the biomaterial. [less ▲]

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See detailDevelopment of entomopathogenic fungi in mosquito control: which kind of production for which efficiency?
Bawin, Thomas ULg; Delvigne, Frank ULg; Francis, Frédéric ULg

Poster (2014, August 06)

Mosquitoes (Diptera: Culicidae) are zoonotic vectors responsible for numerous infectious diseases of medical and veterinary importance such as filariasis, malaria and encephalitis. As part of an ... [more ▼]

Mosquitoes (Diptera: Culicidae) are zoonotic vectors responsible for numerous infectious diseases of medical and veterinary importance such as filariasis, malaria and encephalitis. As part of an integrated vector control, entomopathogenic fungi could be developed as biopesticides in two ways: spores and metabolites recognized as effective virulence factors. Solid-state fermentation enhances spore production and induces the secretion of metabolites quantitatively and qualitatively different from submerged fermentation, which impairs fungal metabolic efficiency. In this context, we showed high spore productivity of solid-state media based on agro-industrial substrates as wheat bran. Spores remained pathogenic, as revealed by classical toxicity tests and electron microscopy. However, the absence of free water makes culture parameter variations difficult to control in large-scale. Recently, we performed a bioreactor design intended for simultaneous spore and metabolite production, combining the technological advantages of submerged and solid-state fermentations. Biofilm fermentation (i.e. growth of fungal biomass on an inert support immerged in a nutrient medium) is a tremendous production system favouring the secretion of insecticidal metabolites in the liquid medium as we showed recently. This is also an interesting tool to provide an overview of the complexity of the metabolic pathways involved in the regulation of extracellular metabolites secretion because corresponding genes are reported to be differentially expressed from classical fermentation systems. Researches in vector control are currently intensified. In this context, the identification of genes and metabolites specifically expressed during biofilm fermentation will help to develop new technologies related both to the design of bioreactor and the production of insecticidal proteins. [less ▲]

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See detailDevelopment of equine models of podal keratinocytes and endothelial cells cultures for the study of equine laminitis
de la Rebière de Pouyade, Geoffroy ULg

Master of advanced studies dissertation (2006)

Laminitis is a painful systemic disease of which the principal manifestation is a diffuse aseptic pododermatitis. An ischaemia-reperfusion and/or an activation of matrix métalloproteinases following a ... [more ▼]

Laminitis is a painful systemic disease of which the principal manifestation is a diffuse aseptic pododermatitis. An ischaemia-reperfusion and/or an activation of matrix métalloproteinases following a proinflammatory status (mainly gastro-intestinal) or hormonal disorders involving metabolic dysfunctions related to the development of insulin resistance, are at the origin of laminitis. The presence of histological lesions of keratinocytes and endothelial cells, and the infiltration of polymorphonuclear neutrophils (PMNs) in laminar tissues, warranted the development of the two cellular culture models corresponding for the study of this disease. Therefore, keratinocytes and endothelial cells are isolated by enzymatic digestion and mechanical separation, respectively from coronary bands and carotids, and are put in culture under controlled atmosphere in DMEM supplemented with additives. Microscopic observations of phenotype, the immunocytochemistry, growth curves, and apoptosis stainings allowed to characterize the cells. The cells can be used, between passage 3 and 5 for the keratinocytes and 3 and 6 for the endothelial cells, in models of interaction with PMNs and their enzymes, in condition of anoxia/reoxygenation with variable glucose.concentrations. [less ▲]

Detailed reference viewed: 110 (19 ULg)
See detailThe development of European Union Citizenship : a critical Evaluation
Martiniello, Marco ULg

in Roche, M.; van Berkel, R. (Eds.) European Citizenship and Social Exclusion, (1997)

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See detailThe development of extended type noun uses : a comparison between English sort/kind and French sorte/espèce
Brems, Lieselotte ULg; Willemse, Peter; Davidse, Kristin

Conference (2007)

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See detailThe development of female sexual behavior requires prepubertal estradiol.
Brock, Olivier; Baum, Michael J; Bakker, Julie ULg

in Journal of Neuroscience (2011), 31(15), 5574-8

The classic view of brain and behavioral sexual differentiation holds that the neural mechanisms controlling sexual behavior in female rodents develop in the absence of ovarian sex hormone actions ... [more ▼]

The classic view of brain and behavioral sexual differentiation holds that the neural mechanisms controlling sexual behavior in female rodents develop in the absence of ovarian sex hormone actions. However, in a previous study, female aromatase knock-out (ArKO) mice, which cannot convert testosterone to estradiol, showed deficient male-oriented partner preference and lordosis behaviors in response to adult ovarian hormones, raising the possibility that estradiol may contribute to the development of these female sexual behaviors. In the present experiments, administering estradiol prepubertally [between postnatal day 15 (P15) and P25] significantly enhanced the ability of ArKO female mice to display lordosis behavior in response to ovarian hormones administered later in adulthood, whereas treatment with estradiol over an earlier postnatal period (P5-P15) had no such effect. Treatment of ArKO females with estradiol between P15 and P25 also rescued their later preference to approach distal cues from an intact male over an estrous female. ArKO females also displayed significantly less female-directed (male-typical) mounting behavior than wild-type control females when treated with testosterone in adulthood. Prepubertal estradiol treatment failed to reverse this deficit in ArKO females, whereas earlier postnatal estradiol augmented later mounting in both genotypes. Our results provide new evidence for an organizing role of prepubertal estradiol in the development of neural mechanisms that control female-typical sexual behavior. [less ▲]

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See detailDevelopment of formulated elicitors to control bioagressors of wheat
Le Mire, Géraldine ULg; Deleu, Magali ULg; Ongena, Marc ULg et al

Scientific conference (2013, July)

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See detailDevelopment of formulated elicitors to control bioagressors of wheat: which interests?
Le Mire, Géraldine ULg; Deleu, Magali ULg; Ongena, Marc ULg et al

Poster (2014, February 07)

Crop plants are constantly exposed to a wide range of environmental stresses that can cause major productivity loss. Fungicide treatments are the most efficient disease control methods used up to now ... [more ▼]

Crop plants are constantly exposed to a wide range of environmental stresses that can cause major productivity loss. Fungicide treatments are the most efficient disease control methods used up to now. However, the environmental and health issues caused by these chemicals make it urgent to develop safer methods for pathogen control. In the optic of a sustainable agriculture, several biocontrol tools have been developed during the last decades. Elicitors are increasingly subject to research as interesting alternatives to phytosanitary products. Yet, few efficient formulations exist on the market, and no product has been designed specifically to protect wheat crops. This study will thus focus on the the manipulation of host natural defenses through the use of elicitors as a preventive treatment against major wheat diseases such as Septoria tritici, Fusarium graminearum and Fusarium culmorum. [less ▲]

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See detailDEVELOPMENT OF FROZEN-FRIED YAM SLICES: OPTIMIZATION OF THE PROCESSING CONDITIONS
Toure, Yetioman ULg; Nindjin, Charlemagne; Brostaux, Yves ULg et al

in African Journal of Food, Agriculture, Nutrition and Development (2012), 12(7), 7055-7071

The research performed on yam processing mainly concerns the production of crisps and flour. However, its transformation into deep-frozen French fries does not necessitate any other equipment than those ... [more ▼]

The research performed on yam processing mainly concerns the production of crisps and flour. However, its transformation into deep-frozen French fries does not necessitate any other equipment than those used for potatoes. The industrial process of production of frozen French fries traditionally includes a pre-frying step. These steps contribute to the development of color and crispness, and the oil partially absorbed inhibits dehydration during the freezing step. The aim of this study was to optimize frying conditions of deep-frozen fried yam (Dioscorea cayenensis var Kponan) slices. The effect of pre-frying time and temperature, final frying time and temperature on the oil uptake, texture, dry matter and colour of the fried yam slices has been studied. Frying conditions optimized with Box-Behnken experimental design were short pre-frying and frying conditions at high temperature characterized by pre-frying temperature at 157-170°C during 5-9s and frying temperature at 181-188°C for 2min 15s-2min 30s; or long pre-frying and frying conditions at low temperature characterized by pre-frying temperature at 150-158°C during 10-15s and frying temperature 170-177°C for 3-3min 15s. An adiabatic system was also developed by means of an insulator in which the core temperature of fried yam slices can be maintained constant at about 55°C after 15min of cooling, facilitating texture measurements at constant temperature. The present results may help in choosing the yam slices frying condition to be applied in order to achieve the desirable fried yam slices quality, required for protection against certain diseases like obesity. These models may also provide guidance as to how to control these quality parameters by altering four key environmental factors, pre-frying temperature and time and, final frying temperature and time. This process can also be commercialized and does not necessitate any other cost for equipment than those used for potatoes French fries and might be an interesting way of added value processing for this highly perishable yam tuber. [less ▲]

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See detailDevelopment of functional material for direct manufacturing for ceramic and metal parts by Optoform process
Clarinval, Anne-Marie; Carrus, Raoul; Vaneetveld, Grégory ULg et al

Conference (2004, September)

Optoform LLC developed a technology to process paste compositions based upon photo-curable resins and fillers. This new process is called by Optoform LLC : the direct composite manufacturing This ... [more ▼]

Optoform LLC developed a technology to process paste compositions based upon photo-curable resins and fillers. This new process is called by Optoform LLC : the direct composite manufacturing This technique is quite flexible and allows the development of very different materials(polymeric, metallic, ceramic). This paper is an overview of the use limitation and the advantages of materials developed by the CRIF or by other teams. Materials requiring or not a post-processing step have been developed. The limits or restrictions of use of these materials have been studied in order to meet the requirements and needs of various industrial sectors in the United States and in Europe (e.g. car racing, aerospace and aeronautical sectors, tooling industries, …). [less ▲]

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See detailDevelopment of functionalized nanoparticles for vaccine delivery to dendritic cells: a mechanistic approach
Silva, Joana M.; Vandermeulen, Gaëlle; Oliveira, Vanessa G. et al

in Nanomedicine (2014), 9(17), 2639-2656

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based ... [more ▼]

Aim: Produce biodegradable nanoparticles to target antigen-presenting cells and evaluate their potential to be used as a vaccine delivery system. Materials & methods: Untargeted PEGylated PLGA-based nanoparticles and mannose-grafted nanoparticles were formulated and physicochemically characterized. Immortalized and primary antigen-presenting cells were used to study nanoparticle internalization patterns. The endocytic pathways and intracellular trafficking followed by nanoparticles were also investigated. Results & discussion: Nanoparticles displayed mannose residues available for binding at the nanoparticle surface. Different nanoparticle internalization patterns by immortalized and primary antigen presenting cells were verified. Macropinocytosis, clathrin-mediated endocytosis, caveolin- and lipid raft-dependent endocytosis are involved in nanoparticles internalization. Nanoparticles demonstrate both endo-lysosomal and cytosolic localizations and a tendency to accumulate nearby the endoplasmic reticulum. Conclusion & future perspective: The developed nanoparticles might drive antigens to be presented through MHC class I and II molecules to both CD8+ and CD4+ T cells, favoring a complete and coordinated immune response. [less ▲]

Detailed reference viewed: 185 (13 ULg)