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See detailEfficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial
Sandor, P. S.; Di Clemente, L.; Coppola, G. et al

in Neurology (2005), 64(4), 713-715

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double ... [more ▼]

Riboflavin, which improves energy metabolism similarly to coenzyme Q10 (CoQ10), is effective in migraine prophylaxis. We compared CoQ10 (3 x 100 mg/day) and placebo in 42 migraine patients in a double-blind, randomized, placebo-controlled trial. CoQ10 was superior to placebo for attack-frequency, headache-days and days-with-nausea in the third treatment month and well tolerated; 50%-responder-rate for attack frequency was 14.4% for placebo and 47.6% for CoQ10 (number-needed-to-treat: 3). CoQ10 is efficacious and well tolerated. [less ▲]

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See detailEfficacy of D-Hormones in primary and corticosteroid-induced osteoporosis: a meta-analysis of their effects on bone mineral density and fracture rate
Richy, Florent; Reginster, Jean-Yves ULg

in Osteoporosis International (2002, November), 13(Suppl.3), 21

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See detailEfficacy of diatomaceous earth formulations admixed with grain against populations of Tribolium castaneum
Arnaud, Ludovic; Lan, H. Tran Thi; Brostaux, Yves ULg et al

in Journal of Stored Products Research (2005), 41(2), 121-130

The efficacy of diatomaceous earth (DE) to control stored-products Coleoptera on stored grain was examined against several populations of the red flour beetle, Tribolium castaneum (Herbst). Four ... [more ▼]

The efficacy of diatomaceous earth (DE) to control stored-products Coleoptera on stored grain was examined against several populations of the red flour beetle, Tribolium castaneum (Herbst). Four commercially available DE formulations were tested: INSECTO(R), Perma-Guard(TM), Protect-It(R) and the diatomite used for the production of Dryacide(R), each at six concentrations (100-1000ppm). A great variation of efficacy was observed among the DE formulations tested. Protect-It at concentrations up to 400 ppm was found to be the most effective formulation to control red flour beetle populations. However, a concentration of 1000 ppm of Protect-It was necessary to control all adults of all populations. Most T castaneum populations, except one from Ivory Coast (Asm), were more than 90% controlled with INSECTO and Dryacide DE at 600 ppm. At this concentration, about 88% and 22% Asm adults died with INSECTO and Dryacide DE, respectively. Perma-Guard was the least efficient DE formulation to control T castaneum adults with three populations exhibiting some survival at 1000 ppm. Reduced susceptibility to DE was observed in two populations, Asm and Lab susceptible from Kansas (Lab-S). As neither population had been previously exposed to DE, it is suggested that red flour beetles may naturally vary in susceptibility to DE. In addition, it was found that some populations can be satisfactorily controlled with some DE formulations but not with others. (C) 2003 Elsevier Ltd. All rights reserved. [less ▲]

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See detailEfficacy of Erlotinib in patients (PTS) with advanced non-small-cell lung cancer (NSCLC) relative to clinical charesteristics : subset analyses from the trust study
Allan, S.; BOSQUEE, Léon ULg; Franke, A. et al

in American Journal of Clinical Oncology (2008), 26(20),

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See detailEfficacy of errorless learning in the acquisition of a new procedural skill in Alzheimer's disease
Schmitz, Xavier ULg; Lejeune, Caroline ULg; Vervecken, Nancy et al

Poster (2011, May 27)

In Alzheimer’s disease (AD), implicit or procedural rehabilitation techniques would be more effective to train new skills than explicit or declarative learning methods (van Halteren-van Tilborg, 2007 ... [more ▼]

In Alzheimer’s disease (AD), implicit or procedural rehabilitation techniques would be more effective to train new skills than explicit or declarative learning methods (van Halteren-van Tilborg, 2007). Following Baddeley and Wilson (1994)’s assumption, Maxwell et al. (2001) showed that reducing errors during motor learning minimizes the building of declarative knowledge and would allow implicit knowledge accumulation. However, most studies on errorless learning focused on learning of face-name associations (Clare et al., , 2001), and very few studies have investigated errorless learning in procedural learning situations, even though some data suggest that errorless learning would be efficient for learning instrumental activities of daily living (e.g., Thivierge et al., 2008). The aim of this study was to examine the efficacy of an error-reducing versus an errorfull method in motor skill learning. We examined the acquisition of a new motor skill in 24 patients with AD and 24 healthy older adults matched for age, sex, and education. In this task, subjects had to follow with a reversed mouse the contour of a form (a star) displayed on a computer screen. Half the subjects learned in an error-reducing condition, and the others in an errorfull condition. After the learning phase, all the subjects had to complete a novel form. Results show an advantage for the error-reducing condition in the AD group, whereas the performance of the healthy participants did not differ between the two conditions, confirming the efficiency of errorless learning principles in AD for procedural learning situations. [less ▲]

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See detailEfficacy of FDG PET/CT for diagnosing synchronous tumors and metastases in head and neck tumors : Initial results and evaluation.
MINON, AL.; DEMEZ, Pierre ULg; MOREAU, Pierre ULg et al

in Journal of Nuclear Medicine (The) (2011), 52(SUPPL), 1863

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See detailThe efficacy of glucosamine sulfate in osteoarthritis: Financial and nonfinancial conflict of interest
Reginster, Jean-Yves ULg

in Arthritis and Rheumatism (2007), 56(7), 2105-2110

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See detailEfficacy of heroin-assisted treatment in Belgium: a randomised controlled trial
Demaret, Isabelle ULg; Quertemont, Etienne ULg; Litran, Géraldine et al

in European Addiction Research (in press)

Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT ... [more ▼]

Background/Aims: Heroin-assisted treatment (HAT) can improve the condition of heroin addicts still using street heroin after a methadone treatment. In Belgium, a new trial compared the efficacy of a HAT to existing methadone maintenance treatment. Methods: In this randomised controlled trial, HAT was limited to 12 months. Participants were assessed every 3 months. They were responders if they showed improvement on the level of street heroin use, health or criminal involvement. Results: 74 participants were randomised in the trial. The experimental group (n=36) counted 30% of responders more than the control group (n=38) at each assessment point (p<0.05), except at 12 months where the difference (11%) was no longer significant (p=0.35). Still, after 12 months, participants in the experimental group reported significantly greater improvements (p<0.05) than the control group on the level of street heroin use and on the level of physical and mental health. Both groups reported significantly less criminal facts after 12 months (p<0.001), but with no significant difference between the groups. Conclusions: This trial confirms the short-term efficacy of HAT for severe heroin addicts, who already failed methadone treatment. [less ▲]

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See detailEfficacy of indapamide SR compared with enalapril in elderly hypertensive patients with type 2 diabetes.
Puig, Juan Garcia; Marre, Michel; Kokot, Franciszek et al

in American Journal of Hypertension : Journal of the American Society of Hypertension (2007), 20(1), 90-7

BACKGROUND: Blood pressure control is the main influential variable in reducing microalbuminuria in patients with type 2 diabetes. In this subanalysis of the Natrilix SR versus Enalapril Study in ... [more ▼]

BACKGROUND: Blood pressure control is the main influential variable in reducing microalbuminuria in patients with type 2 diabetes. In this subanalysis of the Natrilix SR versus Enalapril Study in hypertensive Type 2 diabetics with micrOalbuminuRia (NESTOR) study, we have compared the effectiveness of indapamide sustained release (SR) and enalapril in reducing blood pressure and microalbuminuria in patients > or =65 years of age. METHODS: Of the 570 hypertensive patients with type 2 diabetes and persistent microalbuminuria in the NESTOR study, 187 (33%) individuals > or =65 years of age were included in this analysis. Of these, 95 patients received indapamide SR 1.5 mg and 92 patients received enalapril 10 mg, taken once daily in both cases. Adjunctive amlodipine and/or atenolol was added if required. RESULTS: The urinary albumin-to-creatinine ratio decreased by 46% in the indapamide SR group and 47% in the enalapril group. Noninferiority of indapamide SR over enalapril was demonstrated (P = .0236; 35% limit of noninferiority) with a ratio of 0.95 (95% CI: 0.68, 1.34). Mean arterial pressure decreased by 18 mm Hg and 15 mm Hg in the indapamide SR and the enalapril groups, respectively (P = .1136). The effects of both treatments seen in these elderly patients were similar to those observed in the main population, although the extent of the reduction in microalbuminuria was slightly higher. Both treatments were well tolerated, and no difference between groups was observed regarding glucose or lipid profiles. CONCLUSION: Indapamide SR is not less effective than enalapril in reducing microalbuminuria and blood pressure in patients aged >65 years of age with type 2 diabetes and hypertension. [less ▲]

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See detailEfficacy of interferon-based antiviral therapy in patients with chonic hepatitis C infected HCV genotype 5: a meta-analysis of two large prospective clinical trials
D'Heygere, F.; George, C.; Van Vlierberghe, H. et al

in Journal of Medical Virology (2011), 83(5), 815-819

The characteristics and response rate to pegylated interferon and ribavirin (PEG-INF + RBV) of patients with chronic hepatitis C infected with genotype 5 are poorly documented. A meta-analysis of two ... [more ▼]

The characteristics and response rate to pegylated interferon and ribavirin (PEG-INF + RBV) of patients with chronic hepatitis C infected with genotype 5 are poorly documented. A meta-analysis of two large phase III/IV prospective randomized clinical trials conducted in Belgium in patients with chronic hepatitis C (n = 1,073 patients) was performed in order to compare the response to antiviral therapy of hepatitis C virus (HCV) genotype 5 with that of other HCV genotypes. A subset of HCV-1 infected patients selected from within the study database were selected to match the HCV-5 sample for known prognostic factors. In Belgium HCV-5 is responsible for a significant minority of cases of chronic hepatitis C CHC (4.5%) and is characterized by a more advanced age (58.4 years), a high frequency of cirrhosis (27.7%), a specific mode of HCV acquisition, and a particular geographic origin (66.7% of patients from West Flanders). The primary comparative analysis showed that response to treatment with PEG-INF + RBV of HCV-5 is similar to HCV-1 and lower compared to HCV-2/3. The analysis of the matched patient subgroup demonstrates that the HCV-5 "intrinsic sensitivity" to PEG-IFN + RBV therapy is identical to HCV-1, with a sustained virological response of 55% in both groups. In contrast to previous publications, this meta-analysis suggests that HCV-5 response to treatment is closer to HCV-1 than to HCV-2/3 and suggests that in Belgium HCV-5 infection should be treated with the same antiviral regimen as HCV-1. [less ▲]

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See detailEfficacy of intrasinusal administration of bifonazole cream alone or in combination with enilconazole irrigation in canine sino-nasal aspergillosis: 17 cases.
Billen, Frédéric ULg; Guieu, L. V.; Bernaerts, F. et al

in Canadian Veterinary Journal = Revue Vétérinaire Canadienne (2010), 51

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See detailEfficacy of ivermectin and levamisole against immature Dictyocaulus viviparus in cattle
Pouplard, L.; Lekeux, Pierre ULg; Detry, M.

in Veterinary Record : Journal of the British Veterinary Association (1986), 118

Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six ... [more ▼]

Eighteen calves aged approximately three months were each infected with Dictyocaulus viviparus larvae at a rate of 30/kg bodyweight. Seven days later they were randomly allocated to three groups of six animals. Calves of group 1 were controls. Calves of group 2 were given levamisole at a dose rate of 10 mg/kg and calves of group 3 were given ivermectin at a dose rate of 200 micrograms/kg. The anthelmintic activity of these two drugs was compared using clinical, functional, parasitological and pathological parameters. The results showed that the efficacy of ivermectin, given at a therapeutic dose, against immature D viviparus was higher than that of levamisole, given at double the recommended dose [less ▲]

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See detailEfficacy of long-term treatment of Paget’s disease with tiludronate 400 mg/day
Combe, B; Audran, M; Sebert, JL et al

in Journal of Bone and Mineral Research (1996), 11(S1), 372

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See detailThe efficacy of medical and surgical treatment of endometriosis-associated infertility: arguments in favour of a medico-surgical aproach
Donnez, Jacques; Chantraine, Frédéric ULg; Nisolle, Michelle ULg

in Human Reproduction Update (2002), 8(1), 89-94

This review discusses the efficacy of a combined, medical (GnRH agonist) and surgical, therapy in endometriosis- associated infertility. Because of the limited information currently available on the ... [more ▼]

This review discusses the efficacy of a combined, medical (GnRH agonist) and surgical, therapy in endometriosis- associated infertility. Because of the limited information currently available on the activity of lesions in minimal and mild endometriosis, any absolute statement is inappropriate at this time, although some arguments exist in favour of treating endometriosis at laparoscopy. In moderate and severe endometriosis, this review provides arguments in favour of a medico-surgical approach and discusses the possibility of combining medical and surgical therapy. [less ▲]

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See detailEfficacy of monthly oral ibandronate is maintained over 5 years: The MOBILE LTE study.
Felsenberg, D.; Czerwinski, E.; Stakkestad, J. et al

in Osteoporosis International (2009, March), 20(Suppl.1), 15

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See detailEfficacy of monthly oral ibandronate is sustained over 5 years: the MOBILE long-term extension study.
Miller, P. D.; Recker, R. R.; Reginster, Jean-Yves ULg et al

in Osteoporosis International (2011)

The long-term efficacy and safety of once-monthly ibandronate were studied in this extension to the 2-year Monthly Oral Ibandronate in Ladies (MOBILE) trial. Over 5 years, lumbar spine bone mineral ... [more ▼]

The long-term efficacy and safety of once-monthly ibandronate were studied in this extension to the 2-year Monthly Oral Ibandronate in Ladies (MOBILE) trial. Over 5 years, lumbar spine bone mineral density (BMD) increased from baseline with monthly ibandronate 150 mg (8.4%). Long-term monthly ibandronate is effective and well tolerated for up to 5 years in women with postmenopausal osteoporosis. INTRODUCTION: Once-monthly therapy with ibandronate has been studied for up to 5 years in a long-term extension (LTE) to the 2 year MOBILE trial. METHODS: This multicenter, double-blind extension study of monthly ibandronate involved postmenopausal women who had completed 2 years of the MOBILE core study, with >/=75% adherence. Patients were reallocated, or were randomized from daily therapy, to ibandronate 100 mg monthly or 150 mg monthly for a further 3 years. RESULTS: A pooled intent-to-treat (ITT) analysis of 344 patients receiving monthly ibandronate from the core MOBILE baseline showed increases over 5 years in lumbar spine BMD (8.2% with 100 mg and 8.4% with 150 mg). Three-year data relative to MOBILE LTE baseline in the full ITT population of all 698 patients randomized or reallocated from MOBILE (including those previously on daily treatment) showed, on average, maintenance of proximal femur BMD gains achieved in the core 2-year study, with further small gains in lumbar spine BMD. In general, maintenance of efficacy was also indicated by markers of bone metabolism. CONCLUSIONS: There were no tolerability concerns or new safety signals. Monthly treatment with ibandronate 100 and 150 mg is effective and well tolerated for up to 5 years in women with postmenopausal osteoporosis. [less ▲]

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See detailEfficacy of nonsteroidal antiinflammatory drugs in postoperative pain
Joris, Jean ULg

in Acta Anaesthesiologica Belgica (1996), 47(3), 115-123

Historically, NSAIDs, used for more than 25 years to treat rheumatologic diseases, were then introduced to relieve pain after tooth extraction, and finally about 10 years ago for postoperative analgesia ... [more ▼]

Historically, NSAIDs, used for more than 25 years to treat rheumatologic diseases, were then introduced to relieve pain after tooth extraction, and finally about 10 years ago for postoperative analgesia. NSAIDs have been increasingly used over the past ten years in the treatment of postoperative pain, such that they now play an important role in the management of postoperative analgesia, either alone or combined with opioids. When used alone, they are effective in relieving minor or moderate pain such as that seen after maxillofacial, minor orthopedic, or some ambulatory surgical procedures, and postpartum pain (episiotomy). In these indications, the main benefit as compared with opioids is the lack of respiratory depression, nausea and vomiting. Since these side effects delay discharge from the hospital after ambulatory surgery, the use of NSAIDs may result in faster recovery and earlier discharge. Because of the ceiling effect of NSAIDs, their efficacy as sole agents is usually insufficient to treat pain after major surgery (orthopedic, abdominal, thoracic). NSAIDs should then be combined with opioids. As part of a balanced analgesia regimen, NSAIDs will allow for opioid-sparing, and might subsequently reduce opioid-mediated side effects. A 20 to 50% reduction in opioid consumption, sometimes with improved quality of analgesia, has been reported using different NSAIDs following various types of surgery. Better respiratory function, improved sleep quality, and faster recovery of gastrointestinal function have been reported with NSAIDs. However, the use of NSAIDs has not been shown to be associated with improved outcome or more rapid recovery. [less ▲]

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See detailEfficacy of once-yearly zoledronic acid 5 mg in men with osteoporosis with different levels of serum total testosterone
Boonen, S; Reginster, Jean-Yves ULg; Kaufman, JM et al

in Osteoporosis International (2012, March), 23(S2), 79-80

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See detailEfficacy of powdered maize cobs against the maize weevil Sitophilus zeamais (Coleoptera: Curculionidae) in stored maize in Senegal
Gueye, Talla Momar; Cissokho, Papa Seyni; Goergen, Georg et al

in International Journal of Tropical Insect Science (2012)

Powdered maize cobs were tested as an alternative for pesticide use in stored maize. Five doses (2, 4, 6, 8 and 10 g/250 g seed) of powdered maize cobs applied at particle sizes of 1.4 and 0.4mm diameter ... [more ▼]

Powdered maize cobs were tested as an alternative for pesticide use in stored maize. Five doses (2, 4, 6, 8 and 10 g/250 g seed) of powdered maize cobs applied at particle sizes of 1.4 and 0.4mm diameter were compared with actellic powder against Sitophilus zeamais Motschulsky for 120 days. Mortality and survival data showed that cob powders did not act as fumigant but exerted a potent inhibition of progeny on direct contact with S. zeamais adults. The particle size of powdered cobs had no effect on maize damage and losses. At doses equal to or higher than 6 g powdered maize cobs/250 g grain maize, i.e. 2.4% (w/w), damage to grain was ,5% and weight losses ,1%. The protection offered at the highest dose was comparable to the pesticide control. The use of powdered maize cobs is discussed as a natural alternative to synthetic pesticides for protection of maize against S. zeamais. [less ▲]

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