Diabete sucre iatrogene: l'exemple des anti-psychotiques atypiques.
Scheen, André ;
in Revue Médicale de Liège (2005), 60(5-6), 455-60
As an example of iatrogenic diabetes, we discuss the problem of diabetes mellitus in patients receiving atypical antipsychotics. The risk of diabetes mellitus appears to be different according to various ... [more ▼]
As an example of iatrogenic diabetes, we discuss the problem of diabetes mellitus in patients receiving atypical antipsychotics. The risk of diabetes mellitus appears to be different according to various molecules with, by decreasing order, clozapine, olanzapine, risperidone and quetiapine, and finally amisulpride, aripiprazole and ziprasidone. A careful analysis of published case reports and series indicates the existence of two different problems: 1) the rather common development of impaired glucose tolerance or diabetes mellitus (often associated with metabolic syndrome) related to weight gain in individuals at risk for type 2 diabetes; and 2) the occurrence of rare cases of acute metabolic episodes with severe ketoacidosis and/or pancreatitis whose pathophysiological mechanisms remain largely unknown. Generally speaking, the pathophysiology involves both increased insulin resistance and deficient insulin secretion. Cautious metabolic monitoring of patients receiving atypical antipsychotics is recommended, and the selection of the appropriate drug should be influenced by the metabolic profile of the various molecules and the metabolic risk of the patients who should be treated with atypical antipsychotics. [less ▲]Detailed reference viewed: 239 (1 ULg)
Le diabete sucre: une maladie exemplative a bien des egards. Preambule.
Scheen, André ; Kulbertus, Henri
in Revue Médicale de Liège (2005), 60(5-6), 269-72Detailed reference viewed: 48 (2 ULg)
Diabète, hypertension artérielle et angiopathie: comparaison chez les patients diabétiques insulino-dépendants et non insulino-dépendants.
PAQUOT, Nicolas ; SCHEEN, André ; et al
in Archives des Maladies du Coeur et des Vaisseaux (1991), 84(suppl 1), 35Detailed reference viewed: 16 (0 ULg)
Diabète, hypertension artérielle et insuffisance rénale
Conference (2003, April 17)Detailed reference viewed: 3 (0 ULg)
Le diabete: de la connaissance clinique a la preoccupation de sante publique.
in Journal de la Société de Biologie (2007), 201(2), 133-40
Diabetes mellitus is a chronic disease whose prevalence is increasing worldwide. It remains associated with a high risk of severe complications, essentially micro- and macro-vascular complications. Type 1 ... [more ▼]
Diabetes mellitus is a chronic disease whose prevalence is increasing worldwide. It remains associated with a high risk of severe complications, essentially micro- and macro-vascular complications. Type 1 diabetes is an auto-immune disease that leads to the destruction of insulin-secreting B cells and therefore requires an intensive optimised exogenous insulin therapy. Type 2 diabetes is a polygenic disease whose expression is favoured by inadequate lifestyle, leading to obesity. It combines a relative insulin secretory defect and insulin resistance, the latter being associated with various other cardiovascular risk factors. Treatment consists of lifestyle modifications first, then the prescription of various glucose-lowering oral drugs and finally, when requested, insulin therapy. A multi-risk intervention is mandatory to improve the cardiovascular prognosis. The prevention of diabetes and its complications is a major public health objective. [less ▲]Detailed reference viewed: 50 (0 ULg)
Diabetes does not influence treatment decisions regarding revascularization in patients with stable coronary artery disease
; ; et al
in Diabetes Care (2006), 29(9), 2003-2011
OBJECTIVE - To evaluate whether in stable angina preference for coronary revascularization by either percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) is influenced by ... [more ▼]
OBJECTIVE - To evaluate whether in stable angina preference for coronary revascularization by either percutaneous coronary intervention (PCI) or coronary artery bypass surgery (CABG) is influenced by diabetes status and whether this has prognostic implications. RESEARCH DESIGN AND METHODS - A total of 2,928 consecutive patients with stable angina who were enrolled in the prospective Euro Heart Survey on Coronary Revascularization were studied. Multivariable analyses were applied to evaluate the relation between diabetes, treatment decision, and 1-year outcome. RESULTS - Diabetes was documented in 587 patients (20%) who had more extensive coronary disease. Revascularization was intended in 74% of patients with diabetes and in 77% of those without diabetes. In patients selected for revascularization, CABG was intended in 35% of diabetic and in 33% of nondiabetic patients. Multivariable analyses did not change these findings, but in some subgroups diabetes influenced treatment decisions. For example, diabetic subjects with mild heart failure had more often intended revascularization (91%) than those without diabetes (67%, P < 0.001). Treatment decisions in patients with more extensive (left main, multivessel, or proximal left anterior descending artery) disease were not influenced by diabetes status. Diabetes was not associated with an increased incidence of all-cause death, nonfatal cerebrovascular accident, or nonfatal myocardial infarction at 1 year, regardless of preferred treatment. The incidence of the combined end points was 7.3% in diabetic and 6.8% in nondiabetic patients (adjusted hazard ratio 1.0 [95% CI 01.7-1.41]). CONCLUSIONS - in stable angina, treatment decisions regarding revascularization or the choice for CABG or PCI were not influenced by the presence of diabetes. Diabetes was not associated with a poor prognosis. [less ▲]Detailed reference viewed: 8 (0 ULg)
Diabètes iatrogènes : importance d’une analyse critique du rapport bénéfices/risques des traitements en cause
in Médecine des Maladies Métaboliques (2015), 9(3), 1-3Detailed reference viewed: 30 (5 ULg)
Diabetes is a risk factor for knee osteoarthritis progression
; ; et al
in Osteoarthritis and Cartilage (2015), 23
Purpose Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology ... [more ▼]
Purpose Recent studies have suggested that metabolic factors (obesity, diabetes, hypertension and dyslipidemia) and their clustering in metabolic syndrome (MetS) might be involved in the pathophysiology of knee osteoarthritis (OA). We investigated their impact on radiographic progression by an annualised measure of the joint space narrowing (JSN) of the medial tibiofemoral compartment. Methods 559 patients older than 50 years with symptomatic knee OA were recruited for the placebo arm of the SEKOIA trial. The presence of diabetes, hypertension and dyslipidemia was determined at baseline interview. BMI was calculated, obesity was considered >30 kg/m2. MetS was defined by the sum of metabolic factors ≥3. Minimal medial tibiofemoral joint space on plain radiographs was measured by an automated method at baseline and then annually for up to 3 years. Results The mean age of patients was 62.8 [62.2-63.4] years; 392 were women. A total of 43.8% was obese, 6.6% had type 2 diabetes, 45.1% hypertension, 27.6% dyslipidemia and 13.6% MetS. Mean annualised JSN was greater for patients with type 2 diabetes than without diabetes (0.26 [-0.35 - -0.17] vs. 0.14 [-0.16 - -0.12] mm; p=0.001). This association remained significant after adjustment for sex, age, BMI, hypertension and dyslipidemia (p=0.018). In subgroup analysis, type 2 diabetes was a significant predictor of JSN in males but not females. The other metabolic factors and MetS were not associated with annualised JSN. Conclusion Type 2 diabetes was a predictor of joint space reduction in men with established knee OA. No relationships were found between MetS or other metabolic factors and radiographic progression. [less ▲]Detailed reference viewed: 22 (10 ULg)
Diabetes is still a risk factor for restenosis after drug-eluting stent in coronary arteries.
Scheen, André ; Warzee, Fabian
in Diabetes Care (2004), 27(7), 1840-1Detailed reference viewed: 9 (0 ULg)
Diabetes mellitus in the elderly: insulin resistance and/or impaired insulin secretion?
in Diabètes & Métabolism (2005), 31 Spec No 2
Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function ... [more ▼]
Elderly people are more glucose intolerant and insulin resistant than young individuals, and many of them will develop type 2 diabetes. It remains, however, controversial whether this decrease in function is due to an inevitable consequence of "biological aging" or due to environmental or lifestyle variables. Indeed, increased adiposity/altered fat distribution, decreased fat free mass/abnormal muscle composition, poor dietary habits and physical inactivity all contribute to reduce insulin sensitivity. Insulin resistance in elderly people appears to predominate in skeletal muscle, whereas hepatic glucose output seems to be almost unaffected. Several abnormalities in islet beta-cell and insulin secretion were also pointed out in elderly people such as increased amyloid deposition and decreased amylin secretion, impaired insulin secretion pulsatility, decreased insulin sensitivity of pancreatic beta-cells to insulinotropic gut hormones and diminished insulin response to non-glucose stimuli such as arginine. Controversial results were reported concerning the effects of aging on absolute insulin secretion in response to oral or intravenous glucose. However, insulin secretion appears to decrease with age, with significantly diminished beta-cell sensitivity and acute insulin response to glucose, provided it is analyzed relative to concomitant decreased insulin sensitivity. Thus, there is an interplay between decreased insulin secretion and increased insulin resistance that largely explains the abnormal glucose metabolism seen in elderly. Weight loss, especially reduction of abdominal adiposity, and increased physical activity may contribute to improve insulin sensitivity and glucose tolerance, and prevent the development of type 2 diabetes in elderly people. [less ▲]Detailed reference viewed: 48 (0 ULg)
Diabètes secondaires à une endocrinopathie.
; Betea, Daniela ; Daly, Adrian et al
in Revue Médicale de Liège (2005), 60(5-6), 442-447
Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal ... [more ▼]
Diabetes mellitus may occur in association with endocrine disorders and is termed "other causes of diabetes" by the American Diabetes Association. Hyperglycaemia results from sustained excessive hormonal secretion, which alters insulin secretion or action. It is characterized by the absence of ketosis because of the persistence of endogenous insulin secretion. Diabetes is usually reversible with successful treatment of the underlying endocrine disorder and the correction of hormonal overproduction. Most important endocrine diseases associated with diabetes mellitus are briefly described and the underlying mechanisms of glucose abnormalities are discussed. [less ▲]Detailed reference viewed: 247 (0 ULg)
Diabetes: Time for reconciliation between cardiologists and diabetologists.
in Nature Reviews. Cardiology (2016)Detailed reference viewed: 11 (1 ULg)
Diabetogenic coxsackievirus B4 modifies cytokine secretion by human thymic epithelial cells
; ; et al
in Diabetologia (2000), 43 (Suppl. 1)Detailed reference viewed: 14 (0 ULg)
"Les Diables rouges sont-ils instrumentalisés en politique ?"
Article for general public (2016)
"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de ... [more ▼]
"Les hommes politiques flamands - dont tous les partis se réfèrent à la nation flamande- sont en porte-à-faux avec le "fait belge". On perçoit que la N-VA a donné comme consigne à ses militants de s’abstenir. Ils ne vont pas s’enthousiasmer un drapeau tricolore à la main. Il y a une évidente contradiction entre leur vision flamande avant tout et la diversité et le bilinguisme qu’affichent les Diables." [less ▲]Detailed reference viewed: 30 (4 ULg)
"Diabolo Manques" - Une exploration à la découverte de soi - Rapport d'évaluation de la première année
Grignard, Sophie ; Vandoorne, Chantal
Report (2000)Detailed reference viewed: 20 (11 ULg)
"Diabolo Manques" - Une exploration à la découverte de soi - Rapport d'évaluation de la quatrième année
; Vandoorne, Chantal
Report (2003)Detailed reference viewed: 32 (3 ULg)
"Diabolo Manques" - Une exploration à la découverte de soi - Rapport d'évaluation de la troisième année
; Grignard, Sophie ; Vandoorne, Chantal
Report (2002)Detailed reference viewed: 39 (12 ULg)