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See detailEffects of ciclesonide and fluticasone on cortisol secretion in patients with persistent asthma.
Derom, E.; Louis, Renaud ULg; Tiesler, C. et al

in European Respiratory Journal (2009), 33(6), 1277-86

We compared the systemic and clinical effects of ciclesonide (CIC) and fluticasone propionate (FP) administered, in addition to CIC 160 microg x day(-1) and salmeterol 50 microg twice daily, in 32 ... [more ▼]

We compared the systemic and clinical effects of ciclesonide (CIC) and fluticasone propionate (FP) administered, in addition to CIC 160 microg x day(-1) and salmeterol 50 microg twice daily, in 32 patients with persistent asthma using a randomised double-blind, placebo-controlled, double-dummy, five-period crossover design. All patients exhibited a provocative concentration leading to a 20% decrease in forced expiratory volume in 1 s (PC(20)) methacholine <8 mg x mL(-1) and a PC(20) adenosine <60 mg x mL(-1). Primary outcome was 24-h serum cortisol suppression after 7 days. Secondary outcomes were changes in PC(20) methacholine and adenosine after 9 days. FP 500 microg x day(-1) and 1,000 microg x day(-1) significantly suppressed cortisol secretion versus placebo by -46.2 (95% confidence interval (CI) -83.8- -8.5) nmol x L(-1) and by -76.1 (95% CI -112.9- -39.3) nmol x L(-1), respectively. Neither dose of CIC (320 nor 640 microg x day(-1)) had a significant suppressive effect (-28.2 (95% CI -65.5-9.2) nmol x L(-1) and -37.3 (95% CI -74.7-0.0) nmol x L(-1), respectively). Differences between FP 1,000 microg x day(-1) and both CIC treatments were statistically significant (CIC 320 microg x day(-1): -48.0 (95% CI -84.8- -11.1) nmol x L(-1); CIC 640 microg x day(-1): -38.8 (95% CI -75.7- -1.9) nmol x L(-1)). Compared with placebo, the increase in PC(20) adenosine after the four treatments was small, but significant. Greater improvements in PC(20) adenosine were seen with FP 500 microg x day(-1) (1.8 (95% CI 1.0-2.6) doubling concentrations) compared with CIC 320 microg x day(-1) (0.9 (95% CI 0.1-1.7) doubling concentrations). No significant difference was seen between CIC 640 microg x day(-1) and FP 1,000 microg x day(-1). For a similar decrease in hyperresponsiveness, cortisol secretion was suppressed significantly with moderate-to-high doses of fluticasone propionate, but not with ciclesonide. [less ▲]

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See detailEffects of cis-diamminedichloroplatinum (II) loaded liposomes on mouse Ehrlich tumor cells.
De Pauw, Marie-Claire ULg; Heinen, Ernst ULg; Weber, Géraldine ULg et al

in European Journal of Cancer & Clinical Oncology (1986), 22(10), 1139-47

Cis-diamminedichloroplatinum II (cisplatin) heavily or lightly loaded (fluid, solid, negatively charged or neutral) liposomes were prepared. Cisplatin release from liposomes was observed only after long ... [more ▼]

Cis-diamminedichloroplatinum II (cisplatin) heavily or lightly loaded (fluid, solid, negatively charged or neutral) liposomes were prepared. Cisplatin release from liposomes was observed only after long dialysis times or after liver lysosomal enzymatic disintegration in solution. Mouse Ehrlich tumor cells (ELT) cultured in vitro were treated with cisplatin, liposomes or cisplatin loaded liposomes, and the effects on the mitotic activity, the DNA content and the ultrastructure were compared. Cisplatin (1-10 micrograms/ml) had an antimitotic activity and modified the DNA content in ELT cells. Ribosome aggregation, perichromatin or interchromatin granule accumulation, and chromatin condensation or some degree of dispersion could be observed. Negatively charged fluid liposomes had an antimitotic activity and modified the DNA content in ELT cells at lower concentrations (0.3 mumoles/ml) than in the case of neutral fluid liposomes (1.5 mumoles/ml). Negatively charged solid liposomes were not toxic at these concentrations. Ultrastructural analysis of ELT cells treated in vitro with negatively charged fluid liposomes revealed their extracellular adsorption and their disintegration in phagolysosomes. A fusion between liposomes and the plasma membrane was not definitely demonstrated. Cisplatin loaded liposomes also had an antimitotic activity and modified the DNA content in ELT cells. These effects were similar to or more pronounced than those induced by free cisplatin. Ultrastructural analysis revealed some kind of electron dense material in phagolysosomes which was never observed after the treatment with free cisplatin or liposomes alone. Effects on nucleic acids were rarely observed. [less ▲]

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See detailEffects of Cis-Pt loaded liposomes on Ehrlich tumor cells
Gillet, Marie-Claire ULg; Heinen, Ernst ULg; Bassleer R

Conference (1982, April)

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See detailEffects of climate change on the river Meuse: Hydraulic 2D modeling from Amspin to Maaseik (and beyond)
Huismans, Ymkje; Dewals, Benjamin ULg; van der Mark, Rolien et al

Poster (2013, March 22)

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See detailEffects of CO2 on particle size distribution and phytoplankton abundance during a mesocosm bloom experiment (PeECE II)
Engel, Anja; Schulz, K. G.; Riebesell, U. et al

in Biogeosciences (2008), 5(2), 509-521

The influence of seawater carbon dioxide (CO2) concentration on the size distribution of suspended particles (2-60 mu m) and on phytoplankton abundance was investigated during a mesocosm experiment at the ... [more ▼]

The influence of seawater carbon dioxide (CO2) concentration on the size distribution of suspended particles (2-60 mu m) and on phytoplankton abundance was investigated during a mesocosm experiment at the large scale facility (LFS) in Bergen, Norway, in the frame of the Pelagic Ecosystem CO2 Enrichment study (PeECE II). In nine outdoor enclosures the partial pressure of CO2 in seawater was modified by an aeration system to simulate past (similar to 190 mu atm CO2), present (similar to 370 mu atm CO2) and future (similar to 700 mu atm CO2) CO2 conditions in triplicates. Due to the initial addition of inorganic nutrients, phytoplankton blooms developed in all mesocosms and were monitored over a period of 19 days. Seawater samples were collected daily for analysing the abundance of suspended particles and phytoplankton with the Coulter Counter and with Flow Cytometry, respectively. During the bloom period, the abundance of small particles (< 4 mu m) significantly increased at past, and decreased at future CO2 levels. At that time, a direct relationship between the total-surface-to-total-volume ratio of suspended particles and DIC concentration was determined for all mesocosms. Significant changes with respect to the CO2 treatment were also observed in the phytoplankton community structure. While some populations such as diatoms seemed to be insensitive to the CO2 treatment, others like Micromonas spp. increased with CO2, or showed maximum abundance at present day CO2 (i.e. Emiliania huxleyi). The strongest response to CO2 was observed in the abundance of small autotrophic nano-plankton that strongly increased during the bloom in the past CO2 mesocosms. Together, changes in particle size distribution and phytoplankton community indicate a complex interplay between the ability of the cells to physiologically respond to changes in CO2 and size selection. Size of cells is of general importance for a variety of processes in marine systems such as diffusion-limited uptake of substrates, resource allocation, predator-prey interaction, and gravitational settling. The observed changes in particle size distribution are therefore discussed with respect to biogeochemical cycling and ecosystem functioning. [less ▲]

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See detailEffects of CO2, continental distribution, topography and vegetation changes on the climate at the Middle Miocene: a model study
Henrot, Alexandra ULg; François, Louis ULg; Favre, Eric ULg et al

in Climate of the Past (2010), 6

The Middle Miocene was one of the last warm periods of the Neogene, culminating with the Middle Miocene Climatic Optimum (MMCO, approximatively 17–15 Ma). Several proxy-based reconstructions support ... [more ▼]

The Middle Miocene was one of the last warm periods of the Neogene, culminating with the Middle Miocene Climatic Optimum (MMCO, approximatively 17–15 Ma). Several proxy-based reconstructions support warmer and more humid climate during the MMCO. The mechanisms responsible for the warmer climate at the MMCO and particularly the role of the atmospheric carbon dioxide are still highly debated. Here we carried out a series of sensitivity experiments with the model of intermediate complexity Planet Simulator, investigating the contributions of the absence of ice on the continents, the opening of the Central American and Eastern Tethys Seaways, the lowering of the topography on land, the effect of various atmospheric CO2 concentrations and the vegetation feedback. Our results show that a higher than present-day CO2 concentration is necessary to generate a warmer climate at all latitudes at the Middle Miocene, in agreement with the terrestrial proxy reconstructions which suggest high atmospheric CO2 concentrations at the MMCO. Nevertheless, the changes in sea-surface conditions, the lowering of the topography on land and the vegetation feedback also produce significant local warming that may, locally, even be stronger than the CO2 induced temperature increases. The lowering of the topography leads to a more zonal atmospheric circulation and allows the westerly flow to continue over the lowered Plateaus at mid-latitudes. The reduced height of the Tibetan Plateau notably prevents the development of a monsoon-like circulation, whereas the reduction of elevations of the North American and European reliefs strongly increases precipitation from northwestern to eastern Europe. The changes in vegetation cover contribute to maintain and even to intensify the warm and humid conditions produced by the other factors, suggesting that the vegetation-climate interactions could help to improve the model-data comparison. [less ▲]

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See detailEffects of coal sampling density on the elemental analysis by using laser-induced breakdown spectroscopy
Li, Jie ULg; Lu, Jidong; Lin, Zhaoxiang et al

in Journal of Huazhong University of Science and Technology(Natural Science Edition) (2009), 37(2), 112-116

Three representative coals from different mines were sampled for analysis. In order to investigate t he effect s of density of samples on t he coal analysis by laser-induced breakdown spectroscopy, the ... [more ▼]

Three representative coals from different mines were sampled for analysis. In order to investigate t he effect s of density of samples on t he coal analysis by laser-induced breakdown spectroscopy, the powder samples and pellet samples which pressed with different pressures were selected for the experiment . The spectra of 200~850 nm of powder and pellet coal samples were obtained , and the emission lines of component s such as C , H , O , N , Al , Fe , Ca , Mg , Si , Ti , Na and K were recorded. Emission lines of C , Al , Ca , Mg , Si and Ti element s were chosen for analysis of calibration curve method and internal standardization met hod because of their high intensity and little interference. The results showed that the density of the samples has more effect s on the calibration curve met hod than the internal standardization met hod. [less ▲]

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See detailThe effects of cognitive remediation therapy on AM deficits in schizophrenia patients
Boulanger, Marie ULg; Collet, Denis; Cornet, Lidvine et al

Poster (2008)

Schizophrenia is accompanied by deficit in autobiographical memories (AM). These impairments are correlated to difficulties in imagining specific events that might happen to them in the future ... [more ▼]

Schizophrenia is accompanied by deficit in autobiographical memories (AM). These impairments are correlated to difficulties in imagining specific events that might happen to them in the future (D’Argembeau, Raffard et Van-der-Linden, 2008). Previous study suggested that the specific autobiographical memory (past and future) may be improved by an AM remediation therapy (Blairy et al., accepted). The aim of the present study was to compare performances from individuals involved in an AM remediation intervention to individuals involved in the cognitive remediation therapy program from Brenner (IPT) (Pomini, Neis, Brenner, Hodel et Roder, 1998). The results showed that the participants tend to recall more specific events after therapies, confounded pass and future events (t(7) = 3.28 ; p = .013). These results would be promising for future research. [less ▲]

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See detailEffects of cold and warm ischemia on the mitochondrial oxidative phosphorylation of swine lung.
Willet, Katty; Detry, Olivier ULg; Lambermont, Bernard ULg et al

in Transplantation (2000), 69(4), 582-588

BACKGROUND: The aim of the study was to investigate the consequence of warm and cold ischemia on lung mitochondria in order to define bioenergetic limits within lung could be suitable for pulmonary ... [more ▼]

BACKGROUND: The aim of the study was to investigate the consequence of warm and cold ischemia on lung mitochondria in order to define bioenergetic limits within lung could be suitable for pulmonary transplantation. METHODS: Twenty-two pigs underwent lung harvesting after lung flush with Euro-Collins solution. Mitochondria were isolated from fresh lungs, from lungs submitted to 24 or 48 hr of cold ischemia, to 30 or 45 min of warm ischemia, and to 30 min of warm ischemia followed by 24 or 48 hr of cold ischemia. Mitochondrial oxidative phosphorylation parameters were determined in isolated mitochondria by in vitro measurement of oxygen consumption. RESULTS: Relative to controls, mitochondria submitted to cold ischemia showed an alteration in the oxidoreductase activities of the respiratory chain but no membrane permeability alteration. After 48 hr of cold ischemia, there was a decrease in the yield of the oxidative phosphorylation. Thirty minutes of warm ischemia did not alter the mitochondrial respiratory parameters. However, lung submitted to 45 min of warm ischemia showed mitochondrial damage as a decrease in the oxidative phosphorylation efficiency and ADP availability but no change in the oxidoreductase activities. Relative to cold ischemia alone, 30 min of warm ischemia preceding cold ischemia promoted no significant change in the respiratory parameters. CONCLUSIONS: On bioenergetic basis, lung submitted to warm ischemia could be suitable for transplantation if the warm ischemia duration does not exceed 30 min. This could be a major concern in lung procurement from non-heart beating donors. [less ▲]

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See detailEffects of cold temperatures on the early stages of maize inbreds
Riva-Roveda, Laetitia ULg; Escale, Brigitte; Giauffret, Catherine et al

Poster (2012, July)

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See detailEffects of Collective Fluctuations in 2D-ELDOR spectroscopy
Fresch, Barbara ULg; Moro, Giorgio J.

Poster (2006)

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See detailEffects of colloïdal gold either free or incorporated into liposomes on human synovial cells in culture
Lhoets-Gautier, Marie -Paule; Gillet, Marie-Claire ULg; Van Ophem P et al

in Biology of the Cell (1982, July), 45(1), 3

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See detailEffects Of Commercial Fatty-Acids On Cutinase Release By Ascochyta-Pisi
Nasraoui, B.; Lepoivre, Philippe ULg; Semal, J.

in Journal of Phytopathology-Phytopathologische Zeitschrift (1992), 136(3),

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See detailEffects of compensatory growth on animal performance and plasma metabolites in growing fattening bulls
Hornick, Jean-Luc ULg; Van Eenaeme, Christian ULg; Clinquart, Antoine ULg et al

in Proceedings of the 44th Annual Meeting of E.A.A.P. (1993)

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See detailEffects of compression on human subchondral osteoblast metabolism
Kesteloot, Frédéric ULg; Gabay, Odile; Msika, Philippe et al

Poster (2009, May 24)

Introduction. Recent data showed that subchondral bone plays an important role in osteoarthritis (OA). Metabolic and morphologic modifications in this tissue contribute to the degradation of the ... [more ▼]

Introduction. Recent data showed that subchondral bone plays an important role in osteoarthritis (OA). Metabolic and morphologic modifications in this tissue contribute to the degradation of the overlaying cartilage. It was suggested that abnormal mechanical pressure exerted onto the articulation was responsible to these changes. Here, we evaluated the effects of compression on osteoblasts from subchondral bone. Method. Osteoblasts were isolated from sclerotic (SC) or non-sclerotic (NSC) areas of human OA subchondral bone. After 28 days, osteoblasts were surrounded by their matrix. This osteoblasts-containing membrane was then placed onto a Biopress Flexercell plate and submitted to a 4h 1.67 MPa compression (1 Hz). Expression of IL-6, IL-8, COX-2, VEGF, IGF-1, OPG and RANKL was evaluated by RT-PCR. IL-6, IL-8 and PGE2 were quantified by ELISA. Results. Basal IL-6, VEGF, COX-2, IGF-1 and RANKL mRNA levels were significantly increased in SC osteoblasts as compared to NSC. By contrast, SC osteoblasts expressed less OPG than those from NSC areas. Compressions induced the expression of genes coding for IL-6, IL-8, COX-2, IGF-1, VEGF and RANKL but decreased the expression of OPG in NSC osteoblasts (p<0.01). Interestingly, compressed NSC osteoblasts expressed similar levels of these genes than SC osteoblasts. Conclusions. We show that our model of compression can induce in NSC osteoblasts a phenotype similar to this observed in sclerotic areas. Moreover, SC osteoblasts are less sensitive to mechanical stimuli than NSC osteoblasts. These results clarify the role of compression in the pathogenesis of subchondral bone sclerosis and allow new perspectives of research in this field. [less ▲]

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See detailEffects of concentrate level on milk production and traffic of grazing cows milked by a mobile automatic milking system on pasture
Lessire, Françoise ULg; Hornick, Jean-Luc ULg; Dufrasne, Isabelle ULg

in Hopkins, Alan; Collins, Rosemary; Fraser, Marieacia (Eds.) et al EGF at 50: The future of European Grasslands (2014, September 10)

Cows milked by an automatic milking system in pastures were assigned in 2 groups receiving different amounts of concentrates (2.1 kg vs 4.1 kg). The effect of concentrates’ level on milk yield (MY) and ... [more ▼]

Cows milked by an automatic milking system in pastures were assigned in 2 groups receiving different amounts of concentrates (2.1 kg vs 4.1 kg). The effect of concentrates’ level on milk yield (MY) and returns to the robot was assessed. Concentrates’ level had a positive influence on daily milk production over the grazing period as cows of low concentrates group produced 21.43 ± 0.62 kg compared with 24.33 ± 0.62 kg in high concentrates group. However this effect was modulated subsequently to grass quality and availability. Regarding daily voluntary returns to the robot, high concentrates group showed higher frequency (3.66 ± 0.05, compared with 3.22 ± 0.04 in low concentrates group) demonstrating positive impact of complement distribution on cows’ traffic. [less ▲]

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See detailEffects of concentrate level on milk production and traffic of grazing cows milked by a mobile automatic milking system on pasture
Lessire, Françoise ULg; Hornick, Jean-Luc ULg; Dufrasne, Isabelle ULg

in Hopkins, Alan; Collins, Rosemary; Fraser, Marieacia (Eds.) et al EGF at 50: The future of European Grasslands (2014, September 10)

Cows milked by an automatic milking system in pastures were assigned in 2 groups receiving different amounts of concentrates (2.1 kg vs 4.1 kg). The effect of concentrates’ level on milk yield (MY) and ... [more ▼]

Cows milked by an automatic milking system in pastures were assigned in 2 groups receiving different amounts of concentrates (2.1 kg vs 4.1 kg). The effect of concentrates’ level on milk yield (MY) and returns to the robot was assessed. Concentrates’ level had a positive influence on daily milk production over the grazing period as cows of low concentrates group produced 21.43 ± 0.62 kg compared with 24.33 ± 0.62 kg in high concentrates group. However this effect was modulated subsequently to grass quality and availability. Regarding daily voluntary returns to the robot, high concentrates group showed higher frequency (3.66 ± 0.05, compared with 3.22 ± 0.04 in low concentrates group) demonstrating positive impact of complement distribution on cows’ traffic. [less ▲]

Detailed reference viewed: 58 (5 ULg)